December2010

Laura Davidson Brown, M.D.

CURRENT POSITION

Assistant Professor of Pediatrics

Section of Neonatology

University of Colorado School of Medicine

Mail Stop F441

Perinatal Research Center

13243 East 23rd Avenue

Aurora, Colorado 80045

Phone: 303-724-0106

Fax: 303-724-0898

EDUCATION AND TRAINING

1991-1995University of Colorado at Boulder

Bachelor of Arts, Magna Cum Laude

Major: Molecular, Cellular and Developmental Biology

Minor: Biochemistry

1995-1999University of ColoradoSchool of Medicine

Doctor of Medicine

1999-2002University of ColoradoHealth Sciences Center and Children’s Hospital of Denver

Pediatric Internship and Residency

2002-2005University of Colorado Health Sciences Center

T32 trainee, Neonatal-Perinatal Medicine Fellowship Program

2003-2006University of Colorado Health Sciences Center

Clinical Research Training Program

2005University of Colorado Health Sciences Center

Department of Anesthesiology Clinical Research and Development:

Proteomics Hands-On Workshop

2005-2006University of Colorado Health Sciences Center

Neonatal-Perinatal Medicine Research Fellow

ACADEMIC APPOINTMENTS

2006-2007Instructor of Pediatrics, Section of Neonatology, University of Colorado School of Medicine

2007-presentAssistant Professor of Pediatrics,Section of Neonatology, University of Colorado School of Medicine

HONORS, SPECIAL RECOGNITION, AND AWARDS

University of Colorado at Boulder

1995Chancellor’s Recognition Award, University of Colorado at Boulder

University of ColoradoSchool of Medicine

1997Academic Excellence, School of Medicine Promotions Committee

1999Mosby Award for Outstanding Performance in Pediatrics

2002Outstanding Clinical Teacher, voted by UCHSC Medical School Class

2002Outstanding Resident of the Year, University of Colorado Neonatal Care Unit

2002The L. Joseph Butterfield Award in Perinatal Pediatrics

2005Recipient of the Maxwell Rhys Murray Educational Scholarship Award

2006 Outstanding Clinical Research Training Program (CRTP) Student Award

National Institutes of Health

2005Delegate, 17th Annual NICHD Aspen Conference on Maternal-Fetal-Neonatal-Reproductive Medicine

2005NIH-sponsored Young Investigator Travel Award for the Pediatric Research Society Meeting, Quebec, Canada

Western Society for Pediatric Research

2005Aventis Metabolism Scholar Award, Western Society of Pediatric Research Meeting

2009WSPR Mead Johnson Travel Award

University of Colorado Center for Women’s Health Research

2009Jacqueline Leaffer Center for Women’s Health Research Travel Award

PROFESSIONAL MEMBERSHIPS

2005-presentMember, American Federation of Medical Research

2007-present Member, Western Society for Pediatric Research

2007-presentAmerican Academy of Pediatrics, Section of Perinatal Medicine

2008-presentMember, Perinatal Research Society

2008-presentMember, Society for Pediatric Research

MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES

University of Colorado Hospital

2005-2006Task force member, multidisciplinary team to develop a policy for the recognition and management of a woman who may deliver an infant at the margins of viability. University of Colorado Hospital.

The Children’s Hospital of Denver

2005-presentPhysician consultant, Fetal Concerns Program

2007-presentLiaison, The Children’s Hospital Foundation

Department of Pediatrics

2003-presentDirector, Perinatal/Neonatal Ethics Rounds

2007-2008Neonatal/Perinatal Medicine Fellowship applicant review committeemember

2007-2009Interviewer for Pediatric Residency Selection

2007-presentDirector, Pediatric Resident Neonatal Resuscitation Program (NRP)

2008-presentPrimary mentor and Scholarly Oversight Committee (SOC) member for Susan Soto, Fellow in Neonatal-Perinatal Medicine

2008-presentScholarly Oversight Committee (SOC) member for Jinny Lavezzi, Fellow in Neonatal-Perinatal Medicine

2009-presentCo-mentor and Scholarly Oversight Committee (SOC) member for Annie Maliszewski, Fellow in Neonatal-Perinatal Medicine

2011-presentCommittee Member, Child Maternal Health Section of CCTSI

School of Medicine

2009-presentJunior Faculty Affiliate, Center for Women’s Health Research

LICENSURE AND BOARD CERTIFICATION

United States Medical Licensure Examination I6/97

United States Medical Licensure Examination II8/98

United States Medical Licensure Examination III8/00

Diplomate of the American Board of Pediatrics8/02-12/09

Subspecialty Certification in Neonatal-Perinatal Medicine11/05

REVIEWS AND REFEREE WORK

Ad hoc Manuscript Reviewer

2006-present American Journal of Physiology (AJP) - GI and Liver Physiology

2008-presentAJP - Endocrinology and Metabolism

2009-presentNeonatology

2010-presentPediatric Research

2010-presentAJP - Heart and Circulatory Physiology

2010-presentMolecular and Cellular Endocrinology

National Meetings

2008, 2011Session Moderator and Abstract Reviewer, Developmental Biology. Western Society of Pediatric Research Annual Meeting. Carmel, CA.

