Supplementary Table 1 Genes included in study and minor allele frequencies by race/ethnic group
Race/Ethnic GroupTotala / NHWb / Black / Hispanic / Asian
SNP / Gene / Chromo-
some / Position / Major
Allele / Minor
Allele / N / MAFc / N / MAF / N / MAF / N / MAF / N / MAF
rs1789953 / CBS / 21 / 43356005 / C / T / 1346 / 0.14 / 722 / 0.13 / 224 / 0.07 / 145 / 0.23 / 194 / 0.18
rs719037 / CBS / 21 / 43344056 / T / C / 1342 / 0.39 / 720 / 0.42 / 224 / 0.23 / 145 / 0.48 / 193 / 0.45
rs466791 / CBS / 21 / 43343023 / C / T / 1342 / 0.14 / 716 / 0.13 / 225 / 0.07 / 146 / 0.2 / 194 / 0.2
rs234785 / CBS / 21 / 43377074 / C / G / 1349 / 0.36 / 722 / 0.33 / 225 / 0.44 / 147 / 0.3 / 195 / 0.38
rs9977396 / CBS / 21 / 43380487 / C / G / 1350 / 0.16 / 722 / 0.15 / 225 / 0.29 / 147 / 0.09 / 195 / 0.09
rs4920037 / CBS / 21 / 43354960 / G / A / 1346 / 0.18 / 721 / 0.24 / 224 / 0.15 / 147 / 0.09 / 194 / 0.08
rs11701048 / CBS / 21 / 43364494 / C / T / 1349 / 0.09 / 723 / 0.08 / 225 / 0.17 / 146 / 0.08 / 195 / 0.05
rs234702 / CBS / 21 / 43350612 / C / G / 1336 / 0.13 / 714 / 0.09 / 222 / 0.07 / 147 / 0.22 / 193 / 0.24
rs2839633 / CBS / 21 / 43383090 / A / G / 1343 / 0.44 / 718 / 0.46 / 225 / 0.48 / 144 / 0.46 / 195 / 0.36
rs8130035 / CBS / 21 / 43380734 / C / T / 1332 / 0.31 / 710 / 0.3 / 223 / 0.43 / 146 / 0.39 / 193 / 0.28
rs1788484 / CBS / 21 / 43370010 / C / T / 1344 / 0.25 / 720 / 0.31 / 224 / 0.09 / 145 / 0.23 / 194 / 0.21
rs2850146 / CBS / 21 / 43373655 / C / G / 1347 / 0.08 / 722 / 0.09 / 225 / 0.07 / 145 / 0.05 / 195 / 0.07
rs6586282 / CBS / 21 / 43351566 / C / T / 1344 / 0.16 / 720 / 0.15 / 224 / 0.23 / 145 / 0.18 / 194 / 0.11
rs234709 / CBS / 21 / 43360033 / C / T / 1339 / 0.45 / 717 / 0.44 / 223 / 0.2 / 145 / 0.33 / 193 / 0.27
rs11701664 / CBS / 21 / 43380309 / G / T / 1349 / 0.3 / 721 / 0.3 / 225 / 0.1 / 147 / 0.26 / 195 / 0.4
rs1051319 / CBS / 21 / 43346936 / G / C / 1336 / 0.18 / 715 / 0.11 / 222 / 0.49 / 145 / 0.14 / 194 / 0.13
rs2124458 / CBS / 21 / 43348749 / T / C / 1349 / 0.32 / 722 / 0.37 / 225 / 0.12 / 146 / 0.26 / 195 / 0.35
rs234784 / CBS / 21 / 43376503 / C / T / 1349 / 0.4 / 722 / 0.4 / 225 / 0.46 / 147 / 0.34 / 195 / 0.33
rs3788050 / CBS / 21 / 43347732 / G / T / 1344 / 0.08 / 719 / 0.04 / 222 / 0.23 / 147 / 0.06 / 195 / 0.08
rs234787 / CBS / 21 / 43379954 / A / G / 1318 / 0.36 / 719 / 0.35 / 202 / 0.31 / 142 / 0.46 / 194 / 0.37
rs11700748 / CBS / 21 / 43346131 / C / T / 1340 / 0.4 / 717 / 0.45 / 223 / 0.21 / 146 / 0.36 / 195 / 0.41
rs234705 / CBS / 21 / 43356841 / C / T / 1334 / 0.27 / 711 / 0.34 / 222 / 0.25 / 146 / 0.21 / 194 / 0.16
rs2849729 / CBS / 21 / 43362182 / T / C / 1334 / 0.3 / 715 / 0.34 / 224 / 0.08 / 144 / 0.26 / 192 / 0.34
rs234783 / CBS / 21 / 43376312 / T / C / 1344 / 0.44 / 720 / 0.49 / 224 / 0.23 / 145 / 0.43 / 195 / 0.43
rs8133239 / CBS / 21 / 43342773 / T / C / 1339 / 0.09 / 715 / 0.04 / 222 / 0.28 / 146 / 0.07 / 195 / 0.09
rs234712 / CBS / 21 / 43360522 / G / A / 1349 / 0.07 / 723 / 0.05 / 225 / 0.02 / 147 / 0.16 / 194 / 0.16
rs8127036 / CBS / 21 / 43376242 / C / T / 1344 / 0.14 / 720 / 0.17 / 224 / 0.04 / 146 / 0.14 / 193 / 0.1
rs12517451 / DHFR / 5 / 79955829 / C / T / 1340 / 0.22 / 715 / 0.24 / 225 / 0.11 / 147 / 0.22 / 192 / 0.28
rs6151617 / DHFR / 5 / 79997399 / A / G / 1335 / 0.48 / 714 / 0.41 / 224 / 0.43 / 144 / 0.48 / 193 / 0.42
rs2618372 / DHFR / 5 / 79961366 / C / A / 1350 / 0.23 / 722 / 0.28 / 225 / 0.24 / 147 / 0.22 / 195 / 0.13
rs3797877 / DHFR / 5 / 79998099 / C / G / 1342 / 0.13 / 719 / 0.07 / 225 / 0.05 / 144 / 0.21 / 193 / 0.28
rs10072026 / DHFR / 5 / 79980896 / T / C / 1345 / 0.15 / 718 / 0.1 / 225 / 0.44 / 146 / 0.13 / 195 / 0.07
rs1650654 / DHFR / 5 / 80000776 / G / A / 1344 / 0.25 / 719 / 0.29 / 224 / 0.28 / 145 / 0.22 / 195 / 0.14
rs6151629 / DHFR / 5 / 80001491 / T / C / 1343 / 0.24 / 720 / 0.25 / 225 / 0.2 / 143 / 0.21 / 195 / 0.22
rs380691 / DHFR / 5 / 79987790 / A / G / 1328 / 0.34 / 715 / 0.32 / 222 / 0.17 / 144 / 0.4 / 191 / 0.49
rs1643659 / DHFR / 5 / 79970592 / T / C / 1340 / 0.24 / 718 / 0.28 / 222 / 0.24 / 146 / 0.23 / 193 / 0.13
rs1677693 / DHFR / 5 / 79972074 / G / T / 1345 / 0.23 / 723 / 0.28 / 224 / 0.23 / 145 / 0.22 / 192 / 0.13
rs11951910 / DHFR / 5 / 79975227 / T / C / 1336 / 0.09 / 715 / 0.1 / 225 / 0.15 / 145 / 0.07 / 190 / 0.04
rs11235462 / FOLR1 / 11 / 71586273 / T / A / 1343 / 0.21 / 721 / 0.14 / 222 / 0.38 / 145 / 0.13 / 194 / 0.26
rs12361490 / FOLR1 / 11 / 71568832 / A / G / 1346 / 0.21 / 720 / 0.16 / 225 / 0.41 / 146 / 0.12 / 194 / 0.23
rs1893008 / FOLR1 / 11 / 71572234 / G / A / 1344 / 0.02 / 721 / 0.01 / 223 / 0.01 / 146 / 0.01 / 194 / 0.03
rs3887687 / FOLR1 / 11 / 71570137 / C / T / 1345 / 0.16 / 720 / 0.11 / 224 / 0.36 / 147 / 0.1 / 194 / 0.13
rs3016432 / FOLR1 / 11 / 71574903 / T / C / 1343 / 0.5 / 717 / 0.5 / 225 / 0.34 / 147 / 0.39 / 195 / 0.39
rs2071010 / FOLR1 / 11 / 71578612 / G / A / 1345 / 0.07 / 720 / 0.07 / 225 / 0.03 / 145 / 0.06 / 195 / 0.12
rs519221 / GIF / 11 / 59381112 / A / T / 1342 / 0.23 / 720 / 0.25 / 224 / 0.27 / 145 / 0.19 / 193 / 0.18
rs558660 / GIF / 11 / 59360470 / G / A / 1347 / 0.16 / 722 / 0.16 / 225 / 0.06 / 146 / 0.13 / 194 / 0.25
rs4356243 / GIF / 11 / 59352773 / C / G / 1350 / 0.11 / 722 / 0.05 / 225 / 0.35 / 147 / 0.12 / 195 / 0.08
rs17154227 / GIF / 11 / 59351647 / T / A / 1348 / 0.11 / 722 / 0.05 / 225 / 0.36 / 146 / 0.13 / 194 / 0.08
rs1042613 / GIF / 11 / 59380009 / G / A / 1350 / 0.24 / 722 / 0.21 / 225 / 0.45 / 147 / 0.17 / 195 / 0.18
rs17596862 / GIF / 11 / 59355183 / G / A / 1346 / 0.04 / 720 / 0.04 / 225 / 0.1 / 146 / 0.01 / 194 / 0.03
rs699664 / MAT2A / 2 / 85634047 / C / T / 1301 / 0.39 / 697 / 0.35 / 216 / 0.34 / 141 / 0.32 / 190 / 0.33
rs6739015 / MAT2A / 2 / 85608868 / A / G / 1326 / 0.46 / 713 / 0.43 / 223 / 0.31 / 144 / 0.39 / 188 / 0.4
rs10179195 / MAT2A / 2 / 85616272 / A / G / 1345 / 0.5 / 719 / 0.48 / 225 / 0.32 / 145 / 0.43 / 195 / 0.42
rs1446669 / MAT2A / 2 / 85615720 / T / C / 1340 / 0.33 / 717 / 0.33 / 223 / 0.39 / 145 / 0.29 / 194 / 0.31
rs13406935 / MAT2A / 2 / 85629519 / A / T / 1344 / 0.1 / 719 / 0.1 / 225 / 0.11 / 146 / 0.08 / 194 / 0.08
rs10190585 / MAT2A / 2 / 85600079 / A / G / 1345 / 0.16 / 721 / 0.13 / 222 / 0.32 / 147 / 0.13 / 194 / 0.1
