SCIENTIFIC PROGRAM

FOR THE 21ST INTERNATIONAL CHARLES HEIDELBERGER SYMPOSIUM ON CANCER RESEARCH

Wednesday, May 25, 2016

Introductory Session: Chairmen: Dr. Lyudmilla Gulyaeva, Novosibirsk State University, Novosibirsk, Russia, and Dr. Sergei Kovalenko, Novosibirsk, Institute of Biophysics and Molecular Biology, Novosibirsk, Russia.

8:30 – 8:40 A. M. Dr. Lyudmila Gulyaeva, Conference Chair: Introductory Remarks.

8:40 – 8:50 A. M. Dr. Sergei Kovalenko

8:50 – 9:10 A. M. Introduction of Important Officials of Hosting University

9:10 – 9:25 A. M. Dr. Eliezer Huberman -Introduction to the First Charles Heidelber- ger Symposium on Cancer Research

9:25 – 9:45 A. M. Dr. Joseph R. Landolph, Jr.-Introduction to the Career of Dr. Charles

Heidelberger, the Charles and Patricia

Heidelberger Foundation for Cancer Re-

search, and Continuing Heidelberger

Symposia on Cancer Research

9:45 A. M. – 10:15 A. M. Coffee Break

Session I: Cancer Cause and Prevention; Chairman: Dr. Xiao Nong Zou, National Cancer Center and Cancer Institute of CAMS, Beijing, The People’s Republic of China, and Dr. David Zaridze, Blokhin Russian Cancer Research Centre, Moscow, Russia

10:20 A. M. – 10:50 A. M.Dr. David Zaridze, Blokhin Russian Cancer Research

Centre, Moscow, Russia: “Epidemiology and Prevention of Cancer”

10:50 A. M. – 11:20 A. M. Dr. Xiao Nong Zou, National Cancer Center, Cancer Insti-

tute of CAMS, Beijing, People’s Republic of China: “In-

creased Lung cancer Mortality Rate in the Chinese Populat-

ion from l973-l975 to 2004-20045: An Adverse Health

Effect of Exposure to Smoking”.

Plenary Lecture I: Chairman: Dr. Curtis Harris, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U. S. A.

11:20 A. M. – 12:20 P. M. Dr. Sir Colin Berry, University of London, London,

England, United Kingdom: Plenary Lecture I: “Problems

in the Regulatory Evaluation of Potential Carcinogens.”

12:30 P. M. – 2:00 P. M.Lunch

Session II: Molecular Carcinogenesis. Chairmen: Dr. Joseph R. Landolph, Jr.,

University of Southern California, Los Angeles, Calif., U. S. A., and Dr. Max Costa, New York University, Tuxedo, New York, U. S. A.

2:00 P. M. – 2:30 P. M.Dr. Max Costa, School of Medicine, New York University,

Tuxedo, New York: “Arsenic Induces the Highly Carcino- genic Polyadenylation of Canonical Histone mRNA by Down-Regulating Stem-Loop Binding Protein”

2:30 P. M. – 3:00 P. M.Dr. Aage Haugen, Dept. of Toxicology, National Institute

of Occupational Health, Oslo, Norway: “Inflammatory and Epigenetic Regulation in Lung Cancer.”

3:00 P. M. – 3:30 P. M.Dr. Joseph R. Landolph, Jr., USC/Norris Comprehensive

Cancer Center, University of Southern California, Los

Angeles, California, U. S. A. “Insoluble Carcinogenic Nickel Compounds Induce Morphological and Neoplastic Transformation and Global Disruption of Gene Expression in C3H/10T1/2 Mouse Embryo Fibroblasts”.

3:30 P. M. –4:00 P. M.Coffee Break

4:00 P. M. – 4:30 P. M.Dr. Herman Autrup, Aarhus Universitetet, Arhus,

Denmark: “Genotoxicity of Nanomaterials”

4:30 P. M. – 5:00 P. M.Dr. Yoshimi Homma, School of Medicine, Fukushima Uni-

versity, Fukushima, Japan: “Enhanced Metabolic ROS

Production by a Loss of Protein Phosphorylation in Mito-

chondria”

5:00 P. M. – 6:00 P. M.Networking Time and Free Time

6:00 P. M. – 8:00 P. M. Dinner

Thursday, May 26, 2016

Session III: Cancer Biology. Chairmen: Dr. Lyudmila Gulyaeva, Institute of Molecular Biology and Biophysics, Novosibirsk State University, Novosibirsk, Russia, and Dr. Wei Li, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, U. S. A.

