Table. ROI Analysis Results with Activated Brain Regions, Cluster Size, Cluster Peak Statistics

Table. ROI analysis results with activated brain regions, cluster size, cluster peak statistics and MNI coordinates for fear-relevant > neutral stimuli contrasts in the appropriate fear vs other fear groups.

Brain regions / Side / Voxels / Peak t / x / y / z
Spider pic > Neutral pic – Spider fearful vs Blood fearful
Amygdala / L / 124 / 4.5 / -21 / 0 / -18
ACC / L / 101 / 3.9 / 0 / 8 / 30
ACC / R / 47 / 3.8 / 8 / 18 / 29
Middle Frontal Gyrus / L / 26 / 4.7 / -47 / 3 / 51
Middle Frontal Gyrus / L / 152 / 3.6 / -29 / 53 / 27
Middle Frontal Gyrus / R / 624 / 6.3 / 44 / -5 / 60
Middle Frontal Gyrus / R / 55 / 4.1 / 38 / 2 / 42
Superior Frontal Gyrus / L / 74 / 4.1 / -30 / -5 / 66
Superior Frontal Gyrus / L / 146 / 4.0 / -21 / -6 / 56
Superior Frontal Gyrus / R / 43 / 4.4 / 38 / -6 / 63
Superior Frontal Gyrus / R / 83 / 3.9 / 29 / 0 / 54
Hippocampus / L / 118 / 4.6 / -26 / -21 / -21
Hippocampus / L / 67 / 4.2 / -20 / -38 / -3
Hippocampus / L / 88 / 3.9 / -32 / -26 / -8
Hippocampus / R / 244 / 5.6 / 30 / -36 / -6
Inferior Frontal Gyrus / L / 1445 / 5.8 / -50 / 15 / -3
Inferior Frontal Gyrus / R / 1682 / 5.3 / 47 / 27 / -3
Inferior Frontal Gyrus / R / 89 / 4.5 / 59 / 15 / 24
Inferior Frontal Gyrus / L / 730 / 5.5 / -48 / 15 / -6
Inferior Frontal Gyrus / R / 631 / 5.2 / 47 / 27 / -5
Insula / L / 1966 / 5.8 / -45 / 14 / -2
Insula / R / 973 / 5.1 / 38 / 15 / 2
Insula / R / 75 / 3.9 / 39 / -6 / -11
Spider pic > Neutral pic – Spider fearful vs Social fearful
Middle Frontal Gyrus / L / 17 / 3.5 / -30 / 62 / 9
Middle Frontal Gyrus / R / 98 / 3.8 / 21 / 63 / 26
Superior Frontal Gyrus / L / 69 / 3.9 / -20 / 41 / 38
Superior Frontal Gyrus / R / 91 / 3.9 / 21 / 63 / 24
Hippocampus / L / 18 / 3.7 / -29 / -20 / -21
Inferior Frontal Gyrus / R / 569 / 4.6 / 48 / 24 / -3
Inferior Frontal Gyrus / R / 299 / 4.5 / 48 / 24 / -5
Insula / L / 23 / 4.1 / -26 / 12 / -20
Insula / R / 155 / 4.5 / 47 / 23 / -2
Blood pic > Neutral pic – Blood fearful vs Spider fearful
-
Blood pic > Neutral pic – Blood fearful vs Social fearful
-
Social Exposure pic > Neutral pic – Social fearful vs Spider fearful
ACC / L / 10 / 3.6 / 2 / 20 / 24
Social Exposure pic > Neutral pic – Social fearful vs Blood fearful
-
Angry Faces pic > Neutral pic – Social fearful vs Spider fearful
-
Angry Faces pic > Neutral pic – Social fearful vs Blood fearful
-

Table. Whole brain analyses results with activated brain regions, cluster size, cluster peak statistics and MNI coordinates for fear-relevant > neutral stimuli contrasts in the appropriate fear group vs other fear groups.

