CS-74
5/24/2016 10:30:00 AM - 5/24/2016 11:30:00 AM

Scoping out DNA: The Genetics of Inherited GI Cancers

Approximately 10% of cancers are due to inherited predisposition. Inherited cancer syndromes typically confer a very high lifetime risk of cancer, and the malignancies often occur at young ages before general population screening would begin. Genetic testing is becoming more commonplace, and many centers perform universal screening for Lynch syndrome, the most frequent cause of inherited colorectal cancer. Therefore, recognition and understanding of inherited cancer syndromes is imperative, particularly in gastroenterology, where surveillance often prevents malignancy. This session will use a case-based approach to describe the characteristics and management recommendations of inherited cancer syndromes that predispose to GI (colorectal, gastric and pancreatic) malignancy so that the attendee will be able to identify and manage high-risk patients/families. The short-term and long-term medical and psychosocial impact of an inherited cancer syndrome on the patient and the family will be outlined. We will discuss several approaches to genetic testing, including single-gene, panel-based and direct-to-consumer, as well as the advantages and disadvantages of each of these methods. The attendee will learn the optimal approach to genetic evaluation in a patient/family and how to engage genetic providers in the process.

Objective / Content / Time Frame / Presenter / GI / Not GI
Identify patients/families at risk for inherited predisposition to gastrointestinal malignancy / Overview inherited syndromes that predispose to GI malignancy / 20 minutes / Jennifer Axilbund
Describe recommended medical management for patients/families with inherited predisposition to gastrointestinal malignancy / Describe how management differs in the setting of a genetic syndrome / 20 minutes / Jennifer Axilbund
Recognized psychosocial implications of inherited cancer susceptibility / Using case examples, introduce varying psychosocial responses to the diagnosis of inherited cancer susceptibility / 10 minutes / Jennifer Axilbund
Understand the optimal approach to genetic evaluation for inherited cancer susceptibility / Discuss how to integrate genetic professionals into the care of GI patients / 10 minutes / Jennifer Axilbund
Total