CV

as ofMay 2017

Michael Bretthauer, MD PhD

Professor of Medicine

Institute of Health and Society, University of Oslo

Department of Transplantation Medicine, Oslo University Hospital

E-mail:

Date of birth: 23rd Sept 1969; married, 3 children

ORCID identifier: 0000-0001-9653-6886

EDUCATION

  • Medical School at Georg August University Gottingen, Germany, 1990-1996
  • PhD, University of Oslo, Norway, 2004; “Colorectal cancer screening by flexible sigmoidoscopy. The NORCCAP trial.”
  • Dr. med. (Germany), University of Gottingen, Germany 1996: “Active compression decompression cardiopulmonary resuscitation. A clinical trial”.
  • Board certification in Internal Medicine, Norwegian Medical Association, 2007
  • Board certification in Gastroenterology, Norwegian Medical Association, 2014

CURRENT AND PREVIOUS POSITIONS

Leadership and management positions

  • President, Frontier Science, Boston, USA, starts July 2017
  • Head, Clinical Research Centre, Dep. of Transplantation Medicine, Oslo University Hospital, since Jan. 2014
  • Principal Investigator; K.G. Jebsen Center for Colorectal Cancer Research (established August 2014)
  • Head, Program for Knowledge Acquisition, Health Management and Quality Improvement, University of Oslo Medical School, since March 2012
  • Head, Clinical Effectiveness Research Group, University of Oslo and Oslo University Hospital, 2012-2014
  • Head, Colorectal Cancer Screening Group of South-East Norway, since Jan. 2011
  • Principal Investigator, The Nordic Initiative on Colorectal Cancer (NordICC) study group, since 2006
  • Head, Centre for Colorectal Cancer Screening, Cancer Registry of Norway, April 2010-June 2011
  • Supervisor for Editors, The Journal of the Norwegian Medical Association, 2007-2012
  • Head, NORCCAP (Norwegian Colorectal Cancer Prevention) clinical trial endoscopy centre, 200-2001

Clinical positions

  • Gastroenterologist/Endoscopist, OsloUniversity Hospital, since March 2006
  • Resident in Internal Medicine and Gastroenterology, OsloUniversity Hospital, Rikshospitalet, August 2003-February 2006
  • Resident in Medicine and Gastroenterology, Telemark Hospital, Skien, Norway, Jan 2001-Aug. 2003
  • Physician at the NORCCAP center, August 1998- January 2001
  • Resident in Internal Medicine, Skien, Telemark Hospital, February-July 1998
  • Internship Telemark Hospital, Skien, Norway, January 1997-January 1998

Research positions

  • Full (tenured) Professor of Medicine, University of Oslo, since 2012
  • Guest Researcher, Harvard School of Public Health, Boston, MA, USA, since 2010
  • Head, Colorectal Cancer Screening group of South-East Norway, since 2011
  • Head, Network for Clinical Effectiveness in Gastroenterology South-East Norway, since 2013
  • Principal Investigator, The Nordic Initiative on Colorectal Cancer (NordICC) study group, since 2007
  • Visiting scientist, Dep. of Epidemiology, Harvard School of Public Health, Boston, MA, USA, since July 2008
  • Researcher, The Cancer Registry of Norway, Aug 2003-2008
  • PhD Fellow, University of Oslo, 2000-2003

Editorial positions

  • Co-Editor-in-Chief, Endoscopy, since 2013
  • Co-Editor, Endoscopy, 2010-2012
  • Editor-at-Large,Journal of the Norwegian Medical Association. since 2014
  • CME Editor,New England Journal of Medicine. June 2009-December 2009
  • Editorial Fellow, New England Journal of Medicine. August 2008- June 2009
  • Co-Editor, Journal of the Norwegian Medical Association. 2003-2012
  • Guest Editor, Nature Reviews Gastroenterology Hepatology 2016

