Supplementary Material 1: Survival Analysis for Mirnas

Supplementary Material 1: Survival analysis for miRNAs

SignS2, a web-based tool for gene selection for survival data( used to investigate miRNAs related to outcome in SMZL using the FCMS method, a stepwise model selection for filtering and clustering genes. For significant miRNAs, survival distributions were estimated with SPSS (v.17.0) for a univariate (gene-by-gene) Cox analysis and Kaplan-Meier curves. In all comparisons, miRNAs with values of p<0.05 were considered significant.

To search for miRNAs related to outcome in SMZL, 28 of 31 cases (cases 2, 13 and 31 had no overall survival data) were subjected to the FCMS method using SignS2. The significant miRNAs (p<0.05) were used in a univariate Cox regression, identifying34 miRNAs that correlated positively or negatively with OS. Survival probabilities were estimated using the Kaplan-Meier method obtaining a set of eight miRNAs (Supp Table 1; Supp Figure 1). Four of them (miR-382, miR-768-3p,miR-28 and miR-141) were selected for qRT-PCR validation in an independent FFPE series.

The four miRNAs tested by RT-PCR were not significant in the Cox and Kaplan-Meier analysis possibly due to the clinical data of the FFPE independent series being relatively incomplete, as only 57 of 77 cases of the FFPE series had OS data.

Supp Table 1. Survival analysis. MiRNAs with significant p-valuesin SignS and Kaplan-Meier analyses. 28 of 31 SMZL cases were subjected to a univariate (gene-by-gene) Cox analysis after FCMS using SignS ( Thirty-four miRNAs were correlated positively or negatively with overall survival. The Cox regression analysis showed significant values for all 34 miRNAs(p<0.05; data not shown). Survival distributions were estimated using the Kaplan-Meier method obtaining a set of 8 miRNAs with p<0.05. NS, not significant.

miRNA / SignS
p / Kaplan-Meier
p
hsa-miR-675 / 0.006 / NS
hsa-miR-141 / 0.009 / 0.010
hsa-miR-596 / 0.011 / NS
hsa-miR-634 / 0.012 / 0.010
hsa-miR-210 / 0.012 / 0.030
hsa-miR-519d / 0.013 / NS
hsa-miR-380-5p / 0.015 / NS
hsa-miR-382 / 0.016 / 0.002
hsa-miR-452* / 0.016 / NS
hsa-miR-613 / 0.016 / NS
hsa-miR-200b / 0.016 / 0.049
hsa-miR-517b / 0.017 / NS
hsa-miR-517* / 0.017 / NS
hsa-miR-208 / 0.021 / NS
hsa-miR-629 / 0.023 / NS
hsa-miR-199b / 0.023 / NS
hsa-miR-330 / 0.023 / NS
hsa-miR-453 / 0.024 / 0.044
hsa-miR-28 / 0.025 / 0.037
hsa-miR-363 / 0.026 / NS (0.059)
hsa-miR-363* / 0.026 / NS (0.059)
hsa-miR-182* / 0.032 / NS
hsa-miR-539 / 0.033 / NS
hsa-miR-423 / 0.037 / NS
hsa-miR-518b / 0.039 / NS
hsa-miR-409-3p / 0.040 / NS
hsa-miR-25 / 0.042 / NS (0.064)
hsa-miR-299-5p / 0.042 / NS
hsa-miR-346 / 0.044 / NS
hsa-miR-335 / 0.045 / NS
hsa-miR-768-5p / 0.046 / 0.012
hsa-miR-642 / 0.046 / NS
hsa-miR-611 / 0.047 / NS
hsa-miR-192 / 0.047 / NS (0.059)
hsa-miR-369-3p / 0.047 / NS
hsa-miR-181a* / 0.048 / NS
hsa-miR-181a / 0.048 / NS

Supplementary Table 2. SMZL gene expression signature. We used a t-test ( to obtain the SMZL gene signature when comparing its expression with that of the RLH. The comparison considered genes with FDR<0.01 to be significant.Genes with more than two-fold upregulation or downregulationwere also selected. The fold change (FC) corresponds to a log2 difference between the SMZL and RLH averages. FDR values are those from the t-test. To identify associations between differentially expressed miRNAs (FDR<0.05) and gene expression signatures (FDR<0.05) we followed the previously described procedure1.

