Table S4. List of enriched IPA Pathways in IL-10 expressing mice

IL-10/Tg vs Control/Tg

Ingenuity Canonical Pathways / P-value / IPA Score / Log Ratio / Molecules
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses / 1.00E-19 / 19.0 / 1.00E-19 / IFIH1,TLR2,MAP2K4,TLR4,C5AR1,NLRP3,C3,IL10,TLR1,MAPK8,IL1B,C1QA,CCL5, C1QB,TLR9,C3AR1, PRKCB
Acute Phase Response Signaling / 1.00E-16 / 16.0 / 1.00E-16 / MAP2K4,SERPING1,FTL,C3,C1S,IL6R,MAPK8,VWF,SERPINA3,STAT3,IL1R1,C1R, C4A/C4B,HMOX1,FOS,CFB, IL1B,C2
Complement System / 1.58E+01 / 15.8 / 1.58E-16 / C1R,C4A/C4B,SERPING1,C3,C5AR1,C1S, CFB,C1QA,C1QB,C3AR1,C2
IL-10 Signaling / 1.51E+01 / 15.1 / 7.94E-16 / MAP2K4,CCR1,IL10,FCGR2A,MAPK8,STAT3,IL1R1,FCGR2B,HMOX1,FOS,IL10RB, IL1B,CD14
Dendritic Cell Maturation / 1.44E+01 / 14.4 / 3.98E-15 / MAP2K4,B2M,TYROBP,IL10,FCGR2A,MAPK8,HLADRB1,TLR9,FCGR2B,TREM2, FCGR1A,TLR2,TLR4,HLA-DRA,FCER1G, IL1B,FCGR3A
Communication between Innate and Adaptive Immune Cells / 1.34E+01 / 13.4 / 3.98E-14 / B2M,IL10,HLADRB1,CCL5,TLR9,CXCL10,TLR2,TLR4,HLA-DRA,TLR1,FCER1G,IL1B, CCL3L1/CCL3L3
TREM1 Signaling / 1.30E+01 / 13.0 / 1.00E-13 / TLR2,TLR4,NLRP3,MPO,CCL7,IL10,TYROBP,TLR1, IL1B,STAT3,FCGR2B,TLR9
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis / 1.26E+01 / 12.6 / 2.51E-13 / MAP2K4,C5AR1,IL10,AXIN1,IL6R,STAT3,IL1R1,CCL5,TLR9,FCGR1A,TLR2,TLR4,FOS,TGFB1,CSF1,TLR1,IL1B, FCGR3A,PRKCB
Hepatic Fibrosis / Hepatic Stellate Cell Activation / 1.22E+01 / 12.2 / 6.31E-13 / CXCL9,TGFBR1,MYL2,IL10,IL6R,IL1R1,CCL5,TLR4, CSF1,TGFB1,TIMP1,IGFBP3, CD14,IL1B
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis / 1.08E+01 / 10.8 / 1.58E-11 / TLR2,TLR4,CSF1,IL10,TGFB1,HLA-DRA,TLR1, FCER1G, HLA-DRB1,IL1B,TLR9
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages / 1.07E+01 / 10.7 / 2.00E-11 / TLR2,MAP2K4,FOS,TLR4,APOE,NCF1,PTPN6,MPO,PPP2CA,CAT,MAPK8,S100A8, JAK3,PRKCB
T Helper Cell Differentiation / 1.05E+01 / 10.5 / 3.16E-11 / STAT6,TGFBR1,IL10,TGFB1,HLA-DRA,IL6R,IL10RB, FCER1G,HLA-DRB1,STAT3
LXR/RXR Activation / 1.04E+01 / 10.4 / 3.98E-11 / C4A/C4B,TLR4,APOE,C3,MSR1,CCL7,CD36,CD14, IL1B, S100A8,IL1R1,ABCA1
Granulocyte Adhesion and Diapedesis / 9.72E+00 / 9.7 / 1.91E-10 / CXCL9,C5AR1,CXCR4,IL1R1,CCL5,CXCL10,ITGB2, ITGAM,CCL7,Ccl8,Ccl2,IL1B, CCL3L1/CCL3L3
Agranulocyte Adhesion and Diapedesis / 9.39E+00 / 9.4 / 4.07E-10 / CXCL9,C5AR1,MYL2,CXCR4,IL1R1,CCL5,CXCL10, ITGB2,CCL7,Ccl8,Ccl2,IL1B, CCL3L1/CCL3L3
IL-12 Signaling and Production in Macrophages / 8.73E+00 / 8.7 / 1.86E-09 / MAP2K4,TLR2,TLR4,STAT6,APOE,FOS,IL10,TGFB1, MAPK8,S100A8,PRKCB
Toll-like Receptor Signaling / 8.41E+00 / 8.4 / 3.89E-09 / MAP2K4,TLR2,TLR4,FOS,TLR1,MAPK8,CD14,TLR9
Colorectal Cancer Metastasis Signaling / 7.97E+00 / 8.0 / 1.07E-08 / MAP2K4,TGFBR1,AXIN1,IL6R,MAPK8,STAT3,TLR9, TLR2,TLR4,FOS,TGFB1,TLR1, JAK3
Chemokine Signaling / 7.67E+00 / 7.7 / 2.14E-08 / FOS,CCL7,MYL2,CXCR4,MAPK8,CCL5, LIMK1, PRKCB
NF-kB Signaling / 7.57E+00 / 7.6 / 2.69E-08 / TLR2,TLR4,TGFBR1,TLR1,MAPK8,FCER1G,IL1B, IL1R1, CASP8,TLR9,PRKCB
Systemic Lupus Erythematosus Signaling / 7.42E+00 / 7.4 / 3.80E-08 / PTPRC,FOS,PTPN6,IL10,FCGR2A,IL6R,FCER1G, IL1B, FCGR2B,TLR9,FCGR1A, FCGR3A
Tec Kinase Signaling / 6.96E+00 / 7.0 / 1.10E-07 / MAP2K4,TLR4,STAT6,FOS,MAPK8,HCK,FCER1G, STAT3, JAK3,PRKCB
Atherosclerosis Signaling / 6.83E+00 / 6.8 / 1.48E-07 / ITGB2,APOE,MSR1,CSF1,CXCR4,TGFB1,CD36,IL1B, S100A8
Pathogenesis of Multiple Sclerosis / 6.61E+00 / 6.6 / 2.45E-07 / CXCL10,CCR1,CXCL9,CCL5
PPARa±/RXRa± Activation / 6.44E+00 / 6.4 / 3.63E-07 / MAP2K4,TGFBR1,TGFB1,MAPK8,CD36,IL1B,MEF2C, IL1R1,ABCA1,PRKCB

