CURRICULUM VITAE

NAME
Kothapalli, Sesha Durga Kumar

CornellUniversity, Ithaca, NY-14853
Email:
Weblink: / Senior Research Associate
EDUCATION/TRAINING (Beginning with bachelor’s degree.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
AndhraUniversity / B.S. / 1993 / Botany, Zoology, ChemistryCChemistry
AndhraUniversity / M.S. / 1995 / Human Genetics
OsmaniaUniversity / Ph.D. / 2001 / Human Genetics
CornellUniversity / Post doctorate / 2002-2004 / Genetics & Genomics

Personal Statement

I have over 21 years of research experience and cross-training in Human Genetics, Genomics,Pharmaco & Nutrigenomics. I started my research career, investigating Cytogenetic, Biochemical and Molecular aspects of Human Genetic diseases and have published several research articles. My PhD work involved investigating etiological factors responsible for recurrent pregnancy loss. The medical genetics experience gained during my PhD program has helped me to perform cutting edge genetics and genomics work at CornellUniversity.

As a postdoctoral fellow at CornellUniversity, I carried out genome-wide linkage studies in collaboration with the Marshfield clinic and J. Craig Venter Institute. The comparative genomics experience gained in postdoctoral training added a unique vantage to explore functional genomics studies.

In the last tenyears as a research faculty member at Cornell, my work focused on genetic and molecular aspects of long chain polyunsaturated fatty acids (LCPUFA) biosynthesis.LCPUFA are nutrients and bioactive metabolites associated with most of the human diseases, specifically cardiovascular (CVD), neurological, cancer, metabolic syndrome, and are also critical for growth and development. LCPUFA are precursors for bioactive cell signaling eicosanoid and docosanoid molecules.

First, I was involved in studying global gene expression patterns in neonate primatessupplemented with LCPUFA. This work has resulted in identifying a biological network associated with nervous system development.

We initiated a research thrust on characterization of molecular mechanisms controlling LCPUFA biosynthesis, especially the fatty acid desaturases (FADS). Since 2009, we are publishing significant novel findings:

1) an alternative biochemical pathway to the biosynthesis of eicosanoid precursors

2) discovery of multiple alternatively spliced isoforms of FADSgenes

3) novel function of a splice variant of FADS1. This splice variant enhances FADS2 activity leading to increased production of eicosanoid precursors.

4) conservation of alternative transcripts in several animal species.

5) unusual fatty acid synthesis in cancer cells and disturbance in eicosanoid signaling.

My personal interests:are in the areas of individualized medicine and nutrition based on pharmaco & nutrigenetics and genomics approaches, human genetics, genetic counseling and molecular biology.

Accomplishments

It is important to note that I have an extensive research experience in Genetics, Genomics, Pharmaco & Nutrigenomics, Molecular and Cell Biology of Lipids, conducted at many different institutions with an interdisciplinary group of colleagues. In addition to research as a part of continuous medical education (CME) program to Medical doctors, Human Genetics and Pharmacy students in India, I have given several talks about diagnosing and managing inherited and acquired human genetic disease conditions (Medical Genetics).I am also involved in promoting the growth of genetics education in high schools across the globe.

Positions and Employment

1995-1997: Junior Research Fellow, Institute of Genetics, Osmania University, India.

1997-2001: Senior Research Fellow, Institute of Genetics, Osmania University, India.

2002-2004: Postdoctoral Associate, Baker Institute, Cornell University, USA.

2004- Present: Research Associate/Senior Research Associate, Nutritional Sciences, Cornell University, USA.

Professional Memberships

2005-Present: American Society of Human Genetics

2005-2008: International Society of Neurochemistry

2006-Present: The International Society for the Study of Fatty Acids & Lipids

Work Experience:

Research Associate/Senior Research Associate, Cornell University,Dec. 2004 – Till Date

Key Responsibilities:

Designed, performed and analyzed the gene expression microarray(DNA Chip) experiments (First author on the manuscript and co-author on the Patent Invention Disclosures). Bristol-Myers Squibb funded project.

