*CHEMISTRY 436

GENERAL BIOCHEMISTRY II

SPRING2017

Instructor: Duane Smith, Jr., Ph.D., M.B.A.Course Section: CHEM 436 – 1M

Office: Beauregard 134Meeting Room: BEA 210

Office Hours: MWF10:45 a.m. – 12:45p.m.Meeting Time: MWF 7:30 – 8:25 a.m.

TR 9:00 a.m. – 12:00 noon

(or as arranged)

Phone: (985) 448-4165Email:

COURSE DESCRIPTION: *CHEM 436. Biochemistry II. 3-3-0. Prerequisite: CHEM 435. Pentose phosphate pathway; gluconeogenesis, metabolism of glycogen, fatty acids and amino acids; urea cycle; photosynthesis; biosynthesis of membrane lipids; steroids; amino acids; heme, nucleotides and integration of metabolism. (26.0202)

PRE- & CO-REQUISITES: Prerequisite – Chemistry 435

REQUIRED TEXT: Biochemistry: A Short Course, 3rd., Tymoczko, Berg, and Stryer, 2015, W.H. Freeman Co., New York (ISBN–13: 978-1-4641-2613-0, ISBN-10: 1-4641-2613-5)

Case Report - Handouts.

COURSE GOAL: To provide students with an understanding of the basic principles of biochemistry.

STUDENT OUTCOME OBJECTIVES: Upon successful completion of this course, the students will have content knowledge in these general subject areas:

  1. Structure and function of cell membranes
  2. Signal transduction pathways
  3. Cellular metabolism and energy transformation
  4. Photosynthesis and energy transformation

* CHEM 436 may be taken for graduate level credit; however to receive graduate level credit, the student must also successfully complete a 10-page research paper over one of the following content areas, and present a class lecture (45 minutes) over that topic area.

COURSE CONTENT:

  1. Membrane structure and function
  2. Receptor-mediated cell signaling
  3. Signal transduction cascades
  4. Photosynthesis
  5. Basic metabolic pathways in
  6. Glycolysis
  7. Citric acid cycle
  8. Oxidative phosphorylation
  9. Pentose phosphate shunt and gluconeogenesis

METHOD OF EVALUATION:

Grades will be based on a 10-point grading scale.

90 – 100A

80 – 89B

70 – 79C

60 – 69D

< 60F

Grades will be based on the average of four exams,fourcasestudy reports, and a Final Comprehensive Exam. The case study reports and presentation will count as 20% of final grade. This grading policy may be amended due to any unforeseen changes in schedule.

COLLEGE AND CLASSROOM POLICIES:

Absence and Drop/Adds – Absences amounting to the equivalent of 10% of class time, whether consecutive or not, are grounds for the student being dropped from the course. You are expected to be present, prepared, and alert at all sessions. The responsibility for withdrawing from the course, if you decide not to continue, lie completely with the student. Failure to drop a course by the final deadline will result in your receiving a grade of “F”. The last day to drop the course with a “W” is Friday, March 24, 2017.

If a student misses a class, he or she is still responsible for the material covered during that class period. If a student misses an exam, a makeup will not be given unless the student notifies the instructor in advance of his or her absence. If no advance notice is given, the student must provide documentation as to the reason for having been absent, such as death of a close family friend (death notice), illness (doctor’s bill), or court appearance (summons).

Please notify the Instructor if you have a disability, so accommodations can be made. If you have a documented disability that requires assistance, you will need to register with the office of Disability Services for coordination of your academic accommodations. The Office of Disability Services is located in Peltier Hall, Room 100-A. The phone number is (985) 448-4430 (TDD 449-7002).

ACADEMIC GRIEVANCES: The proper procedure for filing a grade appeal or grievances related to other academic matters is listed in Section 5 of the Code of Student Conduct and at the following link:

CONTINUED LEARNING FOLLOWING AN EXTREME EMERGENCY: In order to make continued learning possible following an extreme emergency, students are responsible for:

  • reading regular emergency notification on the NSU website;
  • knowing how to use and access Moodle (or university designated electronic delivery system);
  • being familiar with emergency guidelines;
  • evacuating with textbooks and other course materials;
  • knowing their Moodle (or designated system) student login and password;
  • contacting faculty regarding their intentions for completing the course.

Faculty are responsible for:

  • their development in the use of the Moodle (or designated) software;
  • having a plan for continuing their courses using only Moodle and email;
  • continuing their course in whatever way suits the completion of the course best, and being creative in the continuation of these courses;
  • making adjustments or compensations to a student’s progress in special programs with labs, clinical sequences or the like, only in the immediate semester following the emergency.

Academic dishonesty will not be tolerated. The University’s Academic Honesty Policy, as stated in the “Code of Student Conduct” booklet will be followed.