8:30 A. M. – 9:00 A. M.Dr. Ping Gao, University of Science and Technology of

China, Heifei University, Heifei, Peoples’ Republic of China: “Regulation of Cancer Metabolic Reprogramming”

9:00 A. M. – 9:30 A. M.Dr. Lyudmila Gulyaeva, Institute of Molecular Biology

and Biophysics and Novosibirsk State University, Novo-

sibirsk, Russia: “Role of MicroRNA in Mechanisms of

Hormonal Carcinogenesis”

9:30 A. M. – 10:00 A. M.Dr. Irina Demidova Moscow Oncological Hospital #62,

Moscow, Russia: “Genetic Disorder in Non-Small Cell

Lung Cancer”

10:00 A. M. – 10:30 A. M. Coffee Break

10:30 A. M. – 11:00 A. M.Dr. Mikhail Krasil’kikov, N. N. Blokhin Russian Cancer

Research Center, Moscow, Russia: “Cell Signaling and the Development of the Resistant Phenotype of Tumor Cells”

11:00 A. M. – 11:30 A. M.Dr. Wei Li, USC/Norris Comprehensive Cancer Center,

Keck School of Medicine, University of Southern Califor-

nia, Los Angeles, California, U. S. A. “The Extra-Cellular

Function and Mechanisms of Action by Heat Shock Pro- tein-90 alpha (HSP90α)”

11:30 A. M. – 12:00 P. M.Dr. Arne Klungland, Center for Molecular Biology and

Neuroscience, BIG CAS-OSLO Genome Research Corpor- ation, and University Hospital, Rikshospitalet, Oslo, Nor-way: “Reversible Modifications in RNA”

12:00 P. M. – 12:30 P. M.Dr. Miwako K. Homma, School of Medicine, Fukushima

Medical University, Fukushima, Japan: “Function of protein kinase CK2 on cell cycle progression”

12:30 P. M. – 2:00 P. M.Lunch

Plenary Lecture 2. Chairman: Dr. Aage Haugen, Dept. of Toxicology, National Institute of Occupational Health, Oslo, Norway

2:00 P. M. – 3:00 P. M.Dr. Curtis Harris, National Cancer Institute, National

Institutes of Health, Bethesda, Maryland, U. S. A. Plenary Lecture 2: “Aging and Cancer”

Session IV: Cancer Diagnostics. Chairmen: Dr. Sergei P. Kovalenko, Institute of

Molecular Biology and Biophysics, Novosibirsk, Russia, and Dr. Sergey Shevchen- ko, Surgical Pathology Unit, Novosibirsk State University, and Head and Neck Surgery Department, Novosibirsk Clinical Hospital No. 1, Novosibirsk, Russia

3:00 P. M. – 3:30 P. M.Dr. Maxim Filipenko, Institute of Chemical Biology and

Fundamental Medicine, Novosibirsk, Russia: “Digitizing

of Onco-markers in Clinical Diagnostics”

3:30 P. M. – 4:00 P. M Coffee Break

4:00 P. M. – 4:30 P. M.Dr. Sergei P. Kovalenko, Institute of Molecular Biology

and Biophysics, Novosibirsk, Russia: “NGS in Hereditary

Cancer Diagnostics”

4:30 P. M. – 5:00 P. M.Dr. Sergey Shevechenko, Surgical Pathology Unit,

Novosibirsk State University, Head and Neck Surgery

Dept.,Novosibirsk Clinical Hospital No. 1, Novosibirsk,

Russia: “Clinical and Molecular-Genetic Approaches to

Diagnostics and Treatment of Thyroid Cancer”

5:00 P. M. – 5:30 P. M. To Be Determined

6:00 P.M. – 8:00 P. M. Dinner

Friday, May 27, 2016

Session V. Neuro-Oncology. Chairman: Dr. Clark Chin-Chung Chen, Division

of Neurosurgery, Dept. of Surgery, University of California at San

Diego, San Diego, U. S. A. and Dr. Mihkail F. Chernov, Dept. of

Neurosurgery, Tokyo Women’s Medical University, Tokyo , Japan

8:30 A. M. – 9:00 A. M. Dr. Marina G. Sergeeva, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia: “Coexpression Network Analysis of Glioma Transcriptome”

9:00 A. M. – 9:30 A. M. Dr. Clark Chin-Chun Chen, Division of Neurosurgery,

Dept. of Surgery, Univ. of California at San Diego, San Diego, California: “Micro-Vesicles as a Platform for Glioma Diagnostic and Therapeutic Development”

9:30 A. M. – 10:00 A. M. Dr. Ian E. McCutcheon, Dept. of Neurosurgery, University

of Texas M. D. Anderson Cancer Center, and Dept of Neurosurgery, Baylor College of Medicine, Houston, Texas: “Rational Clinical Trials of Targeted Kinase Therapy for Hemangioblastoma”

