# * Linear Regression Model with the Reference Group Those Without AKI

Supplemental Table 1: Bivariate outcomes including children without a measured SCr during ICU admission

Variable / Overall / Acute Kidney Injury / P- value*
N = 4016 / No
(N =3279) / Yes
(N =737)
Length of Mechanical ventilation (days), Median (IQR) / 0(0,2) / 0(0,1) / 3(1,8) / <0.001
Intensive Care Unit LOS (hours), Median (IQR) / 48(24,122) / 42(23,87) / 214(74,417) / <0.001
Hospital LOS (hours), Median (IQR) / 142(71,344) / 117(62,250) / 475(237,904) / <0.001
Intensive Care Unit Mortality [N(%)] / 108(2.7) / 25(0.8) / 83(11.3) / <0.001
Variable / Acute Kidney Injury Stage
Stage 0 (N=3279) / Stage 1 (N =193) / Stage 2 (N =189) / Stage 3 (N= 355)
Length of Mechanical ventilation (days), Median (IQR)* / 0(0,1) / 1(0,3) / 3(1,7) / 4(1,11)
Intensive Care Unit LOS (hours), Median (IQR)* / 42(23,87) / 94(43, 235) / 188(71,355) / 309(144,521)
Hospital LOS (hours), Median (IQR)* / 117(62,250) / 270(137,552) / 397(233,689) / 624(344,1299)
Intensive Care Unit Mortality [N(%)]* / 25(0.8) / 6(3.1) / 11(5.8) / 66(18.6)

Supplemental Table 2: Multivariate linear regression including children without a measured SCr during ICU admission

Length of Mechanical Ventilation *
Variable / Increased length of ventilation in Days / SE / P- value
Acute Kidney Injury (yes) / 2.4 / 0.6 / <0.001
Age (year) / -0.1 / 0.02 / <0.001
PRISM III Score / 0.2 / 0.1 / 0.003
Diuretic Drip (yes) / 5.4 / 0.8 / <0.001
Increased length of ventilation in Days / SE / P- value
Acute Kidney Injury Stage 1 / 0.7 / 0.9 / 0.42
Acute Kidney Injury Stage 2 / 0.5 / 0.8 / 0.48
Acute Kidney Injury Stage3 / 4.2 / 0.9 / <0.001
Age (year) / -0.1 / 0.02 / 0.005
PRISM III Score / 0.2 / 0.1 / 0.006
Diuretic Drip (yes) / 5.1 / 0.8 / <0.001
Intensive Care Unit Length of Stay *
Increased LOS in Hours / SE / P- value
Acute Kidney Injury (yes) / 131.5 / 16.3 / <0.001
Mechanical Ventilation (yes) / 87.6 / 7.3 / <0.001
Vasopressor (yes) / 56.0 / 9.8 / <0.001
Age (year) / -1.5 / 0.5 / 0.002
Unit (CICU) / -64.8 / 10.6 / <0.001
Diuretic Drip (yes) / 270.9 / 28.7 / <0.001

* Linear Regression model with the reference group those without AKI.

Supplemental Table 2 (continued)

Intensive Care Unit Length of Stay (continued) *
Variable / Increased LOS in Hours / SE / P- value
Acute Kidney Injury Stage 1 / 46.9 / 18.5 / 0.012
Acute Kidney Injury Stage 2 / 80.2 / 25.2 / 0.001
Acute Kidney Injury Stage 3 / 224.3 / 31.2 / <0.001
Mechanical Ventilation (yes) / 84.9 / 7.3 / <0.001
Vasopressor (yes) / 50.3 / 9.9 / <0.001
Age (year) / -1.0 / 0.5 / 0.024
Unit (CICU) / -56.7 / 10.5 / <0.001
Diuretic Drip (yes) / 249.7 / 28.1 / <0.001
Hospital Length of Stay *
Increased LOS in Hours / SE / P- value
Acute Kidney Injury (yes) / 310.5 / 43.6 / <0.001
Mechanical Ventilation (yes) / 95.5 / 22.7 / <0.001
Age (year) / -4.4 / 1.3 / 0.001
PRISM III Score / 14.9 / 3.4 / <0.001
Diuretic Drip (yes) / 323.4 / 55.7 / <0.001
Increased LOS in Hours / SE / P- value
Acute Kidney InjuryStage 1 / 136.0 / 61.8 / 0.028
Acute Kidney Injury Stage 2 / 95.3 / 51.3 / 0.063
Acute Kidney Injury Stage 3 / 573.4 / 73.5 / 0.001
Mechanical Ventilation (yes) / 94.2 / 22.6 / <0.001
Age (year) / -3.5 / 1.3 / 0.008
PRISM III Score / 13.8 / 3.4 / <0.001
Diuretic Drip (yes) / 272.5 / 54.7 / <0.001

Supplemental Table 3: Multivariate logistic regression including children without ameasured SCr during ICU admission

Intensive Care Unit Mortality *
Variable / Odds ratio / 95% Confidence Interval / P- value
Acute Kidney Injury (yes) / 3.6 / 2.0,6.5 / <0.001
Vasopressor (yes) / 2.4 / 1.3,4.5 / 0.006
PRISM III Score / 1.2 / 1.1,1.2 / <0.001
Odds Ratio / 95% Confidence Interval / P- value
Acute Kidney Injury Stage 1 / 1.4 / 0.5,3.6 / 0.48
Acute Kidney Injury Stage 2 / 1.6 / 0.6,4.0 / 0.34
Acute Kidney Injury Stage 3 / 6.0 / 3.2,11.2 / <0.001
Vasopressor (yes) / 2.2 / 1.2,4.1 / 0.017
PRISM III Score / 1.2 / 1.1,1.2 / <0.001

*Logistic Regression model with the reference group those without AKI.

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