Figure S1. Flow Chart of Study Participants

SUPPLEMENTAL MATERIAL

Figure S1. Flow chart of study participants

SUPPLEMENTAL MATERIAL

Table S1.Hazards ratios (95% confidence interval) for the associations of type 1 and type 2 diabetes mellitus with cardiovascular disease

Cardiovascular disease / No diabetes
(n = 69106) / Type 1 diabetes
(n = 247) / Type 2 diabetes
(n = 2130)
Myocardial infarction
No. of cases / 5797 / 51 / 394
Age- and sex-adjusted HR / 1.00 (reference) / 3.49 (2.65–4.61) / 1.91 (1.72–2.11)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 3.51 (2.66–4.66) / 1.81 (1.64–2.01)
Multivariable-adjusted HR* / 1.00 (reference) / 3.26 (2.47–4.30) / 1.65 (1.48–1.83)
Heart failure
No. of cases / 3945 / 22 / 301
Age- and sex-adjusted HR / 1.00 (reference) / 2.88 (1.89–4.38) / 2.00 (1.78–2.25)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 2.79 (1.84–4.25) / 1.81 (1.61–2.04)
Multivariable-adjusted HR* / 1.00 (reference) / 2.68 (1.76–4.09) / 1.69 (1.50–1.90)
Aortic valve stenosis
No. of cases / 1165 / 4 / 73
Age- and sex-adjusted HR / 1.00 (reference) / 1.52 (0.57–4.07) / 1.62 (1.28–2.05)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.50 (0.56–4.00) / 1.46 (1.15–1.85)
Multivariable-adjusted HR* / 1.00 (reference) / 1.44 (0.54–3.85) / 1.34 (1.05–1.71)
Atrial fibrillation
No. of cases / 9007 / 22 / 392
Age- and sex-adjusted HR / 1.00 (reference) / 1.02 (0.67–1.56) / 1.17 (1.06–1.30)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.02 (0.67–1.55) / 1.07 (0.96–1.18)
Multivariable-adjusted HR* / 1.00 (reference) / 0.99 (0.65–1.50) / 1.01 (0.91–1.12)
Abdominal aortic aneurysm
No. of cases / 1170 / 0 / 31
Age- and sex-adjusted HR / 1.00 (reference) / – / 0.66 (0.46–0.94)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / – / 0.62 (0.44–0.89)
Multivariable-adjusted HR* / 1.00 (reference) / – / 0.57 (0.40–0.82)
Ischemic stroke
No. of cases / 4476 / 28 / 309
Age- and sex-adjusted HR / 1.00 (reference) / 2.76 (1.90–4.00) / 1.89 (1.69–2.13)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 2.73 (1.88–3.96) / 1.81 (1.61–2.04)
Multivariable-adjusted HR* / 1.00 (reference) / 2.61 (1.80–3.79) / 1.68 (1.49–1.89)
Intracerebral hemorrhage
No. of cases / 666 / 1 / 13
Age- and sex-adjusted HR / 1.00 (reference) / – / 0.55 (0.32–0.95)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / – / 0.54 (0.31–0.94)
Multivariable-adjusted HR* / 1.00 (reference) / – / 0.51 (0.30–0.88)

*Hazard ratios were estimated by Cox proportional hazards regression models with age as the time scale, stratified by sex, and adjusted for body mass index, education, family history of myocardial infarction, smoking status and pack-years of smoking, aspirin use, exercise, walking/bicycling, history of hypertension, history of hypercholesterolemia, alcohol consumption, total energy intake, and a modified Dietary Approaches to Stop Hypertension diet score.

SUPPLEMENTAL MATERIAL

Table S2.Hazards ratios (95% confidence interval) for the associations of type 2 diabetes mellitus at baseline or during follow-up with cardiovascular disease

Cardiovascular disease / No diabetes
(n = 63148) / Type 2 diabetes
(n = 7983)
Myocardial infarction
No. of cases / 5002 / 1174
Age- and sex-adjusted HR / 1.00 (reference) / 1.66 (1.56–1.77)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.58 (1.48–1.69)
Multivariable-adjusted HR* / 1.00 (reference) / 1.45 (1.36–1.55)
Heart failure
No. of cases / 3381 / 851
Age- and sex-adjusted HR / 1.00 (reference) / 1.76 (1.63–1.89)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.55 (1.43–1.67)
Multivariable-adjusted HR* / 1.00 (reference) / 1.44 (1.33–1.55)
Aortic valve stenosis
No. of cases / 7887 / 1490
Age- and sex-adjusted HR / 1.00 (reference) / 1.50 (1.29–1.73)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.32 (1.13–1.53)
Multivariable-adjusted HR* / 1.00 (reference) / 1.23 (1.06–1.43)
Atrial fibrillation
No. of cases / 1010 / 224
Age- and sex-adjusted HR / 1.00 (reference) / 1.34 (1.27–1.42)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.19 (1.13–1.26)
Multivariable-adjusted HR* / 1.00 (reference) / 1.14 (1.07–1.20)
Abdominal aortic aneurysm
No. of cases / 1027 / 170
Age- and sex-adjusted HR / 1.00 (reference) / 1.05 (0.89–0.24)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 0.98 (0.83–1.16)
Multivariable-adjusted HR* / 1.00 (reference) / 0.88 (0.74–1.05)
Ischemic stroke
No. of cases / 3843 / 930
Age- and sex-adjusted HR / 1.00 (reference) / 1.72 (1.60–1.85)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 1.65 (1.53–1.77)
Multivariable-adjusted HR* / 1.00 (reference) / 1.54 (1.43–1.66)
Intracerebral hemorrhage
No. of cases / 612 / 67
Age- and sex-adjusted HR / 1.00 (reference) / 0.78 (0.60–1.00)
Age-, sex- and BMI-adjusted HR / 1.00 (reference) / 0.77 (0.59–0.99)
Multivariable-adjusted HR* / 1.00 (reference) / 0.72 (0.55–0.93)