Brain regions / Side / Voxels / Peak t / x / y / z
Spider pic > Neutral pic – Spider fearful vs Blood fearful
18970 / 8.0 / 24 / -57 / -17
Fusiform Gyrus / L+R
Middle Occipital Gyrus / R
Lingual Gyrus / L
Inferior Temporal Gyrus / R
Posterior Cingulate Gyrus / L+R
Precuneus / L+R
Inferior Occipital Gyrus / R
Cuneus / L+R
Cerebellum / L+R
Parahippocampal Gyrus / L+R
Hippocampus / R
Middle Temporal Gyrus / R
952 / 7.1 / 45 / -6 / 60
Precentral Gyrus / R
Middle Frontal Gyrus / R
1879 / 6.7 / -21 / -60 / 54
Precuneus / L
Superior Parietal Lobule / L
Postcentral Gyrus / L
2436 / 6.5 / -39 / -78 / 9
Middle Occipital Gyrus / L
Middle Temporal Gyrus / L
Superior Occipital Gyrus / L
Cuneus / L
1175 / 6.3 / -44 / 0 / 48
Precentral Gyrus / L
Middle Frontal Gyrus / L
Inferior Frontal Gyrus / L
2011 / 6.1 / 8 / 18 / 60
Superior Frontal Gyrus / L
Middle Cingulate Gyrus / L+R
Medial Frontal Gyrus / L
1130 / 6.0 / -50 / 14 / -2
Inferior Frontal Gyrus / L
Inferior Frontal Orbital Gyrus / L
Superior Temporal Gyrus / L
Insula / L
133 / 5.6 / -4 / -3 / 30
Supramarginal Gyrus / L
Inferior Parietal Lobule / L
159 / 5.4 / -23 / -27 / -21
Parahippocampal Gyrus / L
Fusiform Gyrus / L
1256 / 5.3 / 47 / 27 / -3
Inferior Frontal Gyrus / R
Insula / R
Frontal Inferior Orbital Gyrus / R
Superior Temporal Gyrus / R
Spider pic > Neutral pic – Spider fearful vs Social fearful
919 / 5.8 / 60 / -45 / 47
Inferior Parietal Lobule / R
Supramarginal Gyrus / R
320 / 5.0 / 9 / 23 / 63
Superior Frontal Gyrus / R
Medial Frontal Gyrus / R
Supplementary Motor Area / R
16107 / 4.9 / -8 / -68 / -20
Precuneus / L+R
Cuneus / L+R
Posterior Cingulate Gyrus / L+R
Lingual Gyrus / L+R
Cerebellum / L+R
Middle Occipital Gyrus / L+R
Fusiform Gyrus / R
Superior Occipital Gyrus / R
1474 / 4.6 / 48 / 24 / -3
Inferior Frontal Gyrus / R
Frontal Inferior Orbital Gyrus / R
Insula / R
Superior Temporal Gyrus / R
Inferior Frontal Gyrus / R
121 / 4.1 / -26 / 12 / -20
Inferior Frontal Gyrus / L
Insula / L
Superior Frontal Gyrus / L
Frontal Inferior Orbital Gyrus / L
689 / 4.0 / 32 / 0 / 27
Superior Frontal Gyrus / R
Middle Frontal Gyrus / R
Medial Frontal Gyrus / R
302 / 3.9 / 62 / 18 / 27
Inferior Frontal Gyrus / R
Middle Frontal Gyrus / R
Precenral Gyrus / R
397 / 3.9 / -59 / 51 / 33
Supramarginal Gyrus / L
Inferior Parietal Lobule / L
Angular Gyrus / L
100 / 3.7 / -27 / -20 / -23
Parahippocampal Gyrus / L
Hippocampus / L
180 / 3.7 / 50 / -72 / -12
Middle Occipital Gyrus / R
Inferior Occipital Gyrus / R
Inferior Temporal Gyrus / R
547 / 3.5 / -30 / 62 / 9
Middle Frontal Gyrus / L
Superior Frontal Gyrus / L
238 / 3.5 / -8 / 63 / 21
Superior Frontal Gyrus / L
Medial Frontal Gyrus / L
211 / 3.4 / -50 / 18 / -2
Blood pic > Neutral pic – Blood fearful vs Spider fearful
Precentral Gyrus / L / 51 / 3.5 / -56 / 12 / 36
Blood pic > Neutral pic – Blood fearful vs Social fearful
Middle Frontal Gyrus / L / 88 / 3.3 / -54 / 14 / 36
Middle Occipital Gyrus / R / 59 / 3.2 / 47 / -77 / 24
Brain regions / Side / Voxels / Peak t / x / y / z
Social Exposure Pic > Neutral pic – Social fearful vs Blood fearful
-
Social Exposure Pic > Neutral pic – Social fearful vs Spider fearful
Middle Cingulate Gyrus / L / 151 / 3.6 / 2 / 20 / 24
Anterior Orbital Gyrus / L / 83 / 3.3 / -29 / 39 / -12
Brain regions / Side / Voxels / Peak t / x / y / z
Angry Faces Pic > Neutral pic – Social fearful vs Blood fearful
-
Angry Faces Pic > Neutral pic – Social fearful vs Spider fearful
Superior Parietal Lubule / L / 58 / 2.9 / -9 / -63 / -64
Occipital Pole / R / 49 / 2.1 / 15 / -97 / 6

