Table S1: Newly Diagnosed Cases of Haematological Malignancies in Sardinia, 1974-2003
Table S1: Newly diagnosed cases of Haematological Malignancies in Sardinia, 1974-2003
Females / MalesDecade 1
1974-1983 / Decade 2
1984-1993 / Decade 3
1994-2003 / Decade 1
1974-1983 / Decade 2
1984-1993 / Decade 3
1994-2003
Total Haematologic Malignancies (THM) / Cases/AWSR / 1.160 / 12.76 / 1.926 / 17.41 / 3.249 / 24.69 / 1.539 / 17.98 / 2639 / 26.27 / 4.231 / 36.43
Age classes with signific. differences / n.a. / ↑: 25-34; ↑: from 45-54 onward / ↑:from 5-14 onward / n.a. / ↑: from 25-34 onward / ↑: from 15-24 onward
MHRR / n.a. / 1.46(1.36-1.57) / 1.44(1.36-1.52) / n.a. / 1.53(1.44-1.63) / 1.40(1.33-1.47)
Total Lymphoid Malignancies (TLyM) / Cases/AWSR / 901 / 10.01 / 1.410 / 12.91 / 2.239 / 17.66 / 1.111 / 13.30 / 1.832 / 18.83 / 2.678 / 24.40
Age classes with signific. differences / n.a. / ↑25-34; ↑from 45-54 onward / ↑from5-14 onward / n.a. / ↑from 25-34 onward / ↑15-24; ↑25-34; ↑from 55-64 onward
MHRR / n.a. / 1.36(1.25-1.48) / 1.36(1.27-1.45) / n.a. / 1.46(1.35-1.57) / 1.29(1.21-1.36)
Total Myeloid Malignancies (TMyM) / Cases/AWSR / 241 / 2.70 / 492 / 4.23 / 983 / 6.72 / 396 / 4.56 / 780 / 7.27 / 1.513 / 11.59
Age classes with signific. differences / n.a. / ↑5.14; ↑from 55-64 onward / ↑25-34; ↑from 55-64 onward / n.a. / ↑5-14; ↑ from 55-64 onward / ↑25-34;↑35-44; ↑ from 55-64 onward
MHRR / n.a. / 1.79(1.64-2.09) / 1.65(1.48-1.84) / n.a. / 1.74(1.54-1.96) / 1.64(1.50-1.79)
Acute Lymphoid leukaemia (ALL) / Cases/AWSR / 119 / 1.62 / 89 / 1.36 / 118 / 2.03 / 158 / 2.15 / 162 / 2.23 / 140 / 2.35
Age classes with signific. differences / n.a. / none / ↑15-24 / n.a. / none / ↓75+
MHRR / n.a. / 0.81(0.62-1.07) / 1.47(1.12-1.94) / n.a. / 1.08(0.86-1.34) / 0.96(0.76-1.24)
Chronic Lymphocytic leukaemia a (CLL) / Cases/AWSR / 117 / 1.12 / 203 / 1.49 / 353 / 2.08 / 184 / 1.92 / 318 / 2.88 / 527 / 4.03
Age classes with signific. differences / n.a. / ↑75+ / ↑ 55-64; 65-74 / n.a. / ↑ 45-54; 55-64;75+ / ↑65-74
MHRR / n.a. / 1.47(1.17-1.84) / 1.38(1.16-1.64) / n.a. / 1.50(1.25-1.79) / 1.38(1.20-1.59)
Multiple Myeloma (MM) / Cases/AWSR / 174 / 1.66 / 246 / 1.95 / 405 / 2.43 / 147 / 1.57 / 278 / 2.41 / 357 / 2.72
Age classes with signific. differences / n.a. / ↓-35-44; ↑45-54 / ↑25-34; 35-44; ↓45-54 ; ↑75+ / n.a. / ↑55-64;75+ / None
MHRR / n.a. / 1.19(0.98-1.45) / 1.35(1.15-1.59) / n.a. / 1.63(1.34-2.00) / 1.07(0.91-1.25)
Hairy cell leukaemia (HCL) / Cases/AWSR / 6 / n.a. / 7 / 0.06 / 14 / 0.12 / 10 /n.a. / 46 / 0.47 / 53 /0.46
Age classes with signific. differences / n.a. / n.a. / none / n.a. / n.a. / none
MHRR / n.a. / n.a. / 1.71(0.69-4.23) / n.a. / n.a. / 1.01(0.66-1.46)
Hodgkin's Disease (HD) / Cases/AWSR / 155 / 1.88 / 204 / 2.21 / 236 / 2.68 / 197 / 2.44 / 258 / 2.91 / 294 / 3.38
Age classes with signific. differences / n.a. / none / ↑ 5-14; 15-24 / n.a. / ↑25-34 / ↑ 15-24
MHRR / n.a. / 1.18(0.96-1.45) / 1.13(0.94-1.37) / n.a. / 1.19(0.99-1.43) / 1.11(0.94-1.31)
Non Hodgkin's Lymphomas (NHL) / Cases/AWSR / 299 / 3.10 / 617 / 5.47 / 1.026 / 7.69 / 369 / 4.31 / 719 / 7.33 / 1184 / 10.47
Age classes with signific. differences / n.a. / ↑15-24;35-44; ↑from55-64 onward / ↑from25-34 onward / n.a. / ↑from25-34 onward / ↑from5-14 onward
MHRR / n.a. / 1.79(1.56-2.06) / 1.41(1.27-1.51) / n.a. / 1.73(1.53-1.97) / 1.43(1.30-1.51)
