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Supplementary Table 1. Amino acid accession numbers of β-lactamases used in evolutionary analyses, separated by class.

Amino acid / Organism / Name of
accession number / β-lactamase
Class A β-lactamases
AAZ14955 / Acinetobacter baumannii / CTX-M-43
AAU89132 / Aeromonas punctata / PER-3
AAK52328 / Burkholderia pseudomallei / PenP
ABN51008 / Citrobacter freundii / CTX-M-65
AAL55262 / Chryseobacterium gleum / CGA-1
CAA54738 / Citrobacter koseri / PenP
AAK63223 / Citrobacter sedlakii / Sed-1
BAA76882 / Enterobacter cloacae / SFO-1
AAS48620 / Enterobacter cloacae / VEB-3
ABB59946 / Escherichia coli / CTX-M-15 like
AAK32961 / Escherichia coli / CTX-M-16
CAD08929 / Escherichia coli / CTX-M-21
BAD16611 / Escherichia coli / CTX-M-36
AAY84742 / Escherichia coli / CTX-M-42
ABA62022 / Escherichia coli / CTX-M-51
ABN48311 / Escherichia coli / CTX-M-56
AF148067 / Escherichia coli / TLA-1
ABN80430 / Escherichia coli / VEB-5
AAL99990 / Escherichia coli / PenP
CAB55427 / Elizabethkingia meningoseptica / CME-1
ABO21421 / Elizabethkingia meningoseptica / CME-2
CAB59824 / Kluyvera ascorbata / PenP
AAK08976 / Kluyvera cryocrescens / KLUC-1
AAT45022 / Kluyvera sp. N030460 / KLUY-3
AAQ75378 / Klebsiella oxytoca / OXY-2
AAL78161 / Klebsiella oxytoca / PenP
AAF72531 / Klebsiella pneumoniae / CTX-M-13
AAK55534 / Klebsiella pneumoniae / CTX-M-19
AAV70602 / Klebsiella pneumoniae / CTX-M-38
ABD73290 / Klebsiella pneumoniae / CTX-M-59
CAM12803 / Leminorella grimontii / PenP
AAK29174 / Pseudomonas aeruginosa / VEB-2
AAU10324 / Pseudomonas luteola / Lut-1
CAC95175 / Proteus mirabilis / CTX-M-20
ABM54868 / Proteus mirabilis / VEB-4
AAL57765 / Proteus penneri / HugA
CAD99181 / Providencia sp. 4440 / CTX-M-31
BAA07084 / Proteus vulgaris / BlaB
AAK83220 / Rahnella aquatilis / RAHN-1
ABB72225 / Salmonella enterica / CTX-M-53
CAB61635 / Serratia fonticola / FONA-1
CAB61637 / Serratia fonticola / FONA-2
CAB61643 / Serratia fonticola / FONA-5
CAB61645 / Serratia fonticola / FONA-6
AAG24824 / Salmonella typhimurium / CTX-M-5
CAA63714 / Salmonella typhimurium / PER-2
YP_133850 / uncultured bacterium plasmid pRSB101
AAX55643 / Yersinia enterocolitica / A
Metallo-β-lactamases
CAC87665 / Caulobacter vibrioides / CAU-1
AAF04458 / Chryseobacterium meningosepticum / GOB-1
AAT68577 / Chryseobacterium meningosepticum / GOB-10
AAT68578 / Chryseobacterium meningosepticum / GOB-11
AAT68579 / Chryseobacterium meningosepticum / GOB-12
AAT68580 / Chryseobacterium meningosepticum / GOB-13
AAT68582 / Chryseobacterium meningosepticum / GOB-14
AAV65595 / Chryseobacterium meningosepticum / GOB-15
AAW82618 / Chryseobacterium meningosepticum / GOB-16
AAW82619 / Chryseobacterium meningosepticum / GOB17
AAQ54756 / Chryseobacterium meningosepticum / GOB-8
AAT68576 / Chryseobacterium meningosepticum / GOB-9
