Tel-Aviv University
Luba Dubinsky, Antonia Delago, Neri Amara, Pnina Krief, Josep Rayo, Tsaffrir Zor, Vladimir V. Kravchenko and Michael M. Meijler, Species selective diazirine positioning in tag-free photoactive quorum sensing probes,Chemical Communications, 2013, 49, 5826-5828. (pdf)
Yifat Glucksam-Galnoy, Roy Sananes, Nava Silberstein, Pnina Krief, Vladimir V. Kravchenko, Michael M. Meijler and Tsaffrir Zor, The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-L-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages,Journal of Immunology, 2013, 191, 337-344. (pdf)
Avital Parnas, Shahar Nisemblat, Celeste Weiss, Galit Levy-Rimler, Amir Pri-Or, Tsaffrir Zor, Peter A. Lund, Peter Bross and Abdussalam Azem, Identification of Elements that Dictate the Specificity of Mitochondrial Hsp60 for its Co-chaperonin, 2012,PLoS ONE, 7, e50318. (pdf)
Yifat Glucksam-Galnoy, Tsaffrir Zor and Rimona Margalit, Hyaluronan-modified and regular multilamellar liposomes provide sub-cellular targeting to macrophages, without eliciting a pro-inflammatory response,Journal of Controlled Release,2012, 160, 388-393. (pdf)
Dorit Avni, Yifat Glucksam and Tsaffrir Zor , The Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in mouse macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism,Biochemical Pharmacology,2012, 83, 106-114. (pdf)
Meir Goldsmith, Ala Daka, Nadia F. Lamour, Roi Mashiach, Yifat Glucksam, Charles E. Chalfant, Michael M. Meijler and Tsaffrir Zor, A ceramide analog inhibits cPLA2 activity and consequent PGE2 formation in LPS-stimulated macrophages, Immunology Letters, 2011, 135, 136-143. (pdf)
Dorit Avni , Orna Ernst , Amir Philosoph and Tsaffrir Zor , Role of CREB in modulation of TNF a and IL-10 expression in LPS-stimulated RAW264.7 macrophages,Molecular Immunology ,2010, 47, 1396-1403. (pdf)
Orna Ernst and Tsaffrir Zor, Linearization of the Bradford protein assay,Journal of Visualized Experiments, 2010, 38, doi: 10.3791/1918. (video article link) (pdf)
Dorit Avni, Amir Philosoph, Michael M. Meijler and Tsaffrir Zor, The ceramide-1-phosphate analog PCERA-1 modulates TNFα and IL-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner,Immunology, 2010, 129, 375-385. (pdf)
Maya Levi, Michael M. Meijler, Antonio Gómez-Muñoz, and Tsaffrir Zor , Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1),Molecular and Cellular Endocrinology, 2010, 314, 248-255. (pdf)
Meir Goldsmith, Dorit Avni , Orna Ernst , Yifat Glucksam, Galit Levy-Rimler, Michael M. Meijler and Tsaffrir Zor , Synergistic IL-10 induction by LPS and the ceramide-1-phosphate analog PCERA-1 is mediated by the cAMP and p38 MAP kinase pathways,Molecular Immunology2009, 46, 1979-1987. (pdf)
Dorit Avni , Meir Goldsmith, Orna Ernst , Roi Mashiach, Tove Tuntland , Michael M. Meijler, Nathanael Gray, Hugh Rosen and Tsaffrir Zor , Modulation of TNFα , IL-10 and IL-12p40 levels by a ceramide-1-phosphate analog, PCERA-1,in-vivoandex-vivoin primary macrophages,Immunology Letters, 2009, 123, 1-8.(pdf)
Meir Goldsmith, Dorit Avni , Galit Levy-Rimler, Roi Mashiach, Orna Ernst , Maya Levi , Bill Webb, Michael M. Meijler, Nathanael S. Gray, Hugh Rosen and Tsaffrir Zor , A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-α and induces interleukin-10 production in activated macrophages,Immunology, 2008, 127, 103-115. (pdf)
Post-doctoral research
