Supplementarytable 2. Stress Protection, Cell Signalling, Transport and Adhesion

SupplementaryTable 2. Stress protection, cell signalling, transport and adhesion.

Entrez Gene ID) / Name and functional group /

Gene Function

/ Expression levels ratio (polyploid to diploid organs)

Heart

/ Heart (human to mouse ratio)
Stress protection
11219 / Three prime repair exonuclease 2 / 3'-5'-exodeoxyribonuclease activity (GO:0008296);DNA repair (GO:0006281) / 5.22
56949 / XPA binding protein 2 / DNA repair (GO:0006281); RNA processing (GO:0006396 / 2.61
90480 / Growth arrest and DNA-damage-inducible, / DNA repair (GO:0006281) / 5.68
576 / Brain-specific angiogenesis inhibitor 2 / Neuropeptide signaling pathway (GO:0007218);tumor suppressor (GO:0008181) / 7.50
9149 / Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B! / Transferase activity (GO:0016740); Survival, anti-apoptotic factor [EG] / 2.10
942 / CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) / T-cell activation (GO:0042110) / 3.00
951 / CD37 antigen / N-linked glycosylation (GO:0006487) / 12.50
3558 / Interleukin 2 / T-cell differentiation (GO:0030217)(GO:0030307) / 3.73
3594 / Interleukin 12 receptor, beta 1 / Antimicrobial humoral response (GO:0006960) / 3.47
4689 / Neutrophil cytosolic factor 4, 40kDa / Defense response (GO:0006952) / 3.51
9454 / Homer homolog 3 (Drosophila) / Defense response (GO:0006952) / 12.71
926 / CD8 antigen, beta polypeptide 1 (p37) / T-cell activation (GO:0042110); immune response (GO:0006955) / 0.05
940 / CD28 antigen (Tp44) / Cellular defense response (GO:0006968) / 0.12
Stress acceleration (oncoges and pro-inflammatory genes)
10335 / Murine retrovirus integration site 1 homolog / Oncogenesis (GO:0007048); / 0.43
51725 / F-box protein 40 / Postnatal Myogenesis, muscle diseaseassociated / 0.20
6364 / Chemokine (C-C motif) ligand 20 / Inflammatory response (GO:0006954) / 0.35
10803 / Chemokine (C-C motif) receptor 9 / Immune response (GO:0006955);receptor activity (GO:0004872); Imflammation [EG] / 0.15
7293 / Tumor necrosis factor receptor / Immune response (GO:0006955); tumor necrosis factor receptor activity (GO:0005031); Imflammation [EG] / 0.35
6236 / Ras-related associated with diabetes / Small GTPase mediated signal transduction (GO:0007264) / 0.07
Cell adhesion and extracellular matrix
1003 / Cadherin 5, type 2 / Cell adhesion molecule activity (GO:0005194) / 20.42
1311 / Cartilage oligomeric matrix protein / Calcium ion binding (GO:0005509); cell adhesion molecule activity (GO:0005194) / 3.34
5340 / Plasminogen / Calcium ion binding (GO:0005509); chymotrypsin activity (GO:0004263); / 3.51
4324 / Matrix metalloproteinase 15 (membrane-inserted) / DNA binding (GO:0003677);enzyme activator activity (GO:0008047) / 5.75
4585 / Mucin 4, tracheobronchial / Extracellular matrix structural constituent (GO:0005201) / 2.42
7060 / Thrombospondin 4 / Calcium ion binding (GO:0005509); cell adhesion (GO:0007155); / 14.14
11173 / A disintegrin-like and metalloprotease / Metalloendopeptidase activity (GO:0004222) / 3.71
56548 / Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 / Hondroitin 6-sulfotransferase activity (GO:0008459); / 6.07
57159 / Ring finger protein 30 / Microtubule stabilization (GO:0007026) / 0.16
1295 / Collagen, type VIII, alpha 1 / Cell adhesion (GO:0007155);extracellular matrix structural constituent (GO:0005201) / 0.17
54538 / Roundabout homolog 4, magic roundabout / 'Fibronectin, type III (IPR003961)) / 0.29
Cell signaling and transport
6549 / Solute carrier family 9 (sodium/hydrogen exchanger) / Solute:hydrogen antiporter activity (GO:0015299);transport (GO:0006810) / 3.13
5122 / Proprotein convertase subtilisin/kexin type 1 / Cell-cell signaling (GO:0007267) / 2.90
54922 / Ras interacting protein 1Rain / Neuropeptide signaling pathway (GO:0007218) / 2.39
51755 / CDC2-related protein kinase 7 / Protein serine/threonine kinase activity (GO:0004674) / 2.40
6754 / Somatostatin receptor 4 _fetal_Brain / G-protein coupled receptor protein signaling pathway (GO:0007186) / 2.26
8941 / Cyclin-dependent kinase 5, regulatory subunit 2 (p39) / Cell cycle regulator (GO:0003750) / 9.91