FC / FDR / Gene Symbol / Cytoband / Prediction of regulator miRNAs
2.5944 / 0.0000 / LMNB1 / 5q23.2 / miR-145 miR-22 miR-424 miR-130a miR-27b miR-376a miR-136 miR-214
2.3641 / 0.0093 / MMP12 / 11q22.2
2.3229 / 0.0051 / ZBED2 / 3q13.13 / miR-377 miR-27b miR-214
2.2676 / 0.0114 / UBD / 6p22.1
2.2255 / 0.0000 / FCRLM1 / 1q23.3
2.1761 / 0.0012 / ADAMDEC1 / 8p21.2
2.1668 / 0.0005 / CD70 / 19p13
2.1105 / 0.0010 / BIC / 21q21.3
2.0393 / 0.0010 / CD24 / 6q21 / miR-145 miR-377 miR-136
2.0295 / 0.0011 / KBTBD8 / 3p14.1 / miR-145 miR-143 miR-130a miR-27b miR-376a
2.0217 / 0.0000 / KCNN4 / 19q13.31 / miR-424
1.9088 / 0.0004 / E2F5 / 8q21.2
1.8817 / 0.0000 / MCOLN2 / 1p22.3
1.8156 / 0.0136 / ZBTB32 / 19q13.12 / miR-424
1.8141 / 0.0028 / DCAL1 / 12p13.31
1.8083 / 0.0145 / ELL3 / 15q15.3 / miR-145 miR-22 miR-377 miR-638
1.8074 / 0.0017 / TACI / 17p11.2 / miR-22 miR-424 miR-136 miR-214 miR-638
1.7986 / 0.0012 / PFTK1 / 7q21.13 / miR-145 miR-22 miR-424 miR-377 miR-27b miR-376a miR-136
1.7873 / 0.0000 / RALGPS2 / 1q25.2 / miR-22 miR-377 miR-130a miR-27b miR-214
1.7706 / 0.0642 / FCRL4 / 1q23.1 / miR-27b miR-136
1.7392 / 0.0145 / DFNA5 / 7p15.3 / miR-145 miR-22 miR-424 miR-130a miR-27b miR-214
1.7389 / 0.0004 / TNFRSF9 / 1p36.23 / miR-143 miR-22 miR-424 miR-27b
1.7232 / 0.0001 / PARP15 / 3q21.1 / miR-145 miR-377 miR-214 miR-638
1.7101 / 0.0000 / U09197
1.6995 / 0.0029 / FCRL2 / 1q23.1 / miR-424 miR-377 miR-27b miR-376a miR-136 miR-214 miR-638
1.6851 / 0.0001 / SMC6 / 2p24.2 / miR-145 miR-424 miR-377 miR-214 miR-638
1.6379 / 0.0015 / IL2RA / 10p15.1 / miR-145 miR-143 miR-451 miR-22 miR-424 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214 miR-638
1.6233 / 0.0053 / COL9A3 / 20q13.33 / miR-145 miR-451 miR-130a miR-27b miR-214 miR-638
1.6208 / 0.0278 / DNAJC5B / 8q13.1 / miR-27b
1.6116 / 0.1499 / CRYM / 16p12.2 / miR-424
1.5972 / 0.0000 / STAMBPL1 / 10q23.31 / miR-143 miR-451 miR-377 miR-130a miR-27b miR-136 miR-214
1.5966 / 0.0000 / GPX7 / 1p32.3 / miR-27b
1.5825 / 0.0422 / RARRES1 / 3q25.33 / miR-145 miR-143 miR-424 miR-376a
1.5709 / 0.0065 / IL7 / 8q21.12 / miR-22 miR-377 miR-27b miR-376a
1.5437 / 0.0242 / PMCH / 12q23.2
1.5410 / 0.0016 / GUCY2C / 12p13.1
1.5251 / 0.0001 / ZC3H12D / 6q25.1 / miR-145 miR-143 miR-22 miR-377 miR-376a miR-214 miR-638
1.4811 / 0.0007 / MND1 / 4q31.3
1.4758 / 0.0003 / DCLRE1C / 10p13 / miR-143 miR-424 miR-377 miR-130a miR-376a miR-136 miR-214
1.4749 / 0.0003 / CR594705
1.4708 / 0.0011 / CAPG / 2p11.2 / miR-145 miR-143 miR-22 miR-376a miR-214
1.4508 / 0.0214 / TLR10 / 4p14 / miR-143 miR-136
1.4469 / 0.0001 / SIT1 / 9p13.3 / miR-143 miR-424 miR-214
1.4328 / 0.0000 / RHOH / 4p14 / miR-27b
1.4310 / 0.0004 / GPT2 / 16q12.1 / miR-22 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.4286 / 0.0008 / FAM111B / 11q12.1
1.4278 / 0.0313 / ASMT / Yp11.31 / miR-27b miR-376a miR-136
1.4276 / 0.0177 / ST8SIA1 / 12p12.1 / miR-143 miR-22 miR-130a miR-27b miR-376a miR-136 miR-214
1.4250 / 0.0077 / COL4A4 / 2q36.3 / miR-145 miR-143 miR-451 miR-22 miR-424 miR-130a
1.4231 / 0.0001 / FCGR2B / 1q23.3 / miR-143 miR-377 miR-130a miR-638
1.4195 / 0.0002 / LIMK1 / 7q11.23 / miR-145 miR-143 miR-22 miR-377 miR-27b miR-214 miR-638
1.4090 / 0.0105 / IL6 / 7p15.3 / miR-145 miR-136
1.4026 / 0.0015 / FLJ40869 / 2p24.2
1.3947 / 0.0076 / ZDHHC21 / 9p22.3
1.3876 / 0.0101 / HSMPP8 / 13q12.11
1.3858 / 0.0002 / SCG5 / 15q13.3 / miR-130a miR-27b miR-376a miR-136
1.3750 / 0.0006 / DAPP1 / 4q23 / miR-143 miR-27b
1.3705 / 0.0084 / CST6 / 11q13.1 / miR-424
1.3643 / 0.0001 / BTLA / 3q13.2 / miR-143 miR-424 miR-376a miR-136 miR-214
1.3452 / 0.0157 / LRRC56 / 11p15.5 / miR-143 miR-214
1.3356 / 0.0000 / IRF4 / 6p25.3 / miR-145 miR-22 miR-424 miR-27b miR-376a miR-136 miR-214
1.3180 / 0.0001 / BUB1B / 15q15.1 / miR-130a
1.3143 / 0.0075 / OSBPL10 / 3p23 / miR-145 miR-143 miR-22 miR-424 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.2971 / 0.0007 / DLEU1 / 13q14.3 / miR-145 miR-143 miR-22 miR-424 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214 miR-638
1.2863 / 0.0021 / P2RY10 / Xq21.1 / miR-145 miR-377 miR-638
1.2782 / 0.0032 / TMEM163 / 2q21.3 / miR-27b
1.2738 / 0.0004 / KIF15 / 3p21.31 / miR-145 miR-22 miR-424 miR-27b miR-136 miR-214
1.2733 / 0.0001 / TFRC / 3q29 / miR-145 miR-143 miR-22 miR-130a miR-27b miR-136 miR-214
1.2719 / 0.0003 / PTPN1 / 20q13.13 / miR-22 miR-130a miR-214
1.2677 / 0.0075 / MPHOSPH1 / 10q23.31
1.2664 / 0.0024 / TLR9 / 3p21.1
1.2592 / 0.0011 / AP1S3 / 2q36.1 / miR-145 miR-22 miR-424 miR-377 miR-27b miR-376a miR-214
1.2559 / 0.0147 / CD200 / 3q13.2 / miR-145 miR-27b miR-376a miR-638
1.2348 / 0.0012 / ATAD2 / 8q24.13
1.2336 / 0.0116 / CKAP2L / 2q13 / miR-143 miR-377 miR-27b miR-376a
1.2329 / 0.0075 / TYMS / 18p11.32
1.2307 / 0.0008 / TMEM156 / 4p14 / miR-145 miR-130a
1.2282 / 0.0059 / ZNF588 / 7q11.21 / miR-145 miR-143 miR-130a miR-376a
1.2279 / 0.0001 / SFMBT1 / 3p21.1 / miR-145 miR-451 miR-377 miR-130a miR-27b miR-214
1.2251 / 0.0132 / SIDT1 / 3q13.2 / miR-145 miR-143 miR-22 miR-424 miR-27b miR-376a miR-136 miR-214 miR-638
1.2161 / 0.1149 / KREMEN2 / 16p13.3 / miR-143 miR-22 miR-424
1.2127 / 0.0008 / SLC38A1 / 12q13.11 / miR-143 miR-22 miR-424 miR-377 miR-376a miR-136 miR-214
1.2119 / 0.0138 / CCDC50 / 3q28 / miR-145 miR-22 miR-424 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.2110 / 0.0000 / CTSH / 15q25.1 / miR-424 miR-376a
1.2063 / 0.0011 / C1GALT1 / 7p21.3 / miR-145 miR-143 miR-424 miR-27b miR-376a miR-136 miR-214
1.2017 / 0.0844 / CCR6 / 6q27 / miR-143 miR-377 miR-130a miR-376a miR-136
1.1969 / 0.0025 / MYO5B / 18q21.1 / miR-145 miR-143 miR-22 miR-424 miR-377 miR-130a miR-27b miR-136 miR-214 miR-638
1.1921 / 0.0001 / PLA2G2D / 1p36.12 / miR-22 miR-27b miR-136 miR-214
1.1906 / 0.0194 / DDX21 / 10q21.3 / miR-145 miR-638
1.1875 / 0.0344 / TNIP3 / 4q27 / miR-376a
1.1866 / 0.0018 / CENPA / 2p23.3 / miR-145 miR-143 miR-376a miR-136 miR-638
1.1845 / 0.0034 / FAM112A / 20q13.12
1.1832 / 0.0244 / AIM2 / 1q23.1 / miR-143 miR-130a miR-27b miR-136 miR-214
1.1811 / 0.0009 / BCL2 / 18q21.33 / miR-143 miR-424 miR-377 miR-136
1.1791 / 0.0083 / CAMK2D / 4q26 / miR-145 miR-143 miR-22 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.1774 / 0.0833 / BCL2L10 / 15q21.2 / miR-143 miR-424 miR-377 miR-27b miR-214
1.1757 / 0.0022 / LGI2 / 4p15.2 / miR-145 miR-143 miR-424 miR-130a miR-27b miR-376a miR-214
1.1732 / 0.0005 / ZNFN1A3
1.1710 / 0.0034 / TSPAN33 / 7q32.1 / miR-145 miR-143 miR-22 miR-424 miR-130a miR-27b miR-376a miR-136
1.1706 / 0.0835 / HTRA4 / 8p11.23 / miR-376a
1.1698 / 0.0013 / CKS2 / 9q22.2
1.1693 / 0.0011 / SNX25 / 4q35.1 / miR-22 miR-27b miR-376a
1.1628 / 0.0004 / ADORA2A / 22q11.23 / miR-22 miR-424 miR-130a miR-27b miR-376a miR-136 miR-214
1.1591 / 0.0003 / FOXP1 / 3p14.1 / miR-145 miR-143 miR-22 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.1580 / 0.0162 / ARHGEF3 / 3p14.3 / miR-145 miR-143 miR-451 miR-22 miR-377 miR-27b miR-136 miR-214 miR-638
1.1573 / 0.0061 / DEPDC1B / 5q12.1 / miR-145 miR-27b
1.1499 / 0.0001 / MEF2A / 15q26.3 / miR-145 miR-22 miR-377 miR-130a miR-376a
1.1438 / 0.0045 / ZNF608 / 5q23.2 / miR-145 miR-143 miR-27b miR-136
1.1396 / 0.0005 / SLAMF6 / 1q23.2 / miR-214 miR-638
1.1394 / 0.0079 / LAT2 / 7q11.23 / miR-143 miR-130a miR-376a
1.1389 / 0.0010 / LRMP / 12p12.1
1.1347 / 0.0162 / UGT8 / 4q26 / miR-145 miR-377 miR-130a miR-27b miR-376a miR-214
1.1289 / 0.0012 / UBE2T / 1q32.1 / miR-377 miR-376a
1.1249 / 0.0001 / RCSD1 / 1q24.2 / miR-143 miR-22 miR-424 miR-377 miR-136 miR-214
1.1218 / 0.0000 / NKRF / Xq24 / miR-377
1.1208 / 0.0063 / SKIL / 3q26.2 / miR-143 miR-424 miR-377 miR-376a miR-136
1.1182 / 0.0001 / ZNFN1A1
1.1179 / 0.0001 / ZNF681 / 19p12 / miR-145 miR-22 miR-377 miR-27b
1.1176 / 0.0054 / FUT8 / 14q23.3 / miR-143 miR-377 miR-27b
1.1167 / 0.0037 / SYK / 9q22.2 / miR-143 miR-22 miR-424 miR-377 miR-130a miR-27b miR-136
1.1142 / 0.0233 / CELSR1 / 22q13.31 / miR-145 miR-143 miR-451 miR-22 miR-377 miR-130a miR-27b miR-136 miR-214 miR-638
1.1084 / 0.0002 / NFATC1 / 18q23 / miR-145 miR-143 miR-27b miR-136 miR-214
1.1083 / 0.0045 / RP4-747L4.3 / 1q24.2
1.1078 / 0.0002 / SLC35F2 / 11q22.3 / miR-145 miR-22 miR-214
1.1018 / 0.0001 / ZNF101 / 19p13.11 / miR-145 miR-130a miR-376a miR-136
1.1015 / 0.0135 / CHEK1 / 11q24.2 / miR-424