rs11627387 / MTHFD1 / 14 / 63993730 / G / A / 1346 / 0.29 / 719 / 0.31 / 225 / 0.24 / 147 / 0.23 / 195 / 0.29
rs3783726 / MTHFD1 / 14 / 63974093 / C / T / 1345 / 0.2 / 722 / 0.22 / 223 / 0.07 / 145 / 0.17 / 194 / 0.24
rs11849530 / MTHFD1 / 14 / 63988165 / A / G / 1343 / 0.22 / 718 / 0.23 / 225 / 0.11 / 146 / 0.25 / 194 / 0.28
rs17824591 / MTHFD1 / 14 / 63957464 / G / A / 1348 / 0.16 / 722 / 0.22 / 225 / 0.07 / 146 / 0.16 / 194 / 0.09
rs3783728 / MTHFD1 / 14 / 63957957 / A / G / 1349 / 0.07 / 723 / 0.09 / 225 / 0.02 / 145 / 0.06 / 195 / 0.06
rs8016556 / MTHFD1 / 14 / 63973201 / T / C / 1348 / 0.33 / 722 / 0.33 / 225 / 0.26 / 145 / 0.25 / 195 / 0.39
rs2236224 / MTHFD1 / 14 / 63978904 / G / A / 1341 / 0.36 / 720 / 0.4 / 224 / 0.14 / 146 / 0.44 / 191 / 0.4
rs17751556 / MTHFD1 / 14 / 63953859 / T / C / 1348 / 0.05 / 720 / 0.07 / 225 / 0 / 147 / 0.04 / 195 / 0.02
rs1256146 / MTHFD1 / 14 / 63990418 / G / A / 1349 / 0.18 / 723 / 0.19 / 225 / 0.15 / 146 / 0.21 / 194 / 0.17
rs1256143 / MTHFD1 / 14 / 63981380 / C / T / 1343 / 0.09 / 719 / 0.06 / 224 / 0.21 / 146 / 0.08 / 195 / 0.06
rs8003379 / MTHFD1 / 14 / 63943352 / A / C / 1339 / 0.21 / 717 / 0.26 / 223 / 0.24 / 146 / 0.2 / 193 / 0.08
rs8012229 / MTHFD1 / 14 / 63981315 / T / C / 1341 / 0.08 / 716 / 0.09 / 225 / 0.03 / 147 / 0.05 / 194 / 0.11
rs3818239 / MTHFD1 / 14 / 63984290 / T / C / 1348 / 0.14 / 720 / 0.12 / 225 / 0.26 / 147 / 0.07 / 195 / 0.15
rs1956545 / MTHFD1 / 14 / 63922658 / T / C / 1345 / 0.1 / 721 / 0.07 / 224 / 0.05 / 146 / 0.05 / 193 / 0.24
rs11627525 / MTHFD1 / 14 / 63964115 / C / T / 1348 / 0.09 / 723 / 0.09 / 223 / 0.03 / 147 / 0.06 / 194 / 0.12
rs2236225 / MTHFD1 / 14 / 63978598 / G / A / 1315 / 0.4 / 701 / 0.45 / 223 / 0.22 / 144 / 0.49 / 187 / 0.39
rs2295640 / MTHFD1 / 14 / 63956179 / G / C / 1344 / 0.12 / 721 / 0.09 / 224 / 0.03 / 145 / 0.14 / 193 / 0.24
rs1950902 / MTHFD1 / 14 / 63952133 / G / A / 1319 / 0.16 / 705 / 0.16 / 221 / 0.15 / 145 / 0.09 / 191 / 0.18
rs1885031 / MTHFD1 / 14 / 63957808 / T / C / 1351 / 0.12 / 723 / 0.1 / 225 / 0.04 / 147 / 0.14 / 195 / 0.22
rs11629135 / MTHFD1 / 14 / 63982864 / G / A / 1343 / 0.12 / 720 / 0.09 / 224 / 0.22 / 146 / 0.07 / 194 / 0.13
rs4899135 / MTHFD1 / 14 / 63938907 / A / G / 1333 / 0.08 / 717 / 0.05 / 224 / 0.07 / 141 / 0.05 / 191 / 0.18
rs1256093 / MTHFD1 / 14 / 63912505 / C / T / 1349 / 0.39 / 723 / 0.48 / 225 / 0.13 / 147 / 0.44 / 194 / 0.37
rs2983736 / MTHFD1 / 14 / 63917718 / G / T / 1255 / 0.5 / 659 / 0.45 / 216 / 0.22 / 137 / 0.47 / 185 / 0.39
rs3783731 / MTHFD1 / 14 / 63931140 / G / A / 1347 / 0.19 / 722 / 0.17 / 225 / 0.26 / 145 / 0.2 / 194 / 0.15
rs1994798 / MTHFR / 1 / 11777342 / A / G / 1350 / 0.42 / 723 / 0.45 / 225 / 0.45 / 147 / 0.28 / 195 / 0.31
rs17037396 / MTHFR / 1 / 11784634 / C / T / 1350 / 0.11 / 723 / 0.11 / 225 / 0.09 / 147 / 0.08 / 195 / 0.15
rs17037397 / MTHFR / 1 / 11784750 / C / A / 1290 / 0.06 / 723 / 0.05 / 225 / 0.03 / 147 / 0.08 / 195 / 0.14
rs4846048 / MTHFR / 1 / 11768839 / A / G / 1351 / 0.29 / 723 / 0.33 / 225 / 0.45 / 147 / 0.16 / 195 / 0.15
rs17367504 / MTHFR / 1 / 11785365 / A / G / 1290 / 0.16 / 723 / 0.16 / 225 / 0.11 / 147 / 0.12 / 195 / 0.2
rs3753584 / MTHFR / 1 / 11787173 / T / C / 1290 / 0.16 / 723 / 0.16 / 225 / 0.11 / 147 / 0.12 / 195 / 0.2
rs17421511 / MTHFR / 1 / 11780375 / G / A / 1351 / 0.13 / 723 / 0.17 / 225 / 0.06 / 147 / 0.12 / 195 / 0.09
rs1476413 / MTHFR / 1 / 11774887 / C / T / 1349 / 0.24 / 723 / 0.27 / 225 / 0.17 / 147 / 0.2 / 195 / 0.25
rs12121543 / MTHFR / 1 / 11777258 / C / A / 1351 / 0.22 / 723 / 0.25 / 225 / 0.15 / 147 / 0.19 / 195 / 0.21
rs6541003 / MTHFR / 1 / 11778454 / A / G / 1351 / 0.42 / 723 / 0.44 / 225 / 0.44 / 147 / 0.28 / 195 / 0.3
rs2274976 / MTHFR / 1 / 11773514 / C / T / 1347 / 0.06 / 723 / 0.05 / 225 / 0.03 / 147 / 0.06 / 195 / 0.11
rs1537516 / MTHFR / 1 / 11770448 / G / A / 1290 / 0.1 / 723 / 0.1 / 225 / 0.12 / 147 / 0.06 / 195 / 0.11
rs17421560 / MTHFR / 1 / 11780911 / G / A / 1290 / 0.1 / 723 / 0.11 / 225 / 0.07 / 147 / 0.09 / 195 / 0.14
rs1801131 / MTHFR / 1 / 11777063 / T / G / 1348 / 0.28 / 723 / 0.33 / 225 / 0.17 / 147 / 0.23 / 195 / 0.24
rs13306556 / MTHFR / 1 / 11774697 / C / T / 1351 / 0.12 / 723 / 0.1 / 225 / 0.12 / 147 / 0.09 / 195 / 0.14
rs1801133 / MTHFR / 1 / 11778965 / G / A / 1295 / 0.29 / 723 / 0.33 / 225 / 0.08 / 147 / 0.39 / 195 / 0.34
rs13306553 / MTHFR / 1 / 11782704 / A / G / 1290 / 0.11 / 723 / 0.11 / 225 / 0.09 / 147 / 0.08 / 195 / 0.14
rs9651118 / MTHFR / 1 / 11784801 / T / C / 1351 / 0.21 / 723 / 0.2 / 225 / 0.06 / 147 / 0.28 / 195 / 0.31
rs2066470 / MTHFR / 1 / 11785644 / G / A / 1290 / 0.11 / 723 / 0.11 / 225 / 0.09 / 147 / 0.08 / 195 / 0.14
rs7553194 / MTHFR / 1 / 11786736 / G / A / 1290 / 0.11 / 723 / 0.11 / 225 / 0.09 / 147 / 0.08 / 195 / 0.14
rs11121832 / MTHFR / 1 / 11782707 / C / T / 1351 / 0.24 / 723 / 0.27 / 225 / 0.3 / 147 / 0.15 / 195 / 0.14
rs7556238 / MTR / 1 / 235015165 / G / A / 1336 / 0.16 / 718 / 0.11 / 221 / 0.26 / 146 / 0.13 / 191 / 0.21
rs10158222 / MTR / 1 / 235117305 / C / T / 1323 / 0.24 / 711 / 0.2 / 217 / 0.45 / 145 / 0.2 / 189 / 0.2
rs10925228 / MTR / 1 / 235012928 / T / C / 1341 / 0.06 / 720 / 0.06 / 223 / 0.08 / 142 / 0.04 / 195 / 0.08
rs10802569 / MTR / 1 / 235121928 / C / G / 1350 / 0.36 / 722 / 0.4 / 225 / 0.23 / 147 / 0.37 / 195 / 0.3
rs1252252 / MTR / 1 / 235122625 / A / T / 1341 / 0.31 / 716 / 0.39 / 224 / 0.1 / 147 / 0.35 / 193 / 0.22
rs2385511 / MTR / 1 / 235078420 / A / C / 1323 / 0.32 / 710 / 0.39 / 220 / 0.18 / 143 / 0.34 / 190 / 0.22
rs4120874 / MTR / 1 / 235013434 / A / G / 1338 / 0.18 / 718 / 0.2 / 222 / 0.1 / 145 / 0.22 / 194 / 0.19
rs4659730 / MTR / 1 / 235079143 / G / C / 1333 / 0.14 / 713 / 0.16 / 222 / 0.14 / 145 / 0.12 / 194 / 0.12
rs2275568 / MTR / 1 / 235082251 / C / T / 1339 / 0.44 / 715 / 0.43 / 225 / 0.44 / 146 / 0.46 / 193 / 0.49
rs3768150 / MTR / 1 / 235119415 / A / T / 1346 / 0.32 / 722 / 0.39 / 223 / 0.21 / 147 / 0.35 / 194 / 0.23
rs12060264 / MTR / 1 / 235054986 / G / A / 1340 / 0.38 / 716 / 0.39 / 224 / 0.23 / 147 / 0.44 / 193 / 0.46
rs12070633 / MTR / 1 / 235124985 / T / C / 1305 / 0.43 / 701 / 0.43 / 213 / 0.47 / 145 / 0.39 / 187 / 0.34
rs12567062 / MTR / 1 / 235038950 / G / A / 1296 / 0.35 / 689 / 0.38 / 220 / 0.13 / 140 / 0.43 / 189 / 0.45
