CURRICULUM VITAE
Changchun Xiao, PhD
Assistant Professor
Department of Immunology and Microbial Science
The Scripps Research Institute
10550 North Torrey Pines Road, R202
La Jolla, CA 92037
Mail code: IMM-18
Tel: (858) 784 7640 (office)
(858) 784 7642 (lab)
Fax: (858) 784 7643 (fax)
Email:
Website: http://www.scripps.edu/xiao
EDUCATION
05/2002 Doctor of Philosophy
Department of Immunobiology
Yale University, New Haven, CT, USA
05/1998 Master of Science
Department of Immunobiology
Yale University, New Haven, CT, USA
07/1995 Bachelor of Science
Department of Biological Science and Biotechnology
Tsinghua University, Beijing, China
PROFESSIONAL APPOINTMENTS
11/2010-present Adjunct Assistant Professor
La Jolla Institute of Allergy and Immunology
11/2008-present Assistant Professor
Department of Immunology and Microbial Science
The Scripps Research Institute
01/2004-10/08 Postdoctoral fellow
Immune Disease Institute, Harvard Medical School
06/2002-12/2003 Postdoctoral associate
Department of Immunobiology
Yale University School of Medicine
AWARDS AND FELLOWSHIPS
2010 Pew Scholar in Biomedical Sciences
2009 Cancer Research Institute Investigator Award
2004 Cancer Research Institute Posdoctoral Fellowship
EDITORIAL SERVICES
Molecular & Cellular Biology, member of the Editorial Board, 2013-present
Ad hoc reviewer for:
Athritis & Rheumatism
Blood
BMC Medical Genomics
Critical Reviews in Immunology
Genome Research
Journal of Biological Chemistry
Journal of Clinical Investigation
Journal of Experimental Medicine
Journal of Immunology
Molecular and Cellular Biology
Nature Genetics
Oncogene
Proceedings of National Academy of Sciences
RNA
Virology
INSTITUTIONAL SERVICE
PhD Student Admission Committee 2009-present
INVITED SEMINARS
1. University of Washington, Department of Immunology, Seattle, July 2001
2. Tsinghua University, School of Life Sciences, Beijing, China, March 2006
3. First International Conference on Functional Annotation of the Mammalian Genome, Tegernsee, Tottach-Egern, Bavaria, Germany, January 2008
4. University of Massachusetts Medical School, Department of Pathology, Worcester, February, 2008
5. MD Anderson Cancer Center, Department of Cancer Genetics, Houston, February 2008
6. University of Chicago, The Ben May Department for Cancer Research, Chicago, February 2008
7. Yale University, Department of Pathology, New Haven, March 2008
8. The Scripps Research Institute, La Jolla, April 2008
9. Washington University, Department of Pathology & Immunology, St. Louis, April 2008
10. Wistar Institute, Philadelphia, April 2008
11. Memorial Sloan-Kettering Cancer Center, New York City, May 2008
12. 10th International Conference of Malignant Lymphoma, Lugano, Switzerland, June 2008
13. University of Pennsylvania, School of Veterinary Medicine, Department of Pathobiology, Philadelphia, June 2008
14. Brigham and Women's Hospital, Boston, July 2008
15. Tsinghua University, School of Life Sciences, Beijing, China, September 2008
16. National Institute of Biological Sciences, Beijing, China, September 2008
17. Genomics Institute of the Novartis Research Foundation, La Jolla, March 2009
18. La Jolla Institute of Allergy and Immunology, La Jolla, September 2009
19. NIH 7th Symposium on the Functional Genomics of Critical Illness & Injury, Bethesda, December 2009
20. University of Michigan, Department of Surgery, Ann Arbor, December 2009
21. University of California, San Diego, Division of Biomedical Informatics, La Jolla, November, 2010
22. American Association of Blood Banks (AABB) Annual Meeting, San Diego, October 2011
23. The 3rd International Conference on Regulatory T Cells and TH Subsets and Clinical Application in Human Diseases, Shanghai, China, October 2012
24. Gordon Research Conference: T follicular helper cells, Hong Kong, China, July 2013
XIAO LAB PERSONNEL
1. Jovan Shepherd, Research Technician, 2008-present
2. Maoyi Lai, Postdoctoral Fellow, 2009-present
3. Hiroyo Oda, Postdoctoral Fellow, 2009-2011
4. Wen-Hsien Liu, Postdoctoral Fellow, 2009-present
5. Mohsen Sabouri-Ghomi, Postdoctoral Fellow, 2010-2012
6. Alissa Ramirez Borrero, Summer Intern, 2010
7. Seung Goo Kang, Postdoctoral Fellow, 2010-present
8. Hyun Yong Jin, PhD student, 2011-present
9. Alicia Gonzalez Martin, 2011-present
10. Isaiah Song, UCSD Undergraduate Student Intern, 2011-2013
PUBLICATIONS
Selected Peer-reviewed Publications (Note: * indicates co-first authors.)
1. Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S. (1999) ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development 13: 2059-2071. PMCID: PMC316957
2. Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes & Development 17: 2933-2949. PMCID: PMC289152
3. Xiao C, Ghosh S. (2005) NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses. Advances in Experimental Medicine and Biology 560:41-45. PMID: 15932018
4. Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes & Development 19: 2668-2681. PMCID: PMC1283960
5. Shim JH*, Xiao C*, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S. (2006) CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. Journal of Cell Biology 172: 1045-1056. PMCID: PMC2063762
6. Monticelli S*, Ansel KM*, Xiao C*, Socci ND*, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. (2005) MicroRNA profiling of the murine hematopoietic system. Genome Biology 6(8): R71. PMCID: PMC1273638
7. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. (2007) Regulation of the germinal center response by microRNA-155. Science 316: 604-608. PMID: 17463289
8. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. (2007) MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131: 146-159. PMID: 17923094
9. Xiao C*, Srinivasan L*, Calado DP, Patterson HC, Zhang B, Wang J, Henderson JM, Kutok JL, Rajewsky K. (2008) Lymphoproliferative disease and autoimmunity in mice with elevated miR-17-92 expression in lymphocytes. Nature Immunology 9:405-14. PMCID: PMC2533767
10. Xiao C and Rajewsky K. (2009) MicroRNA Control in the Immune System: Basic Principles. Cell 136: 26-36. PMID: 19135886
11. Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P. (2010) The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res. 70:8547-57. PMCID: PMC2970743
12. Yoshizuka N, Lai M, Liao R, Cook R, Xiao C, Han J, Sun P. (2012) PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res. 10:810-20. PMCID: PMC3378811
13. Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J. (2012) An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response. Cell Rep. 2:1048-60. PMCID: PMC3487471
14. Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MBA, Qi H, Teijaro JR, Xiao C (2013) MiR-17~92 family microRNAs are critical regulators of T follicular helper cell differentiation. Nature Immunology, 14:849-57. PMID: 23812097 [PubMed - in process]
15. Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C (2013) MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. The EMBO J., 2013 Aug 6. doi: 10.1038/emboj.2013.178. [Epub ahead of print]
16. Shim EJ, Bang BR, Kang SG, Ma J, Otsuka M, Kang J, Stahl M, Han J, Xiao C, Vallance BA, Kang YJ (2013) Activation of p38α in T Cells Regulates the Intestinal Host Defense against Attaching and Effacing Bacterial Infections. J Immunol. 2013 Aug 5. [Epub ahead of print]
RESEARCH SUPPORT
Ongoing Research Support
PEW Scholar in Biomedical Sciences Xiao (PI) 07/01/10 - 06/30/14
The PEW Charitable Trusts
The Roles of Small Regulatory RNAs in the Immune System
This is a career development award to support studying the roles of small regulatory RNAs in the immune system, under health and disease conditions.
Role: PI
R01 AI087634-03 Xiao (PI) 05/15/10 - 04/30/15
NIH/NIAID
The Role of miR-17~92 in Autoimmune Diseases
The major goal of this project is to study the role of miR-17~92 in autoimmune diseases.
Role: PI
RC4 AI092763-03 Kronenberg & Rao (PI) 09/30/10 - 09/29/13
NIH/NIAID
New Players in Immune Function: Identification through RNAi and MicroRNA Screens
The major goal of this project is to build an RNAi/ miRNA screening facility and use this facility to identify novel genes that play important roles in immune functions such as fighting off infectious and autoimmune diseases and cancers.
Role: Project 2 Co-Investigator
R01AI089854-02 Xiao (PI) 09/21/11- 08/31/15
NIH/NIAID
Functional Analysis of MicroRNAs in Lymphocyte Development and Immune Tolerance
The major goal of this project is to perform functional analysis of hundred of miRNAs in lymphocyte develop and immune tolerance, to identify miRNAs that are critical regulators of these processes.
Role: PI
Completed Research Support
RC1 CA146299-02 Xiao (PI) 09/29/09 - 08/31/12 (NFE)
NIH/NCI
Deep Sequencing of Small Regulatory RNAs in Diffuse Large B Cell Lymphoma
The major goal of this project is to deep sequence small RNA species in a large collection of human DLBCL samples and to discover small RNAs with diagnostic and prognostic values.
Role: PI
Novel Research Grant Xiao (PI) 12/01/09 - 11/30/12
Lupus Research Institute
Functional Analysis of MicroRNAs in Systemic Immune Tolerance
This grant provides seed money to support a pilot study of functional analysis of known microRNAs in systemic immune tolerance.
Role: PI
Investigator Award Xiao (PI) 07/01/09 - 06/30/13
Cancer Research Institute
The Role of miR-17~92 in the Immune System and During Lymphogenesis
This is a career development award to support studying the role of miR-17~92 in lymphocyte development, immune responses, and immune system-related diseases.
Role: PI
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