Caffeine
Concentration (ng/mL) as function of time after injection
Blood / Bile / VH
0.5h / Rabbit 16 / 13911 / 5821 / 5931
Rabbit 17 / 18796 / 10967 / 6851
Rabbit 18 / 11970 / 9780 / 6503
Rabbit 19 / 13616 / 13458 / 6101
Rabbit 20 / 18205 / 8621 / 5702
Median / 13911 / 9780 / 6101
1h / Rabbit 11 / 12514 / 9093 / 3626
Rabbit 12 / 11033 / 7803 / 8262
Rabbit 13 / 11391 / 8979 / 7231
Rabbit 14 / 12686 / AP / 5933
Rabbit 15 / 12439 / 25573 / 7438
Median / 12439 / 9036 / 7231
2h / Rabbit 21 / 11565 / 11252 / 9638
Rabbit 22 / 12182 / 16823 / 10275
Rabbit 23 / 12926 / 38296 / 10308
Rabbit 24 / 13969 / 8753 / 9731
Rabbit 25 / 11787 / 11525 / 7736
Median / 12182 / 1125 / 9731
4h / Rabbit 1 / 11411 / 8265 / 9065
Rabbit 2 / 9148 / 3467 / 8900
Rabbit 3 / 8138 / 609 / 2662
Rabbit 4 / 10618 / 8826 / 9531
Rabbit 5 / 10236 / 9627 / 7427
Median / 10236 / 8265 / 8900
7h / Rabbit 6 / 6118 / 4662 / 5411
Rabbit 7 / 3314 / 1413 / 4369
Rabbit 8 / 4716 / 1007 / 6000
Rabbit 9 / 6459 / 5588 / 6603
Rabbit 10 / 4151 / 9216 / 5797
Median / 4716 / 4662 / 5797
17h / Rabbit 26 / 1568 / AP / 2375
Rabbit 27 / 88 / AP / 296
Rabbit 28 / 2368 / 2560 / 2402
Rabbit 29 / 1123 / 746 / 1527
Rabbit 30 / 1381 / 2601 / 2778
Median / 1381 / 2560 / 2375

AP: AnalyticalProblem

Citalopram
Concentration (ng/mL) as function of time after injection
Blood / Bile / VH
2h / Rabbit 11 / 158 / 4285 / 122
Rabbit 12 / 230 / 2691 / 44
Rabbit 13 / 142 / 2715 / 50
Rabbit 14 / 187 / 2812 / 65
Rabbit 15 / 127 / 3688 / 49
Median / 158 / 2812 / 50
4h / Rabbit 16 / 76 / 3028 / 34
Rabbit 18 / 104 / 4971 / 29
Rabbit 19 / 80 / 2501 / 38
Rabbit 20 / 71 / 3063 / 35
Median / 78 / 3046 / 34
7h / Rabbit 21 / 30 / 3991 / 10
Rabbit 23 / 24 / 913 / 13
Rabbit 24 / 25 / 3542 / 28
Rabbit 25 / 16 / 3183 / 7.7
Median / 25 / 3362 / 12
17h / Rabbit 6 / 2.7 / 1525 / 4.8
Rabbit 7 / <LLOQ / 1050 / 4.1
Rabbit 8 / 3.5 / 2652 / 4.5
Rabbit 9 / 3.8 / 1955 / 2.8
Rabbit 10 / 3.4 / 3737 / 4.4
Median / 3.5 / 1955 / 4.4
32h / Rabbit 1 / <LLOQ / 1315 / <LLOQ
Rabbit 2 / 8.5 / NA / <LLOQ
Rabbit 3 / <LLOQ / 380 / <LLOQ
Rabbit 4 / <LLOQ / 1308 / <LLOQ
Rabbit 5 / <LLOQ / 13.5 / <LLOQ
Median / 2.35 / 844 / -

