Supplementary Table E-3(AD Vs Non-AD Dementia)

Supplementary Table e-3(AD vs non-AD dementia)

100 times 10-fold cross-validation results for the naive Bayes classifier for all possible marker combinations (AD vs non-AD dementia data) including the composite marker Abeta/Tau. Models are ranked according to the average of cross-validation sensitivity and cross-validation specificity.

No. / Markers in the model / Accuracy (reclassification) / Sensitivity (reclassification) / Specificity (reclassification) / Accuracy (cross- validation) / Sensitivity (cross- validation) / Specificity (cross- validation)
1 / age, Tau, Aβ42, chitinase activity, stathmin / 0.8963 / 0.9362 / 0.8049 / 0.8408 / 0.8920 / 0.7234
2 / chitinase activity, stathmin, Aβ42/Tau / 0.8741 / 0.9255 / 0.7561 / 0.8421 / 0.8968 / 0.7166
3 / age, Tau, Aβ42, stathmin / 0.8741 / 0.9255 / 0.7561 / 0.8463 / 0.9086 / 0.7034
4 / Tau, Aβ42, stathmin / 0.8741 / 0.9255 / 0.7561 / 0.8440 / 0.9047 / 0.7049
5 / age, Aβ42, chitinase activity, stathmin, Aβ42/Tau / 0.8741 / 0.9149 / 0.7805 / 0.8327 / 0.8822 / 0.7193
6 / age, Aβ42, stathmin, Aβ42/Tau / 0.8667 / 0.9255 / 0.7317 / 0.8400 / 0.9011 / 0.7000
7 / age, Tau, chitinase activity, stathmin, Aβ42/Tau / 0.8667 / 0.9149 / 0.7561 / 0.8298 / 0.8759 / 0.7241
8 / age, chitinase activity, stathmin, Aβ42/Tau / 0.8889 / 0.9362 / 0.7805 / 0.8403 / 0.9029 / 0.6968
9 / age, Aβ42, chitinase activity, stathmin / 0.9037 / 0.9255 / 0.8537 / 0.8311 / 0.8802 / 0.7185
10 / Tau, chitinase activity, stathmin, Aβ42/Tau / 0.8593 / 0.9149 / 0.7317 / 0.8270 / 0.8712 / 0.7256
11 / Aβ42, chitinase activity, stathmin, Aβ42/Tau / 0.8667 / 0.9043 / 0.7805 / 0.8276 / 0.8739 / 0.7215
12 / Tau, Aβ42, chitinase activity, stathmin / 0.8815 / 0.9149 / 0.8049 / 0.8315 / 0.8856 / 0.7073
13 / age, Tau, stathmin, Aβ42/Tau / 0.8519 / 0.9043 / 0.7317 / 0.8306 / 0.8840 / 0.7080
14 / Tau, stathmin, Aβ42/Tau / 0.8444 / 0.9043 / 0.7073 / 0.8299 / 0.8833 / 0.7073
15 / Aβ42, stathmin, Aβ42/Tau / 0.8667 / 0.9255 / 0.7317 / 0.8345 / 0.8962 / 0.6932
16 / age, Tau, Aβ42, stathmin, Aβ42/Tau / 0.8519 / 0.9043 / 0.7317 / 0.8287 / 0.8880 / 0.6929
17 / Tau, Aβ42, stathmin, Aβ42/Tau / 0.8519 / 0.9149 / 0.7073 / 0.8272 / 0.8853 / 0.6939
18 / Aβ42, chitinase activity, stathmin / 0.8889 / 0.9149 / 0.8293 / 0.8198 / 0.8689 / 0.7071
19 / stathmin, Aβ42/Tau / 0.8444 / 0.9149 / 0.6829 / 0.8327 / 0.9030 / 0.6717
20 / age, Tau, Aβ42, chitinase activity, stathmin, Aβ42/Tau / 0.8815 / 0.9149 / 0.8049 / 0.8204 / 0.8736 / 0.6983
21 / Aβ42, stathmin / 0.8815 / 0.9149 / 0.8049 / 0.8229 / 0.8801 / 0.6917
22 / Tau, chitinase activity, stathmin / 0.8667 / 0.8723 / 0.8537 / 0.8187 / 0.8698 / 0.7015
23 / age, Aβ42, stathmin / 0.8667 / 0.9149 / 0.7561 / 0.8213 / 0.8797 / 0.6873
24 / Tau, Aβ42, chitinase activity, stathmin, Aβ42/Tau / 0.8815 / 0.9149 / 0.8049 / 0.8163 / 0.8683 / 0.6971
25 / age, stathmin, Aβ42/Tau / 0.8519 / 0.9255 / 0.6829 / 0.8313 / 0.9089 / 0.6532
26 / age, Tau, chitinase activity, stathmin / 0.8815 / 0.8936 / 0.8537 / 0.8154 / 0.8704 / 0.6893
