Program Overview
2:30 pm Registration, Regina Hall, Refreshments served
3:00 pm-5:15 pm Technical Sessions (see below)
5:15-5:30 pm Adjourn to Administration Building
5:30-6:30 pm Plenary talk, Performing Arts Center, Ground Floor Administration Building
6:30 pm Dinner, Performing Arts Center, Musical arrangements by Sung-Soo Cho, Doctoral Candidate, Cleveland Institute of Music
7:30 pm Student Awards, Performing Arts Center
Plenary Talk
Venus in a bottle: Simulating Interactions Between the Crust and Atmosphere of Venus (and Venus-like Exoplanets), Dr. Ralph Harvey, Senior Fellow, NASA Glenn Research Center, Assoc. Professor, Case Western Reserve University
Both historical and current investigations of Venus suggest that atmosphere/rock interactions may play a critical role in the evolution of that planet's atmosphere and crust, particularly in producing or maintaining that planet's thick CO2-rich atmosphere in its current massive greenhouse state. Using GEER (the Glenn Extreme Environment Rig) we are exploring such interactions by creating "Venus in a Bottle"- mixing plausible Venus surface simulants with a high-fidelity recreation of that planet's thick, hot and corrosive atmosphere. These "naturalistic" simulations complement prior and ongoing highly constrained experiments and help us understand the messy and complex nature of Venus' rocks, atmosphere and history.
Technical Sessions (Schedule/Titles, Abstracts)
Biochemistry I Regina 019
Biochemistry II Regina 024
Biochem/Organometallic/Polymers Regina 025
Organic Regina 201
Analytical Regina 202
Inorganic/Materials/Analytical I Regina 210
Inorganic/Materials/Analytical II Regina 211
American Chemical Society- Cleveland Section would like to thank the faculty, staff, and administration of Notre Dame College for hosting this event. Special thanks to all the organizers, sponsors, judges, session moderators, and especially our Notre Dame College student ambassadors from NDC Biology Club and NDC Chemistry Club for their assistance.
Biochemistry I, Regina 019 * - Denotes undergraduate presenter ** - Denotes graduate presenter
3:00 pm RNase L is involved in type I diabetes onset, Qiaoyun Zheng**, Chun Zeng, Xin Yi, and Aimin Zhou, Clinical Chemistry Program, Department of Chemistry; Center for Gene Regulation in Health and Diseases, Cleveland State University, Cleveland, OH
3:20 pm Graphene-Based Composites for Detection and Quantification of Peroxynitrite, Haitham Kalil**, Mekki Bayachou, Department of Chemistry, Cleveland State University, Cleveland, OH
3:40 pm Incorporation of Azide Functionality into Recombinant ProteinviaRecombinant, Enzymatic, and Chemical Approaches for Bio-Orthogonal Modification Lin Wang1**, Rui Jiang1, Lin Wang2and Xue-Long Sun1.
1Department of Chemistry, Chemical and Biomedical Engineering and Center for Gene Regulation of Health and Disease (GRHD), Cleveland State University, Cleveland, OH
2Department of Medicinal Chemistry, China Medical University, Shenyang, Liaoning, China.
4:00-4:10 pm break
4:10 pm Dissolution of Aggregated Islet Amyloid Polypeptide (IAPP) in Rat Insulinomas Using Novel Beta-Sheet Breakers Melissa Barranger-Mathys, Ph.D. Ursuline College, Department of Chemistry
4:40 pm Profiling Sialylation Status during Monocytes Differentiation, Dan Wang**1, Evgeny Ozhegov2, Aimin Zhou1, Xue-Long Sun1*
1Department of Chemistry, Chemical and Biomedical Engineering and Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, Cleveland, Ohio 2Department of Biological, Geological, and Environmental Sciences (BGES), Cleveland State University, Cleveland, Ohio
Biochemistry II, Regina 024 * - Denotes undergraduate presenter ** - Denotes graduate presenter
3:00 pm Lipids AffectThrombomodulin's Capacity to Generate APC and TAFI, Valentinas Gruzdys**1 and Xue-Long Sun1,2
1Department of Chemistry, Cleveland State University
2 Department of Biomedical Engineering, Cleveland State University
3:20 pm The Role Of Lipid-Free Apolipoprotein A-I Self-Association In The Formation Of High Density Lipoprotein, Celalettin Topbas**1,2, Joseph A. Didonato2,3, Jonathan D. Smith2, Stanley L. Hazen2,3,4, Valentin Gogonea1,2,3
1Department of Chemistry, Cleveland State University, Cleveland, OH
2Department Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH
3Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, OH, 4Cardiovascular Medicine Department, Cleveland Clinic, Cleveland, OH
3:40 pm Simultaneous Determination Of Dihydrotestosterone And Its Metabolites In Mouse Sera By Lc-Ms/Ms With Chemical Derivatization, Shashank Gorityala** a, Shuming Yang b, Monica M. Montano c, Yan Xu a,b
aDepartment of Chemistry, Cleveland State University, Cleveland, Ohio
b Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
cDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH
4:00-4:10 pm break
4:10 pm Evaluating The Pro-Mutagenic Replication Of 8-Oxoguanine Anvesh Dasari1**, Anthony J Berdis1, 2, 3
1Department of Chemistry, Cleveland State University, Cleveland, OH
2Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 3Red5 Pharmaceuticals, LLC, Cleveland, OH
4:30 pm Role of RNase L in Kidney Norah J Alghamdi**, Qiaoyun Zheng, Danting Liu, and Aimin Zhou, Clinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH
4:50 pm Determination of Monosialogangliosides in Human Plasma by a Novel UPLC/MS/MS Assay Coupled to Chemical Derivatization, Qianyang Huang**1, Xiang Zhou1, Danting Liu1, Baozhong Xin2, Karen Cechner2, Heng Wang2, and Aimin Zhou1
1Clinical Chemistry Program, Cleveland State University Cleveland, OH
2DDC Clinic, Center for Special Needs Children, Middlefield, OH
Biochem/Organometallic/Polymers, Regina 025 * - undergraduate presenter ** - graduate presenter
3:00 pm Histidine-Tagged Peptide Binding to Anionic Lipid in Asymmetric Supported Lipid Bilayers, Xiaosi Li** and Adam W. Smith, Department of Chemistry, The University of Akron
3:20 pm Ferreting out homo- and heterodimerization of G-protein coupled receptors (GPCR) via PIE-FCCS William D. Comar** and Adam W. Smith, University of Akron, Akron, OH
3:40 pm Stimuli-Responsive Liquid Crystalline Elastomer Actuators, Brian T. Michal**, Blayne M. McKenzie, Simcha E. Felser and Stuart J. Rowan, Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH
4:00-4:10 pm break
4:10 pm Optimizing the formation of [3]catenates containing 2,6-bis(N-alkylbenzimidazolyl)pyridine
Qiong Wu**, Rudy J. Wojtecki, Stuart J. Rowan, Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio
4:30 pm Synthesis of Lead Oxide Carboxylate Single Crystals and Nanostructures, Calvin Gang*,1 Venkata Shiva Mandala,1 Matthias Zeller,2 Catherine M. Oertel1
1Department of Chemistry and Biochemistry, Oberlin College, Oberlin, OH
2Department of Chemistry, Youngstown State University, Youngstown, OH
4:50 pm Selective nitrosylation of GAPDH occurs via the S100A8/A9 protein complex: A theoretical investigation, Arlene Praniewicz*1,2 and Valentin Gogonea1,2,3
1Department of Chemistry, Cleveland State University, Cleveland, OH
2Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH
3Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, OH
Organic Chemistry , Regina 201 * - undergraduate presenter ** - graduate presenter
3:00 pm Conjugated Organophosphorus Materials, Alexandra Grimm**, Dr. John Protasiewicz
Case Western Reserve University, Dept. of Chemistry, Cleveland, OH
3:20 pm Synthesis and anti-proliferative activity of N,N’-bis(arylmethyl)imidazolium salts with lipophilic or hydrophilic substituents on the imidazole and benzimidazole rings, Kerri L. Shelton**, Patrick O. Wagers, Michael A. DeBord, Marie Southerland, Matthew J. Panzner, Claire A. Tessier, Wiley J. Youngs, Department of Chemistry, The University of Akron, Akron, OH
3:40 pm DiPhosphonato Catechol (DPC): From bifunctional electrolytes to conjugated polymers
Joshua Gaffen**, Dr. John D. Protasiewicz, Department of Chemistry, Case Western Reserve University, Cleveland, OH
4:00-4:10 pm break
4:10 pm Ene-Type Cyclization Chemistry from Cyclohexadiene-Tricarbonyliron Derivatives
Keith B. Beach**, Anthony J. Pearson. Case Western Reserve University, Department of Chemistry
4:30 pm Aziridination via Photolysis Using Hypervalent Iodine, Andrew Kollar**, Bindu Meprathu, John Protasiewicz, Department of Chemistry, Case Western Reserve University, Cleveland, OH
4:50 pm Investigation of Thia-Michael Reversible Addition Towards Dynamic Materials, Katie M. Greenman**, Joy Romulus, Jonathon Onorato, Stuart J. Rowan, Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH
