Table S1 Stepwise linear regression analyses for showing the association between clinical variables and epicardial adipose tissue mass or percentage.

Epicardial adipose tissue mass, g / Epicardial adipose tissue percentage, %
Variables / β / Standard error / R2 change / P / β / Standard error / R2 change / P
Age, years / 1.03 / 0.11 / 0.039 / <0.001 / 0.005 / 0.001 / 0.092 / <0.001
Male / - / - / - / - / 0.089 / 0.012 / 0.052 / <0.001
Body mass index, kg/m2 / - / - / - / - / -0.011 / 0.002 / 0.018 / <0.001
Body surface area, m2 / 45.5 / 7.9 / 0.033 / <0.001 / - / - / - / -
Waist circumference, cm / 0.65 / 0.22 / 0.286 / 0.003 / - / - / - / -
Body fat mass, kg / 0.84 / 0.32 / 0.005 / 0.003 / - / - / - / -
LDL cholesterol, mg/dL / - / - / - / - / - / - / - / -
HDL cholesterol, mg/dL / - / - / - / - / - / - / - / -
Triglyceride, mg/dL / 0.04 / 0.01 / 0.007 / 0.002 / 0.0002 / 0.00007 / 0.007 / 0.008
Hypertension / - / - / - / - / - / - / - / -
Smoking / - / - / - / - / - / - / - / -
Metabolic syndrome / - / - / - / - / - / - / - / -
Diabetes mellitus / - / - / - / - / - / - / - / -
HOMA-IR / - / - / - / - / - / - / - / -
γ-glutamyl transpeptidase, U/L / 0.12 / 0.04 / 0.012 / 0.001 / 0.0006 / 0.0002 / 0.013 / 0.002
C-reactive protein, mg/L / 2.46 / 0.49 / 0.023 / <0.001 / 0.013 / 0.003 / 0.024 / <0.001
Model R2 / 0.41 / 0.21

The above independent variables were considered for the model. Only the variables that had p 0.05 were considered in the final fitted model.

HOMA-IR homeostasis model assessment of insulin resistance index

Table S2 Spearman rank correlations of adiposity parameters with coronary plaque scores and insulin resistance

Variable / BMI, kg/m2 / BSA, m2 / WC, cm / Body fat mass, kg / EAT
mass, g / %EAT / BMI-indexed EAT / BSA-indexed EAT / WC-indexed EAT
Calcium score / 0.17** / 0.14** / 0.20** / 0.10** / 0.24** / 0.23** / 0.22** / 0.23** / 0.22**
Total plaque SSS / 0.16** / 0.14** / 0.18** / 0.08* / 0.24** / 0.24** / 0.22** / 0.22** / 0.22**
Total plaque SIS / 0.17** / 0.15** / 0.19** / 0.09** / 0.24** / 0.24** / 0.22* / 0.23** / 0.22**
Noncalcified plaque SSS / 0.03 / 0.04 / 0.04 / -0.02 / 0.12** / 0.15** / 0.13** / 0.12** / 0.12**
Noncalcified plaque SIS / 0.03 / 0.04 / 0.05 / -0.01 / 0.12** / 0.15** / 0.13** / 0.12** / 0.12**
Mixed plaque SSS / 0.10** / 0.07* / 0.07* / 0.04 / 0.18** / 0.20** / 0.17** / 0.17** / 0.18**
Mixed plaque SIS / 0.10** / 0.07* / 0.07* / 0.04 / 0.17** / 0.20** / 0.17** / 0.17** / 0.18**
Calcified plaque SSS / 0.16** / 0.13** / 0.20** / 0.11** / 0.19** / 0.15** / 0.16** / 0.17** / 0.16**
Calcified plaque SIS / 0.16** / 0.14** / 0.20** / 0.11** / 0.19** / 0.15** / 0.16** / 0.17** / 0.16**
HOMA-IR / 0.52** / 0.37** / 0.45** / 0.50** / 0.29** / -0.05 / 0.14** / 0.22** / 0.21**
γ-GT, U/L / 0.39** / 0.34** / 0.33** / 0.32** / 0.33** / 0.13** / 0.24** / 0.27** / 0.28**
C-reactive protein, mg/L / 0.34** / 0.21** / 0.32** / 0.34** / 0.30** / 0.08* / 0.21** / 0.27** / 0.25**

EAT epicardial adipose tissue, HOMA-IR homeostasis model assessment of insulin resistance index, γ-GT γ-glutamyl transpeptidase, SSS segment stenosis score, SIS segment involvement score, WC waist circumference, **P 0.01, *P 0.05

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