Created an assay by design Taqman probes (quantitative real time PCR) in association with ABI Biosystems technical team for microarray (DNA Chip)data validation.

Cloned and sequenced several partial and complete gene sequences. Sequences are deposited with National Center for Biotechnology Information, USA.

Effectively used several microarray (DNA Chip), next generation sequencing analysis software’s including novel ingenuity pathway analysis software.

Delivered talks on genetics and genomics research in various National and International Conferences.

Taught, trained and led severalpostdoctoral, graduate and undergraduate students in genomics and molecular biology laboratory techniques.

We identified a novel alternative biochemical pathway to the biosynthesis of eicosanoid precursors involved in inflammation and several spliced transcript variants for fatty acid desaturases. Novel findings. Published several articles on gene splicing.

We have identified unusual fatty acid synthesis in cancer cells and disturbance of eicosanoid and docosanoid signaling.

Co-investigator: Functional characterization of desaturase genes (FADS1, FADS2 and FADS3).

Co-investigator: Branched Chain Fatty Acids and Gut Development. (NIH funded project)

Co-investigator:Docosahexaenoic acid supplementation and CNS function (Bristol-Myers Squibb, USAfunded project).

Co-PI: Long chain polyunsaturated fatty acid (LCPUFA) Status and Birth Outcome in India (NIH-NICHD, USA funded project).

Co-investigator: Genetic Regulation of Fatty Acid Biosynthesis. Supervised the work of several employees for this project. Martek Biosciences/DSM, USA funded project.

Co-investigator:Fatty Acid Bioequivalence.Supervised the work of several employees for this project. Mead Johnson Nutrition, USA funded project

Co-investigator: Regulation of FADS gene expression by statin, LXR agonist GW3965, rosiglitazone and hormone treatments.

Collaborations with Cornell Scientists 1) Fatty acid analysis in FABP9 knockout mice 2) TSPO null mouse study 3) RNA-sequencing of human milk fat globule transcriptome (Next Generation Sequencing).

Collaborated with Scientists at University of Buffalo, USA on FADS Proteomic project.

Collaborating with Scientists at University of Cincinnati, USA on bipolar disease genetic studies.

Collaborating with Scientists at Kaohsiung Medical University, Taiwan on diabetes genetic studies.

Collaborating with Scientists at Massachusetts general Hospital on characterizing fatty acid profiles of primary human fetal intestinal cells.

Collaborating with Scientists atUniversity of Kansas Medical Center on FADS2 INDELgenetic studies.

Collaborating with Scientists atUniversity of Pune, India on FADS2 INDELgenetic studies.

Collaborating with Scientists at University of Texas Medical Branch on characterizing adipose tissue fatty acid profiles.

Collaborating with Scientists at Gangneung-Wonju National University, Korea on characterization of FADS alternative transcripts.

Collaborating with Scientists at Jilin University, China on studying efficacy of dietary DHA using animal models.

Collaborating with medical doctor(s) at Arnot Health, Elmira, NY on studying fatty acid profiles of tumor tissues.

Collaborating with medical doctors at Arnot Health, Elmira, NY and HyderabadIndia on studying the effects of coconut oil nutrition and lipid parameters.

Collaborating with medical doctor(s) at Cayuga Medical Center, Ithaca, NY on studying fatty acid profiles of tumor tissues.

Co-investigator: Efficacy of dietary docosahexaenoic acid (DHA) as a triglyceride or phospholipids.

Co-investigator: Fatty acid profiling of brown and white adipose tissue.

Co-investigator: Fatty acid profiling of meconium samples from several animal species.

Co-PI: Molecular mechanism of omega-3 response.(NIH-NCCIH, USA funded project)

Postdoctoral Research Associate,CornellUniversity(Jan.2002 to Nov. 2004)

Key Responsibilities:

Performed genome-wide DNA marker association study in collaboration with Marshfield clinic to identify candidate gene responsible for canine Sry-negative sex reversal syndrome.

Designed, developed, optimized and validated several genetic markers individually and in collaboration with J. Craig Ventor Institute for fine mapping project.