FELLOWSHIPS AND AWARDS

  • Nominee and runner-up, Felix Burda Award 2017, Berlin, Germany
  • Sadie Gerson Distinguished Scholar Award 2014, University of Pittsburgh Cancer Institute, PA, USA
  • Best scientific lecture Award for, Norwegian Society of Surgery, Oct. 2006
  • OMED Train the Trainer 2006, Port Elizabeth, South Africa
  • Various grants from The Norwegian Gastroenterology Society 2002-2006
  • Norwegian delegate, ”Young Investigators Marked”, United European Gastroenterology Week (UEGW) Amsterdam, 2001

SUPERVISION OF GRADUATE STUDENTS AND RESEARCH FELLOWS

Research Supervsion Activities (PhD Candidates)

  • Birgitte Seip MD, 2009-2012
  • Øyvind Holme MD, 2010-2015
  • Magnus Løberg MD, 2011-2015
  • Anders Huitfelt MD, 2012-2015
  • Kjetil Garborg MD, 2011-present
  • Aleidis S. Brandrud MSc, 2012-2017
  • Kristin Ranheim Randel MD, 2015-present
  • Anna Schult MD, 2015-present
  • Henriette Jodal MD, 2015-present
  • Lise Helsingen MD, 2016-present
  • Mari Nanna Øines MD, 2016-2017
  • Christer Tønnesen MD, 2017-present
  • Frederik Emil Juul MD, 2017-present

TEACHING ACTIVITIES

Teaching activities

  • Professor of Medicine, University of Oslo, 2012
  • Lecturer, University of Tromsø, 2012-2015
  • Lecturer, Harvard School of Public Health, Boston, MA, since 2008
  • Supervisor for Editors, Journal of the Norwegian Medical Association, 2007-2011

COMMISSIONS OF TRUST

Ad Hoc Reviewer

  • Ad hoc review for more than 20 medical journals, including
  • New England Journal of Medicine
  • The Lancet
  • Journal of the American Medical Association (JAMA)
  • BMJ
  • PLoS Medicine
  • The Lancet Oncology
  • Gastroenterology
  • Gut

Board and committee positions

  • Member, the national Board of directors, Norwegian colorectal cancer screening program 2016
  • Member, The National Advisory Committee of Colorectal Cancer Screening 2016
  • Board member, The Norwegian Directorate of Health Board Certification Committee for Medical Doctors in Norway 2015/16
  • Mentor, The US Embassy Young Ambassadors Program 2015/2016
  • Chair, European Society of Gastrointestinal Endoscopy QA in colonoscopy working group
  • Board Member, Norwegian national Advisory board on colorectal cancer screening
  • Board member, CRC screening committee, World Organisation of Gastrointestinal Endoscopy ( OMED)
  • Co-Editor, European Union CRC screening guidelines
  • Board member, Norwegian Colorectal Cancer Prevention study (NORCCAP)
  • Board member, The Norwegian National Endoscopy Quality Network (Gastronet) Co-author, European Union CRC screening guidelines committee
  • PI/chair, Nordic Initiative on Colorectal Cancer (NordICC) group
  • Consultant, PROSPR Harvard group for statistical expertise and quality control in cancer screening
  • Member, data safety and monitoring board, The C5S study (PI: Prof. T. Rosch, Germany)