NA: Not Available

LLOQ: Concentration inferior to 2.5 ng/mL

Cyamemazine
Concentration (ng/mL) as function of time after injection
Blood / Bile / VH
0.5h / Rabbit 16 / 731 / 1234 / 139
Rabbit 17 / 967 / 2513 / 44
Rabbit 18 / 507 / 1964 / 73
Rabbit 19 / 464 / 3983 / 35
Rabbit 20 / 1072 / 1949 / 33
Median / 731 / 1964 / 44
1h / Rabbit 11 / 470 / 4340 / 96
Rabbit 12 / 458 / 1953 / 64
Rabbit 13 / 705 / 5855 / 65
Rabbit 14 / 312 / 3182 / 45
Rabbit 15 / 590 / 2021 / 63
Median / 470 / 3182 / 64
2h / Rabbit 21 / 144 / 4279 / 45
Rabbit 22 / 192 / 7186 / 33
Rabbit 23 / 339 / 5903 / 42
Rabbit 24 / 336 / 2008 / 33
Rabbit 25 / 209 / 2818 / 47
Median / 209 / 4279 / 42
4h / Rabbit 1 / 140 / 4565 / 36
Rabbit 2 / 205 / 2523 / 29
Rabbit 3 / 70 / 2898 / 37
Rabbit 4 / 43 / 14719 / 48
Rabbit 5 / 145 / 12564 / 46
Median / 140 / 4565 / 37
7h / Rabbit 6 / 68 / 4703 / 17
Rabbit 7 / 63 / 2285 / 13
Rabbit 8 / 57 / 737 / 19
Rabbit 9 / 66 / 2518 / 18
Rabbit 10 / 89 / 6925 / 24
Median / 66 / 2518 / 18
17h / Rabbit 26 / 23 / NA / 6.4
Rabbit 27 / 16 / 3812 / 9.7
Rabbit 28 / 20 / 2119 / 5.2
Rabbit 29 / 19 / 2400 / 7.7
Rabbit 30 / 13 / 2896 / 2.2
Median / 19 / 2648 / 6.4

NA: Not Available

Diazepam
Concentration (ng/mL) as function of time after injection
Blood / Bile / VH
2h / Rabbit 11 / 102 / 440 / 21
Rabbit 12 / 91 / 262 / 13
Rabbit 13 / 83 / 380 / 10
Rabbit 14 / 92 / 536 / 17
Rabbit 15 / 98 / 598 / 13
Median / 92 / 440 / 13
4h / Rabbit 16 / 95 / 402 / 10
Rabbit 18 / 34 / 363 / 6.8
Rabbit 19 / 71 / 374 / 12
Rabbit 20 / 43 / 276 / 7.7
Median / 57 / 368 / 9.0
7h / Rabbit 21 / 14 / 167 / 4.7
Rabbit 23 / 24 / 65 / 6.1
Rabbit 24 / 58 / 437 / 14
Rabbit 25 / 52 / 493 / 8.4
Median / 38 / 302 / 7.3
17h / Rabbit 6 / 2.1 / 60 / 3.9
Rabbit 7 / <LLOQ / 32 / 3.4
Rabbit 8 / 2.1 / 84 / 3.6
Rabbit 9 / 2.7 / 81 / 3.4
Rabbit 10 / 5.3 / 176 / 4.6
Median / 2.4 / 81 / 3.6
32h / Rabbit 1 / <LLOQ / 32 / 3.8
Rabbit 2 / <LLOQ / NA / 3.4
Rabbit 3 / <LLOQ / 22 / 2.8
Rabbit 4 / <LLOQ / 46 / 3.3
Rabbit 5 / <LLOQ / <LLOQ / 3.0
Median / - / 27 / 3.3

NA: Not Available

LLOQ: Concentration inferior to 2.0 ng/mL

Meprobamate
Concentration (ng/mL) as function of time after injection
Blood / Bile / VH
0.5h / Rabbit 16 / 20781 / 16223 / 11812
Rabbit 17 / 27899 / 30889 / 14016
Rabbit 18 / 17297 / 28621 / 13726
Rabbit 19 / 19912 / 38916 / 12288
Rabbit 20 / 26504 / 30983 / 11373
Median / 20781 / 30889 / 12288
1h / Rabbit 11 / 19437 / 34722 / 11371
Rabbit 12 / 15871 / 31528 / 15154
Rabbit 13 / 17636 / 39372 / 13102
Rabbit 14 / 18784 / AP / 9639
Rabbit 15 / 19171 / 46421 / 13460
Median / 18784 / 37047 / 13102
2h / Rabbit 21 / 16966 / 38817 / 6763
Rabbit 22 / 14463 / 49417 / 6616
Rabbit 23 / 16586 / 83507 / 6871
Rabbit 24 / 19497 / 50912 / 6487
Rabbit 25 / 16024 / 32341 / 5142
Median / 16586 / 49417 / 6616
4h / Rabbit 1 / 14331 / 38099 / 9002
Rabbit 2 / 10064 / 24315 / 8200
Rabbit 3 / 10639 / 26861 / 2994
Rabbit 4 / 8751 / 32427 / 7905
Rabbit 5 / 11753 / 44413 / 7101
Median / 10639 / 32427 / 7905
7h / Rabbit 6 / 6024 / 21054 / 3016
Rabbit 7 / 5162 / 22402 / 3413
Rabbit 8 / 2817 / 6326 / 2610
Rabbit 9 / 5847 / 19943 / 3548
Rabbit 10 / 5263 / 40368 / 4241
Median / 5263 / 21054 / 3413
17h / Rabbit 26 / 400 / AP / 758
Rabbit 27 / 221 / 2541 / 662
Rabbit 28 / 253 / 1158 / 568
Rabbit 29 / 285 / 1655 / 521
Rabbit 30 / 284 / 1598 / 454
Median / 284 / 1627 / 568