IL-10/nTg vs Control/nTg

Ingenuity Canonical Pathways / P-value / IPA Score / Log Ratio / Molecules
Dendritic Cell Maturation / 2.51E-16 / 15.6 / 6.16E-02 / B2M,TYROBP,FCGR2A,IL10,FCER1G,IL1B,HLA-DRB1,LTBR,TLR9,TREM2, FCGR2B,FCGR1A,FCGR3A
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses / 2.51E-14 / 13.6 / 9.17E-02 / IFIH1,C5AR1,IL10,TLR1,IL1B,C1QA,C1QB,CCL5,TLR9, C3AR1
Communication between Innate and Adaptive Immune Cells / 5.01E-11 / 10.3 / 7.14E-02 / B2M,IL10,TLR1,FCER1G,HLA-DRB1,IL1B,CCL5,TLR9
Systemic Lupus Erythematosus Signaling / 1.26E-10 / 9.9 / 3.92E-02 / PTPRC,PTPN6,IL10,FCGR2A,FCER1G, IL1B, FCGR2B,TLR9,FCGR1A,FCGR3A
TREM1 Signaling / 5.89E-10 / 9.2 / 7.78E-02 / IL10,TYROBP,TLR1,IL1B,STAT3, FCGR2B,TLR9
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis / 2.75E-09 / 8.6 / 2.92E-02 / C5AR1,IL10,TLR1,IL1B,STAT3,LTBR, CCL5,TLR9, FCGR1A,FCGR3A
IL-10 Signaling / 1.51E-08 / 7.8 / 7.69E-02 / IL10,FCGR2A,IL10RB,IL1B,STAT3, FCGR2B
Complement System / 1.62E-08 / 7.8 / 1.43E-01 / C4A/C4B,C5AR1,C1QA,C1QB,C3AR1
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis / 6.31E-08 / 7.2 / 6.00E-02 / IL10,TLR1,FCER1G,HLA-DRB1,IL1B, TLR9
Granulocyte Adhesion and Diapedesis / 2.09E-07 / 6.7 / 3.85E-02 / CXCL9,ITGAM,C5AR1,Ccl8,Ccl2,IL1B, CCL5
T Helper Cell Differentiation / 7.08E-07 / 6.2 / 6.94E-02 / IL10,IL10RB,FCER1G,HLA-DRB1,STAT3
Crosstalk between Dendritic Cells and Natural Killer Cells / 2.69E-06 / 5.6 / 4.72E-02 / TYROBP,HLA-DRB1,LTBR,TREM2,TLR9
Role of NFAT in Regulation of the Immune Response / 3.63E-06 / 5.4 / 3.00E-02 / FCGR2A,FCER1G,HLA-DRB1,FCGR2B, FCGR1A,FCGR3A
Agranulocyte Adhesion and Diapedesis / 5.75E-06 / 5.2 / 3.12E-02 / CXCL9,C5AR1,Ccl8,Ccl2,IL1B,CCL5
Natural Killer Cell Signaling / 7.24E-06 / 5.1 / 4.24E-02 / PTPN6,FCGR2A,TYROBP,FCER1G, FCGR3A
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F / 1.10E-05 / 5.0 / 1.67E-01 / IL10,IL1B,CCL5
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F / 2.34E-05 / 4.6 / 1.30E-01 / IL10,IL1B,CCL5
Allograft Rejection Signaling / 5.01E-05 / 4.3 / 4.12E-02 / B2M,IL10,FCER1G,HLA-DRB1
NF-kB Signaling / 6.46E-05 / 4.2 / 2.76E-02 / TLR1,FCER1G,IL1B,LTBR,TLR9
Fcg Receptor-mediated Phagocytosis in Macrophages and Monocytes / 7.94E-05 / 4.1 / 3.77E-02 / NCF1,FCGR2A,FCGR1A,FCGR3A
CD28 Signaling in T Helper Cells / 1.86E-04 / 3.7 / 2.94E-02 / PTPRC,PTPN6,FCER1G,HLA-DRB1
Graft-versus-Host Disease Signaling / 1.95E-04 / 3.7 / 5.88E-02 / FCER1G,HLA-DRB1,IL1B
Autoimmune Thyroid Disease Signaling / 2.09E-04 / 3.7 / 4.84E-02 / IL10,FCER1G,HLA-DRB1
Pathogenesis of Multiple Sclerosis / 2.09E-04 / 3.7 / 2.00E-01 / CXCL9,CCL5
Hepatic Fibrosis / Hepatic Stellate Cell Activation / 3.72E-04 / 3.4 / 2.58E-02 / CXCL9,IL10,IL1B,CCL5