rs12759827 / MTR / 1 / 235038809 / A / G / 1343 / 0.19 / 721 / 0.29 / 224 / 0.05 / 145 / 0.2 / 193 / 0.07
rs10737812 / MTR / 1 / 235125451 / T / C / 1340 / 0.46 / 714 / 0.46 / 223 / 0.46 / 147 / 0.41 / 195 / 0.38
rs1804742 / MTR / 1 / 235129251 / C / T / 1331 / 0.17 / 713 / 0.16 / 221 / 0.24 / 146 / 0.15 / 192 / 0.14
rs883396 / MTR / 1 / 235063013 / G / A / 1347 / 0.35 / 721 / 0.35 / 224 / 0.21 / 147 / 0.42 / 194 / 0.42
rs12563688 / MTR / 1 / 235079512 / A / G / 1350 / 0.39 / 723 / 0.4 / 225 / 0.24 / 147 / 0.44 / 194 / 0.49
rs12138911 / MTR / 1 / 235043766 / T / C / 1342 / 0.2 / 718 / 0.18 / 224 / 0.29 / 146 / 0.18 / 195 / 0.19
rs10925252 / MTR / 1 / 235088985 / T / C / 1340 / 0.39 / 717 / 0.4 / 223 / 0.23 / 146 / 0.43 / 193 / 0.49
rs4659744 / MTR / 1 / 235126081 / G / C / 1308 / 0.39 / 705 / 0.39 / 211 / 0.23 / 144 / 0.43 / 191 / 0.48
rs6668344 / MTR / 1 / 235067949 / C / T / 1340 / 0.4 / 718 / 0.4 / 222 / 0.3 / 146 / 0.44 / 193 / 0.49
rs1805087 / MTR / 1 / 235115123 / A / G / 1350 / 0.18 / 722 / 0.18 / 225 / 0.25 / 147 / 0.18 / 195 / 0.16
rs6676866 / MTR / 1 / 235131249 / G / T / 1348 / 0.43 / 721 / 0.43 / 224 / 0.48 / 147 / 0.39 / 195 / 0.36
rs4659723 / MTR / 1 / 235039351 / C / T / 1344 / 0.1 / 721 / 0.13 / 223 / 0.03 / 145 / 0.09 / 194 / 0.1
rs8065874 / SHMT1 / 17 / 18216572 / C / T / 1343 / 0.34 / 721 / 0.25 / 224 / 0.47 / 145 / 0.34 / 192 / 0.39
rs9901160 / SHMT1 / 17 / 18215868 / G / A / 1346 / 0.19 / 721 / 0.15 / 224 / 0.23 / 145 / 0.2 / 195 / 0.24
rs11868708 / SHMT1 / 17 / 18185338 / T / C / 1343 / 0.25 / 718 / 0.25 / 224 / 0.16 / 147 / 0.32 / 194 / 0.26
rs643333 / SHMT1 / 17 / 18207764 / G / T / 1343 / 0.22 / 720 / 0.3 / 224 / 0.07 / 146 / 0.17 / 193 / 0.15
rs1563632 / SHMT1 / 17 / 18161495 / A / G / 1344 / 0.3 / 719 / 0.29 / 224 / 0.16 / 145 / 0.31 / 195 / 0.42
rs9910090 / SHMT1 / 17 / 18191124 / A / C / 1335 / 0.28 / 717 / 0.26 / 222 / 0.27 / 143 / 0.34 / 194 / 0.27
rs2461837 / SHMT1 / 17 / 18206192 / C / T / 1345 / 0.25 / 720 / 0.31 / 223 / 0.22 / 146 / 0.18 / 195 / 0.16
rs3783 / SHMT1 / 17 / 18172742 / G / C / 1284 / 0.25 / 682 / 0.32 / 217 / 0.21 / 143 / 0.19 / 183 / 0.14
rs2273027 / SHMT1 / 17 / 18191252 / C / T / 1337 / 0.41 / 718 / 0.37 / 222 / 0.46 / 143 / 0.49 / 193 / 0.41
rs2273026 / SHMT1 / 17 / 18197704 / C / T / 1341 / 0.11 / 717 / 0.11 / 224 / 0.09 / 146 / 0.14 / 193 / 0.13
rs1979277 / SHMT1 / 17 / 18172821 / G / A / 1351 / 0.29 / 723 / 0.33 / 225 / 0.36 / 147 / 0.21 / 195 / 0.17
rs7207306 / SHMT1 / 17 / 18188087 / C / T / 1344 / 0.28 / 720 / 0.32 / 221 / 0.37 / 147 / 0.19 / 195 / 0.16
rs4925172 / SHMT1 / 17 / 18169330 / C / A / 1137 / 0.36 / 614 / 0.36 / 196 / 0.42 / 110 / 0.26 / 166 / 0.22
rs2168781 / SHMT1 / 17 / 18181471 / C / G / 1342 / 0.45 / 721 / 0.45 / 222 / 0.33 / 146 / 0.37 / 192 / 0.31
rs2838951 / SLC19A1 / 21 / 45754148 / C / G / 1337 / 0.37 / 719 / 0.41 / 221 / 0.28 / 143 / 0.35 / 193 / 0.38
rs2838958 / SLC19A1 / 21 / 45772995 / G / A / 1348 / 0.46 / 722 / 0.47 / 224 / 0.27 / 147 / 0.42 / 195 / 0.46
rs2236484 / SLC19A1 / 21 / 45756112 / G / A / 1325 / 0.46 / 712 / 0.42 / 223 / 0.47 / 142 / 0.47 / 188 / 0.47
rs12482346 / SLC19A1 / 21 / 45762055 / C / T / 1340 / 0.47 / 721 / 0.45 / 222 / 0.49 / 143 / 0.5 / 194 / 0.49
rs1051266 / SLC19A1 / 21 / 45782222 / C / T / 1344 / 0.48 / 721 / 0.45 / 224 / 0.44 / 146 / 0.48 / 193 / 0.47
rs7499 / SLC19A1 / 21 / 45756756 / G / A / 1334 / 0.43 / 714 / 0.41 / 223 / 0.41 / 144 / 0.46 / 192 / 0.46
rs2297291 / SLC19A1 / 21 / 45769768 / G / A / 1331 / 0.45 / 718 / 0.43 / 220 / 0.5 / 144 / 0.42 / 190 / 0.44
rs3939250 / SLC19A1 / 21 / 45789927 / T / C / 1323 / 0.23 / 704 / 0.27 / 224 / 0.07 / 145 / 0.28 / 191 / 0.24
rs3788205 / SLC19A1 / 21 / 45788806 / C / T / 1340 / 0.24 / 715 / 0.29 / 225 / 0.07 / 146 / 0.29 / 193 / 0.24
rs3827266 / SLC19A1 / 21 / 45800276 / C / T / 1332 / 0.34 / 717 / 0.3 / 221 / 0.4 / 142 / 0.32 / 193 / 0.37
rs12483377 / SLC19A1 / 21 / 45755537 / G / A / 1340 / 0.06 / 718 / 0.08 / 223 / 0.04 / 144 / 0.04 / 194 / 0.04
rs17004785 / SLC19A1 / 21 / 45757046 / G / C / 1346 / 0.11 / 721 / 0.11 / 224 / 0.12 / 146 / 0.14 / 194 / 0.11
rs9966612 / TYMS / 18 / 639311 / G / A / 1349 / 0.3 / 722 / 0.31 / 225 / 0.28 / 146 / 0.29 / 195 / 0.29
rs3744962 / TYMS / 18 / 664320 / A / G / 1337 / 0.09 / 715 / 0.08 / 222 / 0.03 / 145 / 0.16 / 194 / 0.12
rs495139 / TYMS / 18 / 666008 / C / G / 1341 / 0.36 / 718 / 0.4 / 223 / 0.29 / 147 / 0.38 / 193 / 0.3
rs10502290 / TYMS / 18 / 665903 / C / T / 1340 / 0.35 / 717 / 0.33 / 223 / 0.35 / 147 / 0.31 / 193 / 0.41
rs2612101 / TYMS / 18 / 666473 / C / T / 1318 / 0.22 / 705 / 0.22 / 218 / 0.36 / 143 / 0.22 / 191 / 0.15
rs2298583 / TYMS / 18 / 667302 / G / A / 1339 / 0.36 / 719 / 0.34 / 223 / 0.39 / 144 / 0.31 / 192 / 0.41
rs2790 / TYMS / 18 / 663086 / A / G / 1347 / 0.25 / 721 / 0.23 / 225 / 0.24 / 145 / 0.23 / 195 / 0.34
rs2298581 / TYMS / 18 / 667931 / C / G / 1343 / 0.25 / 721 / 0.23 / 224 / 0.23 / 145 / 0.22 / 192 / 0.34
rs1001761 / TYMS / 18 / 652103 / A / G / 1349 / 0.44 / 721 / 0.48 / 225 / 0.22 / 147 / 0.43 / 195 / 0.39
rs2853741 / TYMS / 18 / 647352 / C / T / 1350 / 0.35 / 723 / 0.3 / 225 / 0.39 / 147 / 0.31 / 194 / 0.46
rs502396 / TYMS / 18 / 649236 / C / T / 1344 / 0.45 / 719 / 0.5 / 223 / 0.34 / 147 / 0.46 / 195 / 0.36
rs7237052 / TYMS / 18 / 632678 / C / A / 1346 / 0.44 / 722 / 0.35 / 224 / 0.44 / 145 / 0.38 / 194 / 0.45
rs11664283 / TYMS / 18 / 640968 / G / A / 1348 / 0.3 / 721 / 0.29 / 225 / 0.41 / 146 / 0.21 / 195 / 0.27
rs2853533 / TYMS / 18 / 648064 / G / C / 1338 / 0.25 / 718 / 0.15 / 222 / 0.36 / 147 / 0.19 / 194 / 0.42
rs1059394 / TYMS / 18 / 662792 / C / T / 1338 / 0.42 / 720 / 0.34 / 220 / 0.48 / 145 / 0.36 / 193 / 0.46
rs699517 / TYMS / 18 / 663016 / C / T / 1343 / 0.42 / 719 / 0.34 / 224 / 0.47 / 144 / 0.36 / 195 / 0.46
rs9948583 / TYMS / 18 / 665000 / C / T / 1337 / 0.42 / 717 / 0.35 / 224 / 0.47 / 145 / 0.36 / 190 / 0.47
rs2260821 / TYMS / 18 / 665787 / T / C / 1330 / 0.25 / 716 / 0.26 / 223 / 0.15 / 144 / 0.32 / 189 / 0.26
rs2298582 / TYMS / 18 / 667621 / T / G / 1336 / 0.09 / 717 / 0.11 / 221 / 0.07 / 144 / 0.08 / 193 / 0.07
aIncludes 61 individuals who characterized their race/ethnic group as ‘other.’
bNon-Hispanic white
cFor each race/ethnic group the MAF is the minor allele frequency for all subjects.