INVITED LECTURES AND PRESENTATIONS

Research Oriented: Regional/National

2004Effect of Amino Acids on the Regulation of Signal Transduction in the Late Gestation Ovine Fetus.Mead Johnson Nutritionals 32nd Aspen Conference on Perinatal Research. Aspen, CO.

2007Independent and interactive effects of insulin and amino acids in the regulation of fetal skeletal muscle growth pathways in-vivo and in-vitro. Aspen Perinatal Biology Symposium. Aspen, CO.

Research Oriented: Local (University of Colorado)

2005Metabolomics: A technique to study metabolic changes in intrauterine growth restriction.Proteomics and Metabolomics Research Symposium

2006Nutrient Regulation of Skeletal Muscle Signal Transduction in an Ovine Model of Intrauterine Growth Restriction (IUGR) Perinatal Research Center Conference and Pediatric HeartLungCenter Conference

2007 Postprandial plasma concentrations of galactose suggest a postnatal ductus venosus shunt in newborns.Perinatal Research Center Conference

2007Independent and interactive effects of insulin and amino acids in the regulation of fetal skeletal muscle growth pathways in-vivo and in-vitro. Perinatal Research Center Conference

2007Techniques in primary myocyte culture.Perinatal Research Center Conference

2008Inositol and Mannose Utilization in the Late Preterm Neonate”Perinatal Research Center Conference

2008Fetal effects of prolonged maternal amino acid infusion in late gestation pregnant sheep: In vivo and in vitro correlates.Perinatal Research Center Conference

2009Functional adaptations of fetal skeletal muscle to nutrient and anabolic hormone deficiencies in IUGR Part 1. Perinatal Research Center Conference and BIRCWH Scholarly Oversight Committee

2009Functional adaptations of fetal skeletal muscle to nutrient and anabolic hormone deficiencies in IUGR Part 2. BIRCWH Scholarly Oversight Committee

2009How can we improve lean body mass growth in IUGR: Proposed Specific Aims.Perinatal Research Center Conference and Metabolism Club

2010Can we improve skeletal muscle growth in IUGR? A developmental approach. Leinwand laboratory, University of Colorado Boulder and BIRCWH Scholarly Oversight Committee

2010Gene expression in IUGR muscle. Friedman laboratory, University of Colorado Anschutz Medical Campus

2010Inflexibility of leucine disposal to nutrient reintroduction in the IUGR fetus.

BIRCWH Scholarly Oversight Committee

Clinical Oriented: Regional/National

2005Considerations for infants at the margin of viability. Annual Perinatal Clinical Update, The Children’s Hospital, Denver, CO.

2007Hypoglycemia in neonates. Annual Perinatal Clinical Update, The Children’s Hospital, Denver, CO.

2007 Best practices: Parenteral nutrition in the NICU. Front Range Association of Neonatal Nurse Practitioners Annual Conference. Keystone, CO.

2009Predicting neurodevelopmental outcomes in the preterm infant: Assessment in the NICU. Annual Perinatal Clinical Update. The Children’s Hospital, Denver, CO

Clinical Oriented: Local

2004Non-immune hydrops fetalis.University of Colorado Hospital NICU Nursing Staff

2005 Case review: Inborn Errors of Metabolism.Neonatal Noon Conference

2005Considerations for infants at the margin of viability. Neonatal Noon Conference

2005Considerations for infants at the margin of viability: Ethical and Legal Considerations.Department of OB/GYN Prenatal Diagnosis Conference

2006Guidelines for management of ELBW infants.Neonatal Noon Conference

2006Hypoglycemia in neonates. Regis Neonatal Nurse Practitioner Training Program

2006Panel discussant for career development. The Children’s Hospital of Denver Fellow’s Retreat

2007, 2008Congenital hydrocephalus and congenital brain abnormalities. Neonatology Fellow Teaching Conference

