Table S1. Socio-demographic data from HIV-1-positive individualsfrom Rio de Janeiro, Brazil,according to the classification of progression to AIDS and HLA-B alleles typing(n=496).
Classified individuals / HLA-B alleles typing(n=496) / No (n =278) / Yes (n=218) / p-valuea
RP
(n=182) / TP
(n=289) / LNTP (n=25) / RP
(n=96) / TP
(n=174) / LNTP (n=8) / RP
(n=86) / TP
(n=115) / LNTP (n=17) / RP vs. RP / TP vs. TP / LNTP vs. LNTP
n / % / n / % / n / % / n / % / n / % / n / % / n / % / n / % / n / %
Gender / 0.27 / 0.57 / 1.00
Male / 136 / 74.7 / 184 / 63.7 / 11 / 44.0 / 68 / 70.8 / 108 / 62.1 / 3 / 37.5 / 68 / 79.1 / 76 / 66.1 / 8 / 47.1
Female / 46 / 25.3 / 105 / 36.3 / 14 / 56.0 / 28 / 29.2 / 66 / 37.9 / 5 / 62.5 / 18 / 20.9 / 39 / 33.9 / 9 / 52.9
Ethnicity / 0.14 / 0.69 / 1.00
White / 110 / 60.4 / 156 / 54.0 / 14 / 56.0 / 53 / 55.2 / 97 / 55.7 / 4 / 50.0 / 57 / 66.3 / 59 / 51.3 / 10 / 58.8
Mulattoes / 46 / 25.3 / 85 / 29.4 / 6 / 24.0 / 30 / 31.3 / 48 / 27.6 / 2 / 25.0 / 16 / 18.6 / 37 / 32.2 / 3 / 17.6
Black / 25 / 13.7 / 47 / 16.3 / 5 / 20.0 / 12 / 12.5 / 28 / 16.1 / 2 / 25.0 / 13 / 15.1 / 19 / 16.5 / 4 / 23.5
Other b / 1 / 0.5 / - / 0.0 / - / 0.0 / 1 / 1.0 / - / 0.0 / - / 0.0 / - / 0.0 / - / 0.0 / - / 0.0
Age (years) / 0.34 / 0.57 / 0.72
< 30 / 69 / 37.9 / 134 / 46.4 / 15 / 60.0 / 41 / 42.7 / 85 / 48.9 / 6 / 75.0 / 28 / 32.6 / 49 / 42.6 / 9 / 52.9
30-39 / 72 / 39.6 / 95 / 32.9 / 6 / 24.0 / 34 / 35.4 / 54 / 31.0 / 1 / 12.5 / 38 / 44.2 / 41 / 35.7 / 5 / 29.4
≥ 40 / 41 / 22.5 / 60 / 20.8 / 4 / 16.0 / 21 / 21.9 / 35 / 20.1 / 1 / 12.5 / 20 / 23.3 / 25 / 21.7 / 3 / 17.6
Mean age (SD) / 33.6 / (8.9) / 32.2 / (9.3) / 30.7 / (8.9) / 32.9 / (9.1) / 31.8 / (9.7) / 27.0 / (8.1) / 34.3 / (8.7) / 32.8 / (8.8) / 32.4 / (9.0) / <0.001 / <0.001 / <0.001
Schooling / 0.87 / 0.28 / 0.82
Fundamentalc / 66 / 36.3 / 128 / 44.3 / 16 / 64.0 / 33 / 34.4 / 74 / 42.5 / 6 / 75.0 / 33 / 38.4 / 54 / 47.0 / 10 / 58.8
Middle / 71 / 39.0 / 107 / 37.0 / 6 / 24.0 / 38 / 39.6 / 62 / 35.6 / 1 / 12.5 / 33 / 38.4 / 45 / 39.1 / 5 / 29.4
Graduation / 44 / 24.2 / 53 / 18.3 / 3 / 12.0 / 24 / 25.0 / 37 / 21.3 / 1 / 12.5 / 20 / 23.3 / 16 / 13.9 / 2 / 11.8
NR / 1 / 0.5 / 1 / 0.3 / 0 / 0.0 / 1 / 1.0 / 1 / 0.6 / 0 / 0.0 / 0 / 0.0 / 0 / 0.0 / 0 / 0.0
Exposure category / 0.67 / 0.93 / 0.66
MSM/Bissexual / 106 / 58.2 / 106 / 36.7 / 8 / 32.0 / 51 / 53.1 / 60 / 34.5 / 2 / 25.0 / 55 / 64.0 / 46 / 40.0 / 6 / 35.3
Heterosexual / 64 / 35.2 / 129 / 44.6 / 15 / 60.0 / 36 / 37.5 / 77 / 44.3 / 6 / 75.0 / 28 / 32.6 / 52 / 45.2 / 9 / 52.9
IDU / 1 / 0.5 / 9 / 3.1 / 0 / 0.0 / 1 / 1.0 / 6 / 3.4 / 0 / 0.0 / 0 / 0.0 / 3 / 2.6 / 0 / 0.0
Other d / 2 / 1.1 / 14 / 4.8 / 0 / 0.0 / 1 / 1.0 / 8 / 4.6 / 0 / 0.0 / 1 / 1.2 / 6 / 5.2 / 0 / 0.0
NR / 9 / 4.9 / 31 / 10.7 / 2 / 8.0 / 7 / 7.3 / 23 / 13.2 / 0 / 0.0 / 2 / 2.3 / 8 / 7.0 / 2 / 11.8
NR = not reported; SD = standard deviation; IDU = injecting drug users
RP = rapid progressors; TP = typical progressors; LTNP = long-term non-progressors.
