TITLE: FUNCTIONAL GENOMICS AND METABOLOMICS REVEAL THE TOXICOLOGICAL EFFECTS OF CADMIUM IN Musmusculus MICE

JOURNAL TITTLE: Metabolomics

AUTHORS: M.A. García-Sevillanoa,b,c,§, N. Abrild,e,§, R. Fernández-Cisnald,e,T. García-Barreraa,b,c, C. Pueyod,e, J. López-Baread,e, J.L. Gómez-Arizaa,b,c, *

aDepartment of Chemistry and Materials Sciences, Faculty of Experimental Science, eAgrifood Campus of International Excellence (ceiA3-UHU) and cResearch Center of Health and Environment (CYSMA), University of Huelva, Campus de El Carmen, 21007-Huelva, SPAIN.

dDepartment of Biochemistry and Molecular Biology and eAgrifood Campus of International Excellence (ceiA3-UCO), University of Córdoba, Severo Ochoa Building, Rabanales Campus, 14071-Córdoba, SPAIN.

§Both authors contributed equally to this work and should be considered first authors.

*CorrespondingAuthor: José Luis Gómez Ariza. Tel.: +34 959 219968, fax: +34 959 219942, e-mail address:

Supporting Information Table 3. Variance in mouse gene expression

Target
Mouse / A170 / Mogat1 / Gpx1
moleculesa / mean±SDb / moleculesa / mean±SDb / moleculesa / mean±SDb
1 / 33 / 34 / ± / 1.0 / 0.0199 / 0.0216 / ± / 0.0016 / 489 / 475 / ± / 16
34 / 0.0230 / 477
35 / 0.0220 / 458
2 / 28 / 28 / ± / 0.6 / 0.0196 / 0.0206 / ± / 0.0014 / 496 / 495 / ± / 5
28 / 0.0199 / 489
29 / 0.0222 / 499
3 / 35 / 35 / ± / 0.6 / 0.0235 / 0.0230 / ± / 0.0027 / 512 / 505 / ± / 6
34 / 0.0201 / 501
35 / 0.0255 / 503
4 / 30 / 29 / ± / 0.6 / 0.0250 / 0.0287 / ± / 0.0035 / 601 / 600 / ± / 2
29 / 0.0290 / 600
29 / 0.0320 / 598
5 / 28 / 28 / ± / 0.6 / 0.0262 / 0.0267 / ± / 0.0011 / 589 / 563 / ± / 55
28 / 0.0280 / 600
29 / 0.0260 / 499
6 / 29 / 31 / ± / 1.5 / 0.0256 / 0.0233 / ± / 0.0021 / 489 / 491 / ± / 4
32 / 0.0230 / 496
31 / 0.0214 / 489
7 / 32 / 31 / ± / 2.1 / 0.0333 / 0.0285 / ± / 0.0055 / 532 / 565 / ± / 32
33 / 0.0298 / 566
29 / 0.0225 / 596
8 / 33 / 33 / ± / 0.6 / 0.0263 / 0.0250 / ± / 0.0047 / 587 / 558 / ± / 51
33 / 0.0198 / 588
32 / 0.0289 / 499
mean ± SDc / 31 / ± / 2.5 / 0.0247 / ± / 0.0021 / 531 / ± / 45
aTranscript molecules per picogram of total RNA
b Mean ± SD of 3 repetitions
c Mean ± SD of 8 mice