1.0978 / 0.0197 / BIRC3 / 11q22.2
1.0975 / 0.0103 / TMEM154 / 4q31.3 / miR-424 miR-130a miR-214
1.0970 / 0.0001 / ERH / 14q24.1
1.0969 / 0.0030 / NCOA3 / 20q13.12 / miR-145 miR-143 miR-451 miR-22 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.0948 / 0.0572 / PDCD1 / 2q37.3 / miR-424 miR-214
1.0937 / 0.0010 / LRBA / 4q31.3 / miR-143 miR-377 miR-27b
1.0917 / 0.0008 / SMARCB1 / 22q11.23 / miR-143 miR-424 miR-377 miR-27b miR-214 miR-638
1.0882 / 0.0150 / LDHB / 12p12.1 / miR-145 miR-424 miR-27b miR-376a miR-136 miR-214
1.0862 / 0.0008 / AKAP11 / 13q14.11 / miR-143 miR-424 miR-377 miR-130a
1.0858 / 0.0001 / NUP88 / 17p13.2
1.0848 / 0.0337 / SCRN1 / 7p15.1 / miR-145 miR-22 miR-424 miR-377 miR-376a miR-136 miR-214 miR-638
1.0843 / 0.0299 / MTHFD2 / 2p13.1 / miR-22 miR-27b miR-136 miR-214
1.0840 / 0.0038 / POU2F2 / 19q13.2 / miR-22
1.0826 / 0.1023 / FBXO15 / 18q22.3
1.0819 / 0.1799 / FLJ23834 / 7q22.2
1.0760 / 0.0252 / FFAR1 / 19q13.12 / miR-214
1.0755 / 0.0143 / CDCA5 / 11q13.1 / miR-143 miR-214
1.0742 / 0.0224 / HCAP-G
1.0727 / 0.0015 / BLNK / 10q23.33 / miR-143 miR-424 miR-377 miR-130a miR-376a miR-136 miR-214
1.0722 / 0.0002 / ZNF675 / 19p12 / miR-145 miR-377 miR-130a
1.0713 / 0.0144 / DDX26B / Xq26.3 / miR-424 miR-27b
1.0706 / 0.0065 / STRBP / 9q33.2 / miR-145 miR-143 miR-424 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.0690 / 0.0073 / PTPN22 / 1p13.2 / miR-145 miR-143 miR-376a miR-136 miR-214
1.0685 / 0.0003 / BAG2 / 6p12.1 / miR-27b
1.0662 / 0.0058 / DSU
1.0644 / 0.0584 / SOX5 / 12p12.1 / miR-424 miR-130a miR-136
1.0629 / 0.0229 / CEP55 / 10q23.33 / miR-143 miR-424 miR-377 miR-130a miR-376a miR-136
1.0602 / 0.0056 / HSH2D / 19p13.11 / miR-22 miR-27b miR-214 miR-638
1.0551 / 0.0067 / SIGLEC6 / 19q13.33 / miR-145 miR-143 miR-22 miR-377 miR-27b miR-136 miR-214 miR-638
1.0541 / 0.0113 / RPS3A / 4q31.3
1.0492 / 0.0013 / KIF18A / 11p14.1 / miR-22
1.0466 / 0.0017 / TMEM118 / 12q24.22
1.0421 / 0.0003 / CLMN / 14q32.13 / miR-145 miR-143 miR-424 miR-377 miR-27b miR-136 miR-214
1.0408 / 0.0062 / HIVEP1 / 6p24.1 / miR-143 miR-424 miR-377 miR-130a miR-376a miR-136 miR-214 miR-638
1.0407 / 0.0354 / METTL8 / 2q31.1 / miR-143 miR-22 miR-130a miR-27b miR-136
1.0405 / 0.0033 / MLF1IP / 4q35.1 / miR-27b
1.0382 / 0.0135 / ESCO2 / 8p21.1 / miR-145 miR-130a miR-27b miR-214
1.0314 / 0.0004 / RPL29P2 / 17p13.1 / miR-22
1.0245 / 0.0091 / RSPO3 / 6q22.33 / miR-424 miR-27b miR-136
1.0238 / 0.1423 / PRG4 / 1q31.1
1.0217 / 0.0051 / RASGRF1 / 15q25.1 / miR-145 miR-27b miR-136
1.0165 / 0.0040 / TTK / 6q14.1 / miR-377
1.0157 / 0.0001 / CYFIP2 / 5q33.3 / miR-145 miR-143 miR-377 miR-27b miR-136 miR-214 miR-638
1.0151 / 0.0006 / FAM83D / 20q11.23 / miR-130a
1.0135 / 0.0118 / GLOXD1 / 1p34.1
1.0135 / 0.0549 / SIPA1L3 / 19q13.13 / miR-143 miR-27b miR-214
1.0110 / 0.0037 / NUP153 / 6p22.3 / miR-377 miR-27b miR-136
1.0102 / 0.0018 / DARS2 / 1q25.1 / miR-143 miR-377 miR-376a
1.0089 / 0.0024 / TNS4 / 17q21.2 / miR-451 miR-22
1.0087 / 0.0575 / CYP27B1 / 12q14.1 / miR-145 miR-424 miR-377
1.0077 / 0.0034 / CD40 / 20q13.12 / miR-145 miR-143 miR-22 miR-424 miR-214
1.0048 / 0.0092 / BMF / 15q15.1 / miR-145 miR-22 miR-424 miR-377 miR-136 miR-214
1.0047 / 0.0122 / ANKRD29 / 18q11.2 / miR-143 miR-424
1.0033 / 0.0194 / BUB1 / 2q13 / miR-145 miR-143 miR-451 miR-377 miR-130a miR-27b miR-376a miR-136 miR-214
1.0021 / 0.0001 / CD44 / 11p13 / miR-145 miR-143 miR-130a miR-27b miR-376a
1.0015 / 0.0121 / WASF1 / 6q21 / miR-145 miR-143 miR-22 miR-377 miR-130a
1.0011 / 0.0005 / OXCT1 / 5p13.1 / miR-451
1.0008 / 0.0329 / IL21 / 4q27
1.0006 / 0.0049 / U94903
-1.0023 / 0.0002 / UNQ3035
-1.0034 / 0.0151 / HIRA / 22q11.21
-1.0036 / 0.0001 / GNA11 / 19p13.3
-1.0054 / 0.0011 / C1QA / 1p36.12
-1.0057 / 0.0013 / LRG1 / 19p13.3
-1.0080 / 0.0009 / LDB2 / 4p15.32
-1.0092 / 0.0104 / FJX1 / 11p13
-1.0095 / 0.0019 / CTDSPL / 3p22.2
-1.0111 / 0.0002 / DENND2A / 7q34
-1.0112 / 0.0303 / ALDH2 / 12q24.12
-1.0114 / 0.0000 / TCEA3 / 1p36.12
-1.0116 / 0.0633 / SPON1 / 11p15.2
-1.0125 / 0.0068 / SIPA1L2 / 1q42.2
-1.0161 / 0.0326 / SORL1 / 11q24.1
-1.0174 / 0.0169 / COL7A1 / 3p21.31
-1.0174 / 0.0065 / SELPLG / 12q24.11
-1.0183 / 0.0034 / LAPTM4B / 8q22.1
-1.0188 / 0.0018 / PON3 / 7q21.3
-1.0191 / 0.0155 / DSCR1L1 / 6p12.3
-1.0191 / 0.0004 / HSPA2 / 14q23.3
-1.0192 / 0.0034 / GABARAPL1 / 12p13.2
-1.0193 / 0.0229 / FGL2 / 7q11.23
-1.0207 / 0.0002 / IFITM2 / 11p15.5
-1.0215 / 0.0006 / SLC24A6 / 12q24.13
-1.0215 / 0.0592 / CD63 / 12q13.2
-1.0278 / 0.0380 / SLC8A1 / 2p22.1
-1.0282 / 0.0002 / FGD5 / 3p24.3
-1.0284 / 0.0243 / IFI27 / 14q32.13
-1.0336 / 0.0015 / DARC / 1q23.2
-1.0358 / 0.0000 / ADORA1 / 1q32.1
-1.0360 / 0.0000 / LRRN6A / 15q24.3
-1.0372 / 0.0004 / TNFRSF1A / 12p13.31
-1.0398 / 0.0000 / CASKIN2 / 17q25.1
-1.0409 / 0.0002 / TUBB1 / 20q13.32
-1.0421 / 0.0002 / MXRA7 / 17q25.1
-1.0426 / 0.0049 / RAPH1 / 2q33.2
-1.0426 / 0.0001 / RTN4R / 22q11.21
-1.0435 / 0.0037 / C1QTNF5 / 11q23.3
-1.0441 / 0.0087 / AFP / 4q13.3
-1.0442 / 0.0006 / ZBED3 / 5q14.1
-1.0451 / 0.0017 / DAPK1 / 9q21.33
-1.0453 / 0.0013 / LOXL3 / 2p13.1
-1.0469 / 0.0002 / LGR6 / 1q32.1
-1.0476 / 0.0000 / CIDEB / 14q12
-1.0482 / 0.0001 / GFOD1 / 6p24.1
-1.0486 / 0.0001 / TCEAL5 / Xq22.1
-1.0492 / 0.0151 / KCNJ2 / 17q24.3
-1.0511 / 0.0003 / PELI2 / 14q23.1
-1.0519 / 0.0232 / COX7A1 / 19q13.12
-1.0534 / 0.0001 / NCF2 / 1q25.3
-1.0542 / 0.0135 / EMILIN1 / 2p23.3
-1.0548 / 0.0000 / PCDHB15 / 5q31.3
-1.0558 / 0.0025 / FAM59A / 18q12.1
-1.0581 / 0.0002 / TENC1 / 12q13.13
-1.0616 / 0.0003 / ST7OT1 / 7q31.2
-1.0619 / 0.0004 / ANKRD25 / 19p13.2
-1.0627 / 0.0105 / SDC3 / 1p35.2
-1.0633 / 0.0031 / VWF / 12p13.31
-1.0642 / 0.0001 / EPHB4 / 7q22.1
-1.0653 / 0.0000 / BAALC / 8q22.3
-1.0654 / 0.0001 / TUSC1 / 9p21.2
-1.0673 / 0.0003 / CRIP2 / 14q32.33
-1.0689 / 0.0002 / PLEKHG4 / 16q22.1
-1.0692 / 0.0112 / CHST7 / Xp11.3
-1.0696 / 0.0001 / DHCR24 / 1p32.3
-1.0699 / 0.0002 / RILP / 17p13.3
-1.0703 / 0.0016 / SERPINB6 / 6p25.2
-1.0763 / 0.0046 / SLCO2A1 / 3q22.1
-1.0764 / 0.0002 / LAMB2 / 3p21.31
-1.0794 / 0.0067 / SERPINA5 / 14q32.13
-1.0806 / 0.0005 / ASPH / 8q12.3
-1.0815 / 0.0032 / IFITM3 / 11p15.5
-1.0831 / 0.0318 / HOXA7 / 7p15.2
-1.0840 / 0.0068 / PTPRB / 12q15
-1.0844 / 0.0219 / SSTR2 / 17q25.1
-1.0855 / 0.0000 / WFS1 / 4p16.1
-1.0855 / 0.0005 / CTSF / 11q13.1
-1.0858 / 0.0028 / SATB1 / 3p24.3
-1.0861 / 0.0080 / ARRB1 / 11q13.4
-1.0861 / 0.0000 / A4GALT / 22q13.2
-1.0872 / 0.0151 / CLIC5 / 6p12.3
-1.0888 / 0.0002 / PLEKHG3 / 14q23.3
-1.0891 / 0.0001 / CTRB1 / 16q23.1
-1.0911 / 0.0126 / C1QB / 1p36.12
-1.0921 / 0.0385 / KCNQ1 / 11p15.4
-1.0928 / 0.0004 / AMHR2 / 12q13.13
-1.0968 / 0.0111 / FGG / 4q32.1
-1.0984 / 0.0013 / CITED4 / 1p34.2
-1.0990 / 0.0003 / ITGB5 / 3q21.2
-1.0998 / 0.0000 / GIMAP6 / 7q36.1
-1.1002 / 0.0298 / ID4 / 6p22.3
-1.1023 / 0.0001 / EFHD1 / 2q37.1
-1.1032 / 0.0026 / MNDA / 1q23.1
-1.1033 / 0.0141 / CST5 / 20p11.21
-1.1044 / 0.0102 / ZNF366 / 5q13.2
-1.1052 / 0.0006 / PCSK5 / 9q21.13
-1.1060 / 0.0020 / CD300A / 17q25.1
-1.1069 / 0.0391 / TGFBR3 / 1p22.2
-1.1074 / 0.0056 / XCL1 / 1q24.2
-1.1081 / 0.0016 / GAA / 17q25.3
-1.1089 / 0.0000 / ARVCF / 22q11.21
-1.1090 / 0.0000 / PHLDB1 / 11q23.3
-1.1121 / 0.1418 / HMBOX1 / 8p21.1
-1.1123 / 0.0007 / TMEM98 / 17q11.2
-1.1163 / 0.0000 / PPP1R13B / 14q32.33
-1.1180 / 0.0012 / TSPAN5 / 4q23
-1.1181 / 0.0016 / DOK2 / 8p21.3
-1.1184 / 0.0061 / HIPK2 / 7q34
-1.1189 / 0.0004 / LZTS1 / 8p21.3
-1.1199 / 0.0001 / P4HA2 / 5q31.1
-1.1206 / 0.0008 / COL13A1 / 10q22.1
-1.1229 / 0.0000 / NAT8 / 2p13.2
-1.1230 / 0.0046 / MERTK / 2q13
-1.1298 / 0.0408 / LGALS2 / 22q13.1
-1.1299 / 0.0057 / CABLES1 / 18q11.2
-1.1351 / 0.0037 / SLC19A1 / 21q22.3
-1.1361 / 0.0001 / NR5A1 / 9q33.3
-1.1391 / 0.0027 / BTBD14A / 9q34.3
-1.1428 / 0.0000 / MAGI1 / 3p14.1
-1.1444 / 0.1311 / SFRP4 / 7p14.1
-1.1452 / 0.0049 / HRASLS3 / 11q12.3
-1.1456 / 0.0002 / SCARF1 / 17p13.3
-1.1469 / 0.0012 / ARHGAP22 / 10q11.22
-1.1471 / 0.0005 / CD4 / 12p13.31
-1.1472 / 0.0008 / CDH15 / 16q24.3
-1.1478 / 0.0033 / LMO2 / 11p13
-1.1490 / 0.0017 / RPS6KA2 / 6q27
-1.1493 / 0.0100 / SNCG / 10q23.2
-1.1546 / 0.0006 / LMAN1L / 15q24.1
-1.1560 / 0.0008 / ACTN1 / 14q24.1
-1.1613 / 0.0000 / CGI-38 / 16q22.1
-1.1614 / 0.0445 / OAZ1 / 19p13.3
-1.1614 / 0.0030 / SNFT / 1q32.3
-1.1656 / 0.0424 / GZMB / 14q12
