Supplementary FigureTable 1A :. The Association of 98 Apoptosis Related SNPs and Non-Small Cell Lung Cancer among White Females
Gene / Refseq / OR / LowerCI / UpperCI / P-valueAHRR / rs34847072 / 1.075014 / 0.444923 / 2.597429 / 0.872326
AHRR / rs10078 / 0.581806 / 0.281052 / 1.204394 / 0.144568
AKT1 / rs1130233 / 0.596195 / 0.250826 / 1.417113 / 0.241689
APAF1 / rs2278361 / 1.971399 / 0.894674 / 4.343942 / 0.092209
APAF1 / rs2288729 / 0.628091 / 0.244633 / 1.612612 / 0.333697
APAF1 / rs1007573 / 0.520996 / 0.246121 / 1.102859 / 0.088366
APAF1 / rs1866477 / 0.783981 / 0.259649 / 2.367146 / 0.665996
ATM / rs170548 / 1.628125 / 0.624933 / 4.241723 / 0.318422
ATM / rs1800889 / 0.223319 / 0.023914 / 2.085413 / 0.188447
ATM / rs1801516 / 24.14926 / 3.501588 / 166.5492 / 0.001229*
ATM / rs3092993 / 5.688859 / 0.962616 / 33.61995 / 0.05512
BAK1 / rs210145 / 0.531683 / 0.21295 / 1.327478 / 0.176005
BAK1 / rs513349 / 0.349578 / 0.123905 / 0.986276 / 0.047025*
BAK1 / rs210135 / 3.192003 / 0.815702 / 12.49093 / 0.095449
BCL2L1 / rs3181073 / 0.621869 / 0.271341 / 1.42522 / 0.261606
BCL2L1 / rs1994251 / 0.626117 / 0.276717 / 1.416693 / 0.261067
BCL2L1 / rs1484994 / 0.524333 / 0.207579 / 1.324437 / 0.172057
BCR / rs12233352 / 3.232089 / 0.977112 / 10.6911 / 0.054602
BCR / rs140504 / 0.747967 / 0.28503 / 1.962795 / 0.555223
BIRC2 / rs1943781 / 1.80261 / 0.853049 / 3.809162 / 0.122686
BIRC3 / rs3758841 / 1.514723 / 0.747083 / 3.071126 / 0.249557
BIRC3 / rs3460 / 0.267122 / 0.036323 / 1.964429 / 0.194733
CASP10 / rs3900115 / 0.768941 / 0.340689 / 1.735513 / 0.526995
CASP3 / rs1405938 / 1.345593 / 0.458339 / 3.950391 / 0.589059
CASP3 / rs3087455 / 1.114411 / 0.510078 / 2.434749 / 0.785876
CASP3 / rs6948 / 0.772512 / 0.355034 / 1.680896 / 0.515236
CASP3 / rs1049216 / 0.611641 / 0.282194 / 1.3257 / 0.21291
CASP8 / rs2349070 / 0.802717 / 0.378962 / 1.700315 / 0.566073
CASP9 / rs2020898 / 0.883953 / 0.4029 / 1.939373 / 0.758312
CASP9 / rs2020902 / 0.914643 / 0.380001 / 2.201499 / 0.842194
CASP9 / rs1052576 / 0.753564 / 0.227559 / 2.495437 / 0.64327
CD40 / rs3765459 / 0.688296 / 0.248629 / 1.905455 / 0.472146
CD40 / rs1535045 / 0.839215 / 0.306774 / 2.295769 / 0.732811
FAS / rs1324551 / 2.661329 / 0.264639 / 26.7635 / 0.405891
FAS / rs2234768 / 1.819675 / 0.30864 / 10.7284 / 0.508403
FAS / rs1468063 / 1.409111 / 0.694283 / 2.859918 / 0.342296
FASLG / rs929087 / 0.475707 / 0.179103 / 1.263498 / 0.136043
IGF1R / rs2175795 / 2.550063 / 0.815469 / 7.974329 / 0.107555
IGF1R / rs2229765 / 1.499403 / 0.73227 / 3.07019 / 0.267956
