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AHDW/03/04
Application Identifier: Office use only
Registered charity no.210183. 183 Euston Rd, London, NW1 2BE. Tel: +44 (0)20 7611 8888 Fax: +44 (0)20 7611 8545
ANIMAL HEALTH IN THE DEVELOPING WORLD INITIATIVE
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IN CONJUNCTION WITH THIS APPLICATION FORM.
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Animal Health in the Developing World
Wellcome Trust
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London NW1 2BE
UK
Tel: (0)20 7611 8710
Fax: (0)20 7611 7288
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Registered charity no.210183. 183 Euston Rd, London, NW1 2BE. Tel: +44 (0)20 7611 8888 Fax: +44 (0)20 7611 8545
APPLICATION FOR BIOMEDICAL RESEARCH SUPPORT UNDER THE
ANIMAL HEALTH IN THE DEVELOPING WORLD INITIATIVE
(Please read the guidance notes in conjunction with this form)
Q1 Applicants / Principal Applicant / Joint-applicant (1) / Joint-applicant (2)Surname / DE LA ROCQUE / VAN DEN BOSSCHE / ROGERS
Forenames / Stephane / Peter / David John
Title (Professor, Dr, Mrs etc.) / Dr / Dr / Professor
Position / Research Scientist / Research Scientist / Professor of Ecology
Institution / CIRAD-EMVT / ITM / OxfordUniversity
Joint-applicant (3) / Coapplicant (4) / Coapplicant (5)
Surname / SIDIBE / MUBANGA / Matjila
Forenames / Issa / Joseph / Tshepo Paul
Title (Professor, Dr, Mrs etc.) / Dr / Dr / Dr
Position / Research Scientist / Chief Tsetse Biologist / Lecturer
Institution / CIRDES / Ministry of Agriculture / University of Pretoria
Coapplicant (6) / Coapplicant (7) / Coapplicant (8)
Surname / BOUYER / THEVENON / KABORE
Forenames / Jeremy / Sophie / Idrissa
Title (Professor, Dr, Mrs etc.) / Dr / Dr / Mr
Position / Junior Research Scientist / Research Scientist / Research Scientist
Institution / CIRDES / CIRDES / CIRDES
Coapplicant (9) / Coapplicant (10) / Coapplicant (11)
Surname / SIBERT
Forenames / Alexandre
Title (Professor, Dr, Mrs etc.) / Dr
Position / Research Scientist
Institution / CIRAD
Q2 / Name and address of the administering institution(s) (include details of all joint applicants’ institutions)
(maximum of four allowed):
Cirad-emvt: Centre International de Recherche Agronomique pour le Développement, Campus international de Baillarguet, 34398 Montpellier Cedex 5, France-
Prince Leopold Institute of Tropical Medicine, Veterinary Department, Nationalestaat 155, 2000 Antwerpen, Belgique -
University of Oxford, TALA Research Group, Department of Zoology, South Parks Rd., OxfordOX1 3PS, United Kingdom.
Cirdes: Centre International de Recherche-Devloppement sur l’Elevage en zone Sub-humide, BP454, 01 Bobo Dioulasso, Burkina Faso
Q3 / Period for which support is sought (state in months): / 36
Q4 / Proposed start date (dd/mm/yy): / 01-01-2005
Q5 / Title of project (no more than 220 characters):
Environmental changes in Africa and tsetse habitat fragmentation: epidemiological consequences and perspectives for control
Principal applicant: / Stéphane de La Rocque, Cirad-Emvt
Title of project: / Environmental changes in Africa and tsetse habitat fragmentation: epidemiological consequences and perspectives for control
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1.I confirm that I (and all those providing personal information in the application) have read and understood the Wellcome Trust Data Protection Statement above.
2.To the best of my knowledge, the information provided in this application is accurate and complete.