Supplementary Table 2 Single SNP analysis by race/ethnic group
Race/ethnic groupTotal a / NHWb / Black / Hispanic / Asian
Gene / SNP / OR (95% CI)c / Pactd / OR (95% CI) / Pact / OR (95% CI) / Pact / OR (95% CI) / Pact / OR (95% CI) / Pact / p-
heterogeneity
CBS / rs234705 / 0.96 (0.81-1.15) / 1 / 1 (0.8-1.24) / 0.948 / 0.86 (0.55-1.33) / 0.999 / 0.73 (0.41-1.3) / 0.905 / 1.04 (0.6-1.79) / 1 / 0.076
CBS / rs11701048 / 1.18 (0.89-1.55) / 0.982 / 0.83 (0.56-1.23) / 0.992 / 1.84 (1.06-3.18) / 0.328 / 1.68 (0.67-4.21) / 0.779 / 1.04 (0.41-2.65) / 0.989 / 0.092
CBS / rs4920037 / 0.89 (0.73-1.08) / 0.98 / 0.93 (0.73-1.18) / 0.999 / 0.63 (0.37-1.08) / 0.939 / 0.8 (0.36-1.74) / 1 / 0.97 (0.47-2.03) / 0.995 / 0.103
CBS / rs8133239 / 0.96 (0.75-1.23) / 1 / 1.09 (0.64-1.85) / 1 / 0.66 (0.44-0.99) / 0.552 / 0.93 (0.37-2.33) / 1 / 1.81 (0.9-3.63) / 0.934 / 0.141
CBS / rs6586282 / 1.1 (0.89-1.36) / 0.997 / 0.95 (0.71-1.27) / 1 / 1.68 (1.02-2.77) / 0.328 / 1.01 (0.55-1.87) / 0.936 / 0.96 (0.5-1.85) / 0.999 / 0.167
CBS / rs8130035 / 1.08 (0.92-1.26) / 0.995 / 1.01 (0.81-1.28) / 0.998 / 1.36 (0.95-1.94) / 0.755 / 1.37 (0.83-2.27) / 0.953 / 0.84 (0.55-1.29) / 1 / 0.258
CBS / rs2850146 / 0.89 (0.67-1.18) / 0.997 / 0.84 (0.58-1.22) / 0.989 / 0.7 (0.36-1.38) / 0.996 / 0.9 (0.3-2.63) / 1 / 1.19 (0.55-2.55) / 1 / 0.312
CBS / rs234702 / 1 (0.79-1.26) / 0.993 / 0.97 (0.67-1.4) / 1 / 0.63 (0.28-1.41) / 0.918 / 1.06 (0.61-1.86) / 1 / 1.49 (0.91-2.43) / 0.488 / 0.323
CBS / rs234785 / 1.15 (0.98-1.35) / 0.785 / 1.23 (0.98-1.54) / 0.659 / 1.22 (0.83-1.8) / 0.952 / 0.95 (0.58-1.58) / 1 / 0.85 (0.56-1.27) / 0.755 / 0.37
CBS / rs1051319 / 1.06 (0.88-1.28) / 0.998 / 1.02 (0.73-1.41) / 0.995 / 0.84 (0.58-1.22) / 0.999 / 1.25 (0.66-2.39) / 0.999 / 1.58 (0.87-2.86) / 0.944 / 0.39
CBS / rs2839633 / 0.93 (0.8-1.08) / 0.995 / 0.87 (0.7-1.06) / 0.927 / 1.06 (0.74-1.52) / 0.999 / 1.18 (0.73-1.9) / 1 / 0.9 (0.6-1.36) / 1 / 0.391
CBS / rs11700748 / 1.02 (0.87-1.19) / 1 / 1.18 (0.96-1.46) / 0.817 / 1.01 (0.64-1.59) / 0.999 / 0.82 (0.52-1.29) / 0.999 / 0.8 (0.53-1.21) / 0.735 / 0.398
CBS / rs3788050 / 1.03 (0.78-1.38) / 0.999 / 1.05 (0.61-1.8) / 1 / 0.76 (0.46-1.24) / 0.954 / 0.89 (0.32-2.48) / 1 / 1.89 (0.85-4.22) / 0.973 / 0.404
CBS / rs1789953 / 0.81 (0.65-1.01) / 0.682 / 0.76 (0.56-1.04) / 0.791 / 1.17 (0.55-2.47) / 0.998 / 1.13 (0.65-1.96) / 1 / 0.63 (0.35-1.14) / 0.979 / 0.482
CBS / rs234784 / 0.95 (0.81-1.11) / 0.999 / 0.93 (0.75-1.15) / 0.999 / 1.09 (0.74-1.6) / 0.996 / 1.05 (0.63-1.74) / 1 / 0.84 (0.55-1.29) / 0.987 / 0.486
CBS / rs234709 / 1.07 (0.92-1.24) / 0.997 / 0.98 (0.79-1.2) / 1 / 1.13 (0.68-1.88) / 0.999 / 0.83 (0.49-1.42) / 1 / 1.4 (0.88-2.22) / 0.778 / 0.491
CBS / rs234783 / 0.97 (0.84-1.13) / 1 / 1.1 (0.89-1.35) / 0.994 / 1.01 (0.66-1.55) / 0.999 / 0.82 (0.53-1.28) / 0.999 / 0.77 (0.51-1.16) / 0.812 / 0.537
CBS / rs1788484 / 0.92 (0.77-1.09) / 0.995 / 0.96 (0.77-1.2) / 1 / 0.66 (0.33-1.32) / 0.873 / 1.19 (0.68-2.09) / 1 / 0.88 (0.51-1.5) / 1 / 0.608
CBS / rs2124458 / 1.05 (0.9-1.24) / 0.999 / 1.19 (0.95-1.48) / 0.817 / 1.09 (0.61-1.93) / 0.983 / 0.9 (0.54-1.51) / 1 / 0.85 (0.55-1.31) / 0.755 / 0.679
CBS / rs466791 / 0.82 (0.66-1.03) / 0.783 / 0.76 (0.56-1.04) / 0.816 / 0.9 (0.42-1.93) / 0.999 / 1.22 (0.68-2.18) / 1 / 0.78 (0.45-1.33) / 0.985 / 0.711
CBS / rs9977396 / 0.87 (0.71-1.07) / 0.966 / 0.84 (0.63-1.11) / 0.966 / 0.86 (0.57-1.28) / 0.999 / 1.39 (0.58-3.32) / 1 / 0.65 (0.3-1.4) / 0.967 / 0.749
CBS / rs719037 / 0.87 (0.75-1.01) / 0.75 / 0.84 (0.69-1.04) / 0.812 / 0.8 (0.5-1.28) / 0.985 / 1.09 (0.7-1.71) / 1 / 0.91 (0.6-1.37) / 1 / 0.848
CBS / rs2849729 / 1.03 (0.87-1.21) / 1 / 1.15 (0.92-1.44) / 0.961 / 0.88 (0.45-1.73) / 0.998 / 0.91 (0.54-1.53) / 0.999 / 0.97 (0.64-1.47) / 0.978 / 0.866
CBS / rs11701664 / 0.98 (0.84-1.16) / 0.997 / 1.03 (0.82-1.29) / 1 / 0.78 (0.43-1.41) / 0.997 / 0.88 (0.53-1.46) / 1 / 1.08 (0.72-1.61) / 0.978 / 0.882
CBS / rs234787 / 1.05 (0.9-1.23) / 0.999 / 1.05 (0.85-1.3) / 1 / 1.17 (0.79-1.74) / 0.999 / 0.94 (0.58-1.5) / 0.995 / 0.98 (0.63-1.52) / 0.991 / 0.935
CBS / rs234712 / 0.96 (0.72-1.28) / 1 / 0.91 (0.57-1.46) / 1 / 1.16 (0.34-3.96) / 1 / 1.12 (0.6-2.1) / 1 / 1.03 (0.59-1.78) / 0.982 / 0.959
CBS / rs8127036 / 1 (0.8-1.25) / 1 / 1.04 (0.79-1.38) / 1 / 1.02 (0.39-2.65) / 0.919 / 0.9 (0.45-1.8) / 1 / 0.86 (0.43-1.75) / 1 / 0.976
DHFR / rs10072026 / 1.06 (0.87-1.3) / 0.978 / 1.17 (0.82-1.67) / 0.928 / 1.06 (0.73-1.53) / 0.997 / 0.84 (0.42-1.7) / 0.876 / 0.55 (0.24-1.29) / 0.726 / 0.322
DHFR / rs6151629 / 1.03 (0.86-1.23) / 0.989 / 1.04 (0.82-1.32) / 0.988 / 1.04 (0.65-1.66) / 0.996 / 0.9 (0.51-1.58) / 0.994 / 0.87 (0.53-1.43) / 0.671 / 0.574
DHFR / rs1650654 / 0.99 (0.83-1.18) / 0.985 / 0.97 (0.77-1.22) / 0.993 / 0.82 (0.56-1.21) / 0.748 / 1.17 (0.69-1.97) / 0.943 / 1.17 (0.63-2.15) / 0.647 / 0.667
DHFR / rs1677693 / 0.99 (0.82-1.19) / 0.998 / 0.91 (0.71-1.15) / 0.924 / 1 (0.65-1.53) / 0.992 / 1.24 (0.72-2.11) / 0.874 / 1.27 (0.68-2.38) / 0.479 / 0.771
DHFR / rs2618372 / 1.01 (0.84-1.21) / 0.932 / 0.93 (0.73-1.18) / 0.965 / 1.01 (0.66-1.55) / 0.951 / 1.23 (0.72-2.09) / 0.863 / 1.32 (0.71-2.45) / 0.369 / 0.78
DHFR / rs1643659 / 0.98 (0.82-1.18) / 0.991 / 0.9 (0.71-1.15) / 0.921 / 0.99 (0.65-1.53) / 0.996 / 1.15 (0.68-1.94) / 0.95 / 1.29 (0.7-2.41) / 0.405 / 0.81
DHFR / rs6151617 / 1.09 (0.93-1.28) / 0.824 / 1.08 (0.87-1.33) / 0.964 / 1.13 (0.78-1.65) / 0.978 / 0.91 (0.57-1.46) / 0.971 / 1.07 (0.7-1.64) / 0.946 / 0.814
DHFR / rs12517451 / 0.88 (0.73-1.06) / 0.672 / 0.97 (0.76-1.24) / 0.852 / 0.82 (0.45-1.5) / 0.994 / 0.78 (0.43-1.42) / 0.627 / 0.8 (0.5-1.28) / 0.645 / 0.87
DHFR / rs11951910 / 1.01 (0.78-1.32) / 0.999 / 0.9 (0.64-1.28) / 0.972 / 1 (0.6-1.67) / 0.994 / 1.33 (0.51-3.45) / 0.991 / 1.42 (0.48-4.19) / 0.749 / 0.874
DHFR / rs3797877 / 1.09 (0.86-1.38) / 0.972 / 0.98 (0.66-1.45) / 0.976 / 1.18 (0.49-2.83) / 0.997 / 1.18 (0.68-2.07) / 0.937 / 1.33 (0.83-2.13) / 0.63 / 0.9
DHFR / rs380691 / 1.03 (0.88-1.22) / 0.99 / 1.04 (0.83-1.29) / 0.985 / 0.94 (0.57-1.54) / 0.999 / 1.04 (0.64-1.67) / 0.985 / 1.25 (0.82-1.92) / 0.647 / 0.911