Analytical Chemistry Regina 202 * - Denotes undergraduate presenter ** - Denotes graduate presenter
3:00 pm Lipid Nanodiscs as Potential Carriers of Enzymes: a Light Scattering Study, Ghaith Altawallbeh**1, Chris Verdi1, Christian Gunder2, Kiril A. Streletzky2, Mekki Bayachou1
1 Department of Chemistry, Cleveland State University, OH
2 Department of Physics, Cleveland State University, OH
3:20 pm Qualitative and Semi-Quantitative Analysis of Glycerolipids and Phospholipids in Algae Scenedesmus dimorphus by Shotgun Lipidomics Satya Girish Chandra Avula**1, Joanne Belovich2, Yan Xu1
1Department of Chemistry, Cleveland State University, Cleveland, Ohio
2Department of Chemical Engineering, Cleveland State University, Cleveland, Ohio
3:40 pm Detection of Estrogenic Activity in Water using a Yeast Bioassay Hannah Bowie*, Lisa M. Ponton,Department of Chemistry, Baldwin Wallace University
4:00-4:10 pm break
4:10 pm Quantifying Hypomethylating Effect of Decitabine in HL60 Cells by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Sujatha Chilakala**, Yan Xu, Department of Chemistry, Cleveland State University, Cleveland, Ohio
4:30 pm Developing New Schiff Bases for Fluorescent Detection of Aluminum Cation and Their Potential Applications, Lucas McDonald**, Jungfeng Wang, Nick Alexander, Hui Li, Yi Pang
The University of Akron, Department of Integrated Bioscience, Department of Chemistry Akron, OH
4:50 pm Determination Of Bardoxolone Methyl By Ultra Performance Liquid Chromatography Tandem Mass Spectrometry (upLC-MS/MS), Chandana Mannem**, Yan Xu* Department of Chemistry, Cleveland State University, Cleveland, Ohio
Inorganic/Materials/Analytical I Regina 210 * undergraduate presenter ** graduate presenter
3:00 pm Chiral Channels in Molecular Co-Crystals: Unexpected Structures that arise from the co-crystallization of 2,4,6-tris(4-X-phenyl)arenes, Ren A. Wiscons1*, Holden W. H. Lai1, Matthias Zeller2, Jesse L. C. Rowsell1
1Department of Chemistry and Biochemistry, Oberlin College, Oberlin, Ohio
2Department of Chemistry, Youngstown State University, Youngstown, Ohio
3:20 pm Updated Dielectric Thermal Analysis and Differential Scanning Calorimetry studies led to a unified Polaron Theory of Ionic Conduction of organic and inorganic crystalline materials Alan T. Riga, PhD1,2, Hannah Conway1,
1Notre Dame College, South Euclid, Ohio
2Case Western Reserve University, Cleveland Ohio
4:00-4:10 pm break
4:10 pm Computational Techniques for the Design of Mechanically Interlocked Molecules, Eric P. Bruckner*, Katie M. Greenman, Michael J.A. Hore, Stuart J. Rowan, Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio
4:30 pm Excited-State Dynamics as a Benchmark for the Optimization of Small-Molecules for Organic Photovoltaics, Regina DiScipio**, Geneviève Sauvé, and Carlos E. Crespo-Hernández
Department of Chemistry and Center for Chemical Dynamics, Case Western Reserve University, Cleveland, Ohio
4:50 pm Legal Case study to evaluate product Liability used Forensic Polymer Chemistry measured by FTIR spectroscopy and Differential Scanning Calorimetry, Jacob Kirsh*, Hannah Conway, Alan T Riga, Notre Dame College, South Euclid, Ohio
Inorganic/Materials/Analytical II Regina 211 * undergraduate presenter ** graduate presenter
3:00 pm Enhancing the Phototherapeutic Potential of Sulfur-Substituted DNA and RNA Analogues Marvin Pollum** and Carlos E. Crespo-Hernández, Department of Chemistry and Center for Chemical Dynamics, Case Western Reserve University, Cleveland, Ohio
3:20 pm A Critical Assessment Of As A Figure Of Merit For Oxygen Reduction Electrocatalysts In Aqueous Electrolytes, Nicholas S. Georgescu**, Adriel J. J. Jebaraj, and Daniel Scherson
Department of Chemistry, Case Western Reserve University, Cleveland, OH
3:40 pm Effect of Dielectric Properties on Drug Transport Through Shedded Snake Skins Hannah Conway1*, Jacob Kirsh1, Sean Cadden2, Emily Bussis2 , Alan Riga 1,2
1Notre Dame College Ohio, South Euclid Ohio USA
2CWRU, Polymer Science and Engineering, Cleveland, Ohio USA
4:00-4:10 pm break
4:10 pm Photophysics of Bacteriochlorin Dyads, Christopher McCleese**a, Zhanqian Yub, Nopondo Esemotob, Arun Mannac, Barry Dunietzc,*, Marcin Ptaszekb,*, Clemens Burdaa,*
a Department of Chemistry Case Western Reserve University, Cleveland, OH
