S3：SelectedDEGs according to functional classification
Functional classificationb / Gene Discription / ENSSSCG ID / FC(q-valued)cLandrace / Enshi
Inflammatory response / Resistin / ENSSSCG00000013575 / 3.93(4.9E-03) / 1.95(9.2E-03)
S100A8 / ENSSSCG00000006590 / 4.87(1.7E-08) / 1.63(6.1E-02)
S100A9 / ENSSSCG00000006588 / 4.25(1.6E-13) / 2.53(1.8E-12)
S100A12 / ENSSSCG00000006589 / 4.68(5.8E-16) / 2.78(1.5E-11)
CD5L / ENSSSCG00000006455 / 0.44(0) / 2.30(0)
CXCL10 / ENSSSCG00000008977 / 0.45(1.0E-101) / 1.08(2.9E-4)
PMAP23 / ENSSSCG00000021877 / 1.30(0.28) / 0.09(2.2E-03)
IL1B / ENSSSCG00000008088 / 1.19(0.34) / 2.53(2.7E-07)
NPG3a / ENSSSCG00000023733 / 15.3(1.8E-04) / 0.38(3.4E-03)
NPG3b / ENSSSCG00000028664 / 12.7(6.3E-16) / 0.29(2.5E-08)
IGKC / ENSSSCG00000008203 / 2.28(0) / 6.24(0)
IGKV-3 / ENSSSCG00000022682 / 8.77(9.7E-105) / 4.07(5.9E-57)
IGKV-5 / ENSSSCG00000030738 / 22.2(2.7E-101) / 6.57(2.0E-61)
IGKV-6 / ENSSSCG00000027295 / 0.16(8.1E-109) / 119.5(0)
IGKV-7 / ENSSSCG00000030927 / 2.3(0) / 10.6(0)
IGKV-11 / ENSSSCG00000027332 / 1.76(0.089) / 2.98(6.9E-32)
IGLC / ENSSSCG00000010044 / 2.80(0) / 3.46(0)
IGLV-2 / ENSSSCG00000030834 / 3.10(4.0E-57) / 0.09(2.2E-03)
IGLV-3 / ENSSSCG00000030893 / 3.66(0) / 1.21(0.34)
IGLV-4 / ENSSSCG00000030730 / 5.74(1.9E-153) / 1.44(0.65)
IGLV-5 / ENSSSCG00000030830 / 6.62(3.5E-116) / 1.15(0.19)
IGLV-7 / ENSSSCG00000031037 / 10.8(0) / 3.74(3.2E-212)
IGLV-8 / ENSSSCG00000031054 / 2.27(0) / 5.52(0)
IGLV-9 / ENSSSCG00000030825 / 4.94(0) / 4.52(0)
IGLV-10 / ENSSSCG00000030868 / 1.27(0.74) / 3.74(0)
ISG12(A) / ENSSSCG00000002471 / 0.37(6.3E-172) / 0.25(2.4E-205)
PCD1A / ENSSSCG00000025644 / 2.29(6.2E-71) / 1.19(0.39)
CTLA4 / ENSSSCG00000016122 / 0.66(0.96) / 0.42(1.9E-04)
ALOX12 / ENSSSCG00000017923 / 0.48(7.1E-15) / 0.11(2.7E-200)
HBXIP / ENSSSCG00000022631 / nonexpress / 22.8(1.2E-06)
IGJ / ENSSSCG00000008939 / 1.88(0) / 6.93(0)
VPREB1 / ENSSSCG00000022467 / 1.44(0.91) / 2.64(2.8E-39)
OAS1 / ENSSSCG00000009882 / 0.43(2.1E-78) / 0.27(6.0E-279)
OAS2 / ENSSSCG00000009881 / 0.43(0) / 0.46(0)
OASL / ENSSSCG00000009921 / 0.32(1.8E-04) / 1.00(0.5)
SLA-1 / ENSSSCG00000001231 / 2.71(0) / 0.89(9.0E-282)
SLA-5 / ENSSSCG00000001229 / 0.20(0) / 0.51(0.27)
SLA-6 / ENSSSCG00000001398 / 0.43(1.8E-156) / 0.76(6.7E-23)
SLA-DOB / ENSSSCG00000001465 / 6.77(6.1E-31) / 0.88(8.5E-07)
SLA-DOB1 / ENSSSCG00000001459 / 0.30(1.4E-19) / 0.63(9.1E-14)
Mx1 / ENSSSCG00000012077 / 0.688(1.1E-44) / 0.35(0)
DDX58 / ENSSSCG00000017416 / 0.54(1.7E-31) / 0.42(1.2E-101)