FOLR1 / rs11235462 / 1.17 (0.97-1.41) / 0.398 / 1.08 (0.8-1.47) / 0.887 / 1.4 (0.93-2.1) / 0.437 / 0.35 (0.16-0.73) / 0.021 / 1.53 (0.98-2.38) / 0.432 / 0.005
FOLR1 / rs12361490 / 1.11 (0.93-1.33) / 0.625 / 0.97 (0.73-1.29) / 0.976 / 1.23 (0.84-1.8) / 0.474 / 0.5 (0.23-1.09) / 0.175 / 1.27 (0.8-2) / 0.857 / 0.087
FOLR1 / rs2071010 / 0.97 (0.72-1.31) / 0.975 / 1.16 (0.76-1.76) / 0.865 / 0.4 (0.12-1.41) / 0.544 / 0.39 (0.13-1.18) / 0.168 / 1.31 (0.71-2.39) / 0.89 / 0.171
FOLR1 / rs3887687 / 0.99 (0.8-1.22) / 0.919 / 0.81 (0.57-1.16) / 0.764 / 0.91 (0.61-1.37) / 0.623 / 0.85 (0.4-1.8) / 0.999 / 0.99 (0.54-1.84) / 0.998 / 0.37
FOLR1 / rs3016432 / 1.04 (0.9-1.21) / 0.921 / 0.98 (0.79-1.21) / 0.872 / 0.84 (0.56-1.27) / 0.48 / 1.17 (0.74-1.83) / 0.622 / 1.11 (0.74-1.66) / 0.94 / 0.492
FOLR1 / rs1893008 / 1.51 (0.8-2.87) / 0.626 / 1.64 (0.62-4.33) / 0.74 / 3.91 (0.42-36.6) / 0.568 / 0.93 (0.06-15.3) / 0.995 / 1.16 (0.34-4.01) / 0.941 / 0.889
GIF / rs17154227 / 1.08 (0.86-1.36) / 0.858 / 0.96 (0.6-1.53) / 0.848 / 1.28 (0.85-1.93) / 0.815 / 0.45 (0.21-0.93) / 0.036 / 1.56 (0.75-3.23) / 0.347 / 0.097
GIF / rs4356243 / 1.09 (0.86-1.37) / 0.841 / 0.96 (0.6-1.54) / 0.851 / 1.27 (0.84-1.92) / 0.803 / 0.45 (0.21-0.96) / 0.04 / 1.56 (0.75-3.25) / 0.337 / 0.117
GIF / rs1042613 / 1 (0.84-1.2) / 0.969 / 1.01 (0.78-1.31) / 0.967 / 1.17 (0.82-1.67) / 0.86 / 0.66 (0.35-1.25) / 0.28 / 0.89 (0.53-1.49) / 0.798 / 0.429
GIF / rs17596862 / 0.97 (0.67-1.41) / 0.985 / 0.91 (0.52-1.59) / 0.973 / 1.22 (0.64-2.31) / 0.808 / 0.3 (0.03-3.02) / 0.423 / 0.86 (0.24-3.09) / 0.973 / 0.699
GIF / rs519221 / 0.84 (0.7-1.01) / 0.247 / 0.85 (0.66-1.09) / 0.544 / 0.87 (0.57-1.32) / 0.836 / 0.73 (0.4-1.32) / 0.386 / 0.95 (0.56-1.61) / 0.806 / 0.846
GIF / rs558660 / 0.86 (0.7-1.06) / 0.452 / 0.83 (0.62-1.11) / 0.543 / 0.99 (0.43-2.28) / 0.805 / 1.13 (0.53-2.38) / 0.431 / 0.9 (0.58-1.42) / 0.808 / 0.952
MAT2A / rs10179195 / 0.99 (0.86-1.15) / 0.924 / 0.96 (0.78-1.18) / 0.915 / 1.15 (0.78-1.7) / 0.905 / 1.11 (0.7-1.77) / 0.984 / 0.67 (0.44-1.03) / 0.236 / 0.264
MAT2A / rs6739015 / 0.94 (0.81-1.09) / 0.816 / 0.9 (0.73-1.1) / 0.68 / 1.03 (0.69-1.54) / 0.885 / 1 (0.63-1.61) / 0.862 / 0.65 (0.42-1.01) / 0.114 / 0.388
MAT2A / rs1446669 / 0.96 (0.82-1.13) / 0.945 / 0.92 (0.74-1.14) / 0.808 / 1.13 (0.75-1.69) / 0.917 / 1.08 (0.66-1.78) / 0.965 / 0.76 (0.48-1.19) / 0.43 / 0.667
MAT2A / rs13406935 / 0.95 (0.73-1.22) / 0.95 / 0.91 (0.65-1.27) / 0.911 / 1.22 (0.65-2.29) / 0.884 / 0.96 (0.42-2.18) / 0.99 / 0.6 (0.26-1.38) / 0.402 / 0.669
MAT2A / rs10190585 / 0.98 (0.79-1.2) / 0.965 / 0.97 (0.71-1.31) / 0.888 / 0.82 (0.54-1.25) / 0.497 / 1.19 (0.6-2.34) / 0.973 / 0.74 (0.35-1.56) / 0.336 / 0.707
MAT2A / rs699664 / 0.93 (0.8-1.09) / 0.815 / 0.96 (0.78-1.19) / 0.888 / 0.91 (0.62-1.34) / 0.787 / 0.78 (0.47-1.3) / 0.802 / 0.74 (0.47-1.17) / 0.454 / 0.818
MTHFD1 / rs11627525 / 0.92 (0.7-1.2) / 0.998 / 0.57 (0.39-0.83) / 0.053 / 0.67 (0.27-1.7) / 0.999 / 2.92 (0.96-8.87) / 0.495 / 1.68 (0.93-3.03) / 0.968 / 0.0000886
MTHFD1 / rs8012229 / 0.89 (0.68-1.18) / 0.994 / 0.6 (0.41-0.87) / 0.123 / 0.39 (0.11-1.37) / 0.884 / 2.33 (0.75-7.28) / 0.836 / 1.74 (0.95-3.18) / 0.893 / 0.000738
MTHFD1 / rs1885031 / 0.96 (0.76-1.21) / 1 / 0.64 (0.45-0.92) / 0.217 / 0.58 (0.21-1.62) / 0.998 / 1.43 (0.74-2.79) / 0.928 / 1.69 (1.06-2.71) / 0.828 / 0.008
MTHFD1 / rs11629135 / 0.99 (0.79-1.25) / 1 / 0.63 (0.44-0.92) / 0.22 / 1 (0.63-1.57) / 0.989 / 1.68 (0.64-4.43) / 0.986 / 1.7 (0.96-3.02) / 0.96 / 0.008
MTHFD1 / rs3818239 / 1.08 (0.87-1.35) / 0.997 / 0.72 (0.52-1.01) / 0.552 / 1.26 (0.81-1.95) / 0.998 / 1.82 (0.7-4.74) / 0.942 / 1.59 (0.91-2.78) / 0.985 / 0.009
MTHFD1 / rs8016556 / 0.87 (0.74-1.02) / 0.668 / 0.69 (0.55-0.86) / 0.012 / 1.32 (0.85-2.04) / 0.884 / 0.84 (0.47-1.49) / 0.999 / 1.2 (0.81-1.77) / 0.992 / 0.029
MTHFD1 / rs2295640 / 1 (0.8-1.27) / 0.999 / 0.75 (0.52-1.08) / 0.727 / 0.63 (0.21-1.91) / 0.998 / 2.09 (1.03-4.23) / 0.348 / 1.49 (0.94-2.35) / 0.993 / 0.033
MTHFD1 / rs1950902 / 0.94 (0.76-1.15) / 0.999 / 0.84 (0.63-1.12) / 0.826 / 0.56 (0.32-0.99) / 0.837 / 1.71 (0.71-4.16) / 0.826 / 1.61 (0.96-2.69) / 0.984 / 0.043
MTHFD1 / rs11627387 / 0.78 (0.66-0.92) / 0.065 / 0.68 (0.54-0.85) / 0.01 / 0.7 (0.45-1.08) / 0.959 / 1.01 (0.57-1.81) / 0.998 / 1.1 (0.71-1.71) / 0.959 / 0.238
MTHFD1 / rs3783731 / 1.01 (0.83-1.23) / 1 / 1.09 (0.82-1.44) / 0.98 / 1.05 (0.68-1.63) / 0.997 / 1.04 (0.58-1.86) / 0.999 / 0.55 (0.3-0.99) / 0.908 / 0.314
MTHFD1 / rs17824591 / 0.78 (0.63-0.97) / 0.287 / 0.82 (0.63-1.05) / 0.646 / 0.87 (0.45-1.69) / 1 / 0.43 (0.21-0.87) / 0.389 / 0.88 (0.46-1.69) / 0.997 / 0.339
MTHFD1 / rs17751556 / 0.79 (0.54-1.14) / 0.927 / 0.83 (0.55-1.26) / 0.965 / 373320.51 (0-Inf) / 0.998 / 1.19 (0.34-4.13) / 0.979 / 0.37 (0.07-1.86) / 0.991 / 0.346
MTHFD1 / rs4899135 / 0.97 (0.73-1.28) / 1 / 0.67 (0.41-1.1) / 0.705 / 1.18 (0.55-2.55) / 0.999 / 0.75 (0.26-2.21) / 0.98 / 1.37 (0.8-2.32) / 0.998 / 0.368
MTHFD1 / rs8003379 / 0.92 (0.76-1.11) / 0.992 / 0.97 (0.76-1.23) / 0.973 / 0.82 (0.53-1.25) / 0.997 / 0.66 (0.35-1.23) / 0.85 / 1.04 (0.52-2.08) / 1 / 0.418
MTHFD1 / rs2236224 / 1.12 (0.96-1.31) / 0.844 / 1.3 (1.05-1.61) / 0.211 / 1.05 (0.63-1.74) / 1 / 1.26 (0.78-2.03) / 0.989 / 0.88 (0.59-1.32) / 1 / 0.42
MTHFD1 / rs2236225 / 1.05 (0.9-1.22) / 0.998 / 1.23 (0.99-1.52) / 0.534 / 0.91 (0.59-1.4) / 0.999 / 1.02 (0.64-1.63) / 0.978 / 0.83 (0.55-1.26) / 1 / 0.472
MTHFD1 / rs2983736 / 1.02 (0.87-1.19) / 1 / 1.01 (0.81-1.27) / 0.962 / 1.16 (0.72-1.86) / 0.998 / 1.07 (0.65-1.76) / 0.995 / 1.38 (0.89-2.13) / 0.992 / 0.532
MTHFD1 / rs3783728 / 1.31 (0.97-1.75) / 0.653 / 1.26 (0.89-1.79) / 0.846 / 0.74 (0.19-2.87) / 0.999 / 2.49 (0.81-7.63) / 0.893 / 1.92 (0.8-4.59) / 0.651 / 0.559
MTHFD1 / rs11849530 / 0.78 (0.65-0.94) / 0.13 / 0.76 (0.59-0.99) / 0.274 / 0.65 (0.37-1.17) / 0.997 / 0.91 (0.52-1.61) / 0.998 / 0.97 (0.63-1.5) / 0.999 / 0.608
MTHFD1 / rs1956545 / 1.09 (0.85-1.39) / 0.997 / 1.08 (0.71-1.65) / 0.969 / 1.09 (0.5-2.37) / 0.916 / 0.6 (0.21-1.7) / 0.834 / 1.41 (0.9-2.21) / 0.992 / 0.611
MTHFD1 / rs1256143 / 1 (0.76-1.31) / 0.978 / 0.85 (0.54-1.34) / 0.965 / 1.15 (0.71-1.85) / 0.998 / 0.58 (0.25-1.35) / 0.93 / 1.23 (0.51-2.93) / 1 / 0.613