Jennifer L. Best, Carlos A. Amezcua, Bernhard Mayr, Lawrence Flechner, Christopher M. Murawsky,Beverly Emerson, Tsaffrir Zor , Kevin H. Gardner, and Marc Montminy, Identification of Small Molecule Antagonists that Inhibit an Activator: Coactivator Interaction, Proceedings of the national Academy of Sciences USA, 2004, 101, 17622–17627. (pdf)
Tsaffrir Zor , Roberto N. De Guzman, H. Jane Dyson, and Peter E. Wright, Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb, JMB, 2004, 337, 521-534.(pdf)
Natalie K. Goto * , Tsaffrir Zor * , Maria Martinez-Yamout, H. Jane Dyson, and Peter E. Wright, Cooperativity in transcription factor binding to the coactivator CBP: the MLL activation domain binds to an allosteric site on the KIX domain, JBC, 2002, 277, 43168-43174. (pdf)
Tsaffrir Zor , Bernhard M. Mayr, H. Jane Dyson, Marc R. Montminy and Peter E. Wright, Roles of phosphorylation and helix propensity in the binding of the KIX domain of CBP by constitutive (c-Myb) and inducible (CREB) activators, JBC, 2002, 277, 42241-42248. (pdf)
David Parker, Morris Rivera, Tsaffrir Zor , Alexandra Henrion-Caude, Ishwar Radhakrishnan, Alok Kumar, Linda H. Shapiro, Peter E. Wright, Marc Montminy and Paul K. Brindle, Role of secondary structure in discrimination between constitutive and inducible activators, Molecular and Cellular Biology, 1999, 19, 5601-5607. (pdf)
* The first two authors contributed equally to this work.
Ph.D. research
Mickey Kosloff, Tsaffrir Zor and Zvi Selinger, Review article: Substrate Assisted Catalysis: implications for biotechnology and drug design, Drug Development Research, 2000, 50, 250-257. (pdf)
Mohammad Reza Ahmadian *, Tsaffrir Zor * , Dorothee Vogt, Wolfgang Kabsch, Zvi Selinger, Alfred Wittinghofer and Klaus Scheffzek, GTPase stimulation of oncogenic Ras mutants, Proceedings of the national Academy of Sciences USA, 1999, 96, 7065-7070. (pdf)
Tsaffrir Zor , Ronit Andorn, Ilia Sofer, Michael Chorev and Zvi Selinger, GTP analogue hydrolysis by the Gs protein: implication for the role of the catalytic glutamine in the GTPase reaction, FEBS Letters, 1998, 433, 326-330. (pdf)
Tsaffrir Zor , Margalith Bar-Yaacov, Sharona Elgavish, Boaz Shaanan and Zvi Selinger, Rescue of a mutant G-protein by substrate-assisted catalysis, European Journal of Biochemistry, 1997, 249, 330-336. (pdf)
Tsaffrir Zor and Zvi Selinger, Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies, Analytical Biochemistry, 1996, 236, 302-308. (pdf)
Tsaffrir Zor , Irit Halifa, Shira Kleinhaus, Michael Chorev and Zvi Selinger, m-Acetyl Anilido GTP, a novel photoaffinity label For GTP-binding proteins: synthesis and application, Biochemical Journal, 1995, 306, 1, 253-258. (pdf)
* The first two authors contributed equally to this work.
B.Sc. research
Itamar Willner, Shai Rubin, Ronit Shatzmiller and Tsaffrir Zor , Reversible light-stimulated activation and de-activation of a -chymotrypsin by it's immobilization in photoisomerizable copolymers, Journal of the American Chemical Society, 1993, 115, 8690-8694. (pdf)
Itamar Willner, Shai Rubin and Tsaffrir Zor , Photoregulation of a -chymotrypsin by it's immobilization in a photochromic azobenzene copolymer, Journal of the American Chemical Society, 1991, 113, 4013-4014. (pdf)
Bertnard Ballet, Avi Bino, Shmuel Cohen, Hadas Rubin and Tsaffrir Zor , A linear mixed oxidation state trinuclear cobalt complex with six bridging sulfito ligands, Inorganica Chimica Acta, 1991, 188, 91-93. (pdf)