27 / Tau, stathmin / 0.8370 / 0.8830 / 0.7317 / 0.8159 / 0.8744 / 0.6817
28 / stathmin / 0.8222 / 0.8511 / 0.7561 / 0.7973 / 0.8412 / 0.6968
29 / age, stathmin / 0.8296 / 0.8617 / 0.7561 / 0.7995 / 0.8481 / 0.6880
30 / age, chitinase activity, stathmin / 0.8519 / 0.8723 / 0.8049 / 0.7963 / 0.8444 / 0.6861
31 / age, Tau, stathmin / 0.8296 / 0.8830 / 0.7073 / 0.8099 / 0.8807 / 0.6476
32 / Tau, chitinase activity, Aβ42/Tau / 0.8296 / 0.8830 / 0.7073 / 0.7973 / 0.8497 / 0.6773
33 / chitinase activity, stathmin / 0.8444 / 0.8723 / 0.7805 / 0.7939 / 0.8415 / 0.6849
34 / age, Aβ42, Aβ42/Tau / 0.8222 / 0.8830 / 0.6829 / 0.7932 / 0.8421 / 0.6810
35 / Aβ42, chitinase activity, Aβ42/Tau / 0.8148 / 0.8511 / 0.7317 / 0.7897 / 0.8388 / 0.6771
36 / Tau, Aβ42, chitinase activity, Aβ42/Tau / 0.8000 / 0.8404 / 0.7073 / 0.7833 / 0.8265 / 0.6844
37 / age, Aβ42, chitinase activity, Aβ42/Tau / 0.8148 / 0.8617 / 0.7073 / 0.7841 / 0.8289 / 0.6815
38 / Aβ42, Aβ42/Tau / 0.8000 / 0.8617 / 0.6585 / 0.7911 / 0.8474 / 0.6620
39 / age, Tau, Aβ42, chitinase activity, Aβ42/Tau / 0.8000 / 0.8404 / 0.7073 / 0.7789 / 0.8190 / 0.6868
40 / age, Tau, chitinase activity, Aβ42/Tau / 0.8370 / 0.8830 / 0.7317 / 0.7871 / 0.8412 / 0.6632
41 / Tau, Aβ42/Tau / 0.7926 / 0.8511 / 0.6585 / 0.7877 / 0.8470 / 0.6517
42 / age, Tau, Aβ42 / 0.8370 / 0.9043 / 0.6829 / 0.7848 / 0.8489 / 0.6378
43 / Tau, Aβ42 / 0.8296 / 0.9043 / 0.6585 / 0.7869 / 0.8543 / 0.6324
44 / age, Tau, Aβ42, Aβ42/Tau / 0.8074 / 0.8617 / 0.6829 / 0.7729 / 0.8234 / 0.6571
45 / Tau, Aβ42, Aβ42/Tau / 0.7852 / 0.8404 / 0.6585 / 0.7750 / 0.8302 / 0.6485
46 / Tau, Aβ42, chitinase activity / 0.8370 / 0.8830 / 0.7317 / 0.7800 / 0.8429 / 0.6359
47 / age, Tau, Aβ42/Tau / 0.8222 / 0.8830 / 0.6829 / 0.7767 / 0.8369 / 0.6385
48 / age, Tau, Aβ42, chitinase activity / 0.8593 / 0.9149 / 0.7317 / 0.7701 / 0.8261 / 0.6417
49 / chitinase activity, Aβ42/Tau / 0.8444 / 0.9362 / 0.6341 / 0.7848 / 0.8735 / 0.5815
50 / age, chitinase activity, Aβ42/Tau / 0.8444 / 0.9468 / 0.6098 / 0.7693 / 0.8607 / 0.5595
51 / Aβ42, chitinase activity / 0.8148 / 0.8936 / 0.6341 / 0.7443 / 0.8306 / 0.5463
52 / Aβ42/Tau / 0.8074 / 0.9362 / 0.5122 / 0.7593 / 0.8749 / 0.4941
53 / Tau, chitinase activity / 0.8000 / 0.8830 / 0.6098 / 0.7523 / 0.8653 / 0.4932
54 / age, Tau, chitinase activity / 0.8000 / 0.8936 / 0.5854 / 0.7480 / 0.8671 / 0.4749
55 / age, Aβ42/Tau / 0.8222 / 0.9468 / 0.5366 / 0.7448 / 0.8613 / 0.4778
56 / age, Aβ42, chitinase activity / 0.8370 / 0.9255 / 0.6341 / 0.7278 / 0.8266 / 0.5012
57 / Tau / 0.7704 / 0.9255 / 0.4146 / 0.7491 / 0.9076 / 0.3859
58 / age, Aβ42 / 0.7852 / 0.9149 / 0.4878 / 0.7214 / 0.8382 / 0.4537
59 / age, Tau / 0.7630 / 0.9255 / 0.3902 / 0.7450 / 0.9096 / 0.3676
60 / Aβ42 / 0.7778 / 0.8830 / 0.5366 / 0.7142 / 0.8326 / 0.4429
61 / age / 0.7185 / 0.9787 / 0.1220 / 0.7072 / 0.9687 / 0.1076
62 / age, chitinase activity / 0.7259 / 0.9681 / 0.1707 / 0.6813 / 0.9265 / 0.1193
63 / chitinase activity / 0.7111 / 1.0000 / 0.0488 / 0.6913 / 0.9820 / 0.0246