-1.1706 / 0.0119 / STAB2 / 12q23.3
-1.1715 / 0.0012 / NAP5 / 2q21.2
-1.1757 / 0.0125 / FAM107A / 3p14.2
-1.1770 / 0.0000 / MMRN2 / 10q23.2
-1.1781 / 0.0144 / PBEF1 / 7q22.2
-1.1789 / 0.0004 / STARD8 / Xq13.1
-1.1803 / 0.0071 / CEBPB / 20q13.13
-1.1804 / 0.0001 / TLE2 / 19p13.3
-1.1808 / 0.0000 / MPPED2 / 11p14.1
-1.1853 / 0.0260 / SLC16A9 / 10q21.1
-1.1893 / 0.0005 / ABHD9 / 19p13.12
-1.1916 / 0.0001 / POR / 7q11.23
-1.1923 / 0.0079 / FCER1G / 1q23.3
-1.1989 / 0.0044 / RRBP1 / 20p12.1
-1.1998 / 0.0007 / EFNB1 / Xq13.1
-1.2013 / 0.0000 / STOX2 / 4q35.1
-1.2024 / 0.0001 / RHOC / 1p13.2
-1.2036 / 0.0018 / PACSIN3 / 11p11.2
-1.2038 / 0.0007 / RPH3AL / 17p13.3
-1.2063 / 0.0129 / LGMN / 14q32.12
-1.2108 / 0.0011 / GLIS3 / 9p24.2
-1.2120 / 0.0000 / MARVELD1 / 10q24.2
-1.2131 / 0.0016 / KLF4 / 9q31.2
-1.2141 / 0.0002 / TMEM16B / 12p13.31
-1.2155 / 0.0003 / ITSN1 / 21q22.11
-1.2177 / 0.0013 / GLI3 / 7p14.1
-1.2178 / 0.0017 / IGSF9 / 1q23.2
-1.2187 / 0.0093 / PF4V1 / 4q13.3
-1.2189 / 0.0317 / KCNH8 / 3p24.3
-1.2223 / 0.0167 / MFSD7 / 4p16.3
-1.2231 / 0.0317 / PPP1R9A / 7q21.3
-1.2240 / 0.0000 / OSM / 22q12.2
-1.2244 / 0.0004 / DNASE1L3 / 3p14.3
-1.2287 / 0.0006 / FLJ12993 / 4q21.22
-1.2312 / 0.0048 / CYYR1 / 21q21.3
-1.2324 / 0.0015 / NPDC1 / 9q34.3
-1.2331 / 0.0144 / PHACTR3 / 20q13.32
-1.2331 / 0.0014 / CAMTA1 / 1p36.31
-1.2344 / 0.0035 / TSPAN7 / Xp11.4
-1.2347 / 0.0065 / NYD-SP21 / 11q12.2
-1.2380 / 0.0034 / TSHZ3 / 19q12
-1.2380 / 0.0011 / ZNF541
-1.2389 / 0.0117 / RTN1 / 14q23.1
-1.2403 / 0.0000 / JDP2 / 14q24.3
-1.2413 / 0.0003 / ST5 / 11p15.4
-1.2417 / 0.0063 / HEYL / 1p34.2
-1.2426 / 0.0062 / TCF7L1 / 2p11.2
-1.2451 / 0.0064 / PLCE1 / 10q23.33
-1.2462 / 0.0004 / AIG1 / 6q24.2
-1.2491 / 0.0000 / FLJ25084
-1.2506 / 0.0035 / RNF149 / 2q11.2
-1.2511 / 0.0056 / CST3 / 20p11.21
-1.2517 / 0.0179 / CLEC3B / 3p21.31
-1.2545 / 0.0002 / PALM / 19p13.3
-1.2548 / 0.0002 / CDH2 / 18q12.1
-1.2550 / 0.0012 / FLJ13197 / 4p14
-1.2580 / 0.0002 / ROPN1L / 5p15.2
-1.2608 / 0.0013 / MRO / 18q21.2
-1.2628 / < 0.0000001 / KIF26A / 14q32.33
-1.2643 / 0.0000 / MYCT1 / 6q25.2
-1.2647 / 0.0233 / IGSF6 / 16p12.2
-1.2653 / 0.0152 / JUN / 1p32.1
-1.2712 / 0.0345 / MS4A7 / 11q12.2
-1.2737 / 0.0003 / DAB2 / 5p13.1
-1.2776 / 0.0182 / TNFAIP2 / 14q32.32
-1.2797 / 0.0001 / TSPAN18 / 11p11.2
-1.2801 / 0.0014 / NOSTRIN / 2q24.3
-1.2808 / 0.0001 / SCT / 11p15.5
-1.2830 / 0.0001 / BCAR1 / 16q23.1
-1.2859 / 0.0001 / BEX1 / Xq22.1
-1.2871 / 0.0013 / DLL1 / 6q27
-1.2873 / 0.0015 / UACA / 15q23
-1.2919 / 0.0000 / ZNF179 / 17p11.2
-1.2924 / 0.0073 / FRY / 13q13.1
-1.2931 / 0.0009 / IGHG1 / 14q32.33
-1.2940 / 0.0001 / DSCAM / 21q22.2
-1.2949 / 0.0081 / C1QC / 1p36.12
-1.2958 / 0.0013 / PRP2
-1.2959 / 0.0064 / PYGL / 14q22.1
-1.2966 / 0.0017 / FDXR / 17q25.1
-1.2980 / 0.0000 / CSF3R / 1p34.3
-1.2993 / 0.0149 / TFCP2L1 / 2q14.2
-1.3022 / 0.0001 / AVPI1 / 10q24.2
-1.3076 / 0.0091 / RASD1 / 17p11.2
-1.3081 / 0.0012 / CPAMD8 / 19p13.11
-1.3112 / 0.0002 / NDST3 / 4q26
-1.3136 / 0.0173 / PDK4 / 7q21.3
-1.3142 / 0.0001 / RXRA / 9q34.2
-1.3192 / 0.0058 / TMEM37 / 2q14.2
-1.3203 / 0.0007 / LILRA5 / 19q13.42
-1.3238 / 0.0017 / EPS8 / 12p12.3
-1.3253 / 0.0015 / SASH1 / 6q24.3
-1.3266 / 0.0013 / CDKN1C / 11p15.4
-1.3268 / 0.0202 / LRRC25 / 19p13.11
-1.3297 / 0.0000 / OBSL1 / 2q35
-1.3303 / 0.0081 / SHRM
-1.3310 / 0.0000 / EPN2 / 17p11.2
-1.3314 / 0.0176 / CEBPD / 8q11.21
-1.3326 / 0.0241 / CD36 / 7q21.11
-1.3367 / 0.0002 / EMR3 / 19p13.12
-1.3375 / 0.0022 / FLJ20701 / 2q36.3
-1.3375 / 0.0005 / CX788817
-1.3456 / 0.0130 / ADCY4 / 14q12
-1.3478 / 0.0034 / CDC42EP2 / 11q13.1
-1.3512 / 0.0000 / ITGB4 / 17q25.1
-1.3525 / 0.0201 / VEPH1 / 3q25.32
-1.3556 / 0.0052 / KLRF1 / 12p13.31
-1.3561 / 0.0139 / AQP3 / 9p13.3
-1.3565 / 0.0007 / EGFL7 / 9q34.3
-1.3582 / 0.0004 / CMTM5 / 14q11.2
-1.3621 / 0.0014 / SIGLEC7 / 19q13.33
-1.3623 / 0.0000 / HYAL1 / 3p21.31
-1.3637 / 0.0017 / P2RY1 / 3q25.2
-1.3664 / 0.0003 / GPR30 / 7p22.3
-1.3666 / 0.0003 / ATG16L2 / 11q13.4
-1.3679 / 0.0000 / CENTD3 / 5q31.3
-1.3694 / 0.0000 / EPPK1 / 8q24.3
-1.3731 / 0.1186 / MARCO / 2q14.2
-1.3736 / 0.0008 / KIF17 / 1p36.12
-1.3746 / 0.0007 / ARHGAP29 / 1p22.1
-1.3756 / 0.0093 / ZMYND15 / 17p13.2
-1.3766 / 0.0001 / NEFH / 22q12.2
-1.3778 / 0.0012 / GSTP1 / 11q13.2
-1.3789 / 0.0000 / DHDH / 19q13.33
-1.3828 / 0.0007 / TNFRSF10C / 8p21.3
-1.3828 / 0.0005 / HEBP1 / 12p13.1
-1.3849 / 0.0027 / SLC5A1 / 22q12.3
-1.3850 / 0.0496 / P2RY14 / 3q25.1
-1.3856 / 0.0004 / RGL1 / 1q25.3
-1.3859 / 0.0002 / HLF / 17q22
-1.3881 / 0.0001 / LTC4S / 5q35.3
-1.3964 / 0.0015 / UNC45B / 17q12
-1.3971 / 0.0022 / W95609
-1.3999 / 0.0054 / CD33 / 19q13.33
-1.4016 / 0.0000 / CNKSR3 / 6q25.2
-1.4017 / 0.0039 / SCHIP1 / 3q25.33
-1.4092 / 0.0015 / DYSF / 2p13.3
-1.4101 / 0.0172 / CTNND2 / 5p15.2
-1.4115 / 0.0062 / KLRB1 / 12p13.31
-1.4142 / 0.0051 / PPARG / 3p25.1
-1.4157 / 0.0085 / LILRB3 / 19q13.42
-1.4163 / 0.0003 / CCND1 / 11q13.2 / miR-193b
-1.4189 / 0.0003 / SLC37A2 / 11q24.2
-1.4189 / 0.0577 / S100Z / 5q13.3
-1.4206 / 0.0127 / ITGA1 / 5q11.2
-1.4208 / 0.0034 / MGLL / 3q21.3
-1.4225 / 0.0039 / NR0B2 / 1p36.11
-1.4255 / 0.0010 / XCL2 / 1q24.2
-1.4267 / 0.0004 / TPST1 / 7q11.21
-1.4269 / 0.0000 / SELENBP1 / 1q21.3
-1.4319 / 0.0000 / SEMA4C / 2q11.2
-1.4330 / 0.0050 / FLT3 / 13q12.2
-1.4333 / 0.0015 / ST6GALNAC1 / 17q25.1
-1.4334 / 0.0230 / SLC45A3 / 1q32.1
-1.4366 / 0.0000 / RYR2 / 1q43
-1.4376 / 0.0002 / IL8RA / 2q35
-1.4411 / 0.0002 / HYAL2 / 3p21.31
-1.4474 / 0.0046 / WIT1 / 11p13
-1.4490 / 0.0002 / CD93 / 20p11.21
-1.4508 / 0.0055 / F13A1 / 6p25.1
-1.4515 / 0.0001 / TKTL1 / Xq28
-1.4545 / 0.0004 / HCP1
-1.4584 / 0.0195 / ANXA3 / 4q21.21
-1.4600 / 0.0001 / MPP3 / 17q21.31
-1.4644 / 0.0001 / NRXN3 / 14q31.1
-1.4655 / 0.0000 / FXYD6 / 11q23.3
-1.4668 / 0.0016 / RAB32 / 6q24.3
-1.4702 / 0.0000 / AGTRL1 / 11q12.1
-1.4753 / 0.0012 / GP1BB
-1.4775 / 0.0005 / LILRA2 / 19q13.42
-1.4810 / 0.0000 / TIE1 / 1p34.2
-1.4835 / 0.0098 / P2RY6 / 11q13.4
-1.4869 / 0.0000 / RGN / Xp11.3
-1.4876 / 0.0002 / PCSK6 / 15q26.3
-1.4897 / 0.0011 / GUCY1B2
-1.4910 / 0.0050 / MLC1 / 22q13.33
-1.4933 / 0.0003 / SPINK2 / 4q12
-1.4938 / 0.0050 / GATA6 / 18q11.2
-1.4984 / 0.0247 / ATP1B1 / 1q24.2
-1.4995 / 0.0000 / NDRG4 / 16q21
-1.4997 / 0.0000 / FHOD1 / 16q22.1
-1.5017 / 0.0011 / PIR / Xp22.2
-1.5034 / 0.0389 / CD5L / 1q23.1
-1.5075 / 0.0000 / AMICA1 / 11q23.3
-1.5085 / 0.0006 / COL4A2 / 13q34
-1.5112 / 0.0056 / SFRP1 / 8p11.21
-1.5181 / 0.0001 / CYP21A2 / 6p21.32
-1.5182 / 0.0000 / NDRG2 / 14q11.2
-1.5201 / 0.0050 / LHFP / 13q13.3
-1.5261 / 0.0000 / SLC7A8 / 14q11.2
-1.5263 / 0.0010 / KBTBD11 / 8p23.3
-1.5316 / 0.0005 / CREB5 / 7p15.1
-1.5318 / 0.0027 / SLIT2 / 4p15.31
-1.5339 / 0.0000 / PLVAP / 19p13.11
-1.5354 / 0.0006 / MICAL-L2
-1.5364 / 0.0000 / ANGPTL2 / 9q33.3
-1.5370 / 0.0012 / RAB3IL1 / 11q12.3
-1.5397 / 0.0009 / TNFRSF25 / 1p36.31
-1.5427 / 0.0008 / UNC5B / 10q22.1
-1.5442 / 0.0023 / SLC9A5 / 16q22.1
-1.5449 / 0.0017 / CFI / 4q25
-1.5458 / 0.0001 / RAB11FIP5 / 2p13.2 / miR-193b miR-150 miR-142-5p
-1.5481 / 0.0005 / MET / 7q31.2 / miR-155 miR-150 miR-222 miR-181d miR-142-5p miR-30c
-1.5526 / 0.0000 / ROBO4 / 11q24.2 / miR-150 miR-202 let-7g
-1.5556 / 0.0043 / TBX2 / 17q23.2 / miR-150
-1.5563 / 0.0002 / HOXA4 / 7p15.2 / miR-212
-1.5580 / 0.0003 / GLT1D1 / 12q24.32 / miR-150 miR-181d miR-487b miR-30c
-1.5583 / 0.0065 / KLRD1 / 12p13.2 / miR-155 miR-193b miR-150 miR-222
-1.5618 / 0.0002 / COL10A1 / 6q22.1 / miR-155 miR-181d miR-212
-1.5622 / 0.0022 / PRAM1 / 19p13.2
-1.5660 / 0.0000 / NOS3 / 7q36.1 / miR-155 miR-150 miR-30c
-1.5741 / 0.0011 / ECRG4
-1.5744 / 0.0001 / BACE1 / 11q23.3 / miR-155 miR-193b miR-150 miR-142-5p
-1.5756 / 0.0065 / PROCR / 20q11.22 / miR-181d
-1.5772 / 0.0000 / ADRA2B / 2q11.2 / miR-193b miR-150 miR-30c
-1.5778 / 0.0002 / FCGRT / 19q13.33 / miR-193b miR-181d
-1.5780 / 0.0000 / GRB10 / 7p12.2 / miR-193b miR-150 miR-222 miR-181d miR-202 let-7g miR-142-5p miR-30c
-1.5808 / 0.0107 / SCGB3A1 / 5q35.3
-1.5867 / 0.0000 / RHOJ / 14q23.2 / miR-181d miR-142-5p
-1.5873 / 0.0068 / XLKD1 / 11p15.4
-1.5889 / 0.0009 / NPNT / 4q24 / miR-222 miR-212 miR-142-5p
-1.5891 / 0.0006 / ITGA6 / 2q31.1 / miR-155 miR-150 miR-222 miR-181d miR-212 miR-142-5p miR-487b miR-30c
-1.5902 / 0.0026 / TCF21 / 6q23.2 / miR-193b miR-212 miR-202 miR-142-5p miR-30c