2007Case review: Intrathorasic air leaks.Neonatology Fellow Teaching Conference

2007Predicting neurodevelopmental outcomes in the preterm infant: Assessment in the NICU and in follow-up care. Neonatal Noon Conference

2008Hyperbilirubinemia in the Neonate. St. Anthony’s Family Medicine Residency Lecture Series

2008Neonatal Catheter Related Complications.Pediatric Resident Teaching Conference

2009Total Parenteral Nutrition: It is not all glucose, protein and fat.Neonatal Noon Conference

2010TPN Basics. Neonatology Fellow Teaching Conference

TEACHING RECORD

Attending duties

2005-presentSupervision and bedside teaching of Pediatric residents and Neonata-Perinatal Medicine fellows, NICUs at University of Colorado Hospital, The Children’s Hospital of Denver, and Denver Health Medical Center

Research Mentoring Trainees

1. Susan M. Soto, MDNeonatology Fellow7/08 - present

2. Anne MaliszewskiNeonatology Fellow7/09 – present

3. Amy CampfieldPediatric Residen11/09 - present

University of Colorado

2003-presentNeonatal Resuscitation Program (NRP) Instructor

2007-2010Faculty Member NIH T32 Training Grant in Perinatal Medicine and Biology (HD07186, PI, William Hay)

2007-presentDirector, Pediatric Resident Neonatal Resuscitation Program (NRP)

GRANT SUPPORT

Active:

2008-2011K12 HD057022Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Career Development Program Scholar Award

“Functional and structural adaptationsof fetal skeletal muscle to nutrient and anabolic hormone deficiencies under conditions of placental insufficiency and IUGR” $100,000/year

Role: Principle Investigator

2011-2013Gerber Foundation Grant

“Mannose requirements in preterm and IUGR neonates”

$90,000/year

Role: Principle Investigator

Pending:

2010K08 PA-10-059 Mentored Clinician Scientist Research Career Development Award

“Growth factor deficiencies limit fetal skeletal muscle growth in IUGR”

Role: Principle Investigator

Completed:

2002-2006NIH-T32-HD07186, “Training in Perinatal Medicine”

Role: Trainee

2002-2006RO1 DK52138 “Fetal Glucose and Amino Acid Deprivation”

Role: Co-Investigator

2007-20085 R01 HD034837 “Fetal Velocimetry and Amino Acid Transport in Pregnancy”

Role: Collaborator

2006-2008Children’s Hospital of Denver Research Institute Research Scholar Award

“Nutrient Regulation of Skeletal Muscle Signal Transduction in an Ovine Model of Intrauterine Growth Restriction” $70,000/year.

Role: Principle Investigator

2006-2008University of ColoradoCenter for Human Nutrition Pilot Study

“Nutrient Regulation of Skeletal Muscle Signal Transduction in an Ovine Model of Intrauterine Growth Restriction” $15,000/year.

Role: Principle Investigator

BIBLIOGRAPHY

Original, Peer-Reviewed Manuscripts

  1. Brown LD and Hay WW, Jr. Effect of Hyperinsulinemia on Amino Acid Utilization and Oxidation Independent of Glucose Metabolism in the Ovine Fetus. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1333-40. Epub 2006 Jul 25.
  1. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, Loturco D, Regnault T, Friedman JE, Hay Jr WW. Chronic Late Gestation Hypoglycemia Up-Regulates Hepatic PEPCK Associated with Increased PGC1{alpha} mRNA and pCREB in Fetal Sheep. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E365-70. Epub 2007 Dec 4.
  1. Brown LD, Cavalli C, Harwood JF, Casadei A, Teng C, Traggiai C, Serra G, Bevilaqua G, Battaglia FC. Plasma Concentrations of Carbohydrates and Sugar Alcohols in Term Newborns after Milk Feeding. Pediatr Res. 2008 Aug;64(2):189-93.PMCID: PMC2903005
  1. Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW. Glucose Replacement to Euglycemia Causes Hypoxia, Acidosis, and Decreased Insulin Secretion in Fetal Sheep with Intrauterine Growth Restriction. Pediatr Res.2009 Jan;65(1):72-78. Epub 2008 Aug 13.PMCID: PMC2678008
  1. Brown LD, Rozance PJ, Barry JS, Friedman JE, and Hay WW Jr. Insulin is Required for Amino Acid Stimulation of Dual Pathways for Translational Control in Skeletal Muscle in the Late Gestation Ovine Fetus. Am J Physiol Endocrinol Metab. 2009Jan;296(1):E56-63. Epub 2008 Oct 21.PMCID: PMC2636989
  1. Limesand SW, Rozance PJ, Brown LD, and Hay, WW Jr. Effects of Chronic Hypoglycemia and Euglycemia Correction on Lysine Metabolism in Fetal Sheep. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E879-87. Epub 2009 Feb 3.PMCID: PMC2670627
  1. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW Jr, Friedman JE.Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle.Endocrinology. 2009 Jul;150(7):3021-30. Epub 2009 Apr 2.PMCID: PMC2703533
  1. Brown LD, Cheung A, Harwood JF, Battaglia FC. Inositol and Mannose Metabolism in Term and Late Preterm Infants. J Nutr. 2009 Sep;139(9):1648-52. Epub 2009 Jun 3. PMCID: PMC2728690
  1. Rozance PJ, Crispo MM, Barry JS, O’Meara MC, Frost MS, Hansen KC, Hay WW Jr, Brown LD. Prolonged Maternal Amino Acid Infusion in Late Gestation Pregnant Sheep Increases Fetal Amino Acid Oxidation.Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E638-46. Epub 2009 Jul 14.PMCID: PMC2739698
  1. Arroyo JA, Brown LD, Galan HL.Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction.Am J Obstet Gynecol. 2009 Dec;201(6):616.e1-7. Epub 2009 Oct 3. PMCID: PMC2789863

