Supplementary Table 1. HLA class II association and linkage studies for leprosy (1993-present)

Population / Study design / Sample size / Phenotype / Region or variant (serotype, allele or genotype) / lod, OR, P or RRa / Reference
North India / case-control / 93 cases, 47 controls / MB / DRB1*15 / RR = 16.3 / (Rani et al. 1993)
case-control / 93 cases, 47 controls / TT / DRB1*15 / RR = 5.7
North India / case-control / 54 cases, 44 controls / TT / DRB1*15
DRB1*1404 (DR6+)
DRB1*1404 (DR2-)
DRB1*1301 (DR6+) / RR = 4.7
RR = 6.0
RR = 7.1
RR = 0.17 / (Zerva et al. 1996)
Belém, Brazil / linkage / 73 families
(147 sib-pairs) / per se / 6p21.3 (DQB1)
6p21.3 (DQA1)
6p21.3 (DRB1) / lod = 4.978
lod = 4.870
lod = 5.783 / (Shaw et al. 2001)
TDT / 73 families
(147 sib-pairs) / per se / DQB1
DQA1
DRB1 / P = 0.0003
P = 0.018
P = 0.003
TDT / 73 families
(147 sib-pairs) / TT / DQB1
DQA1
DRB1 / P = 0.001
P = 0.002
P = 0.002
(Table 1 continued)
Turkey / case-control / 80 cases, 120 controls / per se / DQ1
DQ3
DR10
DRw52 / OR = 2.769
OR = 2.727
OR = 0.937
OR = 0.886 / (Kocak et al. 2002)
Tamil Nadu, India / TDT (association and/or linkage)b / 223 families (230 affected sib-pairs) / PB / DRB1*15
DRB1*09 / P = 0.012
P = 0.004 / (Tosh et al. 2006)
TDT / 223 single-case families / PB / DRB1*09 / P = 0.016
Rio de Janeiro, Brazil / case-control / 578 cases, 691 controls / per se / DRB1*10
DRB1*15
DRB1*04
DRB1*07
DRB1*12 / P = 0.02102
P = 0.02288
P = 0.04076
P = 0.04753
P = 0.04399 / (Vanderborght et al. 2007)
Rio de Janeiro, Brazil (Euro-Brazilian) / case-control / N/A / per se / DRB1*04/NNc
DRB1*07/NNc / OR = 0.51
OR = 0.53
Rio de Janeiro, Brazil (Afro-Brazilian) / case-control / N/A / per se / DRB1*10/NNc
DRB1*15/NNc / OR = 3.21
OR = 2.72
Ho Chi Minh City, Vietnam / TDT / 194 single-case families / per se / DRB1*10
DRB1*04 / OR = 2.03
OR = 0.48
Rosario city, Argentina / case-control / 71 cases, 81 controls / per se / DRB1*1401
DRB1*1406
DRB1*0808
DRB1*1103 / OR = 16.22
OR = 16.22
OR = 0.1022
OR = 0.0959 / (Borras et al. 2008)
(Table 1 continued)
Paraná, Brazil / case-control / 169 cases, 217 controls / per se / DRB1*16
DQA1*05
DQA1*02
DQA1*04 / OR = 2.52
OR = 1.61
OR = 0.39
OR = 0.42 / (da Silva et al. 2009)
case-control / 63 cases, 217 controls / LL / DRB1*1602
DQA1*05
DQB1*02
DRB1*04
DQA1*03 / OR = 4.29
OR = 2.38
OR = 2.59
OR = 0.31
OR = 0.25
case-control / 44 cases, 217 controls / BL / DRB1*09
DRB1*1601
DQA1*04 / OR = 4.74
OR = 5.81
OR = 0.15
case-control / 45 cases, 217 controls / TT / DRB1*1602
DQA1*05
DQA1*02 / OR = 4.14
OR = 3.85
OR = 0.23
case-control / 63 LL cases, 43 TT cases / LL / DRB1*08
DRB1*04 / OR = 12.0
OR = 0.20
Chinese Han, China / case-control / 305 cases, 527 controls / per se / DRB1*15
DRB1*09 / P = 0.002
P < 0.001 / (Zhang et al. 2009)
case-control / 141 early-onset cases, 527 controls / per se (early-onset) / DRB1*09 / P = 0.003

alod = lod score; OR = odds ratio; RR = relative risk

bwhen all affected siblings are included in theanalysis, TDT is a test for association and/or linkage (Tosh et al. 2006)

cNN = all not significantly different alleles collapsed into a unique group (i.e., DRB1*04, 07, 10, 12 and 15)(Vanderborght et al. 2007)