MTHFD1 / rs1256093 / 0.98 (0.84-1.14) / 1 / 0.98 (0.79-1.21) / 0.869 / 0.95 (0.55-1.65) / 0.98 / 1.36 (0.86-2.16) / 0.688 / 0.95 (0.62-1.46) / 1 / 0.718
MTHFD1 / rs3783726 / 0.75 (0.62-0.91) / 0.071 / 0.77 (0.59-0.99) / 0.276 / 0.62 (0.31-1.26) / 0.996 / 0.59 (0.3-1.14) / 0.876 / 0.93 (0.59-1.46) / 0.988 / 0.765
MTHFD1 / rs1256146 / 1.13 (0.93-1.39) / 0.931 / 1.21 (0.92-1.59) / 0.745 / 1.33 (0.76-2.32) / 0.998 / 0.89 (0.51-1.55) / 0.993 / 0.99 (0.57-1.71) / 0.997 / 0.807
MTHFR / rs17037396 / 0.89 (0.7-1.11) / 0.941 / 1 (0.73-1.37) / 0.999 / 1.01 (0.52-1.96) / 1 / 0.29 (0.11-0.75) / 0.108 / 1.28 (0.75-2.18) / 0.802 / 0.012
MTHFR / rs13306556 / 0.96 (0.76-1.21) / 1 / 1.04 (0.75-1.44) / 0.996 / 1.09 (0.6-1.96) / 1 / 0.34 (0.14-0.84) / 0.198 / 1.48 (0.86-2.52) / 0.444 / 0.015
MTHFR / rs13306553 / 0.97 (0.76-1.23) / 1 / 1.03 (0.74-1.42) / 0.999 / 1 (0.52-1.95) / 1 / 0.29 (0.11-0.77) / 0.108 / 1.37 (0.8-2.34) / 0.662 / 0.033
MTHFR / rs2066470 / 0.97 (0.76-1.23) / 1 / 1.03 (0.74-1.42) / 0.999 / 1 (0.52-1.95) / 1 / 0.29 (0.11-0.77) / 0.107 / 1.37 (0.8-2.34) / 0.662 / 0.033
MTHFR / rs7553194 / 0.97 (0.76-1.23) / 1 / 1.03 (0.74-1.42) / 0.999 / 1 (0.52-1.95) / 1 / 0.29 (0.11-0.77) / 0.107 / 1.37 (0.8-2.34) / 0.662 / 0.033
MTHFR / rs17037397 / 0.85 (0.62-1.17) / 0.949 / 0.82 (0.5-1.37) / 0.992 / 1.05 (0.36-3.04) / 1 / 0.29 (0.11-0.77) / 0.109 / 1.37 (0.8-2.34) / 0.663 / 0.034
MTHFR / rs17367504 / 1.09 (0.88-1.35) / 0.983 / 1.21 (0.92-1.6) / 0.659 / 1.06 (0.58-1.93) / 1 / 0.42 (0.19-0.89) / 0.242 / 1.41 (0.87-2.28) / 0.416 / 0.041
MTHFR / rs3753584 / 1.09 (0.88-1.35) / 0.983 / 1.21 (0.92-1.6) / 0.659 / 1.06 (0.58-1.93) / 1 / 0.42 (0.19-0.89) / 0.241 / 1.41 (0.87-2.28) / 0.417 / 0.041
MTHFR / rs17421560 / 0.98 (0.77-1.26) / 0.998 / 1.03 (0.74-1.42) / 0.998 / 1.19 (0.55-2.54) / 0.998 / 0.34 (0.14-0.85) / 0.197 / 1.37 (0.8-2.34) / 0.662 / 0.055
MTHFR / rs2274976 / 0.92 (0.66-1.26) / 0.998 / 0.82 (0.49-1.37) / 0.991 / 1.05 (0.36-3.05) / 1 / 0.46 (0.17-1.28) / 0.719 / 1.71 (0.93-3.14) / 0.359 / 0.102
MTHFR / rs1476413 / 0.94 (0.79-1.12) / 0.994 / 1 (0.8-1.26) / 0.984 / 0.97 (0.6-1.56) / 1 / 0.57 (0.32-1.01) / 0.649 / 1.25 (0.8-1.97) / 0.695 / 0.151
MTHFR / rs1537516 / 1.07 (0.84-1.38) / 0.998 / 1.04 (0.75-1.44) / 0.996 / 1.09 (0.61-1.97) / 1 / 0.46 (0.17-1.28) / 0.719 / 1.74 (0.95-3.18) / 0.359 / 0.152
MTHFR / rs12121543 / 0.94 (0.78-1.13) / 0.995 / 1 (0.79-1.27) / 0.995 / 0.91 (0.53-1.55) / 0.996 / 0.55 (0.31-1) / 0.599 / 1.3 (0.8-2.12) / 0.711 / 0.228
MTHFR / rs6541003 / 1.04 (0.9-1.22) / 0.998 / 1.14 (0.93-1.41) / 0.737 / 0.89 (0.6-1.31) / 0.972 / 0.71 (0.43-1.16) / 0.65 / 1.22 (0.8-1.87) / 0.707 / 0.244
MTHFR / rs11121832 / 0.98 (0.82-1.17) / 1 / 1.03 (0.82-1.29) / 1 / 0.74 (0.49-1.12) / 0.577 / 1.1 (0.6-2.01) / 0.792 / 0.92 (0.52-1.64) / 1 / 0.369
MTHFR / rs1994798 / 1.01 (0.86-1.17) / 0.938 / 1.07 (0.87-1.32) / 0.986 / 0.89 (0.6-1.31) / 0.972 / 0.73 (0.45-1.19) / 0.748 / 1.19 (0.77-1.84) / 0.828 / 0.412
MTHFR / rs9651118 / 1.03 (0.85-1.24) / 1 / 0.96 (0.74-1.25) / 0.999 / 1.08 (0.47-2.49) / 0.999 / 1.5 (0.89-2.53) / 0.833 / 0.95 (0.62-1.44) / 0.995 / 0.513
MTHFR / rs4846048 / 1.09 (0.92-1.29) / 0.958 / 1.1 (0.88-1.37) / 0.973 / 0.92 (0.61-1.39) / 0.995 / 1.14 (0.63-2.06) / 0.837 / 0.96 (0.53-1.71) / 1 / 0.637
MTHFR / rs1801131e / 0.97 (0.66-1.43) / 1 / 0.98 (0.61-1.58) / 0.969 / 0.95 (0.23-3.95) / 1 / 0.89 (0.21-3.78) / 0.762 / 1.55 (0.55-4.38) / 0.892 / 0.708
MTHFR / rs17421511 / 0.98 (0.79-1.23) / 0.988 / 0.98 (0.74-1.29) / 0.998 / 1.02 (0.47-2.22) / 0.985 / 0.95 (0.48-1.88) / 0.836 / 0.99 (0.49-2) / 0.998 / 0.722
MTHFR / rs1801133e / 0.96 (0.67-1.36) / 1 / 0.94 (0.6-1.47) / 0.996 / 0.49 (0.04-5.49) / 0.992 / 1.67 (0.69-4.03) / 0.76 / 0.82 (0.35-1.95) / 0.899 / 0.744
MTR / rs7556238 / 1.25 (1.01-1.54) / 0.335 / 1.35 (0.96-1.88) / 0.484 / 0.7 (0.45-1.09) / 0.888 / 2.19 (1.1-4.38) / 0.136 / 1.63 (0.97-2.76) / 0.654 / 0.029
MTR / rs10925228 / 1.36 (0.99-1.86) / 0.411 / 1.42 (0.91-2.21) / 0.597 / 0.81 (0.4-1.64) / 1 / 4.62 (0.96-22.35) / 0.141 / 1.42 (0.69-2.9) / 0.996 / 0.255
MTR / rs6668344 / 0.98 (0.84-1.15) / 0.999 / 0.91 (0.74-1.13) / 0.961 / 1 (0.66-1.52) / 0.997 / 1.36 (0.84-2.2) / 0.735 / 1.23 (0.8-1.89) / 0.966 / 0.396
MTR / rs6676866 / 1.01 (0.87-1.18) / 0.999 / 1 (0.81-1.24) / 0.998 / 1.26 (0.86-1.84) / 0.877 / 0.73 (0.46-1.15) / 0.662 / 0.88 (0.57-1.38) / 0.994 / 0.435
MTR / rs10737812 / 1.04 (0.89-1.21) / 0.983 / 1.04 (0.85-1.28) / 0.998 / 1.29 (0.88-1.91) / 0.784 / 0.77 (0.49-1.22) / 0.847 / 0.88 (0.56-1.36) / 0.999 / 0.458
MTR / rs12563688 / 0.97 (0.83-1.14) / 0.991 / 0.93 (0.75-1.15) / 0.984 / 0.94 (0.6-1.47) / 1 / 1.36 (0.84-2.2) / 0.778 / 1.17 (0.77-1.8) / 0.991 / 0.463
MTR / rs4659723 / 1.02 (0.78-1.32) / 0.999 / 1.07 (0.78-1.48) / 0.999 / 0.55 (0.17-1.76) / 0.937 / 0.96 (0.41-2.25) / 0.903 / 0.96 (0.48-1.92) / 0.994 / 0.463
MTR / rs4120874 / 0.88 (0.73-1.08) / 0.815 / 1.05 (0.81-1.36) / 1 / 0.66 (0.35-1.22) / 0.94 / 0.69 (0.4-1.18) / 0.626 / 0.79 (0.45-1.36) / 0.992 / 0.468
MTR / rs12138911 / 1.04 (0.85-1.26) / 0.994 / 1.13 (0.86-1.48) / 0.968 / 0.76 (0.49-1.18) / 0.83 / 1.07 (0.59-1.91) / 0.986 / 1.25 (0.73-2.12) / 0.926 / 0.475
MTR / rs4659744 / 0.98 (0.83-1.15) / 0.997 / 0.94 (0.76-1.17) / 0.995 / 0.92 (0.57-1.48) / 0.999 / 1.31 (0.81-2.13) / 0.847 / 1.2 (0.78-1.85) / 0.989 / 0.521
MTR / rs2275568 / 1.09 (0.93-1.27) / 0.856 / 1 (0.81-1.23) / 0.976 / 1.35 (0.92-1.99) / 0.746 / 1.35 (0.84-2.18) / 0.783 / 1.11 (0.73-1.69) / 1 / 0.558
MTR / rs12759827 / 0.94 (0.77-1.14) / 0.982 / 1.01 (0.8-1.27) / 0.991 / 0.98 (0.39-2.43) / 1 / 0.67 (0.37-1.22) / 0.727 / 0.96 (0.42-2.23) / 0.998 / 0.631
MTR / rs1804742 / 1.07 (0.87-1.32) / 0.984 / 1.2 (0.89-1.61) / 0.893 / 0.81 (0.52-1.27) / 0.942 / 1.13 (0.6-2.15) / 0.976 / 0.91 (0.5-1.65) / 1 / 0.651
MTR / rs10802569 / 0.88 (0.75-1.03) / 0.585 / 0.95 (0.76-1.17) / 0.997 / 0.75 (0.48-1.17) / 0.952 / 0.74 (0.47-1.18) / 0.692 / 0.79 (0.5-1.25) / 0.972 / 0.668
MTR / rs10925252 / 0.99 (0.85-1.17) / 0.994 / 0.98 (0.79-1.22) / 0.998 / 0.92 (0.58-1.46) / 1 / 1.28 (0.79-2.09) / 0.849 / 1.17 (0.76-1.8) / 0.996 / 0.712