51666 / Ankyrin repeat and SOCS box-containing 4 / Intracellular signaling cascade (GO:0007242) / 2.01
1489 / Cardiotrophin 1 / Cytokine activity (GO:0005125) / 5.89
27231 / Integrin beta 1 / Signal transduction (GO:0007165);uridine kinase activity (GO:0004849) / 432.42
658 / Bone morphogenetic protein receptor, type IB / Receptor signaling protein serine/threonine kinase activity (GO:0004702) / 3.51
8856 / Nuclear receptor subfamily 1, group I, member 2 / Ligand-dependent nuclear receptor activity (GO:0004879);signal transduction (GO:0007165) / 4.92
658 / Bone morphogenetic protein receptor, type IB / Receptor signaling protein serine/threonine kinase activity (GO:0004702) / 3.51
2561 / Gamma-aminobutyric acid (GABA) A receptor, beta 2 / Extracellular ligand-gated ion channel activity (GO:0005230) / 2.66
2563 / Gamma-aminobutyric acid (GABA) A receptor, delta / Extracellular ligand-gated ion channel activity (GO:0005230) / 5.58
2701 / Gap junction protein, alpha 4, 37kDa (connexin 37) / Cell communication (GO:0007154) / 7.45
8576 / Serine/threonine kinase 16 / cAMP-dependent protein kinase activity (GO:0004691) / 0.32
212 / Aminolevulinate, delta-, synthase 2 / 5-aminolevulinate synthase activity (GO:0003870) / 0.10
56924 / P21(CDKN1A)-activated kinase 6 signaling pathway. / ATP binding (GO:0005524);protein amino acid phosphorylation (GO:0006468) / 0.30
6450 / SH3 domain binding glutamic acid-rich protein / SH3/SH2 adaptor protein activity (GO:0005070) / 0.31
3062 / Hypocretin (orexin) receptor 2 / Neuropeptide signaling pathway (GO:0007218) / 0.40
136371 / Ankyrin repeat and SOCS / Intracellular signaling cascade (GO:0007242) / 0.15
140456 / Ankyrin repeat and SOCS / Intracellular signaling cascade (GO:0007242) / 0.02
142686 / Ankyrin repeat and SOCS box-containing 14_Sigh _Inhibitor / Intracellular signaling cascade (GO:0007242) / 0.01
78989 / Collectin sub-family member 11 / Phosphate transport (GO:0006817) / 0.34
10052 / Gap junction protein, alpha 7, 45kDa (connexin 45) / Connexon channel activity (GO:0015285);muscle contraction (GO:0006936) / 0.18
348932 / Solute carrier family 6 / Neurotransmitter transport (GO:0006836) / 0.45
8395 / Phosphatidylinositol-4-phosphate 5-kinase, / 1-phosphatidylinositol-4-phosphate 5-kinase activity (GO:0016308) / 0.40
4883 / Natriuretic peptide receptor C/guanylate cyclase C / Receptor activity (GO:0004872);skeletal development (GO:0001501) / 0.23
26658 / Olfactory receptor, family 7 / G-protein coupled receptor protein signaling pathway (GO:0007186) / 0.22
5028 / Purinergic receptor P2Y, G-protein coupled, / G-protein coupled receptor protein signaling pathway (GO:0007186) / 0.26
23266 / Latrophilin 2 (calcitonin) / G-protein coupled receptor activity (GO:0004930) / 0.40
654 / Bone morphogenetic protein 6 / Cytokine activity (GO:0005125) / 0.17
57538 / Likely ortholog of mouse myocytic induction/differentiation originator / ATP binding (GO:0005524); kinase activity (GO:0016301) / 0.07
1791 / Deoxynucleotidyltransferase, terminal / DNA modification (GO:0006304); / 0.40
1441 / Colony stimulating factor 3 receptor / signal transduction (GO:0007165)) / 0.27
7554 / Zinc finger protein 8 / DNA binding (GO:0003677);zinc ion binding (GO:0008270) / 0.35
9464 / Heart and neural crest derivatives expressed 2 b / Heart embryonic development (GO:0007507) / 0.21
9321 / Thyroid hormone receptor interactor 11 - / Protein binding (GO:0003713) / 0.45
859 / Caveolin 3_muscle dystrophy / Muscle development (GO:0007517) / 0.33
189 / Alanine-glyoxylate aminotransferase) / Transferase activity (GO:0016740) / 0.13
9027 / N-acetyltransferase 8 (camello like) / Transferase activity (GO:0016740) / 0.11
51755 / CDC2-related protein kinase 7 / Transferase activity (GO:0016740) / 0.45
LIVER / Liver (mouse to human ratio)
Stress protection
3083 / HGF activator / Proteolisis and peptidolysis (GO:0006508); Hypoxia-responsive gene [EG; GeneRIFs] / 6.28
166824 / Ras association (RalGDS/AF-6) domain family 6 / Neuropeptide signaling pathway (GO:0007218); tumor suppressor [EG] / 3.37
5444 / Paraoxonase 1 / Response to external stimulus (GO:0009605) / 16.26
Stress acceleration (oncoges and pro-inflammatory genes)
1789 / DNA (cytosine-5-)-methyltransferase 3 beta CpG /

