Data sheet for geneticallymodified lines
(GM – strained or non-strained) orstrained mutants

Articles 23and 28 Animal Experiments Ordinance (TVV)

A.Decision of cantonal authority (Art. 127 Animal Welfare Ordinance TSchV)
Decision of cantonal authority
onconstraintand further breeding of the line
/ Line subject to clarification (no decision of cantonal authority)
Non-strained line (no decision of cantonal authority)
Strained line - decision of cantonal authority enclosed:
Date: Number maximumdegree of stress:
B.Study director / owner of animal line
Study director /
owner of the line(of the local population)
Surname,first name, institute, address, e-mail, phone
C.Details of laboratory animal husbandry (Art. 114 TSchV)
C1
Licence number of laboratory animal husbandry / (if necessary, licence according to Art. 142 TSchV, Form-G: )
C2
Husbandry manager
Surname, first name
Address, e-mail, phone
C3
Location of animal husbandry
Address
D.Basic scientific data (Annex 2 TVV)
D1
Animal species
D2
Name of line
(Nomenclatureaccording to: )
D3
Genetic modification
  • Type ofGM
  • Database reference
  • Literature details
  • Purpose of line

D4
Production
  • Producer
  • Method of production
  • Year of production
  • Number of generations
  • Status of breeding
    (ongoing, stopped,
    cryo-preserved)

D5
Genotype
  • Genotype
  • Genetic background
  • Hygienestatus

E.Summary of monitoring of constraint(Annex 3 TVV)
E1
Status of monitoring of constraint / still subject to clarification
still subject to clarification / stress provisionally reported
completed, not strained
completed / constraint definitively reported; decision of authoritypending
completed / strainedline according to decisionof authorities (cf.chapter A)
E2
Record of constraint
  • Scope ofobservations conducted
  • Comparison of mortalityand reproductiondatawith those of wildtype

E3
Phenotype
  • Description of the phenotypeand the constraint
  • Assessment of constraint
  • Degree of severityand age of occurrence
  • Expression of transgene (dominant/recessive, conditional, inducible)
/ Maximumeffective degree of severity (retrospective):
E4
Mitigation of constraint
  • specific needs
  • strain-reducingmeasuresand their expected impact

E5
Criteria for withdrawal
  • Euthanasiaof strained individuals

  1. Remarks
G.Dateand author of revision of data sheet
Date / Author / Contents / reason for revision

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