-1.5961 / 0.0001 / CIAS1
-1.5966 / 0.0000 / TNFAIP1 / 17q11.2 / miR-193b miR-181d miR-212
-1.6035 / 0.0002 / ZBTB16 / 11q23.2
-1.6052 / 0.0005 / HOXD8 / 2q31.1 / miR-193b miR-181d miR-142-5p miR-30c
-1.6064 / 0.0001 / SLC16A5 / 17q25.1
-1.6068 / 0.0017 / CD160 / 1q21.1 / miR-193b miR-150 miR-222 miR-181d let-7g
-1.6075 / 0.0126 / BI836739
-1.6119 / 0.0016 / LAMC3 / 9q34.13 / miR-193b miR-150 miR-30c
-1.6140 / 0.0002 / GABRE / Xq28 / miR-155 miR-193b miR-150 miR-181d miR-212 miR-142-5p miR-30c
-1.6163 / 0.0001 / NES / 1q23.1 / miR-193b
-1.6185 / 0.0002 / ZNF521 / 18q11.2 / miR-212 miR-142-5p miR-30c
-1.6233 / 0.0034 / GIPC2 / 1p31.1 / miR-222 miR-202 let-7g miR-142-5p
-1.6240 / 0.0001 / ARHGAP23 / 17q12
-1.6291 / 0.0001 / NMUR1 / 2q37.1
-1.6308 / 0.0000 / MMP19 / 12q13.2 / miR-193b miR-150 miR-222 miR-30c
-1.6325 / 0.0001 / BLVRB / 19q13.2
-1.6378 / 0.0000 / PDE9A / 21q22.3 / miR-155 miR-150 miR-181d miR-142-5p
-1.6398 / 0.0000 / OSBPL5 / 11p15.4 / miR-193b miR-150
-1.6432 / 0.0105 / LYPD5 / 19q13.31 / miR-150 miR-181d
-1.6451 / 0.0005 / GPBAR1 / 2q35
-1.6507 / 0.0003 / ATP1B2 / 17p13.1 / miR-181d
-1.6543 / 0.0003 / TMPRSS9 / 19p13.3 / miR-150 miR-222 miR-212
-1.6583 / 0.0041 / IGFBP2 / 2q35 / miR-150 miR-30c
-1.6601 / 0.0010 / SPATA13 / 13q12.12 / miR-193b miR-150 miR-181d miR-212 let-7g miR-142-5p miR-30c
-1.6621 / 0.0004 / LRRC32 / 11q13.5 / miR-150 miR-181d miR-212 miR-30c
-1.6653 / 0.0000 / TSPYL5 / 8q22.1 / miR-181d miR-142-5p miR-30c
-1.6724 / 0.0008 / SDPR / 2q32.3 / miR-30c
-1.6756 / 0.0017 / SMOC1 / 14q24.2 / miR-150 miR-142-5p
-1.6802 / 0.0007 / IL18RAP / 2q12.1 / miR-150 miR-222 miR-142-5p
-1.6852 / 0.0008 / RBP7 / 1p36.22
-1.6870 / 0.0002 / PCDH12 / 5q31.3 / miR-193b miR-202 let-7g miR-142-5p
-1.6885 / 0.0002 / GDPD5 / 11q13.4 / miR-155 miR-150 miR-142-5p
-1.6892 / 0.0001 / ACRBP / 12p13.31
-1.6959 / 0.0000 / CIT / 12q24.23 / miR-150 miR-222 miR-181d miR-142-5p miR-30c
-1.6965 / 0.0105 / TMTC1 / 12p11.22 / miR-193b miR-181d miR-142-5p miR-30c
-1.7029 / 0.0001 / MCOLN1 / 19p13.2
-1.7033 / 0.0027 / ZNF683 / 1p36.11 / miR-150
-1.7116 / 0.0009 / ITGA8 / 10p13 / miR-150 miR-181d miR-142-5p miR-30c
-1.7156 / 0.0049 / PTX3 / 3q25.32 / miR-142-5p
-1.7190 / 0.0002 / C20orf102 / 20q11.23
-1.7251 / 0.0093 / KAZALD1 / 10q24.31 / miR-193b miR-150 miR-222 miR-181d
-1.7275 / 0.0111 / S100A9 / 1q21.3 / miR-202 let-7g miR-30c
-1.7348 / 0.0000 / HSD11B2 / 16q22.1 / miR-155
-1.7363 / 0.0462 / EMR1 / 19p13.3
-1.7370 / 0.0000 / RP4-756G23.1 / 22q13.2
-1.7392 / 0.0001 / FLJ14167
-1.7414 / 0.0075 / IGHA1 / 14q32.33 / miR-193b
-1.7426 / 0.0001 / TRIM6 / 11p15.4 / miR-155 miR-150 miR-142-5p
-1.7439 / 0.0000 / TREM1 / 6p21.1
-1.7532 / 0.0000 / FUT1 / 19q13.33 / miR-150 miR-222 miR-181d
-1.7544 / 0.0009 / INSR / 19p13.2 / miR-150 miR-181d miR-202 let-7g
-1.7592 / 0.0008 / NRGN / 11q24.2
-1.7717 / 0.0017 / CEACAM4 / 19q13.2 / miR-150
-1.7726 / 0.0000 / TNS1 / 2q35 / miR-193b miR-150 miR-222 miR-181d miR-202 let-7g miR-142-5p
-1.7772 / 0.0099 / FCGR3B / 1q23.3
-1.7776 / 0.0568 / Y11328
-1.7856 / 0.0004 / ASB9 / Xp22.2 / miR-193b miR-181d miR-212
-1.7977 / 0.0186 / PCDH17 / 13q21.1 / miR-202 let-7g miR-142-5p miR-30c
-1.7977 / 0.0112 / RAPGEF5 / 7p15.3 / miR-155 miR-193b miR-150 miR-222 miR-181d miR-212 miR-202 let-7g miR-142-5p miR-30c
-1.8034 / 0.0012 / HBB / 11p15.4 / miR-181d miR-202 miR-142-5p
-1.8183 / 0.0195 / IGKC / 2p11.2 / miR-150 miR-142-5p
-1.8214 / 0.0046 / CRHBP / 5q13.3 / miR-155 miR-222
-1.8216 / 0.0001 / CPXM2 / 10q26.13 / miR-155 miR-193b miR-150 miR-222 miR-181d let-7g miR-142-5p
-1.8220 / 0.0027 / B3GNT8 / 19q13.2 / miR-212
-1.8311 / 0.0000 / SLC4A3 / 2q35 / miR-193b miR-150 miR-181d miR-202 let-7g
-1.8312 / 0.0001 / MPP1 / Xq28 / miR-155 miR-193b miR-150 miR-142-5p
-1.8388 / 0.0000 / PGA5 / miR-212
-1.8461 / 0.0008 / HBA2 / 16p13.3 / miR-150 miR-30c
-1.8500 / 0.0027 / PKD2L1 / 10q24.31 / miR-193b miR-150
-1.8526 / 0.0002 / NGFRAP1 / Xq22.2
-1.8558 / 0.0007 / NFE2 / 12q13.13
-1.8571 / 0.0010 / RHOBTB1 / 10q21.2 / miR-155 miR-150 miR-181d miR-212 miR-142-5p miR-30c
-1.8574 / 0.0082 / X01147
-1.8675 / 0.0000 / FLJ20489 / 12q13.11
-1.8679 / 0.0003 / FES / 15q26.1 / miR-193b miR-150 miR-202 let-7g
-1.8679 / 0.0005 / PTCRA / 6p21.1 / let-7g
-1.8710 / 0.0000 / PTRF / 17q21.31 / miR-150
-1.8751 / 0.0027 / Z18824
-1.8778 / 0.0003 / ITLN1 / 1q23.3 / miR-150 miR-142-5p
-1.8784 / 0.0002 / IQCA / 2q37.3
-1.8784 / 0.0001 / FZD8 / 10p11.21 / miR-100 miR-150
-1.8785 / 0.0000 / PLEKHG5 / 1p36.31 / miR-155 miR-150 miR-181d
-1.8897 / 0.0021 / FCGR3A / 1q23.3 / miR-150 miR-181d miR-202 let-7g
-1.8931 / 0.0000 / LRFN2 / 6p21.2 / miR-150 miR-222 miR-30c
-1.9012 / 0.0001 / SPON2 / 4p16.3 / miR-202 let-7g
-1.9179 / 0.0099 / VMO1 / 17p13.2
-1.9228 / 0.0000 / ICAM2 / 17q23.3
-1.9327 / 0.0000 / GRASP / 12q13.13 / miR-150 miR-212
-1.9367 / 0.0004 / AXL / 19q13.2
-1.9403 / 0.0028 / MEST / 7q32.2 / miR-155 miR-193b miR-150 miR-222 miR-181d miR-212 miR-202 let-7g miR-142-5p miR-30c
-1.9446 / 0.0055 / CXCL12 / 10q11.21 / miR-150 miR-222 miR-181d miR-142-5p miR-30c
-1.9466 / 0.0005 / TFF3 / 21q22.3 / miR-193b miR-150
-1.9589 / 0.0000 / APOB48R / 16p11.2
-1.9658 / 0.0359 / MRC1L1 / 10p12.33 / miR-155 miR-150 miR-202 let-7g miR-142-5p miR-30c
-1.9722 / 0.0099 / ADAMTS5 / 21q21.3 / miR-155 miR-150 miR-181d miR-212 miR-202 let-7g miR-142-5p miR-30c
-1.9856 / 0.0012 / SIGLEC12 / 19q13.33 / miR-150 miR-30c
-1.9859 / 0.0004 / BET3L / 6q22.1 / miR-181d miR-30c
-1.9963 / 0.0000 / CCDC48 / 3q21.3 / miR-155 miR-193b miR-181d miR-142-5p
-2.0027 / 0.0003 / PTGER1 / 19p13.12
-2.0073 / 0.0107 / CD163 / 12p13.31 / miR-181d miR-212 miR-142-5p
-2.0144 / 0.0002 / FCER1A / 1q23.2
-2.0152 / 0.0005 / TEK / 9p21.2 / miR-150 miR-222 miR-212
-2.0244 / 0.0004 / RGS18 / 1q31.2 / miR-193b miR-150 miR-181d miR-212 miR-142-5p
-2.0445 / 0.0002 / SEMA3D / 7q21.11 / miR-155 miR-193b miR-150 miR-181d miR-212 miR-202 miR-142-5p miR-30c
-2.0458 / 0.0047 / CHODL / 21q21.1
-2.0471 / 0.0002 / LEPREL1 / 3q28 / miR-193b miR-150 miR-222 miR-212 miR-142-5p miR-30c
-2.0514 / 0.0000 / NCR1 / 19q13.42 / miR-150
-2.0522 / 0.0000 / ETS2 / 21q22.2 / miR-150 miR-222 miR-181d miR-142-5p miR-30c
-2.0526 / 0.0197 / CPVL / 7p15.1 / miR-150 miR-142-5p miR-30c
-2.0553 / 0.0001 / PLK2 / 5q11.2 / miR-222 let-7g
-2.0609 / 0.0000 / CDH4 / 20q13.33
-2.0723 / 0.0003 / ABLIM2 / 4p16.1 / miR-150
-2.0746 / 0.0000 / RNASE1 / 0
-2.1017 / 0.0001 / PDE2A / 11q13.4 / miR-150 miR-142-5p miR-30c
-2.1067 / 0.0602 / X57802
-2.1128 / 0.0033 / GDPD2 / Xq13.1 / miR-193b miR-181d
-2.1142 / 0.0001 / HBA1 / 16p13.3
-2.1274 / 0.0000 / HSPA12B / 20p13 / miR-100 miR-150
-2.1371 / 0.0000 / ZDHHC11 / 5p15.33 / miR-30c
-2.1379 / 0.0000 / GALNTL1 / 14q24.1 / miR-150 miR-181d miR-212 let-7g
-2.1580 / 0.0160 / CPLX3 / 15q24.1
-2.1621 / 0.0001 / PTN / 7q33 / miR-155
-2.1642 / 0.0000 / LRP4 / 11p11.2 / miR-193b miR-181d miR-202 miR-142-5p miR-30c
-2.1748 / 0.0046 / CXCL1 / 4q13.3 / miR-181d
-2.1925 / 0.0000 / SNTG2 / 2p25.3 / miR-150 miR-181d
-2.1958 / 0.0004 / FGF12 / 3q28 / miR-193b miR-222 miR-181d miR-142-5p
-2.2240 / 0.0002 / PF4 / 4q13.3
-2.2283 / 0.0308 / HSD17B6 / 12q13.3 / miR-212
-2.2364 / 0.0001 / TGFBI / 5q31.2 / miR-181d miR-212
-2.2469 / 0.0022 / APOBEC3A / 22q13.1 / miR-202 let-7g miR-30c
-2.2689 / 0.0000 / P2RY2 / 11q13.4 / miR-193b
-2.2759 / 0.0007 / PTPRH / 19q13.42
-2.2931 / 0.0000 / SPIC / 12q23.2 / miR-142-5p
-2.3223 / 0.0000 / CD709370
-2.4235 / 0.0018 / TPO / 2p25.3 / miR-100 miR-193b miR-150 miR-222 miR-212 miR-142-5p miR-30c
-2.4245 / 0.0001 / TAC1 / 7q21.3 / miR-155 miR-222 miR-212
-2.4346 / 0.0031 / DEFA3 / 8p23.1
-2.4601 / 0.0001 / IGKV1-5 / 2p11.2 / miR-150 miR-142-5p
-2.4834 / 0.0000 / FLJ10357 / 14q11.2
-2.5432 / 0.0004 / KRT1 / 12q13.13
-2.5507 / 0.0054 / GPR109B / 12q24.31
-2.5934 / 0.0002 / GBA3 / 4p15.31
-2.6493 / 0.0000 / GFRA2 / miR-155 miR-150 miR-222
-2.6634 / 0.0004 / PPBP / 4q13.3
-2.7376 / 0.0002 / VPS18 / 15q15.1 / miR-155
-2.7960 / 0.0000 / HOMER3 / 19p13.11 / miR-222
-3.0494 / 0.0000 / SIGLECP3 / 19q13.33
-3.1140 / 0.0000 / HMOX1 / 22q12.3 / miR-150 miR-202 let-7g
-3.2330 / 0.0030 / N47124
-3.2668 / 0.0019 / CABP7 / 22q12.2 / miR-150 let-7g miR-142-5p
-3.3820 / 0.0000 / IGSF21 / 1p36.13 / miR-150 miR-222 miR-202 let-7g miR-142-5p