IGF1R / rs3743259 / 1.753095 / 0.833522 / 3.687177 / 0.138894
IGF1R / rs9282715 / 1.190128 / 0.585306 / 2.41994 / 0.630721
IGF1R / rs907806 / 1.412591 / 0.690937 / 2.887983 / 0.343788
IGF1R / rs2137680 / 2.550063 / 0.815469 / 7.974329 / 0.107555
IGF1R / rs3743260 / 1.848899 / 0.484966 / 7.048801 / 0.368067
IL1A / rs2071374 / 0.821205 / 0.405081 / 1.664797 / 0.584843
IL1A / rs17561 / 1.76155 / 0.788588 / 3.934958 / 0.167355
IL1B / rs1071676 / 0.834547 / 0.363161 / 1.917796 / 0.670072
IL1B / rs16944 / 0.661019 / 0.272813 / 1.601633 / 0.359244
IL1B / rs3136558 / 0.990893 / 0.438076 / 2.241321 / 0.982473
IL1B / rs1143634 / 0.771793 / 0.320472 / 1.858706 / 0.563501
IL1B / rs1143627 / 1.217216 / 0.45596 / 3.249439 / 0.694794
LTA / rs3093546 / 0.327198 / 0.030803 / 3.475567 / 0.354102
LTA / rs909253 / 1.07293 / 0.492615 / 2.336875 / 0.859319
MDM2 / rs769412 / 0.90979 / 0.370201 / 2.235862 / 0.836731
MYC / rs3891248 / 1.190763 / 0.431958 / 3.282535 / 0.735766
NFKB1 / rs3774937 / 0.738239 / 0.270737 / 2.013013 / 0.553198
NFKB1 / rs230532 / 0.828122 / 0.376353 / 1.822187 / 0.639277
NFKB1 / rs230496 / 1.082146 / 0.523111 / 2.238606 / 0.831435
NFKB1 / rs4648059 / 0.984384 / 0.341988 / 2.833464 / 0.976722
NFKB1 / rs230547 / 0.941807 / 0.430485 / 2.060467 / 0.880688
NFKB1 / rs3774932 / 1.054682 / 0.516366 / 2.1542 / 0.883836
NFKBIE / rs2282151 / 0.410017 / 0.132823 / 1.265696 / 0.121079
NFKBIE / rs513688 / 0.636227 / 0.311538 / 1.299311 / 0.214513
NFKBIE / rs483536 / 0.636227 / 0.311538 / 1.299311 / 0.214513
NFKBIE / rs730775 / 1.284903 / 0.589081 / 2.802626 / 0.528687
OPRD1 / rs204076 / 0.659362 / 0.290923 / 1.494414 / 0.318451
OPRD1 / rs760589 / 0.927779 / 0.440428 / 1.954402 / 0.843672
P53 / rs2909430 / 1.223554 / 0.599637 / 2.496651 / 0.579258
P53 / rs8079544 / 0.909694 / 0.380515 / 2.174796 / 0.831454
P53 / rs12951053 / 0.811283 / 0.348044 / 1.891082 / 0.628134
P53 / rs1614984 / 0.779066 / 0.37597 / 1.614345 / 0.501836
P53 / rs2078486 / 0.715408 / 0.354219 / 1.444893 / 0.350412
PARP1 / rs747657 / 1.069312 / 0.441436 / 2.590247 / 0.881979
PARP1 / rs1136410 / 1.349291 / 0.490025 / 3.715292 / 0.562117
PARP1 / rs1805407 / 1.006307 / 0.487962 / 2.075268 / 0.986418
PARP1 / rs747659 / 0.885663 / 0.433285 / 1.810353 / 0.739238
PARP1 / rs1805415 / 0.874932 / 0.391952 / 1.953062 / 0.744341
PARP1 / rs1805414 / 0.912559 / 0.368445 / 2.260217 / 0.84325
PPP1R13L / rs6966 / 1.724801 / 0.531716 / 5.594978 / 0.363922
TGFB1 / rs1800469 / 0.949698 / 0.470089 / 1.918628 / 0.885621
TNF / rs1800630 / 1.230142 / 0.514295 / 2.942373 / 0.641565
