EllervikPage 129-10-2018
NEUROLOGY MS ID#: NEUROLOGY/2006/157560
Online Supplemental Data: E-Results
Results
As hereditary hemochromatosis presents differently clinically in men and women with a more severe phenotype in men, we hereby present gender-stratified results.
Results
Symptomatic carotid atherosclerosis
In women H63D/wild type versus wild type/wild type had a crude odds ratio of 1.5 (95%CI: 1.1-2.0; p=0.02) and a multifactorially adjusted odds ratio of 1.8(1.2-2.6; p=0.003) (E-Table 1). The crude odds ratio was not significant after correction for multiple comparisons, but the multifactorially adjusted odds ratio was significant.In men there were no significant differences. Crude and multifactorially adjusted odds ratios for symptomatic carotid atherosclerosis in H63D/H63D, C282Y/H63D, and C282Y/wild type versus wild type/wild type individuals were all nonsignificant when stratified by gender. There were no cases withC282Y/C282Y.
Ischemic cerebrovascular disease(ICVD)
Cumulative incidence of ICVD as a function of age was increased in individuals with H63D/H63D compared to wild type/wild type in both men (log-rank, p=0.04)and women(log-rank, p=0.03) (E-Figure 2).These results were not significant after correction for multiple comparisons.
Age- and multifactorially adjusted hazard ratios for ICVD in men with H63D/H63D versus wild type/wild type were 2.1(1.0-4.3;p=0.04) and 2.4(1.2-5.0;p=0.01);the latter was also significant after correction for multiple comparisons (E-Table 2). In women, age- and multifactorially adjusted hazard ratios for ICVD for H63D/H63D versus wild type/wild type were 2.0(1.0-4.0;p=0.04) and 1.8(0.9-3.8;p=0.10); none of these results weresignificant after correction for multiple comparisons.
Age- and multifactorially adjusted hazard ratios for ICVDin H63D/wild type, C282Y/H63D, C282Y/C282Y, and C282Y/wild type versus wild type/wild type individuals were all nonsignificant in both genders (E-Table 2).
Ischemic stroke
Cumulative incidence of ischemic stroke as a function of age was increased in individuals with H63D/H63D compared to wild type/wild type in both men (log-rank, p=0.004)and women(log-rank, p=0.01) (E-Figure 3).These results were also significant after correction for multiple comparisons.
Age- and multifactorially adjusted hazard ratios for ischemic stroke in men with H63D/H63D versus wild type/wild type were 2.7(1.3-5.6;p=0.006) and 3.1(1.5-6.4;p=0.002) (E-Table 2), both of which were also significant after correction for multiple comparisons. In women, age- and multifactorially adjusted hazard ratios for ischemic stroke for H63D/H63D versus wild type/wild type were 2.4(1.2-4.8;p=0.02) and 2.5(1.2-5.1;p=0.01);the latter wassignificant after correction for multiple comparisons.
Age- and multifactorially adjusted hazard ratios for ischemic strokein H63D/wild type, C282Y/H63D, C282Y/C282Y, and C282Y/wild type versus wild type/wild type individuals were all nonsignificant in both genders (E-Table 2).
Legends
E-Figure 1. Plasma levels of ferritin, transferrin saturation, and oxidized LDL according to hereditary hemochromatosis genotype in prospective study of the general population.
Values are medians (interquartile ranges). P values are versus wild type/wild type by Mann-Whitney U test. *P<0.05, **P<0.01, ***P<0.001.
E-Figure 2. Gender-stratified cumulative incidence of ICVDfor H63D/H63D and wild type/wild type individuals in the general population.
Number (No.) at risk is shown beneath the bars.
E-Figure 3. Gender-stratified cumulative incidence of ischemicstroke for H63D/H63D and wild type/wild type individuals in the general population.
Number (No.) at risk is shown beneath the bars.