Performed genotyping using high throughput screening capillary electrophoresis techniques.

Carried out DNA purifications from various animal tissues, blotting techniques, whole mount in situ hybridization, BAC library screening.

Presented results at project team and departmental meetings.

Created a canine pedigree for publication purpose.

By applying modern molecular techniques we have excluded several candidate genes such as PISRT1, WT1, DMRT1, GATA4, FOG2, SOX9, SF1,LHX1 and LHX9 that are involved in gonadal differentiation and are thought to be responsible for canine Sry-negative sex reversal syndrome.

A genome-wide linkage screen revealed highest LOD score of 3.4 on CFA29. Fine mapping narrowed down the locus to a 5.4 Mb candidate region.

Junior and Senior Research Fellow, Institute of Genetics, OsmaniaUniversity (Aug. 1995-Sep. 2001)

Key Responsibilities:

Carried out human chromosomal analysis using various banding techniques and Fluorescence in situ hybridization (FISH).

Optimized and validated an ELISA assay to identify anticardiolipin autoimmune antibodies.

Designed and conducted experiments to identify point mutation 677 C-T in MTHFR gene in women experiencing recurrent pregnancy loss.

HPLC analysis to identify plasma homocysteine levels.

Designed and optimized spectrofluorometric assay for red cell selenium estimation.

Animal cell culture (lymphocyte, chorionic villi, amniocyte and fibroblast cultures). DNA purifications from human lymphocytes.

Performed human cytogenetic, biochemical and molecular studies involving Down syndrome, mental retardation, reproductive disorders, leukemia and sexual ambiguity (resulted in series of publications).

Taught and trained postgraduate medical doctors, postgraduate genetics and nursing students on identification of Human Genetic disorders involving cytogenetic, biochemical and molecular genetic tools.

Seminars Conducted:

Took active part in conducting seminars for MS students, Andhra University, India (1993-1995).

Awards

  1. PhD Research Fellowship by University Grants Commission (UGC). Exam score 91.66 percentile (IIT, Kharagpur, India) being among the first 10% in the country.
  2. Summer Institute in Statistical Genetics, course award to attend Advanced Pedigree MCMC module, NC State University, Raleigh, NC, USA, 2004.
  3. Summer Institute in Statistical Genetics, course award to attend Microarray Analysis module, NC State University, Raleigh, NC, USA, 2005.
  4. Travel grant award offered by Center for Vertebrate Genomics (VERGE), CornellUniversity, to attend ISSFAL conference, Cairns, Australia, 2006.
  5. Young investigator award granted by ISSFAL conference committee, Cairns, Australia, 2006.
  6. Travel grant award offered by Center for Vertebrate Genomics (VERGE), CornellUniversity, to attend European Society of Human Genetics Conference, Nice, France, 2007.
  7. A seed grant from the Cornell Vertebrate Genomics Program to investigate "Functional Characterization of FADS AT (Alternative Transcripts) in Long Chain Polyunsaturated Fatty Acid Biosynthesis."
  8. Travel grant award offered by Center for Vertebrate Genomics (VERGE), CornellUniversity, to attend International Congress of Human Genetics Conference, Montreal, Canada, 2011.
  9. Subject of biographical recordin 2012 Edition of Who's Whoin America (Marquis Who’s Who).

10.Served as ad-hoc judge for Annual DNA Day Essay Contest (2015), conducted by The American Society of Human Genetics (ASHG).

Pending Patent Applications

1. J. Thomas Brenna, K.S.D. Kothapalli, Joshua Anthony, Steven Rumsey, Zeina Jouni. New composition and method useful for beneficiary global regulation of gene expression across diverse biological processes including but not limited to regulation of lipid metabolism in infants and children

2. J. Thomas Brenna, K.S.D. Kothapalli, Joshua Anthony, Steven Rumsey, Zeina Jouni. New composition and method useful for induction of expression of surfactant, pulmonary-associated protein B (SFTPB) and other homologs in infants, children, and animals