TNF / rs1800629 / 0.424418 / 0.181822 / 0.990699 / 0.047527*
TNF / rs1799964 / 1.238754 / 0.566884 / 2.706925 / 0.591388
TNFRSF10A / rs20575 / 0.940972 / 0.465969 / 1.900186 / 0.865264
TNFRSF10A / rs2235126 / 0.835976 / 0.39754 / 1.757952 / 0.636641
TNFRSF1A / rs887477 / 0.54161 / 0.256991 / 1.141447 / 0.106929
TNFRSF1A / rs1800692 / 0.911457 / 0.366857 / 2.264513 / 0.841742
TP63 / rs9840360 / 0.491892 / 0.232905 / 1.038867 / 0.062885
TP63 / rs35592567 / 0.437586 / 0.20069 / 0.954116 / 0.037704*
TP63 / rs1345186 / 1.97646 / 0.954149 / 4.094115 / 0.066707
TP63 / rs7613791 / 2.702534 / 1.255083 / 5.819288 / 0.011068*
TP63 / rs17514215 / 1.230965 / 0.211753 / 7.155844 / 0.817012
TP63 / rs6790167 / 2.850007 / 1.334628 / 6.085995 / 0.006817*
TP63 / rs7653848 / 0.666088 / 0.277341 / 1.599741 / 0.363377
TP63 / rs35861864 / 2.307486 / 0.360055 / 14.78799 / 0.377664
TP63 / rs6789961 / 0.674911 / 0.268557 / 1.696115 / 0.403019
TP63 / rs3856775 / 2.132877 / 1.027588 / 4.42703 / 0.042052*
TP63 / rs34057105 / 1.724484 / 0.370506 / 8.02645 / 0.487357
* Significant Odds Ratio from a logistic regression model (p<0.05) controlling for age, smoking status (ever/never), smoking pack years, family history of lung cancer, history of COPD, education and BMI.
Supplementary Figure Table 1B :. The Association of 98 Apoptosis Related SNPs and Non-Small Cell Lung Cancer among African American Females
Gene / Refseq / OR / LowerCI / UpperCI / P-valueAHRR / rs34847072 / 1.075014 / 0.444923 / 2.597429 / 0.872326
AHRR / rs10078 / 0.581806 / 0.281052 / 1.204394 / 0.144568
AKT1 / rs1130233 / 0.596195 / 0.250826 / 1.417113 / 0.241689
APAF1 / rs2278361 / 1.971399 / 0.894674 / 4.343942 / 0.092209
APAF1 / rs2288729 / 0.628091 / 0.244633 / 1.612612 / 0.333697
APAF1 / rs1007573 / 0.520996 / 0.246121 / 1.102859 / 0.088366
APAF1 / rs1866477 / 0.783981 / 0.259649 / 2.367146 / 0.665996
ATM / rs170548 / 1.628125 / 0.624933 / 4.241723 / 0.318422
ATM / rs1800889 / 0.223319 / 0.023914 / 2.085413 / 0.188447
ATM / rs1801516 / 24.14926 / 3.501588 / 166.5492 / 0.001229*
ATM / rs3092993 / 5.688859 / 0.962616 / 33.61995 / 0.05512
BAK1 / rs210145 / 0.531683 / 0.21295 / 1.327478 / 0.176005
BAK1 / rs513349 / 0.349578 / 0.123905 / 0.986276 / 0.047025*
BAK1 / rs210135 / 3.192003 / 0.815702 / 12.49093 / 0.095449
BCL2L1 / rs3181073 / 0.621869 / 0.271341 / 1.42522 / 0.261606
BCL2L1 / rs1994251 / 0.626117 / 0.276717 / 1.416693 / 0.261067
BCL2L1 / rs1484994 / 0.524333 / 0.207579 / 1.324437 / 0.172057
BCR / rs12233352 / 3.232089 / 0.977112 / 10.6911 / 0.054602