Supplementary Table 3. Gene set enrichment analysis comparing GEP of SMZL with RLH. We carried out at-test in GSEA, significanceconcluded for values of FDR<0.25. p-values and FDRs(false discovery rates)correspond to t-tests.

Gene set / B cells / Upregulated genes
p / FDR
G2 pathway / 0.004 / 0.159 / WEE1, ATM, ATR, PRKDC1, BRCA1, CHEK1, CCNB1, MDM2, MYT1, CDKN1A, EP300, CDC2
B cells IgM+ IgD+ CD27+ / 0.008 / 0.355 / GPX7, CBLB, CD44, DLEU1, CD24, CCDC50, IL6, PDE4B, BCL2, FCRL2, HIST1H2BK, PHKB, IL24, CD1D
BAFF pathway / 0.008 / 0.260 / TRAF3, TACI, MAPK8, NIK, NFKB1, TRAF5
BCR signal pathway / 0.011 / 0.198 / NFATC1, PPP3CA, MAPK8, GRB2, BLNK, BTK, PPP3CB, NFATC4, SYK, NFATC2, NFATC3
NF-KB target genes / 0.063 / 0.242 / MUM1, CD44, CD40, BCL2A1, BIRC3, CCL22, C6, NFKB1, CD83, TNF, BIRC5, TRAF1, TNFAIP3, NFKB2
PRDM1 targets / 0.027 / 0.219 / PARP1, CD24, FCRLA, DUT, RHOH, IKZF1, POU2F2, NPM1, LRMP, PAX5, ODC1, CYFPIP2, CKS2, EBF1
Blood pan B-cell / 0.050 / 0.204 / PFTK1, OSBPL10, CD24, FCRLA, P2RY10, CD40, METTL8, ZCCHC7, ID3, CD200, QRSL1, PAX5, FCRL1
B-cell T-cell calcium signaling / 0.042 / 0.239 / MUM1, CD44, FOXP1, PPP3CA, RHOH, POU2F2, NEK6, CTLA4, IKBKE, BTG2, CD200, BMF, BCL2A1