CTLA4 / ENSSSCG00000016122 / 0.88(0.43) / 0.42(1.9E-04)
Signal transduction / TREM1 / ENSSSCG00000001617 / 1.33(0.83) / 5.4(3.9E-08)
C11ORF53 / ENSSSCG00000015018 / 0.38(0.030) / 2.82(0.059)
C12ORF60 / ENSSSCG00000000609 / 0.16(7.5E-04) / 0.52(0.03)
CCR2 / ENSSSCG00000024270 / 33.8(1.6E09) / 0.43(1.9E-07)
CCR2(Artifactual duplication, Dawson et al. 2013) / ENSSSCG00000024311 / 0.67(1.6E09) / 2.82(5.7E-28)
Acute-phase response / SAA2 / ENSSSCG00000028525 / 0.27(0.15) / 3.01(2.2E-03)
Lactotransferrin / ENSSSCG00000029879 / 5.20(2.2E-27) / 1.41(0.08)
Humoral immune response / CD163 / ENSSSCG00000010787 / 1.78(7.6E-04)/ / 3.3(4.1E-20)
Cell adhesion / CLDN3 / ENSSSCG00000021536 / 1.12(0.08) / 2.19(2.1E-04)
Claudin 4 / ENSSSCG00000007718 / 1.70(7.5E-15) / 2.33(2.3E-04)
mmp9 / ENSSSCG00000007436 / 8.56(5.6E-117) / 0.96(0.48)
Response to oxidative stress / Hsp27 / ENSSSCG00000028568 / 19.7(1.4E-05) / 0.85(0.27)
Homeostasis / BHLHA15 / ENSSSCG00000007600 / 3.10(1.9E-33) / 3.72(5.6E-25)
KRT8 / ENSSSCG00000000252 / 0.32(1.1E-27) / 0.05(1.1E-187)
RYR2 / ENSSSCG00000010142 / 0.40(1.3E-85) / 1.40(0.059)
Carbohydrate metabolic process / CPE / ENSSSCG00000008854 / 0.59(1.0E-04) / 0.30(9.8E-27)
HK3 / ENSSSCG00000014048 / 1.00(0.5) / 2.58(5.1E-183)
Response to wounding / Annexin A8 / ENSSSCG00000010370 / 1.1(0.19) / 0.23(5.0E-20)
Other responses to stimulus / GEM / ENSSSCG00000006105 / 0.72(0.15) / 0.31(3.1E-16)
Chondrolectin / ENSSSCG00000012018 / 0.97(0.77) / 2.26(1.0E-154)
Tranport / TAP1 / ENSSSCG00000020893 / 13.6(3.8E-74) / 0.19(3.9E-07)
LCN2 / ENSSSCG00000005638 / 0.88(0.21) / 0.30(5.1E-35)
Transferrin / ENSSSCG00000011640 / 1.16(0.40) / 0.15(7.7E-29)
Organismal physiological process / PSMF1 / ENSSSCG00000025875 / 22.9(1.8E-06) / 12.4(8.3E-04)
MYL4 / ENSSSCG00000017307 / 3.5(7.9E-04) / 0.18(4.9E-05)
osteoglycin / ENSSSCG00000008074 / 0.31(4.9E-06) / 0.38(1.1E-05)
FOLH1 / ENSSSCG00000027093 / 0.13(2.3E-26) / 0.29(4.4E-05)
ACTA1 / ENSSSCG00000010190 / 40.3(4.5E-293) / 0.36(1.5E-03)
GZMB / ENSSSCG00000001978 / 0.28(6.9E-29) / 0.78(0.55)
Ubiquitin cycle / SUMO1 / ENSSSCG00000008514 / 0.72(1.7E-26) / 0.05(1.7E-05)
UBCH5B / ENSSSCG00000024306 / 0.19(1.7E-09) / 9.04(2.2E-29)
Others / INSRR / ENSSSCG00000006465 / 0.36(2.5E-03) / 1.40(0.32）
CPNE5 / ENSSSCG00000001567 / 0.42(7.5E-04) / 0.84(0.47)
GRIP1 / ENSSSCG00000000478 / 0.38(2.8E-17) / 0.84(0.36)
KHDRBS3 / ENSSSCG00000005941 / 0.34(1.1E-04) / 0.61(0.29)
PLEKHA6 / ENSSSCG00000015281 / 0.29(1.1E-30) / 0.71(0.12)
CAMK1G / ENSSSCG00000015619 / 0.33(1.2E-4) / 0.51(0.10)