3. J. Thomas Brenna, Holly T Reardon, K.S.D. Kothapalli. “FADS Regulation”

CornellUniversity Commercialization: Biomarker Discovery

1.Treatment of Cardiovascular Disease by Personalized Medicine. J.T. Brenna, H.T. Reardon, K.S.D. Kothapalli

Review Activities

1. European Journal of Obstetrics & Gynecology and Reproductive Biology

2. Metabolism

3. Genetic Testing and Molecular Biomarkers

4. European Journal of Human Genetics

5. Journal of Lipid Research

6. British Journal of Nutrition

7. Gene

8. PLoS ONE

Consulting Activity

2011 TurtleMountain, LLC, Oregon, USA

Research Publications

I have published under two last names (Kumar; Kothapalli); underlined below.*Co-corresponding Author,

† Equal Contribution.

  1. H.G. Park, K.S.D. Kothapalli*,W.J. Park WJ, C. DeAllie, L. Liu, A. Liang, P. Lawrence, J.T. Brenna. Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation. Biochim Biophys Acta. 2016Feb;1861(2):91-7.
  2. J.Y. Zhang, K.S.D. Kothapalliand J.T. Brenna. Desaturase and elongase limiting endogenous long chain polyunsaturated fatty acid biosynthesis. Current Opinion in Clinical Nutrition and Metabolic Care. In Press (Invited Review Article).
  3. X. Qin, H.G. Park, J.Y. Zhang, P. Lawrence, G. Liu, N. Subramanian, K.S.D. Kothapalli*, J. Thomas Brenna. Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. Prostaglandins Leukot Essent Fatty Acids. 2016 Jan;104:19-24.
  4. H. G. Park, W. J. Park, K. S. Kothapalli* and J.T. Brenna. The fatty acid desaturase 2 (FADS2) gene product catalyze delta 4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. FASEB J 2015; 29(9):3911-9.
  5. V. Wijendran, Brenna JT, Wang DH, Zhu W, Meng D, Ganguli K, Kothapalli KS, Requena P, Innis S, Walker WA.Long chain poly-unsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelialcells. doi: 10.1038/pr.2015.154.
  6. J. T. Brenna and K.S.D. Kothapalli. Commentary on Influence of virgin coconut oil enriched diet on the transcriptional regulation of fatty acid synthesis and oxidation in rats–A comparative study. British Journal of Nutrition. Br J Nutr. 2014 Sep 12:1-2.
  7. L. Liu, N. Bartke, H.V. Daele, P. Lawrence, X. Qin, H.G. Park, K.S.D. Kothapalli, A. Windust, J. Bindels, Z. Wang, J.T. Brenna. Higher efficacy of dietary DHA provided as a phospholipid than as a
    triglyceride for brain DHA accretion in neonatal piglets.J Lipid Res. 2014 Mar;55(3):531-9.
  8. V. Wijendran, I. Downs, C.T. Srigley, K.S. D. Kothapalli, W.J. Park, B.S. Blank, J.P. Zimmer, C.M. Butt, Jr N. Salem, J.T. Brenna. Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. Prostaglandins Leukot Essent Fatty Acids 2013; 89(5):345-350.
  9. H.T. Reardon, A.T. Hsieh, W.J. Park, K.S.D. Kothapalli, J.C. Anthony, P.W. Nathanielsz and J. T. Brenna. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. Prostaglandins Leukot Essent Fatty Acids 2013; 88(1):15-19.
  10. Woo Jung Park, K.S.D. Kothapalli*, J. Thomas Brenna et al. A novel fatty acid desaturase 1 isoform potentiates FADS2-mediated production of eicosanoid precursor polyunsaturated fatty acids. J Lipid Res. 2012; 53(8):1502-12.
