Supplement Table 2: Genes encoding ERK pathway components and some of known direct ERK targets
Abbreviation and gene description / Official symbol and name: / Locus / Genes or loci implicated in mood disorder genetic studiesERK pathway components
Raf-1: v-raf-1 murine leukemia viral oncogene homolog 1 / RAF1: v-raf-1 murine leukemia viral oncogene homolog 1 / 3p25 / No
B-Raf: v-raf murine sarcoma viral oncogene homolog B1 / BRAF: v-raf murine sarcoma viral oncogene homolog B1 / 7q34 / Yes (1)
MEK1: MAPK/ERK kinase 1 / MAP2K1: mitogen-activated protein kinase kinase 1 / 15q22.1-q22.33 / No
MEK2: MAPK/ERK kinase 2 / MAP2K2: mitogen-activated protein kinase kinase 2 / 19p13.3 / Yes (2, 3)
ERK1: extracellular signal-regulated kinase 1 / MAPK3: mitogen-activated protein kinase / 16p11.2 / No
ERK2: Extracellular signal-regulated kinase 2 / MAPK1: mitogen-activated protein kinase 1 / 22q11.21a / Yes (2, 4-6)
Some of known direct ERK targets
RSK1: Ribosomal protein S6 kinase 1 / RPS6KA1: ribosomal protein S6 kinase, 90kDa, polypeptide 1 / 1p36.11a / Yes (7)
RSK2: Ribosomal protein S6 kinase 2 / RPS6KA2: ribosomal protein S6 kinase, 90kDa, polypeptide 2 / 6q27 / No
RSK3: Ribosomal protein S6 kinase 3 / RPS6KA3: ribosomal protein S6 kinase, 90kDa, polypeptide 3 / Xp22.2-p22.1a / Yes (8)
MSK1: Mitogen- and stress-activated protein kinase-1 / RPS6KA5: ibosomal protein S6 kinase, 90kDa, polypeptide 5 / 14q31-q32.1 / No
MSK2: Mitogen- and stress-activated protein kinase-2 / RPS6KA6: ribosomal protein S6 kinase, 90kDa, polypeptide 6 / Xq21 / No
CRY1:Cryptochrome-1
(9) / CRY1:Cryptochrome-1 / 12q23-q24.1 / Yes (10)
CRY2: Cryptochrome-2
(9) / CRY21:Cryptochrome-2 / 11p11.2 / Yes (11)
BMAL1: brain and muscle Arnt-like protein 1
(12) / ARNTL: aryl hydrocarbon receptor nuclear translocator-like / 11p15 / Yes (13); (14-18)
I-2: Phosphatase Inhibitor-2
(19) / PPP1R2: protein phosphatase 1, regulatory (inhibitor) subunit 2 / 3q29 / Yes (20)
Spinophilin or neurabin II
(21) / PPP1R9B: protein phosphatase 1, regulatory subunit 9B, spinophilin / 17q21.33 / No
ELK1 / ELK1: ELK1, member of ETS oncogene family / Xp11.2 / No
HDAC4: histone deacetylase 4
(22) / HDAC4: histone deacetylase 4 / 2q37.2 / No
Synapsin I
(23) / SYN1 / Xp11.23
MAO-B / No
Kv4.2: POTASSIUM VOLTAGE-GATED CHANNEL, SHAL-RELATED SUBFAMILY, MEMBER 2; KCND2
(24) / KCND2: potassium voltage-gated channel, Shal-related subfamily, member 2 / 7q31 / Yes (4)
GABAA alpha 1 receptor
(25) / GABRA1: gamma-aminobutyric acid (GABA) A receptor, alpha / 5q34-q35 / Yes (26, 27)
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