MTR / rs12567062 / 0.95 (0.81-1.12) / 0.972 / 0.97 (0.77-1.2) / 0.996 / 0.91 (0.53-1.55) / 0.999 / 1.36 (0.84-2.2) / 0.817 / 0.93 (0.61-1.43) / 0.994 / 0.725
MTR / rs12070633 / 1 (0.85-1.16) / 0.964 / 1.03 (0.83-1.27) / 0.999 / 1.03 (0.7-1.53) / 1 / 0.74 (0.46-1.19) / 0.683 / 0.9 (0.58-1.4) / 0.996 / 0.768
MTR / rs1805087 / 1.02 (0.84-1.24) / 0.999 / 1.08 (0.82-1.42) / 0.998 / 0.79 (0.51-1.23) / 0.937 / 1.07 (0.6-1.93) / 0.984 / 1 (0.56-1.77) / 1 / 0.795
MTR / rs12060264 / 0.94 (0.8-1.1) / 0.95 / 0.92 (0.74-1.14) / 0.972 / 0.94 (0.59-1.5) / 1 / 1.23 (0.77-1.97) / 0.937 / 0.98 (0.65-1.49) / 1 / 0.802
MTR / rs1252252 / 0.89 (0.75-1.04) / 0.691 / 0.95 (0.77-1.17) / 0.998 / 0.7 (0.36-1.37) / 0.988 / 0.74 (0.46-1.17) / 0.721 / 0.9 (0.54-1.5) / 1 / 0.823
MTR / rs4659730 / 1.14 (0.91-1.43) / 0.845 / 1.18 (0.88-1.6) / 0.909 / 0.95 (0.55-1.62) / 0.972 / 1.15 (0.56-2.36) / 0.979 / 1.1 (0.59-2.05) / 0.998 / 0.857
MTR / rs2385511 / 0.9 (0.76-1.06) / 0.805 / 0.94 (0.76-1.16) / 0.992 / 1.02 (0.6-1.73) / 0.98 / 0.73 (0.46-1.17) / 0.716 / 0.82 (0.49-1.38) / 0.999 / 0.866
MTR / rs10158222 / 1.2 (1-1.43) / 0.341 / 1.17 (0.9-1.53) / 0.861 / 1.3 (0.89-1.9) / 0.923 / 1.07 (0.6-1.88) / 0.985 / 1.01 (0.6-1.69) / 0.999 / 0.889
MTR / rs883396 / 1.05 (0.9-1.24) / 0.984 / 1.08 (0.87-1.34) / 0.986 / 1.01 (0.63-1.62) / 1 / 1.12 (0.71-1.77) / 0.977 / 1.2 (0.79-1.82) / 0.949 / 0.891
MTR / rs3768150 / 0.92 (0.78-1.09) / 0.907 / 0.96 (0.78-1.19) / 0.999 / 1 (0.61-1.65) / 0.996 / 0.78 (0.49-1.24) / 0.809 / 0.9 (0.54-1.48) / 1 / 0.943
SHMT1 / rs1563632 / 1.08 (0.92-1.27) / 0.898 / 1.12 (0.9-1.4) / 0.853 / 1.01 (0.61-1.69) / 0.914 / 0.6 (0.36-1.01) / 0.536 / 1.55 (1.03-2.33) / 0.515 / 0.068
SHMT1 / rs2461837 / 0.93 (0.78-1.12) / 0.927 / 0.99 (0.79-1.24) / 0.976 / 0.99 (0.63-1.57) / 0.997 / 1.17 (0.64-2.13) / 0.972 / 0.44 (0.23-0.83) / 0.206 / 0.125
SHMT1 / rs2168781 / 1.01 (0.87-1.18) / 0.995 / 1.09 (0.89-1.34) / 0.862 / 0.95 (0.62-1.45) / 0.874 / 1.17 (0.72-1.89) / 0.891 / 0.69 (0.43-1.09) / 0.794 / 0.177
SHMT1 / rs7207306 / 0.99 (0.83-1.17) / 0.987 / 1.01 (0.8-1.26) / 0.981 / 1.08 (0.74-1.58) / 0.942 / 1.11 (0.62-1.99) / 0.973 / 0.51 (0.27-0.95) / 0.379 / 0.248
SHMT1 / rs11868708 / 0.91 (0.76-1.08) / 0.838 / 0.78 (0.61-1) / 0.294 / 1.17 (0.69-1.97) / 0.991 / 1.31 (0.82-2.1) / 0.891 / 0.84 (0.52-1.34) / 0.842 / 0.252
SHMT1 / rs9910090 / 0.93 (0.78-1.1) / 0.91 / 0.81 (0.64-1.03) / 0.426 / 1.13 (0.73-1.74) / 0.994 / 1.35 (0.84-2.17) / 0.899 / 0.79 (0.5-1.25) / 0.81 / 0.255
SHMT1 / rs643333 / 0.91 (0.75-1.1) / 0.879 / 0.99 (0.78-1.24) / 0.961 / 0.84 (0.4-1.78) / 0.975 / 1.17 (0.62-2.21) / 0.972 / 0.51 (0.27-0.97) / 0.466 / 0.29
SHMT1 / rs8065874 / 1.17 (0.99-1.37) / 0.36 / 1.18 (0.93-1.49) / 0.689 / 1.41 (0.95-2.07) / 0.7 / 1.28 (0.76-2.17) / 0.804 / 0.94 (0.63-1.41) / 0.873 / 0.327
SHMT1 / rs9901160 / 1.14 (0.94-1.4) / 0.723 / 1.05 (0.78-1.42) / 0.991 / 1.5 (0.93-2.42) / 0.658 / 1.62 (0.89-2.97) / 0.657 / 0.83 (0.52-1.34) / 0.809 / 0.333
SHMT1 / rs1979277 / 0.97 (0.81-1.15) / 0.981 / 1 (0.8-1.24) / 0.992 / 1.03 (0.7-1.52) / 0.986 / 1.11 (0.63-1.95) / 0.934 / 0.52 (0.28-0.96) / 0.416 / 0.339
SHMT1 / rs2273026 / 0.99 (0.78-1.26) / 0.954 / 1.14 (0.81-1.6) / 0.959 / 0.87 (0.47-1.6) / 0.843 / 1.05 (0.54-2.01) / 0.923 / 1 (0.55-1.83) / 0.949 / 0.352
SHMT1 / rs2273027 / 0.95 (0.81-1.11) / 0.944 / 0.89 (0.72-1.1) / 0.749 / 0.98 (0.67-1.43) / 0.995 / 1.35 (0.86-2.11) / 0.716 / 0.87 (0.59-1.3) / 0.914 / 0.37
SHMT1 / rs4925172 / 0.98 (0.82-1.16) / 0.992 / 1.02 (0.8-1.29) / 0.985 / 0.86 (0.56-1.32) / 0.984 / 1.32 (0.69-2.55) / 0.804 / 0.63 (0.35-1.14) / 0.637 / 0.471
SHMT1 / rs3783 / 0.94 (0.79-1.14) / 0.939 / 0.96 (0.77-1.21) / 0.99 / 1.07 (0.67-1.71) / 0.976 / 1.14 (0.62-2.12) / 0.985 / 0.57 (0.29-1.11) / 0.779 / 0.565
SLC19A1 / rs2838951 / 0.78 (0.67-0.92) / 0.02 / 0.7 (0.57-0.88) / 0.009 / 1.28 (0.85-1.92) / 0.97 / 0.97 (0.58-1.62) / 0.998 / 0.71 (0.46-1.09) / 0.64 / 0.083
SLC19A1 / rs2838958 / 0.79 (0.68-0.93) / 0.024 / 0.73 (0.59-0.91) / 0.022 / 1.3 (0.85-1.98) / 0.846 / 0.85 (0.51-1.42) / 0.999 / 0.75 (0.49-1.15) / 0.912 / 0.128
SLC19A1 / rs2236484 / 1.26 (1.08-1.47) / 0.025 / 1.44 (1.16-1.79) / 0.005 / 0.9 (0.63-1.28) / 0.995 / 0.92 (0.57-1.49) / 0.997 / 1.39 (0.91-2.13) / 0.904 / 0.138
SLC19A1 / rs12482346 / 1.24 (1.06-1.44) / 0.041 / 1.42 (1.15-1.76) / 0.007 / 0.88 (0.61-1.26) / 0.993 / 1.06 (0.66-1.71) / 0.961 / 1.19 (0.79-1.8) / 1 / 0.231
SLC19A1 / rs12483377 / 1.13 (0.82-1.57) / 0.643 / 1.14 (0.77-1.68) / 0.657 / 2.44 (0.81-7.39) / 0.185 / 1.66 (0.5-5.52) / 0.943 / 0.42 (0.12-1.43) / 0.769 / 0.253
SLC19A1 / rs7499 / 1.22 (1.04-1.42) / 0.067 / 1.38 (1.11-1.71) / 0.014 / 0.92 (0.64-1.32) / 0.996 / 1 (0.62-1.6) / 1 / 1.21 (0.79-1.86) / 1 / 0.346
SLC19A1 / rs3827266 / 1.16 (0.99-1.36) / 0.186 / 1.14 (0.91-1.43) / 0.482 / 1.58 (1.07-2.32) / 0.142 / 0.93 (0.54-1.6) / 1 / 1.01 (0.67-1.53) / 0.999 / 0.349
SLC19A1 / rs3788205 / 0.82 (0.68-0.98) / 0.113 / 0.77 (0.61-0.98) / 0.089 / 1.21 (0.55-2.65) / 0.995 / 0.99 (0.56-1.74) / 0.999 / 0.74 (0.45-1.2) / 0.945 / 0.438
SLC19A1 / rs3939250 / 0.8 (0.66-0.96) / 0.077 / 0.75 (0.58-0.96) / 0.089 / 1.02 (0.47-2.24) / 0.992 / 0.97 (0.55-1.72) / 0.995 / 0.72 (0.44-1.18) / 0.824 / 0.495
SLC19A1 / rs1051266 / 1.24 (1.06-1.44) / 0.041 / 1.34 (1.08-1.65) / 0.031 / 0.98 (0.68-1.41) / 0.998 / 1.14 (0.71-1.82) / 0.999 / 1.19 (0.79-1.77) / 0.98 / 0.679
SLC19A1 / rs2297291 / 1.22 (1.04-1.42) / 0.068 / 1.27 (1.03-1.57) / 0.095 / 1 (0.68-1.46) / 0.917 / 1.11 (0.69-1.78) / 0.999 / 1.22 (0.81-1.84) / 1 / 0.748
SLC19A1 / rs17004785 / 0.97 (0.76-1.25) / 0.823 / 0.98 (0.69-1.38) / 0.907 / 0.85 (0.46-1.54) / 0.993 / 1.19 (0.58-2.42) / 0.981 / 0.96 (0.48-1.92) / 0.956 / 0.973
TYMS / rs2790 / 0.94 (0.79-1.13) / 0.998 / 0.97 (0.75-1.25) / 1 / 1.08 (0.68-1.72) / 0.985 / 1.56 (0.9-2.68) / 0.741 / 0.64 (0.4-1) / 0.366 / 0.101
TYMS / rs11664283 / 1.03 (0.88-1.21) / 1 / 1.08 (0.87-1.36) / 0.992 / 1.03 (0.7-1.51) / 0.954 / 0.49 (0.27-0.9) / 0.176 / 1.33 (0.83-2.13) / 0.88 / 0.106
TYMS / rs2298581 / 0.95 (0.8-1.14) / 0.999 / 0.99 (0.77-1.27) / 0.965 / 1.15 (0.72-1.84) / 0.976 / 1.45 (0.84-2.49) / 0.856 / 0.64 (0.41-1.01) / 0.39 / 0.128