No audible beepers,cellphones, or laptops will be allowed in class. Be sure that these devices are turned off as you enter the classroom. These devices are a distraction to the instructor as well as your classmates. If there is an emergency and you need to respond please let the instructor know of this before the class starts.

THIS SYLLABUS, IN NO WAY, IS TO BE MISCONSTRUED AS A CONTRACT, AND MAY BE AMENDED BY THE INSTRUCTOR AS DEEMED NECESSARY.

OUTLINE OF TOPICS

CHAPTER(S)POINTS

16 Glycolysis

17Gluconeogenesis

18 Preparation for the Citric Acid Cycle

EXAM 1 (Fri., Feb. 10)100

19 Harvesting Electrons

20 The Electron Transport Chain

21 The Proton-Motive Force

22 Photosynthesis: The Light Reactions

23 The Calvin Cycle

EXAM 2 (Weds., Mar. 15)100

Last day to drop course with a “W” grade is Friday,Mar. 24, 2017

33 The Structure of Informational macromolecules: DNA and RNA

34 DNA Replication

35 DNA Repair and Recombination

EXAM 3 (Fri., Apr. 7)100

37 Gene Expression in Eukaryotes

39 The Genetic Code

40 The Mechanism of Protein Synthesis

EXAM 4 (Weds., May. 3)100

COMPREHENSIVE FINAL EXAM (Weds., Mar. 10)100

CASE REPORTS100

TOTAL POINTS600

Monday – Wednesday – Friday

Date / Topic / Date / Topic / Date / Topic
Jan. 16 / Martin Luther King Holiday / Jan. 18 / Chapter 14 &15:
Metabolism Overview / Jan. 20 / Chapter 14 &15:
Metabolism Overview
Jan. 23 / Chapter 16:
Glycolysis / Jan. 25 / Chapter 16:
Glycolysis / Jan. 27 / Chapter 16 Case Study: Glycolysis and Gluconeogenesis
Jan. 30 / Chapter 17.
Gluconeogenesis / Feb. 1 / Chapter 17.
Gluconeogenesis / Feb. 3 / Chapter 18:
Preparation for the Citric Acid Cycle
Feb. 6 / Chapter 18:
Preparation for the Citric Acid Cycle / Feb. 8 / Chapter 17 Case Study: The Citric Acid Cycle / Feb. 10 / Exam 1
(Chpts 14-18)
Feb. 13 / Chapter 19:
Harvesting Electrons / Feb. 15 / Chapter 20.
The Electron Transport Chain / Feb. 17 / Chapter 20.
The Electron Transport Chain
Feb. 20 / Chapter 20.
The Electron Transport Chain / Feb. 22 / Chapter 18 Case Study: Oxidative Phosphorylation / Feb. 24 / Chapter 21.
The Proton-Motive Force
Feb. 27 / Chapter 21.
The Proton-Motive Force / Mar. 1 / Chapter 22
The Light Reactions / Mar. 3 / Chapter 22
The Light Reactions
Mar. 6 / Chapter 19 Case Study: The Light Reactions / Mar. 8 / Chapter 23
The Calvin Cycle / Mar. 10 / Chapter 23
The Calvin Cycle
Mar. 13 / Chapter 20 Case Study: Pentose Phosphate Pathway / Mar. 15 / Exam 2
(Chpts 19-23) / Mar. 17 / Chapter 33.
The Structure of Informational Macromolecules- DNA and RNA
Mar. 20 / Chapter 33.
The Structure of Informational Macromolecules- DNA and RNA / Mar. 22 / Chapter 34.
DNA Replication / Mar. 24 / Chapter 34.
DNA Replication
Mar. 27 / The Double Stranded Helix - Presentations / Mar. 28 / Chapter 35.
DNA Repair and Recombination / Mar. 31 / Chapter 35.
DNA Repair and Recombination
Apr. 3 / Chapter 36. / Apr. 5 / Chapter 36. / Apr. 7 / EXAM 3
(Chpts 33-36)
Apr. 10 / Chapter 37.
Gene Expression in Eukaryotes / Apr. 12 / Chapter 37.
Gene Expression in Eukaryotes / Apr. 14 / GOOD FRIDAY
Apr. 17 / EASTER BREAK / Apr. 19 / EASTER BREAK / Apr. 21 / EASTER BREAK
Apr. 24 / Chapter 39.
The Genetic Code / Apr. 26 / Chapter 39.
The Genetic Code / Apr. 28 / Chapter 40.
The Mechanism of Protein Synthesis
May 1 / Chapter 40.
The Mechanism of Protein Synthesis / May 3 / EXAM 4
(Chpts 37,39,40) / May 5 / FINALS
May 8 / . FINALS / May 10 / COMPREHENSIVE FINAL EXAM / May 11
(THURSDAY)
Grades Due 9:00 am