Altered Expression of Multiple Genes Involved in Retinoic Acid Biosynthesis in Human Colorectal CancerPathology and Oncology Research journal

Ekaterina S. Kropotova, Olga L. Zinovieva, Alisa F. Zyryanova, Vera I. Dybovaya, Vladimir S. Prasolov, Sergey F. Beresten, Nina Yu. Oparina,

Tamara D. Mashkova

Corresponding author: Tamara D. Mashkova, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia;

E-mail address:

Supplementary Table S2 Characterization and expression of genes involved in all-trans-retinoicacid biosynthesis in colorectal tissues

Official gene symbol / Commonly used
gene symbols / Protein name / Preferred retinoid-related function / EST data, normalized counts / RNA-seqdata, RPKM / Downregulation in colorectal cancer, microarray studies ONCOMINE / Overexpression in colorectal cancer, microarray studies ONCOMINE
N/T / Normal tissues / Maximal fold change / Maximal fold change
ADH1A / ADH1A / alcohol dehydrogenase 1A (class I), alpha polypeptide / retinol oxidation / 0/0 / 0.1 / -6.9 / notdetected
ADH1B / ADH1B / alcohol dehydrogenase 1B (class I), beta polypeptide / retinol oxidation / 24/0 / 8.7 / -14.1 / notdetected
ADH1C / ADH1C / alcohol dehydrogenase 1C (class I), gamma polypeptide / retinol oxidation / 34/2 / 14.5 / -34.9 / notdetected
ADH4 / ADH2 / alcohol dehydrogenase 4 (class II), pi polypeptide / retinol oxidation / 0/0 / 0.5 / -8.9 / 2.6
ADH5 / ADH3 / alcohol dehydrogenase 5 (class III), chi polypeptide / retinol oxidation / 12/4 / 6.0 / -2.4 / notdetected
ADH6 / ADH6 / alcohol dehydrogenase 6 (class V) / retinol oxidation / 0/0 / 1.5 / -4.5 / notdetected
ADH7 / ADH4 / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide / retinol oxidation / 0/0 / 0.0 / -2.1 / notdetected
RDH10 / RDH10 / retinoldehydrogenase 10 (all-trans) / retinol oxidation / 2/3 / 1.8 / notdetected / 2.7
DHRS9 / RDHL / dehydrogenase/reductase (SDR family) member 9 / retinol oxidation / 22/3 / 1.7 / -37.7 / notdetected
RDH5 / RDH5 / retinol dehydrogenase 5 (11-cis/9-cis) / retinol oxidation / 2/1 / 2.8 / -4.4 / notdetected
HSD17B6 / RoDH / hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) / retinol oxidation / 0/0 / 0.5 / -2.9 / notdetected
RDH16 / RoDH4 / retinol dehydrogenase 16 (all-trans) / retinol oxidation / 0/0 / 0.0 / notdetected / notdetected
SDR16C5 / RDHE2 / short chain dehydrogenase/reductase family 16C, member 5 / retinol oxidation / 0/0 / 0.0 / -24.7 / 2.9
XDH / XOR / xanthinedehydrogenase / retinol oxidation / 0/0 / 0.8 / -4.4 / notdetected
RDH8 / RDH8 / retinol dehydrogenase 8 (all-trans) / retinaldehyde reduction / 0/0 / 0.0 / notdetected / notdetected
RDH11 / RDH11 / retinol dehydrogenase 11 (all-trans/9-cis/11-cis) / retinaldehyde reduction / 10/5 / 4.0 / notdetected / 2
RDH12 / RDH12 / retinol dehydrogenase 12 (all-trans/9-cis/11-cis) / retinaldehyde reduction / 0/0 / 0.1 / notdetected / 2.4
RDH13 / RDH13 / retinol dehydrogenase 13 (all-trans/9-cis) / retinaldehydereduction / 0/0 / 1.1 / notdetected / 2.7
RDH14 / RDH14 / retinol dehydrogenase 14 (all-trans/9-cis/11-cis) / retinaldehydereduction / 0/0 / 2.0 / notdetected / notdetected
DHRS3 / RDH17 / dehydrogenase/reductase (SDR family) member 3 / retinaldehydereduction / 0/0 / 1.0 / notdetected / notdetected
DHRS4 / DHRS4 / dehydrogenase/reductase (SDR family) member 4 / retinaldehydereduction / 4/1 / 1.2 / -2.3 / notdetected
DHRS4L2 / DHRS4L2 / dehydrogenase/reductase (SDR family) member 4 like 2 / retinaldehydereduction / 3/1 / 1.1 / notdetected / notdetected
SDR9C7 / SDR9C7 / short chain dehydrogenase/reductase family 9C, member 7 / retinaldehydereduction / 0/0 / 0.1 / notdetected / notdetected
AKR1B1 / AKR1B1 / aldo-ketoreductase family 1, member B1 (aldosereductase) / retinaldehydereduction / 3/3 / 0.4 / -3.5 / notdetected
AKR1B10 / AKR1B10 / aldo-ketoreductase family 1, member B10 (aldosereductase) / retinaldehyde reduction / 26/0 / 3.4 / -12.8 / notdetected
ALDH1A1 / RALDH1 / aldehydedehydrogenase 1 family, member A1 / retinaldehydeoxidation / 50/18 / 10.0 / -4.1 / notdetected
ALDH1A2 / RALDH2 / aldehydedehydrogenase 1 family, member A2 / retinaldehydeoxidation / 0/0 / 0.0 / -7.3 / 3.1
ALDH1A3 / RALDH3 / aldehydedehydrogenase 1 family, member A3 / retinaldehydeoxidation / 0/11 / 1.7 / notdetected / 2.1
CYP26A1 / CYP26A1 / cytochrome P450, family 26, subfamily A, polypeptide 1 / atRAdegradation / 4/6 / 1.9 / notdetected / 2.3
CYP26B1 / CYP26B1 / cytochrome P450, family 26, subfamily B, polypeptide 1 / atRAdegradation / 0/0 / 0.1 / -3.4 / notdetected
CYP26C1 / CYP26C1 / cytochrome P450, family 26, subfamily C, polypeptide 1 / atRAdegradation / 0/0 / 0.1 / notdetected / notdetected
RBP1 / CRBP1 / retinolbindingprotein 1, cellular / retinolbinding / 4/4 / 4.0 / notdetected / 2.3

Abbreviations: RNA-Seq RNASequencing, ESTExpressed Sequence Tags, RPKMReadsPerKilobaseper Millionmapped reads