Book Chapters, Invited Articles and Reviews

  1. Davidson L and Thilo EH. How to Make Kernicterus a “Never Event”. NeoReviews 2003;4:308-314.

2.Hay Jr., WW., Regnault, TH., Brown, LD.Chapter 55: “Fetal

Requirements and Placental Transfer of Nitrogenous Compounds.” In Fetal and Neonatal Physiology, 4th ed., Polin, Richard A., Fox, William W., and Abman, Steven H.,editors, WB Saunders, Philadelphia. (in press)

  1. Brown LD, Regnault TR, Rozance PJ, Barry JS, Hay WW. “Pregnancy and Feto-placental Growth: Macronutrients” In Maternal-Fetal Nutrition During Pregnancy and Lactation. Symonds, Michael and Ramsay, Margaret, editors, ©Cambridge University Press 2010, New York.
  1. Brown LD, Green AS, Limesand SW, Rozance PJ. “Maternal Amino Acid Supplementation During Pregnancy for Intrauterine Growth Restriction.” Frontiers in Bioscience. V. S3, 428-444. January 2011.
  1. Thorn SR, Rozance PJ, Brown LD, Hay WW Jr. “The Intrauterine Growth Restriction (IUGR) phenotype:fetal adaptations and potential implications for later life insulin resistance and diabetes” Accepted, Seminars in Reproductive Medicine, August 2010.