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Signature of Principal Applicant / S. de La Rocque / Date:Signature of Head of Department / E. Camus / Date:
Signature of Joint-applicant (1)
(delete “Joint” or “Co” as appropriate) / P. Van den Bossche / Date:
Signature of Head of Department / P. Dorny / Date:
Signature of Joint-applicant (2) / D. J. Rogers / Date:
Signature of Head of Department / P. Harvey / Date:
Signature of Joint-applicant (3) / I. Sidibe / Date:
Signature of Head of Department / A. Gouro / Date:
Signature of Coapplicant (4) / J. Mubanga / Date:
Signature of Head of Department / P. Sinyangwe / Date:
Signature of Coapplicant (5) / T.P.Matjila / Date:
Signature of Head of Department / J. A. W. Coetzer / Date:
Signature of Coapplicant (6) / J.Bouyer / Date:
Signature of Head of Department / E. Camus / Date:
Signature of Coapplicant (7) / S. Thevenon / Date:
Signature of Head of Department / E. Camus / Date:
Signature of Coapplicant (8) / I. Kabore / Date:
Signature of Head of Department / A. Gouro / Date:
Signature of Coapplicant (9) / A. Sibert / Date:
Signature of Head of Department / E. Camus / Date:
For and on behalf of the Institution(s) of the Principal and Joint Applicants (maximum of 4 Joint Applicants):
Signature of Secretary of Institution/Finance Officer / G. Lacombe / Date:Position: / Finance officer / Institution:Cirad-Emvt
Signature of Secretary of Institution/Finance Officer / J Van Lint / Date:
Position: / Finance officer / Institution:ITM
Signature of Secretary of Institution/Finance Officer / P.M. Espinasse / Date:
Position: / Finance officer / Institution:University of Oxford
Signature of Secretary of Institution/Finance Officer / O. Koné / Date:
Position: / Finance officer / Institution: CIRDES
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AHDW/03/04
Application Identifier: Office use only
Principal ApplicantName: / Stephane de La Rocque
Title: / Dr
Post held: / Head of the Ecology of Vectorial Diseases Unit
Address: / Cirad-emvt, TA30/E, campus international de Baillarguet, 34398 Montpellier, France
Tel: / (33) 4 67 59 37 22
Fax: / (33) 4 67 59 39 18
E-mail: /
Joint-applicant (1)
Name: / Peter Van Den Bossche
Title: / Dr
Post held: / Principal Biologist
Address: / Prince Leopold Institute of Tropical Medicine, Veterinary Department, Nationalestaat 155
2000 Antwerpen, Belgique
Tel: / 32-(0)3-2476396
Fax: / 32-(0)3-2476268
E-mail: /
Joint-applicant (2)
Name: / David John Rogers
Title: / Professor
Post held: / Professor of Ecology
Address: / University of Oxford, TALA Research Group, Department of Zoology, South Parks Rd., OxfordOX1 3PS, United Kingdom.
Tel: / 186521240
Fax: / 1865271240
E-mail: /
Joint-applicant (3)
Name: / Issa Sibibe
Title: / Dr
Post held: / Head of Biological and Integrated Control Unit (URBIO)
Address: / CIRDES, BP 454, 01 Bobo Dioulasso, Burkina Faso.
Tel: / (226) 20 972287
Fax: / (226) 20 972320
E-mail: /
Coapplicant (4) / Coapplicant (5)
Name: / Joseph Mubanga / Name: / Tshepo Matjila
Title: / Dr / Title: / Dr
Post held: / Chief Tsetse Biologist / Post held: / Lecturer
Address: / Dep. of Veterinary and Livestock Development, Ministry of Agriculture and Co-operatives, Zambia / Address: / Departement of Veterinary Tropical Diseases, University of Pretoria, P Bag X04, Onderstepoort, South Africa
Tel: / 260-1-252608 / Tel: / + 27 12 5298384
Fax: / 260-1-253608 / Fax: / + 27 12 529 8312
E-mail: / / E-mail: /
Coapplicant (6) / Coapplicant (7)
Name: / Sophie Thevenon / Name: / Idrissa KABORE
Title: / Dr / Title: / M.
Post held: / Research Scientist / Post held: / Research Scientist
Address: / CIRDES, BP 454, Bobo-Dioulasso, 01 Burkina Faso / Address: / CIRDES, BP 454, Bobo-Dioulasso, 01 Burkina Faso
Tel: / (226) 20 97 22 87 / Tel: / (226) 20 97 22 87
Fax: / (226) 20 97 23 20 / Fax: / (226) 20 97 23 20
E-mail: / / E-mail: /
Coapplicant (8) / Coapplicant (9)
Name: / Jeremy Bouyer / Name:
Title: / Dr / Title:
Post held: / Junior Research Scientist / Post held:
Address: / CIRDES, BP 454, Bobo-Dioulasso, 01 Burkina Faso / Address:
Tel: / (226) 20 97 22 87 / Tel:
Fax: / (226) 20 97 23 20 / Fax:
E-mail: / / E-mail:
Q6 Summaries of proposed research (no more than 400 words for each).