10:00 A. M. – 10:30 A. M. Dr. Mihkail F. Chernov, Dept. of Neurosurgery,

Tokyo Women’s Medical University, Tokyo, Japan: “Radiosurgery for Management of Brain Tumors

10:30 A. M. – 11:00 A. M. Dr. Alexei L. Krivoshapkin, Neurosurgery Department,

Novosibirsk State Medical University, Novosibirsk, Russia,

and Neurosurgery Dept., European Medical Center, Mos-

cow, Russia: “Computerized Technologies for Cerebral Malignant Glioma Maximum Safe Resection and Post-Operative Assessment”

11:00 A. M. – 11:30 A. M. Coffee Break

Session VI. Breast Cancer. Chairmen: Dr. Gloria Calaf, University of Tarapaca, Arica, Chile and Columbia University, New York, New York, U. S. A., and Dr. Debra Tonetti, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, U. S. A.

11:30 A. M. -12:00 A. M.Dr. Gloria Calaf, Instituto de Alta Investigacion,

Universidad de Tarapaca, Arica, Chile and Center for

Radiological Research, Columbia University, New York,

New York, U. S. A.: “5-Fluorouracil and Curcumin Inhibit The Epithelial-Mesenchymal Transition in Breast Carcino- genesis”

12:00 A. M. – 12:30 P. M. Dr. Debra Tonetti, College of Pharmacy, University of

Illinois at Chicago, Chicago, Illinois, U. S. A.:” Selective

Estrogen Mimics for the Treatment of Tamoxifen-Resistant

Breast Cancer Using PKCα as a Predictive Biomarker”

12:30 P. M. – 1:30 P. M. Lunch

Plenary Session III: Chairman: Dr. Eliezer Huberman, CEO, Nova Drug, LLC, and School of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, U. S. A.

1:30 P. M. – 2:30 P. M. Dr. Israel Vlodavsky, Cancer and Vascular Biology

Research Center, Rapaport Faulty of Medicine, Tech- nion-Israel Institute of Technology, Haifa, Israel.Plen-ary Lecture III: “Heparanase and Cancer Metastasis”

Session VII. Viral Chemotherapy and Cancer Chemotherapy. Chairmen: Dr. Eli-ezer Huberman, NOVA Drug, LLC and University of Illinois at Chicago, Chicago, Illinois, and Dr. Karl-Heinrich Link, Surgical Center and Asklepios Tumor Treat- ment Center, Asklepios Paulinen Klinik, Weisbaden, Germany

2:30 P. M. – 3:00 P. M.Dr. Evgeny N. Imyanitov, Dept. of Medical Genetics and N. N. Petrov Institute of Oncology, St. Petersburg Pediatric Medical Academy, and Dept. of Oncology, I. I. Mechnikov North-Western Medical University, Saint Petersburg, Russia: “Hereditary Cancer Syndrome: From Molecular Biology of Specific Therapy”

3:00 P. M. –3:30 P. M.Dr. Eliezer Huberman, NOVA Drug, LLC and School of

Pharmacy, University of Illinois at Chicago, Chicago,

Illinois, U. S. A.: “Potential Drugs to Control Hazardous

Viruses, Including Some Involved in Human Malig-

nancies”

3:30 P. M. –4:00 P. M.Dr. Karl-Heinrich Link, Surgical Center and Asklepios Tumor Treatment Center Rhein/Main (ATC), Asklepios Paulinen Klinik (APK), Weisbaden, Germany: “Modern Surgical Oncology in General and Visceral Surgery”

4:00 P. M. – 4:30 P. M. Coffee Break

4:30 P. M. –5:00 P. M.Dr. Marko Kornmann, Department of General and Visceral

Surgery, University of Ulm, Ulm, Germany: “The Role of

Predictive Biomarkers in the Treatment of Advanced Colo- rectal Cancer”

5:00 P. M. –5:30 P. M.Dr. Nadezhda V. Cherdyntseva, Dept. of Molecular Oncol-

ogy and Immunology, Tomsk Cancer Research Institute,

Tomsk, Russia: “The Tumor Microenvironment as a Promi-

sing Target to Anti-TumorTherapy”

5:30 P. M. – 6:00 P. M.Coffee Break

6:00 P. M. – 6:30 P. M. Dr. Robert Ladner, School of Medicine and the Cancer

Center, Queen’s University, Belfast, Ireland, United

Kingdom: “Title to be determined.”

6:30 P. M. – 6:45 P. M.Dr. Joseph R. Landolph, Jr. Concluding Remarks Summar-

izingKey Scientific Points of the Talks of the 21st Heidel- berger Symposium.

6:45 P. M. – 7:00 P. M. Dr. Lyudmila Gulyaeva. Final Statements and Concluding

Remarks Closing the 21st International Charles Heidelberger Symposium.

7:00 P. M. – 9:00 P. M. Dinner

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