Bold numbers indicate p-value ≤ 0.05.
a Chi-square test, Fisher’s exact test or Mann-Whitney test
b Other = Indigenous (n=1)
c Includes illiterate (n=9)
dOther = Blood transfusion (n=14), hemophiliac (n=1), and percutaneous exposure (n=1)
Table S2. Distribution of the HLA-B alleles among the HIV-1-positive individuals from Rio de Janeiro, Brazil, stratified according to ethnic background (n=218).
Allele / Caucasians2n=252 / Non-Caucasians
2n=184 / Caucasiansvs.Non-Caucasians
n / af / n / af / p-valuea / OR
B*07 / 15 / 0.059 / 13 / 0.071 / 0.64 / 0.83
B*08 / 15 / 0.059 / 08 / 0.043 / 0.46 / 1.39
B*13 / 02 / 0.008 / 04 / 0.022 / 0.25 / 0.36
B*14 / 18 / 0.071 / 13 / 0.071 / 0.98 / 1.01
B*15 / 29 / 0.115 / 20 / 0.109 / 0.84 / 1.07
B*18 / 08 / 0.032 / 04 / 0.022 / 0.53 / 1.48
B*27 / 05 / 0.020 / 01 / 0.005 / 0.41 / 3.70
B*35 / 32 / 0.127 / 16 / 0.087 / 0.19 / 1.53
B*37 / 02 / 0.008 / 01 / 0.005 / 1.00 / 1.46
B*38 / 04 / 0.016 / 03 / 0.016 / 1.00 / 0.97
B*39 / 07 / 0.028 / 05 / 0.027 / 0.97 / 1.02
B*40 / 10 / 0.040 / 07 / 0.038 / 0.93 / 1.04
B*41 / 03 / 0.012 / 02 / 0.012 / 1.00 / 1.10
B*42 / 01 / 0.004 / 07 / 0.038 / 0.01 / 0.10
B*44 / 20 / 0.079 / 23 / 0.125 / 0.11 / 0.60
B*45 / 07 / 0.028 / 06 / 0.033 / 0.77 / 0.85
B*47 / 01 / 0.004 / 01 / 0.005 / 1.00 / 0.73
B*48 / 03 / 0.012 / 03 / 0.016 / 0.70 / 0.73
B*49 / 08 / 0.032 / 03 / 0.016 / 0.37 / 1.98
B*50 / 06 / 0.024 / 02 / 0.012 / 0.48 / 2.22
B*51 / 20 / 0.079 / 08 / 0.043 / 0.13 / 1.90
B*52 / 09 / 0.036 / 06 / 0.033 / 0.86 / 1.10
B*53 / 07 / 0.028 / 10 / 0.054 / 0.16 / 0.50
B*56 / 00 / 0.000 / 02 / 0.012 / 0.18 / 0.00
B*57 / 09 / 0.036 / 08 / 0.043 / 0.68 / 0.81
B*58 / 08 / 0.032 / 07 / 0.038 / 0.72 / 0.83
B*67 / 00 / 0.000 / 01 / 0.005 / 0.42 / 0.00
B*81 / 02 / 0.008 / 00 / 0.000 / 0.51 / -
B*82 / 01 / 0.004 / 00 / 0.000 / 1.00 / -
n = observed number of a HLA-B allele; 2n= total number of alleles (allele count); af = allele frequency; OR = odds ratio.
Bold numbers indicate p-value ≤ 0.05.
aChi-square test or Fisher’s exact test.
- = undefined OR value.