Table1 Chi-square test for evaluating the sample representative of G6PD deficiency

Characteristics / South of China / North of China / Total
Number of birth (million) / Project / 0·73 / 1·03 / 1·76
Ministrya / 9·22 / 7·65 / 16·87
P/M(%) / 7·91 / 13·46 / 10·43
Chi-sq / 7.00
P value / 0.008
Gender ratio of birth / Project / 1·18 / 1·24 / 1·21
Ministrya / 1·17 / 1·23 / 1·19
Chi-sq / 4.27E-6
P value / 0.998
Incidence rate (%) / Project / 1·34 / 0·063 / 0·75
Ministryb / 1·37 / 0·061 / 0·74
Chi-sq / 0.013
P value / 0.91

Note: a: The data covered all the provinces of China; b: The data only covered the 18 provinces which performed G6PD deficiency newborn screening; Chi-sq, Chi-square test.

Table 2 The carrier rates of main G6PD mutations of different provinces

G6PDMutations / Provincesa
CQ / FJ / GD / GX / GZ / HA / HN / SC / SD / SX / ZJ / HB
c.95 A>G / 4.23 / 13.72 / 32.60 / 73.04 / 2.38 / 10.22 / 4.13 / 6.57 / 0.37 / 1.04 / 7.39 / 4.31
c.392 G>T / 0.68 / 7.38 / 5.50 / 3.13 / 0.36 / 4.06 / 0.65 / 1.75 / 0.22 / 0.05 / 3.06 / 0.86
c.487 G>A / 0.23 / 2.20 / 0 / 0 / 0 / 0.16 / 0.27 / 1.03 / 0.26 / 0.25 / 0 / 0
c.517 T>C / 0.06 / 0·65 / 1.69 / 0.75 / 0 / 0.81 / 0.19 / 0.31 / 0.03 / 0.05 / 0.10 / 0.86
c.592 G>T / 0 / 0 / 0.25 / 0.38 / 0 / 0 / 0.08 / 0 / 0.04 / 0 / 0.30 / 0
c.871 G>A / 1.07 / 6.99 / 16.85 / 18.67 / 0.24 / 12.33 / 2.41 / 1.85 / 0.17 / 0.18 / 4.04 / 0
c.1004 C>A / 0.17 / 0.13 / 0.68 / 3.63 / 0.12 / 0.32 / 0.08 / 0.82 / 0.03 / 0.03 / 0.69 / 0
c.1024 C>T / 3.10 / 12.04 / 7.79 / 30.57 / 2.14 / 5.84 / 3.14 / 5.03 / 0.39 / 0.74 / 7.10 / 4.31
c.1360 C>T / 0 / 2.98 / 1.10 / 0.63 / 0 / 0.65 / 0 / 0 / 0.11 / 0 / 0.79 / 0
c.1376 G>T / 6.44 / 60.44 / 83.14 / 103.61 / 5.23 / 100.63 / 11.18 / 15.20 / 1.08 / 1.99 / 21.00 / 2.58
c.1388 G>A / 7.34 / 31.45 / 96.60 / 153.85 / 4.39 / 48.85 / 10.26 / 12.32 / 0.85 / 2.32 / 15.68 / 6.03
Others / 0.40 / 1.42 / 1.10 / 1.25 / 0.12 / 0 / 0.31 / 1.64 / 0 / 0 / 0.79 / 0
Total / 23.71 / 139.40 / 247.31 / 389.52 / 14.97 / 183.89 / 32.69 / 46.52 / 3.55 / 6.64 / 60.93 / 18.95

Note:CQ: Chongqing; FJ: Fujian province; GD: Guangdong province; GX: Guangxi province; HA: Hainan province; HN: Hunan province; SC: Sichuan province; SD: Shandong province; SX: Shanxi province; ZJ: Zhejiang province; HB: Hubei province.

a: The ratio unit is one in ten-thousand.

Table 3 The distribution of G6PD deficiency in different ethnic groups

Ethnicity / Positive Number
(G6PD activity abnormal confirmed by NBT G6PD/6PGD test) / Provinces
Han / 9916 / All 12 provinces
Buyi / 38 / Zhejiang, Hainan, Shanxi
Dai / 4 / Shangdong, Hunan, Guangdong
Dong / 7 / Guangdong, Zhejiang
Hani / 1 / Sichuan
Hui / 3 / Fujian, Hainan
Li / 250 / Fujian, Hainan, Zhejiang, Shangdong
Lili / 1 / Hainan
Man / 1 / Hainan
Miao / 21 / Hainan, Zhejiang, Hunan, Guangdong
She / 44 / Fujian, Zhejiang, Shangdong
Shui / 7 / Zhejiang
Tujia / 2 / Zhejiang, Hunan,
Yao / 7 / Guangdong, Hainan, Zhejiang, Sichuan
Yi / 2 / Shangdong, Zhejiang
Zhuang / 53 / Hainan, Guangdong, Hunan, Shanxi, Sichuan, Shangdong

Table 4 The results of G6PD normal sample representative assay

Characteristics / High incidence zone / Moderate incidence zone / Total
Number of female birth (thousand) / Project / 3·53 / 2·91 / 6·44
Ministrya / 2163·67 / 2092·88 / 4256·55
P/M(%) / 0·16 / 0·14 / 0·15
Chi-sq / 0·634
P value / 0·4257
Gender ratio of birth / Project / 1·17 / 1·15 / 1·16
Ministrya / 1·18 / 1·15 / 1·17
Chi-sq / 0·0018
P value / 0·966

Note: a,The data covered all the provinces of South China

Table 5 Theratios of local infants with G6PD deficiency in all the twelve provinces

Center / Number of local
infants / Number of non-local
infants / Ratio of local infants
(%)
Chongqing / 369 / 1 / 99.7
Fujian / 997 / 19 / 98.1
Guangdong / 2331 / 111 / 95.5
Guangxi / 2877 / 0 / 100
Guizhou / 130 / 0 / 100
Hainan / 1070 / 0 / 100
Hubei / 21 / 1 / 95.5
Hunan / 796 / 13 / 98.4
Sichuan / 395 / 29 / 93.2
Shangdong / 336 / 27 / 92.6
Shanxi / 199 / 21 / 90.5
Zhejiang / 545 / 69 / 88.7