CAC48262 / Caulobacter vibrioides / Mbl1b
ABO21417 / Elizabethkingia meningoseptica / GOB-1
AAY53478 / Elizabethkingia meningoseptica / GOB-18
ABK64103 / Janthinobacterium lividum strain BP / THIN-B
ABK64020 / Janthinobacterium lividum strain BR / THIN-B
CAC33832 / Janthinobacterium lividum strain JAC1 / THIN-B
CAB96921 / Fluoribacter gormanii / FEZ-1
BAF47409 / Stenotrophomonas maltophilia strain GN12873 / L1
BAF47404 / Stenotrophomonas maltophilia strain IAM 12423 / L1
BAF47406 / Stenotrophomonas maltophilia strain IAM 1566 / L1
ABC02083 / Stenotrophomonas maltophilia strain 710 / L1
CAC15063 / Stenotrophomonas maltophilia strain ULA511 / BlaS
CAB63489 / Stenotrophomonas maltophilia strain J675a / L1
CAB63488 / Stenotrophomonas maltophilia strain K279a / L1
CAB75346 / Stenotrophomonas maltophilia strain N531 / L1
AAC21590 / Stenotrophomonas maltophilia strain GN12873 / L1
Class C β-lactamases
AAT70411 / Acinetobacter baumannii / ADC-7
AAV32519 / Acinetobacter baumannii strain CLA-1 / AmpC
CAJ77859 / Acinetobacter baumannii strain AYE / AmpC
CAK95249 / Acinetobacter genomosp. 3 / ADC-12
CAK95245 / Acinetobacter genomosp. 3 / ADC-16
CAK95244 / Acinetobacter genomosp. 3 / ADC-17
CAK95243 / Acinetobacter genomosp. 3 / ADC-18
CAK95240 / Acinetobacter genomosp. 3 / ADC-21
CAK95237 / Acinetobacter genomosp. 3 / ADC-24
CAE00827 / Acinetobacter genomosp. 3 / AmpC
CAB76925 / Aeromonas hydrophila / CepH
AAM46773 / Aeromonas punctata / AmpC
AAA83416 / Aeromonas sobria / AmpC
AAK31368 / Enterobacter aerogenes / CMY-10
ABP49606 / Escherichia coli / ACC-4
BAB72158 / Escherichia coli / CMY-9
CAA71325 / Escherichia coli / FOX-2
CAB89086 / Escherichia coli / FOX-4
AAF86692 / Hafnia alvei / ACC-1a
AAF86698 / Hafnia alvei / ACC-1c
AAF86691 / Hafnia alvei / ACC-2
AAF86696 / Hafnia alvei / ACC-3
CAA71947 / Klebsiella oxytoca / FOX-3
CAB46491 / Klebsiella pneumoniae / ACC-1
CAA63264 / Klebsiella pneumoniae / CMY-1
AAZ03413 / Klebsiella pneumoniae / CMY-8b
BAA02563 / Klebsiella pneumoniae / MOX-1
CAB82578 / Klebsiella pneumoniae / MOX-2
CAA39987 / Lysobacter lactamgenus / AmpC
AAR14270 / Mycobacterium smegmatis / BlaE
CAC04522 / Ochrobactrum anthropi / AmpC
CAC17622 / Ochrobactrum anthropi / OCH-2
CAC17623 / Ochrobactrum anthropi / OCH-3
CAC17624 / Ochrobactrum anthropi / OCH-4
CAC17626 / Ochrobactrum anthropi / OCH-6
AAO43172 / Oligella urethralis / Aba-1
AAM08942 / Pseudomonas aeruginosa strain CF001710 / AmpC
BAE46547 / Pseudomonas aeruginosa strain TUM1786 / AmpC
CAA38522 / Pseudomonas aeruginosa strain PAO1 / AmpC
AAK15702 / Serratia marcescens strain 520R / AmpC
AAK64454 / Serratia marcescens strain serr1 / AmpC
CAB69829 / Serratia marcescens strain SLS73 / AmpC
AAS46849 / Serratia marcescens strain ES-46 / AmpC
AAQ90024 / Serratia marcescens strain HD / AmpC
BAA23131 / Serratia marcescens / SST-1
AAY90134 / uncultured bacterium / pCosCE1