Abstracts, competitive

  1. Davidson LS and Hay WW Jr. Effect of Hyperinsulinemia on Amino Acid Utilization Independent of Glucose Metabolism in the Ovine Fetus. Pediatr Res 2004;55(4):382A. Abstract #2172.Pediatric Academic Society (PAS) Annual Meeting 2004, Oral Platform Presentation.
  1. Brown LD, Fischer SJ, Friedman JE, and Hay WW, Jr. Amino Acid Regulation of Signal Transduction in the Late Gestation Ovine Fetus.Journal of Investigative Medicine 2005;53(1):S134-S135. Abstract #323. Western Society of Pediatric Research(WSPR) Annual Meeting 2005, Oral Platform Presentation.
  1. Brown LD, Friedman JE, Hay WW Jr. Amino Acids Fail to Induce Skeletal Muscle 4E-BP1 Phosphorylation in an Ovine Model of Intrauterine Growth Restriction (IUGR). E-PAS2006:59:3125.7. PAS Annual Meeting 2006,Oral Platform Presentation.
  1. Brown LD, Cavalli C, Traggiai C, Teng CC, Harwood JF, Casadei A, Serra G, Bevilacqua G and Battaglia FC. Postprandial Plasma Concentrations of Galactose Suggest a Postnatal Ductus Venosus Shunt in Newborns. E-PAS2007:61:7925.4 PAS Annual Meeting 2007, Poster Presentation.
  1. Barry JS, Brown LD, Rozance PJ, and Hay WW.Mechanisms to Maintain Myocardial Growth during Ovine Fetal Intrauterine Growth Restriction (IUGR). E-PAS2007:61:5740.2. PAS Annual Meeting 2007, Oral Poster Symposium.
  1. Brown LD, Cheung A, Harwood JF, Battaglia FC. Inositol and Mannose Utilization in Late Preterm Newborns. Journal of Investigative Medicine 2008;56(1):144. Abstract #120. WSPR Annual Meeting 2008, Oral Platform Presentation.
  1. Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW. Glucose Replacement Leads to Fetal Hypoxia, Acidosis, and Decreased Insulin Secretion in an Ovine Model of Intrauterine Growth Restriction. Journal of Investigative Medicine 2008;56(1):199. Abstract #288. WSPR Annual Meeting 2008, Oral Platform Presentation.
  1. Brown LD, Cheung A, Harwood JF, Battaglia FC. Inositol and Mannose Utilization in Late Preterm Newborns. E-PAS2008:63:3050.4. PAS Annual Meeting 2008, Oral Platform Presentation.
  1. Crispo MM, Rozance PJ, Barry JS, O’Meara M, Hay WW Jr.,Brown LD. Adverse Effects of Prolonged Maternal Amino Acid Infusion in Late Gestation Pregnant Sheep. E-PAS2008:63:3773.1. PAS Annual Meeting 2008, Poster Presentation.
  1. Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW. Glucose Replacement Leads to Fetal Hypoxia, Acidosis, and Decreased Insulin Secretion in an Ovine Model of Intrauterine Growth Restriction. E-PAS2008:63:3050.7. PAS Annual Meeting 2008, Oral Platform Presentation.
  1. Rozance PJ, Crispo MM, Barry JS, O’Meara MC, Frost MS, Hansen KC, Hay WW Jr, Brown LD. Prolonged Maternal Amino Acid Infusion in Late Gestation Pregnant Sheep Does Not Increase Fetal Protein Accretion. Oral Platform Presentation, Rocky Mountain Reproductive Sciences Symposium, 2009.
  1. Rozance PJ, Crispo MM, Barry JS, O’Meara MC, Frost MS, Hansen KC, Hay WW Jr, Brown LD. Prolonged Maternal Amino Acid Infusion in Late Gestation Pregnant Sheep Does Not Increase Fetal Protein Accretion.E-PAS2009:5745.2 PAS Annual Meeting 2009, Oral Platform Presentation.
  1. Brown LD, Rozance PJ, Soto SM, Hay WW Jr., Friedman JE. Intrauterine growth restriction results in increased insulin-stimulated proliferation but not hypertrophy in fetal myocytes. Journal of Women’s Health. 2009 Oct 18(10):1510, P62. BIRCWH Directors and Scholars Meeting 2009, Poster Presentation
  1. Brown LD, Soto SM, Rozance PJ, Thorn SR, Hay WW Jr., Friedman JE. Intrauterine growth restriction results in increased insulin-stimulated proliferation but not hypertrophy in fetal myocytes. WSPR Annual Meeting 2010, Oral Platform Presentation.
  1. Lavezzi JR, O’Meara MC, Thorn SR, Brown LD, Rozance PJ. Prolonged experimental hypoglycemia decreases insulin secretion in late gestation ovine fetuses. E-PAS2010:2750.1 PAS Annual Meeting 2010, Poster Symposium Presentation
  1. Brown LD, Harwood JF, Cavalli C, Traggiai C, Casadei A, Serra G, Bevilacqua G, Teng CC, and Battaglia FC. Increased concentrations of galactose in IUGR neonates can be sorted by prenatal surveillance data. E-PAS2010:3737.377

PAS Annual Meeting 2010, Poster Presentation

  1. Soto SM, Rozance PJ, Thorn SR, Hay WW Jr., Friedman JE, and Brown LD. Intrauterine growth restriction results in increased insulin-stimulated proliferation but not hypertrophy in fetal myocytes. E-PAS2010:4416.469 PAS Annual Meeting 2010, Poster Presentation
  1. Maliszewski A, Gadhia M, O’Meara M, Thorn S, Hay WW Jr., Rozance PJ, Brown LD. The effects of a direct fetal amino acid infusion on oxygenation and acid-base balance in fetal sheep. Aspen Perinatal Biology Symposium 2010, Poster Presentation
  1. Gadhia M, Maliszewski A, O’Meara M, Thorn S, Lavezzi J, Hay WW Jr., Brown LD, Rozance PJ. Increased amino acids potentiate glucose stimulated insulin secretion in the ovine fetus. Aspen Perinatal Biology Symposium 2010, Poster Presentation
  1. Brown LD, Rozance PJ, Thorn SR, LoTurco D, Friedman JE, Hay WW Jr. Intrauterine growth restriction (IUGR) causes differential expression of genes that control myogenesis in ovine fetal skeletal muscle. Journal of Women’s Health. 2010 Oct 19(10):1782, P13. BIRCWH Directors and Scholars Meeting 2010, Poster Presentation

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