Supplementary Table 4. MiRNAs with differential expression between SMZL B cells and non-tumoral B cells.We carried out at-test with B cell data obtained from isolated CD19+ B cells from peripheral blood of SMZL patients and healthy donors. FDR is the false discovery rate from t-tests; FC is the fold change (log2 scale) difference between the corresponding averages of classes.

miRNA / B cells / SML vs RLH
FDR / FC / FDR / FC
hsa-miR-21 / 0.0132 / 1.9599 / 0.0474 / 0.8513
hsa-miR-372 / 0.0133 / 1.9591
hsa-miR-520e / 0.0157 / 1.9115
hsa-miR-492 / 0.0234 / 1.7927
hsa-miR-22 / 0.0286 / 1.7310 / 0.0135 / -1.1794
hsa-miR-185 / 0.0295 / 1.7215 / 0.0009 / -1.2452
hsa-miR-99b / 0.0348 / 1.6691
hsa-miR-193b / 0.0350 / 1.6673 / 0.0216 / 1.0595
hsa-miR-433 / 0.0351 / 1.6665
hsa-miR-487a / 0.0431 / 1.5997
hsa-miR-34c / 0.0484 / 1.5613
hsa-miR-330 / 0.0539 / 1.5244 / 0.0010 / 0.8598
hsa-miR-338 / 0.0765 / 1.4012 / 0.0004 / -1.6084
hsa-miR-34a / 0.0784 / 1.3920 / 0.0013 / 1.2810
hsa-let-7b / 0.0816 / 1.3775 / 0.0017 / -1.3838
hsa-miR-451 / 0.0918 / 1.3337 / 0.0011 / -1.0972
hsa-miR-19b / 0.0924 / -1.3312
hsa-miR-519a / 0.0480 / -1.5643
hsa-miR-634 / 0.0475 / -1.5673
hsa-miR-221 / 0.0457 / -1.5804 / 0.0440 / 0.5377
hsa-miR-454-3p / 0.0453 / -1.5836
hsa-miR-609 / 0.0390 / -1.6325
hsa-miR-29b / 0.0390 / -1.6327
hsa-miR-554 / 0.0389 / -1.6332
hsa-miR-26a / 0.0379 / -1.6421
hsa-miR-597 / 0.0363 / -1.6563
hsa-miR-768-3p / 0.0359 / -1.6597 / 0.0211 / 0.9574
hsa-miR-539 / 0.0347 / -1.6701
hsa-miR-141 / 0.0342 / -1.6747
hsa-miR-26b / 0.0329 / -1.6870
hsa-miR-484 / 0.0327 / -1.6891
hsa-miR-549 / 0.0323 / -1.6931
hsa-miR-592 / 0.0316 / -1.7000
hsa-miR-650 / 0.0284 / -1.7339
hsa-miR-647 / 0.0282 / -1.7353 / 0.0000 / -0.7947
hsa-miR-585 / 0.0275 / -1.7434
hsa-miR-454-5p / 0.0261 / -1.7601
hsa-miR-92 / 0.0235 / -1.7913
hsa-miR-200c / 0.0234 / -1.7930
hsa-miR-328 / 0.0222 / -1.8090 / 0.0001 / -0.9722
hsa-miR-485-3p / 0.0198 / -1.8431 / 0.0026 / -1.0844
hsa-miR-574 / 0.0162 / -1.9019
hsa-miR-150 / 0.0159 / -1.9076 / 0.0334 / 0.7168
hsa-miR-222 / 0.0156 / -1.9119
hsa-miR-30b / 0.0154 / -1.9155
hsa-miR-487b / 0.0147 / -1.9299
hsa-miR-342 / 0.0142 / -1.9405
hsa-miR-453 / 0.0139 / -1.9451
hsa-miR-631 / 0.0135 / -1.9546
hsa-miR-383 / 0.0133 / -1.9588
hsa-miR-197 / 0.0108 / -2.0159
hsa-miR-605 / 0.0108 / -2.0167 / 0.0491 / -0.7859
hsa-miR-105 / 0.0107 / -2.0181
hsa-miR-565 / 0.0102 / -2.0327
hsa-miR-206 / 0.0092 / -2.0600
hsa-miR-595 / 0.0084 / -2.0831
hsa-miR-483 / 0.0084 / -2.0841 / 0.0059 / -1.2378
hsa-miR-615 / 0.0083 / -2.0866 / 0.0131 / -0.6387
hsa-miR-324-3p / 0.0076 / -2.1109
hsa-miR-766 / 0.0067 / -2.1445
hsa-miR-339 / 0.0059 / -2.1783
hsa-miR-30c / 0.0046 / -2.2431