  11. H.T. Reardon, J. Zhang, K.S.D. Kothapalli*, A.J. Kim, W.J.Park, and J. T. Brenna. Insertion-Deletions In a FADS2 Intron 1 Conserved Regulatory Locus Control Expression Of Fatty Acid Desaturases 1 and 2 And Modulate Response To Simvastatin. Prostaglandins Leukot Essent Fatty Acids 2012; 87(1):25-33.
  12. C. Tyburczy, K.S.D. Kothapalli, W.J. Park, B.S. Blank, Y. Liu, J.M. Nauroth, J. P. Zimmer, N. Salem Jr., J. T. Brenna. Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid (ARA) and DHA. Br J Nutr 2012;107(6):809-816.
  13. Woo JungPark, K. S. D. Kothapalli*, Peter Lawrence, J. Thomas Brenna. FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids. PLoS ONE 2011, 6 (11): e28186.
  14. H.T. Reardon, W.J.Park, J. Zhang, P. Lawrence, K.S.D. Kothapalli, and J. T. Brenna. PTB/hnRNP I regulates fatty acid desaturase alternative splicing and cellular omega-3 fatty acid composition. J Lipid Res 2011; 52(12):2279-86.
  15. C. Tyburczy, K.S.D. Kothapalli, W.J. Park, B.S. Blank, K.L. Bradford, J. P. Zimmer, C.M. Butt, N. Salem Jr., J. T. Brenna. Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. Prostaglandins Leukot Essent Fatty Acids 2011; 85(6):335-43.
  16. C. Tyburczy,M.E. Brenna,J.A. Demari,K.S.D.Kothapalli,B.S. Blank,H. Valentine,S.P. McDonough,D. Banavara,D.A. Diersen-Schade,J.T. Brenna. Evaluation of bioequivalency and toxicological effects of three sources of arachidonic acid (ARA) in domestic piglets. Food Chem Toxicol2011; 49(9):2320-7.
  17. V. Selvaraj, A. Asano, J.L. Page, J.L. Nelson, K.S.D. Kothapalli, J.A. Foster, J.T. Brenna, R.S. Weiss, A.J. Travis.Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile. Dev Biol 2010; 348(2):177-189.
  18. J.T. Brenna, K.S.D. Kothapalli, W.J.Park. Alternative transcripts of fatty acid desaturase (FADS) genes. Prostaglandins Leukot Essent Fatty Acids, Review Article 2010, 82: 281-285.
  19. W.J.Park, H.T. Reardon, C. Tyburczy, K.S.D. Kothapalli* and J.T. Brenna. Alternative splicing generates a novel FADS2 alternative transcript in baboons. Mol Biol Reports 2010, 37: 2403-2406.
  20. W.J.Park, K.S.D. Kothapalli†, H.T. Reardon, L.Y. Kim and J.T. Brenna. Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing. Gene 2009, 446: 28-34.
  21. W.J.Park, K.S.D. Kothapalli, P. Lawrence, C. Tyburczy and J.T. Brenna. An alternative pathway to long chain polyunsaturates: The FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3. JLipid Res 2009, 50: 1195-1202.
  22. S.Pujar, K.S.D.Kothapalli, H.H.Goring, V.N. Meyers-Wallen. Linkage to CFA29 detected in a genome-wide linkage screen of a canine pedigree segregating Sry-negative XX sex reversal. J Hered, 2007, 98:438-444.
  23. K.S.D.Kothapalli, J.C.Anthony, B.S.Pan, A.T.Hsieh, P.W.Nathanielsz, J.T.Brenna. Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS ONE, 2007 Apr 11;2(4):e370.
  24. K.S.D.Kothapalli,E.F.Kirkness, R.VanWormer, V.N.Meyers-Wallen. Exclusion of DMRT1 as a candidate gene for canine SRY-negative XX Sex Reversal. Vet Journal, 2006, 171: 559-61.
  25. K.S.D.Kothapalli, E.F.Kirkness, S.Pujar, R.VanWormer, V.N.Meyers-Wallen. Exclusion of candidate genes for canine SRY-negative XX Sex Reversal. Journal of Heredity, 2005, 96:759-763.