Oncogenesis (GO:0007048); transferase activity (GO:0016740); tumorigenesis [EG; GeneRIFs]

/ 0.33
7075 / Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains / Transmembrane receptor protein tyrosine kinase activity (GO:0004714); tumorigenesis [EG; GeneRIFs] / 0.38
7476 / Wingless-type MMTV integration site family / Signal transduction (GO:0007165) tumorigenesis [EG; GeneRIFs] / 0.32
9032 / Transmembrane 4 / N-linked glycosylation (GO:0006487); tumor antigen (GO:0008222) / 0.11
5745 / Parathyroid hormone receptor 1a / Parathyroid hormone receptor activity (GO:0004991) tumorigenesis [EG; GeneRIFs] / 0.33
6490 / Silver homolog (mouse) / Tumor antigen (GO:0008222) / 0.40
90480 / Growth arrest and DNA-damage-inducible / DNA-damage-inducible [EG]; DNA repair (GO:0006281) / 0.48
2264 / Fibroblast growth factor receptor 4 / Fibroblast growth factor receptor signaling pathway (GO:0008543); tumorigenesis [EG; GeneRIFs] / 0.42
4197 / Myelodysplasia syndrome 1 / Transcription factor activity (GO:0003700); tumorigenesis [EG; GeneRIFs] / 0.25
1776 /

Deoxyribonuclease I-like 3

/ Apoptosis (GO:0006915); endonuclease activity (GO:0004519) / 0.17
5446 / Paraoxonase 3. / Response to external stimulus (GO:0009605) / 0.04
5309 / Paired-like homeodomain transcription factor 3 / Transcription factor activity (GO:0003700); tumorigenesis [EG; Gene RIFs] / 0.11
4610 / V-myc myelocytomatosis viral oncogene homolog 1 / Transcription factor activity (GO:0003700); tumorigenesis [EG; Gene RIFs] / 0.22