Supplementary Table 5. MiRNAs with differential expression between SMZL and NMZL. FDRis the false discovery rate from a t-test comparing SMZL and NMZL. Fold change (FC) is the log2 difference between the SMZL and RLH averages and between the SMZL and NMZL means.

miRNA / SMZL vs. NMZL / SMZL vs. RLH
FDR / FC / FDR / FC
hsa-miR-342 / 0.0034 / 1.6950
hsa-miR-193a / 0.0239 / 1.4805
hsa-miR-770-5p / 0.0005 / 1.2608
hsa-miR-100 / 0.0012 / 1.2583 / 0.0028 / 1.1235
hsa-miR-146b / 0.0019 / 1.2475
hsa-miR-150 / 0.0018 / 1.2148
hsa-miR-519e / 0.0058 / 1.1338
hsa-let-7g / 0.0272 / 1.1170
hsa-miR-330 / 0.0008 / 1.0633 / 0.0010 / 0.8598
hsa-miR-142-5p / 0.0420 / 1.0448
hsa-miR-196a / 0.0011 / 0.9628
hsa-miR-10b / 0.0263 / 0.9361
hsa-miR-31 / 0.0000 / 0.8960
hsa-miR-155 / 0.0075 / 0.8876 / 0.0001 / 1.3636
hsa-miR-33 / 0.0075 / 0.8821
hsa-miR-539 / 0.0018 / 0.8609
hsa-miR-124a / 0.0021 / -0.8298
hsa-miR-93 / 0.0050 / -0.8908
hsa-miR-486 / 0.0005 / -0.8911
hsa-miR-182 / 0.0000 / -0.9045
hsa-miR-652 / 0.0295 / -0.9200 / 0.0012 / -0.9994
hsa-miR-99b / 0.0034 / -0.9267
hsa-miR-647 / 0.0002 / -0.9580
hsa-miR-451 / 0.0002 / -0.9786 / 0.0011 / -1.0972
hsa-miR-425-5p / 0.0004 / -0.9854
hsa-miR-381 / 0.0394 / -1.0007 / 0.0022 / -0.8884
hsa-miR-22 / 0.0002 / -1.0265 / 0.0135 / -1.1794
hsa-miR-134 / 0.0187 / -1.0316
hsa-miR-194 / 0.0003 / -1.0600
hsa-miR-25 / 0.0140 / -1.0893
hsa-miR-450 / 0.0133 / -1.1366
hsa-miR-199a / 0.0000 / -1.1909 / 0.0005 / -1.2864
hsa-miR-23a / 0.0079 / -1.1995 / 0.0012 / -1.1171
hsa-miR-376a / 0.0195 / -1.2118 / 0.0009 / -1.3704
hsa-miR-24 / 0.0001 / -1.2365 / 0.0000 / -1.7407
hsa-miR-328 / 0.0062 / -1.3057 / 0.0001 / -0.9722
hsa-miR-127 / 0.0001 / -1.3158 / 0.0040 / -1.2176
hsa-miR-483 / 0.0276 / -1.5169 / 0.0059 / -1.2378
hsa-miR-185 / 0.0001 / -1.5339 / 0.0009 / -1.2452
hsa-miR-338 / 0.0007 / -1.5367 / 0.0004 / -1.6084
hsa-miR-16 / 0.0000 / -1.6637
hsa-miR-27b / 0.0001 / -1.6646 / 0.0000 / -1.6847
hsa-miR-376b / 0.0047 / -1.7553 / 0.0081 / -1.0242
hsa-miR-377 / 0.0037 / -1.8887 / 0.0000 / -1.8081

Supplementary Figure 1. Kaplan-Meier survival curves comparing SMZL patients with high- and low-level expression of significant miRNAs. Patients with high-level expression of miR-28, miR-768-5p and miR-141 had significantly shorter disease-related overall survival while miR-382 had significantly longer overall survival. Green and blue colors represent high- and low-level expression, respectively. p-values are those of the Kaplan-Meier analysis; * p<0.05, ** p<0.005.

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