BCR / rs140504 / 0.747967 / 0.28503 / 1.962795 / 0.555223
BIRC2 / rs1943781 / 1.80261 / 0.853049 / 3.809162 / 0.122686
BIRC3 / rs3758841 / 1.514723 / 0.747083 / 3.071126 / 0.249557
BIRC3 / rs3460 / 0.267122 / 0.036323 / 1.964429 / 0.194733
CASP10 / rs3900115 / 0.768941 / 0.340689 / 1.735513 / 0.526995
CASP3 / rs1405938 / 1.345593 / 0.458339 / 3.950391 / 0.589059
CASP3 / rs3087455 / 1.114411 / 0.510078 / 2.434749 / 0.785876
CASP3 / rs6948 / 0.772512 / 0.355034 / 1.680896 / 0.515236
CASP3 / rs1049216 / 0.611641 / 0.282194 / 1.3257 / 0.21291
CASP8 / rs2349070 / 0.802717 / 0.378962 / 1.700315 / 0.566073
CASP9 / rs2020898 / 0.883953 / 0.4029 / 1.939373 / 0.758312
CASP9 / rs2020902 / 0.914643 / 0.380001 / 2.201499 / 0.842194
CASP9 / rs1052576 / 0.753564 / 0.227559 / 2.495437 / 0.64327
CD40 / rs3765459 / 0.688296 / 0.248629 / 1.905455 / 0.472146
CD40 / rs1535045 / 0.839215 / 0.306774 / 2.295769 / 0.732811
FAS / rs1324551 / 2.661329 / 0.264639 / 26.7635 / 0.405891
FAS / rs2234768 / 1.819675 / 0.30864 / 10.7284 / 0.508403
FAS / rs1468063 / 1.409111 / 0.694283 / 2.859918 / 0.342296
FASLG / rs929087 / 0.475707 / 0.179103 / 1.263498 / 0.136043
IGF1R / rs2175795 / 2.550063 / 0.815469 / 7.974329 / 0.107555
IGF1R / rs2229765 / 1.499403 / 0.73227 / 3.07019 / 0.267956
IGF1R / rs3743259 / 1.753095 / 0.833522 / 3.687177 / 0.138894
IGF1R / rs9282715 / 1.190128 / 0.585306 / 2.41994 / 0.630721
IGF1R / rs907806 / 1.412591 / 0.690937 / 2.887983 / 0.343788
IGF1R / rs2137680 / 2.550063 / 0.815469 / 7.974329 / 0.107555
IGF1R / rs3743260 / 1.848899 / 0.484966 / 7.048801 / 0.368067
IL1A / rs2071374 / 0.821205 / 0.405081 / 1.664797 / 0.584843
IL1A / rs17561 / 1.76155 / 0.788588 / 3.934958 / 0.167355
IL1B / rs1071676 / 0.834547 / 0.363161 / 1.917796 / 0.670072
IL1B / rs16944 / 0.661019 / 0.272813 / 1.601633 / 0.359244
IL1B / rs3136558 / 0.990893 / 0.438076 / 2.241321 / 0.982473
IL1B / rs1143634 / 0.771793 / 0.320472 / 1.858706 / 0.563501
IL1B / rs1143627 / 1.217216 / 0.45596 / 3.249439 / 0.694794
LTA / rs3093546 / 0.327198 / 0.030803 / 3.475567 / 0.354102
LTA / rs909253 / 1.07293 / 0.492615 / 2.336875 / 0.859319
MDM2 / rs769412 / 0.90979 / 0.370201 / 2.235862 / 0.836731
MYC / rs3891248 / 1.190763 / 0.431958 / 3.282535 / 0.735766
NFKB1 / rs3774937 / 0.738239 / 0.270737 / 2.013013 / 0.553198
NFKB1 / rs230532 / 0.828122 / 0.376353 / 1.822187 / 0.639277
NFKB1 / rs230496 / 1.082146 / 0.523111 / 2.238606 / 0.831435
NFKB1 / rs4648059 / 0.984384 / 0.341988 / 2.833464 / 0.976722
NFKB1 / rs230547 / 0.941807 / 0.430485 / 2.060467 / 0.880688
