Table S5: The Top 51 pathways associated with systemic progression by Ingenuity Pathway Analysis.
Pathwayp-Value Number of Number of
genes from genes from data pathway
PI3K/AKT Signaling 1.26E-1626144
Aryl Hydrocarbon Receptor Signaling1.26E-1424147
p53 Signaling1.00E-131987
Apoptosis Signaling6.31E-1320111
TGF-β Signaling1.26E-1219106
PTEN Signaling3.98E-1219109
IGF-1 Signaling1.58E-101690
IL-6 Signaling2.69E-101693
B Cell Receptor Signaling1.32E-0919148
Cell Cycle: G1/S Checkpoint Regulation2.88E-091257
Death Receptor Signaling1.02E-081262
Cell Cycle: G2/M DNA Damage
Checkpoint Regulation 1.05E-081042
Integrin Signaling1.78E-0821211
Ephrin Receptor Signaling1.95E-0820207
Axonal Guidance Signaling2.57E-0829407
ERK/MAPK Signaling3.89E-0820202
SAPK/JNK Signaling3.89E-0816130
PPAR Signaling7.41E-081393
T Cell Receptor Signaling1.07E-0714104
NF-κB Signaling1.15E-0716139
PPARα/RXRα Activation1.55E-0716145
Wnt/β-catenin Signaling1.70E-0717162
IL-2 Signaling2.63E-071053
PDGF Signaling1.00E-061175
FGF Signaling3.63E-061184
Actin Cytoskeleton Signaling3.80E-0619254
Neuregulin Signaling5.13E-061189
Huntington's Disease Signaling1.20E-0517229
IL-10 Signaling2.57E-05970
Toll-like Receptor Signaling2.75E-05853
VEGF Signaling2.95E-051090
Neurotrophin/TRK Signaling3.63E-05972
GM-CSF Signaling6.92E-05862
EGF Signaling9.55E-05747
Insulin Receptor Signaling1.55E-0411125
Chemokine Signaling3.39E-04875
p38 MAPK Signaling3.55E-04995
JAK/Stat Signaling3.72E-04759
Fc EpsilonRI Signaling4.79E-049100
G-Protein Coupled Receptor Signaling7.41E-0413200
NRF2-mediated Oxidative Stress Response1.07E-0310142
Hypoxia Signaling in the
Cardiovascular System4.57E-03668
Nicotinate and Nicotinamide Metabolism4.79E-038129
Sonic Hedgehog Signaling4.79E-03431
Leukocyte Extravasation Signaling1.12E-0210186
Estrogen Receptor Signaling1.29E-027113
Natural Killer Cell Signaling1.41E-027110
IL-4 Signaling1.51E-02564
Inositol Phosphate Metabolism1.58E-029178
Xenobiotic Metabolism Signaling1.62E-0211228
Amyotrophic Lateral Sclerosis Signaling3.23E-026103