Grants

  • 2016-2021: TOP RESEARCH (“TOPPFORSK”), Norwegian Research Council Top Researcher Grant (USD 2,500,000)
  • 2016-2018: Research grant, Health Board of South-East Norway (Clinical Effectiveness Network) (USD 1,400,000)
  • 2016-2019: Personal research career development grant; Norwegian Cancer Society (USD 500,000)
  • 2014-2017: Research grant EPoS trial, Norwegian Research Council (USD 2,000,000)
  • 2014-2016: Research grant EPoS trial, Health Board of South-East Norway (USD 1,700,000)
  • 2014-2017: Research grant; SAR trial; Norwegian research Council (PI H-O Adami) (USD 2,000,000)
  • 2014-2017: Jebsen Center of Excellence (PI R. Lothe) (USD 3,200,000)
  • 2013-2015: Research grant; Norway EEA Grants (PI: M. Kaminski, Warsaw); (USD 900,000)
  • 2013-2015: Research grant, Health Board of South-East Norway (Clinical Effectiveness Network) (USD 1,800,000)
  • 2013-2014: Research grant NordICC study, Norwegian Cancer Society (USD 240,000)
  • 2012 and 2013: Research grant, Institute of Health and Society, University of Oslo, (USD 15,000
  • 2011-2014: Research grant The Health Board of South-East Norway (Colorctal cancer Network) (USD 2,000,000)
  • 2010-2013: Research grant (NordICC study), Norwegian Research Council (USD 2,900,000)
  • 2008-2009: Research grant “HelseSør-øst” New England Journal of Medicine, Boston, (USD 300,000)
  • 2008-2009: Research grant by “Raagholtstiftelsen” for the NordICC study and New England Journal of Medicine, Boston, (USD 30,000)
  • 2008-2009: Research grant by The Norwegian Gastroenterology Society for the NordICC study and the New England Journal of Medicine, Boston, (USD 10,000)

PUBLICATION AND PRESENTATIONS

  • More than 160 publications listed in PubMed; H-index 28
  • Over 200invited lectures and presentations at national and international scientific meetings, and at academic and non-academic medical centres.
  • More than30 popular-scientifically lectures and newspaper/magazine perspective and debate papers on various topics of medicine.
  1. García-Albéniz X, Hsu J, Bretthauer M, Hernán MA. Effectiveness of screening colonoscopy to prevent colorectal cancer among medicare beneficiaries aged 70 to 79 years: A prospective observational study. Annals of Internal Medicine. 2017;166(1):18-26.
  2. Bretthauer M, Kaminski MF, Løberg M, et al. Population-based colonoscopy screening for colorectal cancer: a European randomized trial. JAMA Intern Med 2016;176:894
  3. Jover R, Bretthauer M, Dekker E, et al. Rationale and Design of the European Polyp Surveillance (EPoS) trials. Endoscopy 2016;48:571-8
  4. Robertson DJ, Kaminski MF, Bretthauer M. Effectiveness, training and quality assurance of colonoscopy screening for colorectal cancer. Gut. 2015;64:982-90
  5. Løberg M. Kalager M, Holme Ø, Hoff G, Adami H-O, Bretthauer M. Long-term colorectal cancer mortality after adenoma removal. N Engl J Med 2014,371:799-807
  6. Holme Ø, Løberg M. Kalager M, Bretthauer M, et al. Effect of flexible sigmoidoscopy screening on colorectal cancer incidence andmortality: A randomized clinical trial.JAMA 2014;312:1-10
  7. HolmeØ, BretthauerM, FretheimA, Odgaard-Jensen J,Hoff G. Flexible sigmoidoscopy versus faecal occult blood testing for colorectal cancer screening in asymptomatic individuals. Cochrane Database of Systematic Reviews 2013, Issue 9. Art. No.: CD009259.DOI: 10.1002/14651858.CD009259.pub2.
  8. Kalager M, Tamimi EM, Bretthauer M, Adami HO. Prognosis in women with interval breast cancer:population based observational cohort study. BMJ 2012;345:e7536 doi: 10.1136/bmj.e7536
  9. Kalager M, Adami HO, Bretthauer M, Tamimi RM. Overdiagnosis of invasive breast cancer due to mammography screening: results from the Norwegian screening program. Ann Intern Med. 20123;156:491-9.
  10. Hoff G, Grotmol T, Skovlund E, Bretthauer M. Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: A randomised trial. BMJ,2009;338;b1846;doi:10.1136/bmj.b1846

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