(a) / For scientifically qualified assessors:The epidemiology of tsetse-transmitted human or livestock trypanosomiasis is to a large extend determined by tsetse density, infection rate and host preference. All three contributing factors vary between tsetse populations and within a tsetse population may,often due to differences in the well-being of the tsetse population, vary in time and space. A major factor, contributing to tsetse population stress is human encroachment and concomitant fragmentation of tsetse habitat as a result of the introduction and expansion of mixed farming systems. Understanding the impact of habitat fragmentation on the tsetse population may contribute to the development of more effective control strategies.
Riparian and savannah tsetse species play the major role in disease transmission. Therefore, the project will identify study areas in West and southern Africa, where each group is predominant. In those study areas, the fragmentation of riparian vegetation and savannah woodland will be quantified and qualified using environmental and remotely sensed data. Study sites with different degrees of fragmentation will be identified and the tsetse and livestock populations will be monitored. Special attention will go to parameters that can be used to develop population dynamics and disease transmission models. The models will be used to determine (i) the well-being, dynamics and vulnerability of tsetse sub-populations in fragmented habitats, and (ii) the infection rate of hosts and vectors and the related disease transmission risk. Furthermore, analyses of genetic diversity and gene flow between tsetse populations in habitat fragments will make it possible to determine the effect of different levels of fragmentation on the tsetse’s dispersal capacity. This may result in the identification of isolated tsetse populations. Using the findings of the field studies various control approaches will be tested and their appropriateness assessed.
The outcomes of the study will be translated into practical guidelines that will facilitate the selection of priority areas for control and the most appropriate control method(s). The guidelines will be transferred to the beneficiaries.
(b) / For readers who are not scientifically qualified:
The encroachment of people and their livestock has significant impact on the environment and land-use in Africa. One of the consequences of this encroachment is the change in the distribution and occurrence of some diseases, mainly those transmitted by arthropods. Insect like tsetse flies are dependant on suitable habitats and the availability of feeding hosts. Changes in the tsetse’s environment are thus likely to result in variable levels of stress in the tsetse populations, changes in the dynamics of the populations and in some situation their local extinction. Indeed, recent studies have proven that in areas subject to human encroachment, tsetse populations become weakened, more and more fragmented and in some cases isolated. Such vulnerable and isolated populations are ideal priority targets for sustainable vector control even vector removal. However, this can only be exploited when such population can be characterised and identified.
The aim of the proposed project is to provide a description of changes in the distribution and density of tsetse as a result of human encroachment and its repercussions on the epidemiology and control of the disease. Considering the contrasting ecology of savannah and riverine tsetse species, the study will be conducted in two African countries (Zambia and Burkina Faso) representing savannah and riverine habitat. Furthermore, each of the countries is experiencing significant and well-documented changes in land-use. The impact of human encroachment on natural habitats will be assessed by analysing historical records and recent remote sensing data. The effect of thosehabitat changes on the tsetse populations will be assessed through seasonal collections of tsetse from habitats with different degrees of fragmentation. The tsetse samples will be analysed for tsetse density, age-structure (from which mortality rates will be estimated), indicators of ecological stress, parasite infection rates and livestock/tsetse interaction. In addition, the tsetse’s dispersal capacities will be modelled based on evaluation of genetic flow and mathematical tools. The outcomes of the study should facilitatethe mapping of vulnerable tsetse populations, tsetse population isolation probability and the spatial distribution of epidemiological challenge. Those outcomes will be exploited and incorporated in guidelines for improved trypanosomiasis control.
The Trust may wish to put details of recently awarded grants on to its website. If your application
is successful, would you be willing for details of the award to be used in this way? / YES / X / NO
Q7 Previous applications to the Wellcome Trust
This page may be duplicated for each principal, joint and coapplicant.
Applicant’s name: / Stephane DE LA ROCQUEIs this the Applicant’s first application to the Wellcome Trust / YES / X / NO
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
Q8 Details of other current grants held by applicant(s)
State name of awarding body, title of project, amount awarded, start and end dates of support, for all current grants, indicate the proportion of time spent on each project.
Principal Applicant-General Coordinator of EDEN (Emerging Diseases in a Changing European Environment) Integrated Project, EU, 6th PCRDT, Juny 2004-Nov. 2009. Time spend: 50%
-ACI (action Incitative Ciblée) of the French Ministry of Research: Bluetongue ecology in the ecosystems of Corsica. 80000 euros. Time spend : 10%
Applicant’s name: / Peter VAN DEN BOSSCHE
Is this the Applicant’s first application to the Wellcome Trust / YES / X / NO
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
Q8 Details of other current grants held by applicant(s)
State name of awarding body, title of project, amount awarded, start and end dates of support, for all current grants, indicate the proportion of time spent on each project.