Cell adhesion and extracellular matrix

2244 / Fibrinogen, B beta polypeptide / Blood coagulation (GO:0008001). / 5.82
4430 / Myosin IB / Actin binding (GO:0003779) / 2.85
9394 / Heparan sulfate 6-O-sulfotransferase 1 / sulfotransferase activity (GO:0008146) / 3.98
9855 / FERM, RhoGEF and pleckstrin domain protein 2 / Cytoskeletal protein binding (GO:0008092) / 5.59
9953 / Heparan sulfate (glucosamine) 3-O-Sulfotransferase 3B1 / Proteoglycan biosynthesis (GO:0015012) / 12.65
3957 / Lectin, galactoside-binding, soluble, 2 (galectin 2) / Cell adhesion (GO:0007157) / 2.63
57669 / Erythrocyte membrane protein band 4.1 like 5 / Cytoskeletal protein binding (GO:0008092). / 12.43
7980 / Tissue factor pathway inhibitor 2 / Extracellular matrix structural constituent (GO:0005201) / 35.09
404037 / Hyaluronan and proteoglycan link protein 4 / Hyaluronic acid binding (GO:0005540) / 0.08
4324 / Matrix metalloproteinase 15 (membrane-inserted) / Proteolisis and peptidolysis (GO:0006508) / 0.25
10881 / Actin-like 7A / Structural constituent of cytoskeleton (GO:0005200) / 0.37
23562 / Claudin 14_ / Structural molecule activity (GO:0005198) / 0.21
53345 / Transmembrane 6 superfamily member 2 / Cell adhesion (GO:0007155) / 0.27
404037 / Hyaluronan and proteoglycan link protein 4 / Cell adhesion (GO:0007155) / 0.08
54825 / Protocadherin LKC / Cell adhesion molecule activity (GO:0005194) / 0.21
Transport and signaling
6519 / Solute carrier family 3 member 1 / Amino acid transporter activity (GO:0015174) / 12.54
6542 / Solute carrier family 7 ( / Amino acid transport (GO:0006865) / 16.50
282679 / Aquaporin 11 / porin activity (GO:0015288) / 8.84
55089 / Solute carrier family 38 / Amino acid transport (GO:0006865) / 63.69
8647 / ATP-binding cassette, sub-family B / Bile acid porter activity (GO:0015432) / 79.54
1109 / Aldo-keto reductase family 1, / Bile acid transporter activity (GO:0015125) / 78.66
3759 / Potassium inwardly-rectifying channel, / Potassium channel activity (GO:0005267) / 2.30
56670 / G protein-coupled receptor 91 / G-protein coupled receptor activity (GO:0016526) / 45.88
10686 / Claudin 16 / Ion transport (GO:0006811) / 2.76
27232 / Glycine N-methyltransferase / N-methyltransferase activity (GO:0008170) / 6.90
6539 / Solute carrier family 6 / Symporter activity (GO:0015293); / 2.07
23460 / ATP-binding cassette, sub-family A / ATP-binding cassette (ABC) transporter activity (GO:0004009) / 7.90
64240 / ATP-binding cassette,sub-family B / ATP-binding cassette (ABC) transporter activity (GO:0004009) / 4.36
1244 / ATP-binding cassette, sub-family C / ATP-binding cassette (ABC) transporter activity (GO:0004009) / 15.72
7274 / Tocopherol (alpha) transfer protein / Transporter activity (GO:0005215) / 56.88
196410 / Hypothetical protein MGC17301 / S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) / 9.53
3062 / Hypocretin (orexin) receptor 2 / Neuropeptide signaling pathway (GO:0007218) / 2.71
91614 / Novel 58.3 KDA protein / Intracellular signaling cascade (GO:0007242) / 7.52
2041 / EphA1 / Signaling pathway (GO:0007169) / 4.57
10861 / Solute carrier family 26 (sulfate transporter), member 1 / Sulfate porter activity (GO:0008271) / 63.62
84102 / Solute carrier family 41 / Cation transport (GO:0006812) / 4.99