b Department of Chemistry University of Maryland Baltimore County, Baltimore, MD
c Department of Chemistry Kent State University, Kent, OH
4:30 pm Modeling And Measuring Thermal Properties Of Methylammonium Lead Halide Perovskite, Anton Kovalsky**a, Gage Marekb, Lily Wanga, Jeffrey Dyckb, Clemens Burdaa
a Case Western Reserve University, Department of Chemistry, Cleveland, OH
bJohn Carroll University, Department of Physics, Cleveland, OH
Abstracts
Biochemistry I, Regina 019 * - Denotes undergraduate presenter ** - Denotes graduate presenter
3:00 pm RNase L is involved in type I diabetes onset, Qiaoyun Zheng**, Chun Zeng, Xin Yi, and Aimin Zhou, Clinical Chemistry Program, Department of Chemistry; Center for Gene Regulation in Health and Diseases, Cleveland State University, Cleveland, OH
The cause of type I diabetes continues to be a focus of investigation. Studies have revealed that interferon (IFN)-a in pancreatic islets after viral infection or treatment with double-stranded RNA (dsRNA), a mimic of viral infection, is associated with the onset of type I diabetes. However, how IFN-a contributes to the onset of type I diabetes is obscure. In this study, we found that 2-5A dependent RNase L (RNase L), an IFN-a-inducible enzyme that functions in the antiviral and antiproliferative activities of IFN, played an important role in dsRNA-induced onset of type I diabetes. By using RNase L deficient, rat insulin promoter (RIP)-B7.1 transgenic mice which are more vulnerable to environmental harmful factors such as viral infection, we demonstrated that deficiency of RNase L in mice resulted in a significant delay of diabetes onset induced by polyinosinic:polycytidylic acid (poly I:C), a type of synthetic dsRNA, and streptozotocin (STZ), a drug which can artificially induce type I-like diabetes in experimental animals. Immunohistochemical staining showed that the population of infiltrated CD8+ T-cells was remarkably reduced in the islets of RNase L deficient mice, suggesting that RNase L may contribute to type I diabetes onset through regulating immune responses. Furthermore, RNase L was responsible for the expression of certain proinflammatory genes in the pancreas in induced conditions. Our findings provide new insight into the molecular mechanism underlying b-cells destruction and may suggest novel therapeutic strategies for treatment and prevention of the disease based on the selective regulation and inhibition of RNase L.
3:20 pm Graphene-Based Composites for Detection and Quantification of Peroxynitrite, Haitham Kalil**, Mekki Bayachou, Department of Chemistry, Cleveland State University, Cleveland, OH
Recent clinical research indicates that the cytotoxicity role of peroxynitrite (ONOO-) plays an essential role in several cardiovascular dysfunctions and other diseases triggered by oxidative stress. Peroxynitrite (PON) is a strong oxidizing agent produced from the diffusion-controlled reaction between nitric oxide radical (●NO) and superoxide anion-radical (●O2-). PON attacks vital components inside the body and initiates deleterious effects via direct and indirect interactions. It reacts directly with lipids, DNA, and proteins and indirectly serves as a trigger of radical chain reactions. Some of these reactions yield to cellular dysfunctions that may end up with necrosis or apoptosis of cells.
Previously, we have shown that hemin and hemin-modified graphene can be used as catalytic platforms for electrochemical detection and quantification of peroxynitrite. In this work we prepare metal-decorated graphene-based composite materials as potential catalytic interfaces for sensitive electrochemical determination of PON. We first describe the method of preparation of metal-modified graphene materials. We characterize the hybrid materials using a number of methods including scanning electron microscopy (SEM), atomic force microscopy (AFM), raman, and x-ray photoelectron spectroscopy (XPS). The modified metal-graphene composite is then tested on carbon electrodes for PON detection and quantification using voltammetry and dose-response amperometry. We compare and contrast the performance of the new metal-graphene materials with hemin-only based electrodes as well as bare graphene based electrodes.