Buse et al The DURABLE Trial 24-week Results

LISTING OF PARTICIPATING INVESTIGATORS

Participating investigators are as follows: ArgentinaHernan Finkelstein, ClaudiaGoycoa, Mauricio Jadzinsky, Pedro Lobo, Laura Maffei, Fabio Massari, AlejandraOviedo, Maria CarolinaRidruejo; AustraliaHemaloto Akau' loa, William Jeffries, Kris Eun Ja Park, Anthony Roberts, RichardSimpson, BronwynStuckey; BrazilJorge Gross, Nelson Rassi, Rosangela Rea, Joao Eduardo Salles; CanadaGordon Bailey, Ian Blumer, RichardDumas, Irving StanleyGottesman, Stuart Ross, Karen Silver, Bruno St-Pierre, Vincent Woo, George Zimakas; GreeceMarianaBenroubi, IliasMigdalis, EmmanuilPagkalos, StavrosPappas, ConstantinePhenekos; HungaryIrenFoldesi, ElekJuhasz, CsabaRuzsa, ZsoltSudar; IndiaJamal Ahmad, Mala Dharmalingham, Matthew John, Sanjay Kalra, Ravi Mehrotra, Mayur Patel, Vairamuthu Sekar, Bipin Sethi; The Netherlands RuutBianchi, FritsHolleman, Adriaan Kooy, Cees JTack, Joopvan den Bergh, RuudVan Leendert, ReneWouters; RomaniaAdrian Albota, Carmen Crisan, Nicolae Hancu, Radu Lichiardopol, Viorel Serban; SpainJose Angel Diaz Perez, Santiago Durán Garcia, Angel Luis Marco-Mur, AntonioRobles Iniesta, FranciscoTinahones Madueno, Carlos Trescoli Serrano, Luis Alberto Vazquez Salvi; United StatesLisaAbbott, KurianAbraham,FranciscoAbreu, AngelaAdelizzi, JohnAgaiby, IntekhabAhmed, MyriamAllende, LawrenceAlwine, GunnarAnderson, CoreyAnderson, JoseAponte, RichardArakaki, AbrahamAreephanthu, JosephArena, RobertAshley, Jr, JoseAyala, MiraBaron, ElizabethBarranco, GaryBedel, RaymondBell, MarioBelledonne, RajatBhushan, JohnBoeren, DonaldBrautigam, TracyBrobyn, MichaelBryer-Ash, EdwardBusick, RogersCain, JamesCapo, KentCarpenter, MaryCarroll, RobertCater, ChristopherChappel, RichardCherlin, MarcosChertman, RonaldChochinov, AllenChodock, JamieClaudio, Alan JayCohen, EdwardCondon, CliffordCooper, ClintonCorder, SamuelCrockett, LucitaCruz, EdwardCullen, Thuy-TienDam, KennethDawes, RobertDay, JamesDicke, DanielDonovan, H. JacksonDowney, StevenDrosman, HughDurrence, KentFarnsworth, MadeleineFay, JamesFidelholtz, RaymondFink, DavidFitz-Patrick, LeonFogelfeld, KennethFox, NeilFraser, AmyFreeth, MaryFrohnauer, MaryGaffney, LindaGaudiani, StevenGeller, GeoffreyGladstein, Gopalakrishna MurthyGollapudi, ScottGrady, SamGriffin, GeorgeGriffing, StephenGrubb, GeorgeGrunberger, AdarshGupta, FrederickHaller, ForrestHanke, HoadleyHarris, DavidHassman, LydiaHazan, ArchieHearne, MarkHenderson, CarlosHernandez, VernonHershberger, RobertHippert, StephenHippler, RaseanHodge, PriscillaHollander, RaymondHooft, BarryHorowitz, RobertHudrick, RandalJacks, WilliamJacks, LarryJohnson, DavidJohnson, ZeviKahn, RoyKaplan, KarenKartun, SaleemKhan, AllenKing, LeslieKlaff, EricKlein, MarianandaKumar, LloydKuritsky, DerekLeRoith, PhilipLevin, DerekLewis, DonaldLiebelt, RobertLipetz, AlfredoLopez, KathrynLucas, LonLynn, AnneMacek, RobertMadder, HipolitoMariano, Jr, JoseMartinez, RuchiMathur, MichaelMcCartney, RichardMcDavid, ElyseMichelson, DavidMiller, DebraMiller, WilliamMiser, C. BrendanMontano, MarkNielsen, AlanNolasco, PaulNorwood, EdgardoOsea, EileenPalace, JesusPenabad, RubenPipek, JuliePoludniak, RichardPratley, KevinPritchett, LawrenceRatcliff, AnneReddy, DennisRiff, SyedRizvi, VictorRoberts, MichaelRobinson, SergioRovner, LuisRuiz, PeterRutherford, RichardSachson, MarcSandberg, KarlSaxman, DavidSchlitt, ElhamyShaker, NatalieShemonsky, YshayShlesinger,RamShrivastava, GregSilver, RobertSilver, DomingoSingson, TimothySmith, JamesSnyder, IreneSobolevsky, MiguelSosa-Padilla, JosephSoufer, RobertSpees, MalcolmSperling, DavidStanton, JewelStevens, RodolfoTrejo, DavidTurk, MatthewUlven, DanielVan Hamersveld, JackWahlen, MarkWarren, DaveWebster, SandraWeber, RuthWeinstock, RanceWentworth, FredWhite, JonathanWise, YelenaWood, LouisWright, AlanWynne, StevenYale, WilliamZigrang.

Buse et al The DURABLE Trial 24-week Results

Table A1—Insulin dose titration algorithms

LM75/25a / Glargineb
Plasma-Equivalent Glucose Valuesc / Glucose / Dose Changed / Plasma-Equivalent Valuese / Glucose / Dose Changed
mg/dL / mM / mg/dL / mM
<80 / <4.4 / -2 Units / <80 / <4.4 / -2 Units
80-109 / 4.4-6.0 / 0 / 80-100 / 4.4-5.5 / 0
110-139 / 6.1-7.7 / +2 Units / 101-120 / 5.6-6.7 / +2 Units
140-179 / 7.8-9.9 / +4 Units / 121-140 / 6.8-7.8 / +4 Units
≥180 / ≥10.0 / +6 Units / 141-160 / 7.9-8.9 / +6 Units
>160 / >8.9 / +8 Units

aHirsch et al. 200512

bAdapted from Fritsche et al. 200313

cFasting and pre-evening meal glucose values were considered for LM75/25

dBased on most values during the last 3-7 days, but with no increase made if hypoglycemia present

eFasting glucose values were considered for glargine

Buse et al The DURABLE Trial 24-week Results

FigureA1. Self-monitored plasma glucose 7-point profiles at baseline and endpoint for patients treated with LM75/25 (open triangle = baseline; solid triangle = endpoint) or glargine (open square = baseline; solid square = endpoint). *p<0.05; †p<0.001 for comparison of endpoint values between treatment groups.