  26. S.Pujar, K.S.D.Kothapalli, E.F.Kirkness, R.H. Van Wormer, V.N.Meyers-Wallen. Exclusion of LHX9 as a candidate gene for canine SRY-negative XX Sex Reversal in the American cocker spaniel model. Journal of Heredity, 2005, 96:452-454.
  27. K.S.D.Kothapalli, E.F.Kirkness, S.Pujar, V.N.Meyers-Wallen. Exclusion of WT1 as a candidate gene for canine SRY-negative XX Sex Reversal. Animal Genetics, 2004, 35: 466-467.
  28. K.S.D.Kothapalli, E.Kirkness, L.J.Natale, V.N.Meyers-Wallen. Exclusion of PISRT1 as a candidate locus for canine SRY-negative XX sex reversal. Animal Genet, 2003, 34:467-469.
  29. K.S.D.Kumar*, V.Govindaiah, S.E.Naushad, R.R.Devi, A.Jyothy. Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss. J Obstet Gynaecol, 2003, 23:55-8.
  30. A.Jyothy, K.S.D.Kumar, G.N.Mallikarjuna Rao, M.Rajasekhar, B.Uma Devi, M.Sujatha, C.K.Kumari and P.P.Reddy. Cytogenetic investigations in 1843 referral cases of disordered sexual development from Andhra Pradesh, India. Int J Hum Genet India, 2002, 2: 55-59.
  31. K.S.D.Kumar, M. Shiva Prakash and A.Jyothy. Beta2-glycoprotein I dependent anticardiolipin antibodies in women experiencing recurrent pregnancy loss. Int J Hum Genet India, 2002, 2: 65-67.
  32. K.S.D.Kumar*, A.Jyothy, M.Shiva Prakash, H.S.Rani, P.P.Reddy. Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus anticoagulant in patients with recurrent pregnancy loss. J Postgrad Med, 2002, 48: 5-10.
  33. K.S.D.Kumar*, Abhay Kumar, M.Shiva Prakash, V.Jagadeesan, A.Jyothy. Role of red cell selenium in recurrent pregnancy loss. Journal of Obstetrics and Gynaecology, 2002, 22: 181-183.
  34. A.Jyothy, G.N.Mallikarjuna Rao, K.S.D.Kumar, V.Babu Rao,B.Uma Devi, and P.P.Reddy. Translocation Down syndrome. Indian J Med Sci, 2002, 56: 122-126.
  35. V.Durga Rao, K.S.D.Kumar, V.Sridevi, M.Hema Prasad and P.P.Reddy. Adenosine Deaminase estimation in petrol filling station workers. J Human Ecology, 2002, 13: 275-277.
  36. A.Jyothy, K.S.D.Kumar, G.N.Mallikarjuna Rao, M.Rajasekhar, S.Ramesh Babu, C.Kusuma Kumari, M.Sujatha and P.P.Reddy. Chromosomal role in the aetiology of amenorrhoea, sterility and reproductive failure. J Obstet & Gynecol India, 2001, 51: 129-132.
  37. B.Uma Devi, K.S.D.Kumar, S.Ramesh Babu, M.Swarna, P.P.Reddy. Serum adenosine deaminase in tobacco factory workers. J Human Ecology, 2001, 12: 323-325.
  38. A.Jyothy, K.S.D.Kumar, G.N.Mallikarjuna Rao, V.Babu Rao, B.Uma Devi, M.Sujatha, P.P.Reddy. Parental age and the origin of extra chromosome 21 in Down syndrome. Journal of Human Genetics,2001, 46: 347-350.
  39. A.Jyothy, K.S.D.Kumar, G.N.Mallikarjuna Rao, V.Babu Rao ,M.Swarna ,B.Uma Devi, M.Sujatha, C.Kusuma Kumari, P.P.Reddy. Cytogenetic studies of 1001 Down syndrome cases from Andhra Pradesh, India. Indian J Med Res, 2000, 111: 133-137.
  40. M.Rajasekhar, K.S.D.Kumar, M.D.Sadhnani, A.Jyothy. Sexual ambiguity:Clinical and Cytogenetic evaluation of 105 cases. Medical Science Research, 1999, 27:205-207.
  41. K.S.D.Kumar, G.N.Mallikarjuna Rao, C.Kusuma Kumari, A.Jyothy. Etiology of recurrent miscarriage:A review. Int J Gynecol & Obstet India, 1999, 2: 25-34.

Selected Presentations