AP: AnalyticalProblem

Morphine
Concentration (ng/mL) as function of time after injection
Blood / Bile / VH
0.5h / Rabbit 16 / 87 / 165 / 35
Rabbit 17 / 116 / 341 / 38
Rabbit 18 / 145 / 452 / 32
Rabbit 19 / 65 / 411 / 27
Rabbit 20 / 106 / 439 / 25
Median / 106 / 411 / 32
1h / Rabbit 11 / 52 / 683 / 18
Rabbit 12 / 56 / 584 / 37
Rabbit 13 / 30 / 652 / 23
Rabbit 14 / 59 / 340 / 26
Rabbit 15 / 61 / 178 / 33
Median / 56 / 584 / 26
2h / Rabbit 21 / 5.0 / 301 / 16
Rabbit 22 / 11 / 877 / 28
Rabbit 23 / 26 / 581 / 19
Rabbit 24 / 16 / 465 / 21
Rabbit 25 / 15 / 276 / 13
Median / 16 / 465 / 19
4h / Rabbit 1 / 4.5 / 467 / 18
Rabbit 2 / 7.1 / 173 / 26
Rabbit 3 / 4.7 / 369 / 14
Rabbit 4 / 5.5 / 1537 / 19
Rabbit 5 / 5.4 / 1185 / 17
Median / 5.4 / 467 / 18
7h / Rabbit 6 / <LLOQ / 495 / 3.1
Rabbit 7 / <LLOQ / 186 / 3.5
Rabbit 8 / <LLOQ / 99 / 2.7
Rabbit 9 / <LLOQ / 173 / 2.8
Rabbit 10 / 1.5 / 454 / 4.2
Median / - / 186 / 3.1
17h / Rabbit 26 / 1.5 / NA / <LLOQ
Rabbit 27 / <LLOQ / 174 / <LLOQ
Rabbit 28 / <LLOQ / 73 / <LLOQ
Rabbit 29 / <LLOQ / 132 / <LLOQ
Rabbit 30 / <LLOQ / 200 / <LLOQ
Median / - / 153 / -

NA: Not Available

LLOQ: Concentration inferior to 1.25 ng/mL

Correlation curve between blood and VH caffeine concentrations, (a) in humans (n=23), (b) in rabbit (median n=18), and between blood and bile caffeine concentrations, (c) in humans (n=23), (d) in rabbit (median, n=18),  Median values for rabbits sacrificed at a given time points

Correlation curve between blood and VH citalopram concentrations, (a) in humans (n=23), (b) in rabbit (median n=18), and between blood and bile citalopram concentrations, (c) in humans (n=23), (d) in rabbit (median, n=18),  Median values for rabbits sacrificed at a given time points

Correlation curve between blood and VH cyamemazine concentrations, (a) in humans (n=23), (b) in rabbit (median n=18), and between blood and bile cyamemazine concentrations, (c) in humans (n=23), (d) in rabbit (median, n=18),  Median values for rabbits sacrificed at a given time points

Correlation curve between blood and VH meprobamate concentrations, (a) in humans (n=23), (b) in rabbit (median n=18), and between blood and bile meprobamate concentrations, (c) in humans (n=23), (d) in rabbit (median, n=18),  Median values for rabbits sacrificed at a given time points

Correlation curve between blood and VH morphine concentrations, (a) in humans (n=23), (b) in rabbit (median n=18), and between blood and bile morphine concentrations, (c) in humans (n=23), (d) in rabbit (median, n=18),  Median values for rabbits sacrificed at a given time points