TYMS / rs2298583 / 1 (0.85-1.18) / 0.996 / 1.02 (0.82-1.28) / 1 / 1.25 (0.86-1.82) / 0.882 / 1.16 (0.7-1.94) / 0.982 / 0.7 (0.44-1.1) / 0.554 / 0.225
TYMS / rs2853533 / 0.98 (0.82-1.17) / 1 / 1.03 (0.77-1.37) / 0.999 / 0.69 (0.45-1.07) / 0.642 / 1.7 (0.9-3.19) / 0.31 / 0.92 (0.62-1.36) / 0.714 / 0.225
TYMS / rs10502290 / 1 (0.85-1.17) / 0.976 / 1.03 (0.82-1.29) / 1 / 1.25 (0.85-1.83) / 0.883 / 1.13 (0.68-1.88) / 0.969 / 0.7 (0.44-1.11) / 0.514 / 0.236
TYMS / rs495139 / 1.09 (0.93-1.29) / 0.95 / 1.02 (0.82-1.26) / 1 / 1.32 (0.85-2.05) / 0.916 / 1.39 (0.85-2.29) / 0.729 / 1.26 (0.81-1.97) / 0.887 / 0.301
TYMS / rs7237052 / 0.98 (0.84-1.15) / 1 / 0.86 (0.69-1.07) / 0.805 / 0.98 (0.65-1.48) / 0.982 / 0.91 (0.56-1.46) / 0.997 / 1.41 (0.93-2.14) / 0.951 / 0.316
TYMS / rs502396 / 0.96 (0.82-1.12) / 0.999 / 1.01 (0.82-1.24) / 1 / 0.75 (0.5-1.13) / 0.901 / 1.08 (0.69-1.7) / 0.928 / 1.1 (0.71-1.69) / 0.87 / 0.384
TYMS / rs1001761 / 1 (0.85-1.16) / 0.999 / 1 (0.81-1.23) / 0.996 / 1.12 (0.71-1.77) / 0.979 / 1.12 (0.7-1.79) / 0.926 / 1.12 (0.73-1.72) / 0.874 / 0.455
TYMS / rs2853741 / 0.99 (0.84-1.16) / 0.999 / 1.04 (0.83-1.3) / 1 / 0.84 (0.56-1.24) / 0.992 / 1.38 (0.83-2.28) / 0.796 / 0.83 (0.55-1.25) / 0.673 / 0.491
TYMS / rs2298582 / 1.06 (0.81-1.39) / 1 / 1.06 (0.75-1.5) / 1 / 1.39 (0.66-2.91) / 0.959 / 0.53 (0.21-1.37) / 0.512 / 1.4 (0.62-3.18) / 0.922 / 0.533
TYMS / rs2260821 / 1.03 (0.86-1.22) / 1 / 1.02 (0.8-1.3) / 1 / 1.11 (0.65-1.9) / 0.989 / 0.97 (0.58-1.6) / 0.996 / 1.32 (0.85-2.05) / 0.941 / 0.554
TYMS / rs2612101 / 0.92 (0.77-1.11) / 0.987 / 0.97 (0.75-1.25) / 1 / 0.89 (0.6-1.31) / 0.985 / 0.84 (0.49-1.43) / 0.996 / 0.71 (0.4-1.26) / 0.96 / 0.629
TYMS / rs9948583 / 1.01 (0.87-1.19) / 1 / 1.05 (0.84-1.31) / 1 / 0.86 (0.59-1.26) / 0.986 / 0.88 (0.53-1.44) / 0.926 / 1 (0.67-1.49) / 0.94 / 0.673
TYMS / rs3744962 / 0.81 (0.62-1.06) / 0.717 / 0.76 (0.52-1.11) / 0.782 / 1.68 (0.54-5.25) / 0.883 / 0.85 (0.45-1.6) / 0.999 / 0.72 (0.38-1.37) / 0.948 / 0.699
TYMS / rs1059394 / 0.97 (0.83-1.13) / 1 / 0.98 (0.78-1.22) / 1 / 0.84 (0.57-1.23) / 0.975 / 0.86 (0.53-1.41) / 0.908 / 0.99 (0.66-1.48) / 0.931 / 0.701
TYMS / rs9966612 / 0.81 (0.68-0.95) / 0.135 / 0.74 (0.58-0.93) / 0.108 / 0.98 (0.63-1.51) / 0.905 / 0.74 (0.45-1.21) / 0.838 / 0.98 (0.62-1.54) / 0.817 / 0.706
TYMS / rs699517 / 0.98 (0.84-1.15) / 1 / 0.98 (0.79-1.23) / 1 / 0.85 (0.58-1.24) / 0.984 / 0.92 (0.56-1.5) / 0.976 / 0.99 (0.66-1.49) / 0.946 / 0.811
aIncludes 61 individuals who characterized their race/ethnicity as ‘other.’
bNon-Hispanic white
cOdds ratios (OR) and 95% confidence limits estimated assuming a log additive(per allele) model by unconditional logistic regression controlling for the matching factors (age, sex, clinic and examination date) and study phase. The total population OR’s are also adjusted for race/ethnicity.
dAdjusted for multiple testing taking into account correlated tagSNPs using a modified test of Conneely and Boehnke [26].
eOR’s and 95% confidence limitsfor MTHFR rs1801131 and rs1801133 estimated assuming a recessive model controlling for the matching factors (age, sex, clinic and examination date)and study phase. The total population OR’s are also adjusted for race/ethnicity.
Supplemental Table 3 Interactions between SNPs in selected genesa and the MTHFR C 677T genotype
Gene / SNP / MTHFR 677 Genotype / Sample sizes by number of minor alleles(0/1/2) / OR (95% CI)b / P-interaction
SLC19A1 / rs1051256 / CC+CT Cases
Controls / 136/269/151
185/286/117 / 1.33 (1.21, 1.56) / 0.02
TT Cases
Controls / 21/33/14
18/37/22 / 0.74 (0.47, 1.17)
SLC19A1 / rs17004785 / CC+CT Cases
Controls / 441/115/3
451/133/5 / 0.88 (0.68, 1.15) / 0.01
TT Cases
Controls / 48/18/1
65/10/0 / 2.64 (1.15, 6.06)
SLC19A1 / rs2297291 / CC+CT Cases
Controls / 149/275/126
199/285/98 / 1.3 (1.1, 1.54) / <0.01
TT Cases
Controls / 25/34/9
21/35/20 / 0.64 (0.4, 1.02)
SLC19A1 / rs3788205 / CC+CT Cases
Controls / 340/189/25
309/235/41 / 0.73 (0.6, 0.89) / 0.01
TT Cases
Controls / 35/27/6
48/26/3 / 1.52 (0.88, 2.62)
SLC19A1 / 3939250 / CC+CT Cases
Controls / 348/181/19
316/226/35 / 0.78 (0.58, 0.87) / 0.01
TT Cases
Controls / 37/26/5
51/22/3 / 1.57 (0.9, 2.74)
SLC19A1 / 3827266 / CC+CT Cases
Controls / 227/252/74
278/249/54 / 1.28 (1.07, 1.52) / 0.01
TT Cases
Controls / 39/21/7
34/30/13 / 0.67 (0.41, 1.07)
MTR / rs1252252 / CC+CT Cases
Controls / 280/225/53
292/227/66 / 0.96 (0.8, 1.16) / 0.02
TT Cases
Controls / 33/27/8
23/33/18 / 0.53 (0.33, 0.86)
MTR / rs4659730 / CC+CT Cases
Controls / 402/142/9
421/153/7 / 1.01 (0.79, 1.29) / 0.02
TT Cases
Controls / 43/22/3
62/14/1 / 2.3 (1.17, 4.54)
MTR / rs6676866 / CC+CT Cases
Controls / 264/233/54
274/234/66 / 1.05 (0.89, 1.25) / 0.02
TT Cases
Controls / 32/27/8
23/36/17 / 0.59 (0.36, 0.95)
MTR / rs2385511 / CC+CT Cases
Controls / 264/233/54
274/234/66 / 0.97 (0.81, 1.16) / 0.03
TT Cases
Controls / 32/27/8
23/36/17 / 0.54 (0.33, 0.88)
MTR / rs3768150 / CC+CT Cases
Controls / 258/243/58
272/251/65 / 1.0 (0.83, 1.2) / 0.03
TT Cases
Controls / 31/28/8
24/35/18 / 0.57 (0.35, 0.92)
MTR / rs10802569 / CC+CT Cases
Controls / 247/249/63
251/258/81 / 0.93 (0.78, 1.1) / 0.03
TT Cases
Controls / 30/30/8
21/38/18 / 0.52 (0.32, 0.86)
MTR / rs12759827 / CC+CT Cases
Controls / 367/163/29
387/172/26 / 1.06 (0.85, 1.31) / 0.01
TT Cases
Controls / 44/21/3
35/33/8 / 0.5 (0.29, 0.88)
MTR / rs10737812 / CC+CT Cases
Controls / 157/277/121
181/287/117 / 1.09 (0.92, 1.29) / 0.02
TT Cases
Controls / 26/31/11
19/37/20 / 0.59 (0.37, 0.95)
MTR / rs12070633 / CC+CT Cases
Controls / 175/268/101
196/265/107 / 1.03 (0.87, 1.22) / 0.05
TT Cases
Controls / 27/27/10
22/33/19 / 0.63 (0.39, 1.01)
TYMS / rs2298582 / CC+CT Cases
Controls / 447/104/3
485/97/2 / 1.19 (0.88, 1.6) / 0.05
TT Cases
Controls / 58/8/1
55/20/0 / 0.5 (0.22, 1.14)
aGenes for which one or more prior studies indicated an interaction between a SNP and the MTHFRC677T genotype.
bOR’s estimated assuming a log additive model (per allele risk) and controlling for age, sex, clinic, examination date, race/ethnicity and study phase.
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