NFKB1 / rs3774932 / 1.054682 / 0.516366 / 2.1542 / 0.883836
NFKBIE / rs2282151 / 0.410017 / 0.132823 / 1.265696 / 0.121079
NFKBIE / rs513688 / 0.636227 / 0.311538 / 1.299311 / 0.214513
NFKBIE / rs483536 / 0.636227 / 0.311538 / 1.299311 / 0.214513
NFKBIE / rs730775 / 1.284903 / 0.589081 / 2.802626 / 0.528687
OPRD1 / rs204076 / 0.659362 / 0.290923 / 1.494414 / 0.318451
OPRD1 / rs760589 / 0.927779 / 0.440428 / 1.954402 / 0.843672
P53 / rs2909430 / 1.223554 / 0.599637 / 2.496651 / 0.579258
P53 / rs8079544 / 0.909694 / 0.380515 / 2.174796 / 0.831454
P53 / rs12951053 / 0.811283 / 0.348044 / 1.891082 / 0.628134
P53 / rs1614984 / 0.779066 / 0.37597 / 1.614345 / 0.501836
P53 / rs2078486 / 0.715408 / 0.354219 / 1.444893 / 0.350412
PARP1 / rs747657 / 1.069312 / 0.441436 / 2.590247 / 0.881979
PARP1 / rs1136410 / 1.349291 / 0.490025 / 3.715292 / 0.562117
PARP1 / rs1805407 / 1.006307 / 0.487962 / 2.075268 / 0.986418
PARP1 / rs747659 / 0.885663 / 0.433285 / 1.810353 / 0.739238
PARP1 / rs1805415 / 0.874932 / 0.391952 / 1.953062 / 0.744341
PARP1 / rs1805414 / 0.912559 / 0.368445 / 2.260217 / 0.84325
PPP1R13L / rs6966 / 1.724801 / 0.531716 / 5.594978 / 0.363922
TGFB1 / rs1800469 / 0.949698 / 0.470089 / 1.918628 / 0.885621
TNF / rs1800630 / 1.230142 / 0.514295 / 2.942373 / 0.641565
TNF / rs1800629 / 0.424418 / 0.181822 / 0.990699 / 0.047527*
TNF / rs1799964 / 1.238754 / 0.566884 / 2.706925 / 0.591388
TNFRSF10A / rs20575 / 0.940972 / 0.465969 / 1.900186 / 0.865264
TNFRSF10A / rs2235126 / 0.835976 / 0.39754 / 1.757952 / 0.636641
TNFRSF1A / rs887477 / 0.54161 / 0.256991 / 1.141447 / 0.106929
TNFRSF1A / rs1800692 / 0.911457 / 0.366857 / 2.264513 / 0.841742
TP63 / rs9840360 / 0.491892 / 0.232905 / 1.038867 / 0.062885
TP63 / rs35592567 / 0.437586 / 0.20069 / 0.954116 / 0.037704*
TP63 / rs1345186 / 1.97646 / 0.954149 / 4.094115 / 0.066707
TP63 / rs7613791 / 2.702534 / 1.255083 / 5.819288 / 0.011068*
TP63 / rs17514215 / 1.230965 / 0.211753 / 7.155844 / 0.817012
TP63 / rs6790167 / 2.850007 / 1.334628 / 6.085995 / 0.006817*
TP63 / rs7653848 / 0.666088 / 0.277341 / 1.599741 / 0.363377
TP63 / rs35861864 / 2.307486 / 0.360055 / 14.78799 / 0.377664
TP63 / rs6789961 / 0.674911 / 0.268557 / 1.696115 / 0.403019
TP63 / rs3856775 / 2.132877 / 1.027588 / 4.42703 / 0.042052*
TP63 / rs34057105 / 1.724484 / 0.370506 / 8.02645 / 0.487357
* Significant Odds Ratio from a logistic regression (p<0.05) controlling for age, smoking status (ever/never), smoking pack years, family history of lung cancer, history of COPD, education and BMI.