Acute Myeloid leukaemia b (AML) / Cases/AWSR / 104 / 1.17 / 175 / 1.73 / 222 / 1.73 / 178 / 2.07 / 246 / 2.42 / 302 / 2.56
Age classes with signific. differences / n.a. / ↑ 5-14; 55-64 / ↓ 5-14 ; ↑75+ / n.a. / ↓45-54; ↑5-14; 55-64; 75+ / none
MHRR / n.a. / 1.50(1.17-1.91) / 1.11(0.90-1.31) / n.a. / 1.23(1.02-1.50) / 1.08(0.91-1.28)
Chronic Myeloid leukaemia (CML) / Cases/AWSR / 77 / 0.87 / 83 / 0.754 / 74 / 0.61 / 111 / 1.30 / 134 / 1.29 / 134 / 1.15
Age classes with signific. differences / n.a. / none / none / n.a. / none / none
MHRR / n.a. / 0.93(0.68-1.27) / 0.86(0.56-1.04) / n.a. / 1.05(0.82-1.35) / 0.98(0.68-1.09)
Myelodysplasias c (MDS) / Cases/AWSR / 21 / n.a. / 96 / 0.68 / 323 / 1.86 / 49 / n.a. / 198 / 1.65 / 609 / 4.12
Age classes with signific. differences / n.a. / n.a. / ↑ from 55-64 onward / n.a. / n.a. / ↑25-34;↑35-44; ↑ from 55-64 onward
MHRR / n.a. / n.a. / 2.68(2.14-3.37) / n.a. / n.a. / 2.54(2.16-2.98)
Polycythemia Vera (PV) / Cases/AWSR / 15 / n.a. / 35 / 0.31 / 36 / 0.25 / 16 / n.a. / 54 / 0.54 / 84 / 0.70
Age classes with signific. differences / n.a. / ↑75+ / none / n.a. / ↑65-74 / none
MHRR / n.a. / 2.18(1.11-3.74) / 0.83(0.52-1.34) / n.a. / 2.91(1.68-5.12) / 1.29(0.92-1.82)
Idiopathic Myelofibrosis (IMF) / Cases/AWSR / 16 / n.a. / 31 / 0.22 / 30 / 0.19 / 24 /n.a. / 40 / 0.34 / 63 / 0.49
Age classes with signific. differences / n.a. / ↑75+ / none / n.a. / ↑75+ / ↑65-74
MHRR / n.a. / 1.67(0.88-2.99) / 0.79(0.48-1.30) / n.a. / 1.44(0.87-2.44) / 1.35(0.89-1.96)
Essential Thrombocythemia (ET) / Cases/AWSR / 5 / n.a. / 59 / 0.54 / 266 / 1.95 / 8 / n.a. / 77 / 0.72 / 263 / 2.13
Age classes with signific. differences / n.a. / n.a. / ↑from 15-24 onward / n.a. / n.a. / ↑from 25-34 onward
MHRR / n.a. / n.a. / 4.36(2.86-5.03) / n.a. / n.a. / 2.89(2.24-3.33)
The following diagnostic groups do not appear in the table because they are unsuitable for temporal comparisons (the numbers of cases are shown in the brackets by decade):
*Chronic Lymphoid malignancies, undefined type (Females: 10, 20, 25 Males: 23, 16, 25) Solitary Plasmocytoma (Females: 7, 3, 4 Males: 6, 8, 7) *Waldenstrom’s Disease (Females: 13, 21, 43 Males: 12, 25, 65) *Chronic Myeloid Malignancies, undefined type (Females: 3, 10, 30 Males: 9, 30, 51) *Acute Leukemia undefined type (Females: 17, 19, 10 Males: 32, 24, 24) *Others that are: Atypical Lymphoproliferative Disease: 29 (Male 20) Primary AL Amyloidosis: 21 (Male 13) Systemic Mastocytosis: 12 (Male 8) Granulocytic Sarcoma: 2 (Male 1)
Abbreviations : AWSR= Age Word Standardized incidence rate x 100.000 person years; MHRR=Mantel-Haenszel weighted relative risk ( in brackets: 95%CL
↑: statistically significant increase (p value 0.05 or less) with respect to the previous decade
"↓: statistically significant decrease (p value 0.05 or less) with respect to the previous decade
n.a : not assessed
aDecade 3 included 21 cases with a histological diagnosis of NHL in the leukemic phase
bThe considered blasts threshold was 30% for all 3 decades
cThis diagnostic group also includes cases that are now defined as myelodysplastic/myeloproliferative neoplasms (14.9 and 10.4 %, respectively, in decades 2 and 3).
The prevalence of cases with 20-29% bone marrow blasts were 7.1% in decade 2 and 4.6% in decade 3