Table. Results from whole brain analyses with activated brain regions, cluster size, cluster peak statistics and MNI coordinates illustrating the main effects of group in fear > neutral picture contrasts.

Brain regions / Side / Voxels / Peak F / x / y / z
Blood pic > Neutral Pic – Main effect of group
Parahippocampal Gyrus / L / 233 / 14.7 / -20 / -23 / -18
Postcentral Gyrus / R / 568 / 13 / 38 / -51 / 63
Inferior Parietal Lobule / R
Superior Parietal Lobule / R
Precuneus / L / 202 / 11.2 / -8 / -81 / 44
Superior Occipital Gyrus / L
Lingual Gyrus / L / 193 / 8.7 / -8 / -89 / -17
Thalamus / L / 76 / 7.7 / -5 / -27 / 9
Inferior Frontal Gyrus / R / 63 / 7.3 / 59 / 17 / 26
Superior Frontal Gyrus / R / 121 / 6.5 / 17 / 63 / 0
Medial Frontal Gyrus / R
Thalamus / R / 97 / 6.5 / 6 / -26 / 11
Postcentral Gyrus / L / 77 / 6 / -21 / -42 / 74
Social Exposure pic > Neutral Pic – Main effect of group
Middle Frontal Gyrus / R / 70 / 10.4 / 33 / 15 / 62
Superior Frontal Gyrus / R / 116 / 9.5 / 18 / -2 / 68
Middle Temporal Gyrus / L / 246 / 8.4 / -44 / -71 / 11
Middle Occipital Gyrus / L
Superior Frontal Gyrus / L / 127 / 8.1 / -24 / 44 / 24
Middle Frontal Gyrus / L
Inferior Frontal Gyrus / R / 121 / 7.7 / 44 / 36 / 0
Middle Frontal Gyrus / R
Angry Faces pic > Neutral Pic – Main effect of group
Precentral Gyrus / R / 133 / 12.6 / 36 / -12 / 36
Middle Occipital Gyrus / R / 225 / 11.5 / 39 / -71 / 5
Anterior Cingulate Gyrus / L / 104 / 11.1 / -2 / 2 / 27
Fusiform Gyrus / R / 186 / 8.1 / 41 / -41 / -14
Lingual Gyrus / L / 237 / 7.8 / -9 / -74 / -14
Cerebellum / L
Spider pic > Neutral pic – Main effect of group *
Precentral Gyrus / L / 158 / 25.8 / -42 / -5 / 60
Middle Frontal Gyrus / L
Fusiform Gyrus / R / 1750 / 25 / 24 / -56 / -9
Parahippocampal Gyrus / R
Inferior Temporal Gyrus / R
Cerebellum / R
Fusiform Gyrus / L / 1207 / 22.9 / -23 / -60 / -3
Lingual Gyrus / L
Inferior Temporal Gyrus / L
Inferior Occipital Gyrus / L
Precentral Gyrus / R / 76 / 21.5 / 44 / -8 / 60
Superior Occipital Gyrus / R / 266 / 19 / 23 / -81 / 35
Precuneus / R
Cuneus / R
Superior Parietal Lobule / L / 162 / 18.9 / -20 / -53 / 54
Precuneus / L
Lingual Gyrus / R / 98 / 17 / 6 / -56 / 3
Posterior Cingulate Gyrus / R
Inferior Frontal Gyrus / L / 51 / 16.9 / -50 / 14 / -2
Precentral Gyrus / L / 77 / 16.5 / -42 / -2 / 47
Middle Frontal Gyrus / L

Notes. All of the listed brain regions were cluster corrected and met the significance threshold of p 0.05. L is left; R is right; Cluster size is the number of voxels activated in the regional cluster. The x, y, z coordinates are the MNI coordinates. Only the main peaks of activation within each cluster and their corresponding brain structures are reported.
* FWE corrected (p = 0.05)