343 / Aquaporin 8water-channel protein / Porin activity (GO:0015288) / 17.72
6330 / Sodium channel, voltage-gated, type IV, beta / Cation transport (GO:0006812) / 2.66
29928 / Translocase of inner mitochondrial membrane / Intracellular protein transport (GO:0006886) / 2.77
27329 / Angiopoietin-like 3 / Integrin-mediated signaling pathway (GO:0007229) / 84.39
7104 / Transmembrane 4 superfamily member 4 / N-linked glycosylation (GO:0006487) / 3.25
1950 / Epidermal growth factor (beta-urogastrone) / Epidermal growth factor receptor signaling pathway (GO:0007173) / 2.50
5881 / Ras-related C3 botulinum toxin substrate 3 / GTPase mediated signal transduction (GO:0007264) / 0.28
5957 / Recoverin . / Signal transduction (GO:0007165) / 0.23
64284 / RAB17, member RAS oncogene family / GTPase mediated signal transduction (GO:0007264) / 0.17
57761 / Tribbles homolog 3 (Drosophila) / Protein kinase activity (GO:0004672) / 0.07
6276 / S100 calcium binding protein A5 differentiation / Calcium ion binding (GO:0005509) / 0.40
1907 / Endothelin 2 toxin activity Growth / Tyrosine kinase signaling pathway (GO:0007169) / 0.36
80176 / SPRY domain-containing SOCS box protein SSB-1 / Intracellular signaling cascade (GO:0007242) / 0.15
11057 / Abhydrolase domain containing 2 / Catalytic activity (GO:0003824) / 0.31
4041 / Low density lipoprotein receptor-related protein 5 / Signal transduction (GO:0007165) / 0.17
433 / Asialoglycoprotein receptor 2 galactose transport / Receptor activity (GO:0004872); / 0.23
81031 / Solute carrier family 2 (facilitated glucose transporter) / Carbohydrate transport (GO:0008643 / 0.20
1468 / Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), / Mitochondrial transport (GO:0006839) / 0.09
364 / Aquaporin 7 (water, glycerol, ures transport) / Glycerol transport (GO:0015793) water transport (GO:0006833) / 0.43
6505 / Solute carrier family 1 (glutamate transporter, system) / L-glutamate transport (GO:0015813) / 0.16
6506 / Solute carrier family 1 / L-glutamate transport (GO:0015813) / 0.10
3741 / Potassium voltage-gated channel, shaker-related subfamily, member 5 / Potassium ion transport (GO:0006813) / 0.20
3764 / Potassium inwardly-rectifying channel, subfamily J, member 8 / Potassium ion transport (GO:0006813) / 0.17
27012 / Potassium channel, subfamily V, member 1 / Potassium ion transport (GO:0006813) / 0.18
6549 / Solute carrier family 9 (sodium/hydrogen exchanger), isoform 2 / Transport (GO:0006810) / 0.30
154664 / ATP binding cassette gene, sub-family A (ABC1), member 13 / ATP-binding cassette (ABC) transporter activity (GO:0004009) / 0.21
4284 / Major intrinsic protein of lens fiber / Cell-cell signaling (GO:0007267) / 0.25
367 / Androgen receptor ( / Transcription factor activity (GO:0003700); transport (GO:0006810) / 0.11
51266 / C-type lectin-like receptor-2 / Transmembrane receptor activity (GO:0004888) / 0.19
83729 / Inhibin, beta E / Growth factor activity (GO:0008083) / 0.06

*Note that in heart and liver polyploidy is associated with increased protection from carcinogenesis, apoptosis, various pathogens and impaired pro- inflammatory, pro-apoptotic and pro – tumorigenic processes. Note also moderate induction of cell adhesion and extracellular matrix proteins and slight impairment of cell signalling and transport.