Joint-ApplicantDGOS (Directorate General of Development Co-operation). The provision of Animal Health Care to African smallholders. € 100000. September 2000 – January 2003.
FWO (Foundation for Scientific Research). Genetic diversity in Trypanosoma congolense populations. € 20000. January 2002 - January2005.
IAEA (International Atomic Energy Agency). Investigation into the effect of trypanocidal drugs on tsetse’s vectorial capacity. € 13000. September 2003 – September 2005.
DGOS (Directorate General of Development Co-operation). Development if a decision-support system for a sustainable control of animal diseases in southern Africa. € 100000. January 2003 – January 2005.
Applicant’s name: / David J. ROGERS
Is this the Applicant’s first application to the Wellcome Trust / YES / NO / X
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
- Wellcome Showcase Award, 2003-2004: Exploring the use of oceanographic analytical techniques for studying disease epidemiology. Total Grant to OxfordUniversity £125,000 over 2 years. 15% time spend
Q8 Details of other current grants held by applicant(s)
State name of awarding body, title of project, amount awarded, start and end dates of support, for all current grants, indicate the proportion of time spent on each project.
Joint-Applicant- HATEL, European Union, 2001-2003, Phillip Mellor/Matthew Baylis IAH, UK: Satellite imagery to map and predict the distribution of Bluetongue virus vectors around the Mediterranean basin.Total Grant (subcontract) to Oxford University/DJR £77,777 over 2 years. 10% time spend.
- NY01, NIAID, 2002 – 2007:Laura Kramer NYSDoH, USA: Habitat identification of West Nile Virus vectors in the NY State.Total Grant (subcontract) to TALA Research/DJR $~100,000 over 5 years. 5% time spend.
- ISU01, NIH, 2002 – 2007, ElliotKrafsurIowaStateUniversity: Relating tsetse genomics and physiology to environmental variables.Total Grant (subcontract) to Oxford University/DJR ~$60,000 over 3 years. 5% time spend.
- BBSRC, 2003-2006, IAH: Assessing the risks of new viral disease arrival in the UK. Total grant (subcontract) to Oxford University/DJR c. £160,000 over 3 years. 10% time spend.
- DEFRA, 2003-2006: Assessing the risk of West Nile Virus to the UK. c £220,000 over 3 years. 10% time spend
Applicant’s name: / Issa SIDIBE
Is this the Applicant’s first application to the Wellcome Trust / YES / X / NO
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
Q8 Details of other current grants held by applicant(s)
State name of awarding body, title of project, amount awarded, start and end dates of support, for all current grants, indicate the proportion of time spent on each project.
Joint-ApplicantGermany (BMZ-GTZ): Improving the management of trypanocidal resistance in the cotton zone of West Africa: a regional study, € 1.1 Mill. (ILRI, FU-Berlin, CIRDES, ITC, Vet. Serv. of Burkina Faso, Mali, Guinea), 2003-2005.- the proportion of time spent on: 15%
EU: Programme concerté de Recherche-Développement sur l'Elevage en Afrique de l'Ouest (PROCORDEL), Projet N° 8 ACP ROC 011 ; convention n° 6157/REG: € 2.8 Mill (for the sub-programme of Low inputs production systems); 2000- mars 2005- the proportion of time spent on: 40%
International Atomic Energy Agency(IAEA): application et validation de la PCR et de la PCR-ELISA pour l’amélioration du diagnostic des trypanosomoses africaines dans les zones à faciès épidémiologiques différents au sud-ouest du Burkina Faso, € 41000; 1999-2005: the proportion of time spent on: 15%
-
Applicant’s name: / Joseph MUBANGA
Is this the Applicant’s first application to the Wellcome Trust / YES / X / NO
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
Q8 Details of other current grants held by applicant(s)
State name of awarding body, title of project, amount awarded, start and end dates of support, for all current grants, indicate the proportion of time spent on each project.
Applicant’s name: / Tshepo MATJILAIs this the Applicant’s first application to the Wellcome Trust / YES / X / NO
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
Q8 Details of other current grants held by applicant(s)
State name of awarding body, title of project, amount awarded, start and end dates of support, for all current grants, indicate the proportion of time spent on each project.
Applicant’s name: / Jeremy BOUYERIs this the Applicant’s first application to the Wellcome Trust / YES / X / NO
If no, please give details of previous approaches over the last 5 years, including publications resulting from Trust support.
Q8 Details of other current grants held by applicant(s)