IRG1 / ENSSSCG00000009469 / 0.46(0.58) / 7.67(2.4E-07)
CD300c / ENSSSCG00000017236 / 0.37(1.3E-209) / 0.95(0.04)
PHF21B / ENSSSCG00000000020 / 22.1(4.9E-21) / 0.35(9.2E-08)
ACYP2 / ENSSSCG00000026100 / 0.381(6.0e-4) / 1.58(0.04)
SCARA5 / ENSSSCG00000009672 / 0.31(2.6E-130) / 0.24(1.6E-110)
BNC1 / ENSSSCG00000001798 / 0.27(8.1E-03) / 0.15(1.1E-09)
MUC19 / ENSSSCG00000000785 / 4.73(2.3E-04) / 3.26(4.7E-03)
DCDC5 / ENSSSCG00000013326 / nonexpress / 58.1(1.0E-16)
PPAPDC3 / ENSSSCG00000005713 / 1.11(0.19) / 0.33(2.1E-05)
ICA / ENSSSCG00000028203 / 2.98(2.1E-03) / 3.11(2.5E-03)
STEAP4 / ENSSSCG00000015299 / 2.39(1.2E-25) / 4.86(9.3E-73)
HOOK1 / ENSSSCG00000003826 / 2.23(5.3E-06) / 3.64(3.3E-22)
OAZ3 / ENSSSCG00000027091 / 13.7(4.7E-31) / 5.70(8.2E-03)
CDA / ENSSSCG00000021259 / 2.32(1.2E-04) / 2.50(7.0E-05)
CCDC80 / ENSSSCG00000011928 / 0.49(1.1E-25) / 0.35(2.2E-66)
CGN / ENSSSCG00000006621 / 0.30(6.2E-04) / 0.19(2.6E-09)
PLEKHB1 / ENSSSCG00000014827 / 8.56(1.4E-09) / 0.21(9.4E-05)
CALN1 / ENSSSCG00000007730 / 0.13(8.1E-04) / 5.18(4.1E-05)
EDARADD / ENSSSCG00000025986 / 0.39(0.025) / 4.15(2.3E-06)
CD209 / ENSSSCG00000013579 / 0.45(0.071) / 7.92(2.5E-15)
ABP1 / ENSSSCG00000016442 / 0.36(3.7E-224) / 3.33(0)
SNCG / ENSSSCG00000021159 / 4.19(3.1E-19) / 0.30(1.3E-17)
NAALAD2 / ENSSSCG00000014933 / 13.7(5.8E-12) / 0.40(1.6E-05)
FAM84A / ENSSSCG00000008664 / 17.5(4.3E-42) / 0.03(4.0E-45)
NLRP12 / ENSSSCG00000003251 / 0.47(0.028) / 8.72(2.3E-41)
ZNF215 / ENSSSCG00000014600 / 0.31(0.032) / 9.54(1.2E-09)
ELOVL3 / ENSSSCG00000010577 / 0.34(4.2E-03) / 4.41(3.5E-03)
PPP1R11 / ENSSSCG00000028347 / 0.15(1.7E-17) / 11.4(1.6E-18)
CSPG4 / ENSSSCG00000001873 / 0.65(0.035) / 0.31(2.3E-15)
DCN / ENSSSCG00000000915 / 0.73(0.066) / 0.33()1.0E-147
STAB2 / ENSSSCG00000000854 / 0.60(2.6E-03) / 0.38(3.1E-61)
interferon-induced transmembrane protein 1-like / ENSSSCG00000014565 / 0.01(2.0E-86) / 0.60(6.2E-012)
ABAT / ENSSSCG00000007909 / 1.26(2.0E-86) / 8.42(1.7E-046)
TPMT / ENSSSCG00000001073 / 0.84(0.37) / 3.75(3.4E-17)
agenes which putative functions assigned based on GO term and manual annotation. Many genes could be classified into multiple categories but only the most specific biology processes were listed. bTop informative BLASTX hit. cFC: fold change, gene expression level following infection compared to the control, i.e. infection/control. "FC≥2" represents significant up-regulation; "FC≤0.5" represents significant down-regulation; 2≤FC≥0.5 represents no significant. dq-value is adjusted p-value (Benjamini-Hochberg correction).