Title: the Diagnostic Accuracy of US, CT, MR-Imaging and 1H-MRS for the Evaluation of Hepatic

Title: The diagnostic accuracy of US, CT, MR-imaging and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: A meta-analysis

Journal name: European Radiology

Authors:

Anneloes E. Bohte, MD. Corresponding author ()

Jochem R. van Werven, MD

Shandra Bipat, PhD

Jaap Stoker, MD, PhD

Institution:

Department of Radiology

Academic Medical Center

University of Amsterdam

Meibergdreef 9

1105 AZ Amsterdam

The Netherlands

ESM 6: Characteristics of of liver biopsy examination

Study / No of patients biopsied / Semi-quantitative steatosis grades (%): / Examination of:
Fibrosis / Inflammation / Iron
Yajima 1983 / 45 / <30; 30-50; >50 / yes / no / no
Korte, de 1986 / 100 / <5; 5-33; 33-66; >66 / yes / no / no
Saverymuttu 1986 / 85 / None; mild; moderate; severeb / yes / no / no
Lossner 1988 / 187 / <10; 10-30; >30 / yes / yes / no
Joseph 1991 / 50 / None; 0-25; 25-50; >50 / yes / yes / yes
Caturelli 1992 / 35 / <30; 30-60; >60 / no / no / no
Hultcrantz 1993 / 83 / None vs. any steatosisb / yes / yes / no
Dietrich 1998 / 68 / None; mild; moderateb / yes / yes / no
Kutcher 1998 / 64 / None vs. any steatosisb / yes / yes / no
Graif 2000 / 28 / None; mild; moderate; severeb / yes / yes / no
Rinella 2001 / 33 / None; <10; 10-30; 30-60; >60 / no / no / no
Mathiesen 2002 / 165 / None; <33; 33-66; >66 / yes / yes / no
Saadeh 2002 / 25 / 10-30; 30-70; >70 / yes / yes / no
Kichian 2003 / 49 / <33; 33-66; >66 / yes / yes / yes
Rinella 2003 / 22 / None; <15; 15-30; 30-60; >60 / no / no / no
Iwasaki 2004 / 266 / None; <30; 30-60; >60 / no / no / no
Limanond 2004 / 42 / <5; 5-30; >30 / yes / yes / yes
Hepburn 2005 / 122a / <2; 2-10; 10-30; 30-60; >60 / yes / yes / no
Kim SH 2005 / 94 / <5; 5-30; 30-60; >60 / no / no / no
Kim SH 2006 / 57 / <5; 5-30; 30-60; >60 / no / no / no
Palmentieri 2006 / 216a / 0-2; 3-30; 30-50; >50 / yes / unclear / unclear
Park 2006 / 154 / <30 vs. >30 / no / no / no
Hamaguchi 2007 / 94 / >10 / yes / unclear / no
Hirche 2007 / 122 / <25; 25-50; >50 / no / no / no
Lee JY 2007 / 589 / <5; 5-30; 30-60; >60 / yes / yes / unclear
Lee SW 2007 / 48 / <30 vs. >30 / no / no / no
Perez 2007 / 131 / None; <33; 33-66; >66 / yes / yes / no
Bahl 2008 / 52 / <5; 5-33; 33-66; >66 / yes / no / yes
Chen 2008 / 108 / <5; 5-30; 30-70; >70 / yes / no / no
Cho 2008 / 131 / None; <30; 30-60; >60 / no / no / no
Moura Almeida 2008 / 105 / 5-25; 25-50; 50-75; >75 / no / no / no
Orlacchio 2008 / 30 / None; <10; 10-30; >30 / yes / yes / no
Yoshimitsu 2008 / 58 / None; <10; 10-30; 30-60; >60 / no / no / no
Crum-Cianflone 2009 / 55a / None; <5; 5-33; 33-66; >66 / yes / yes / no
Dasarathy 2009 / 73 / 5-35; 35-65; >65 / yes / yes / unclear
d'Assignies 2009 / 20 / From 0-100 with 10% precisionc / no / no / no
Friedrich-Rust 2009 (Epub) / 44a / None; <10; 10-33; 33-66; >66 / yes / yes / unclear
Kim DY 2009 (Epub) / 179 / From 0-100 with 5% precision / no / no / yes
Krssak 2009 (Epub) / 28a / None; <10; 10-30; >30d / yes / yes / no
McPherson 2009 / 94 / <5; 5-33; 33-66; >66 / yes / yes / yes
Mennesson 2009 / 40 / <5; 5-33; 33-66; >66 / yes / yes / unclear
O'Rourke 2009 / 37 / None; <30; 30-60; >60 / unclear / yes / unclear
Tobari 2009 / 118 / 10-30; 30-70; >70 / yes / yes / no
Webb 2009 / 111 / <5; 5-25; >25 / yes / yes / no
Yamashiki 2009 / 78 / <10 vs. >10 / yes / yes / no
Yu 2009 / 171a / <5; 5-33; 33-66; >66 / unclear / unclear / no

aDiffers from total number of patients analysed in study (Table 1)

bNo percentage defined

cLiver steatosis was also assessed by automatic vacuole segmentation

dLiver steatosis was also assessed by gas-liquid chromatography