Sudin Bhattacharya, Ph.D.
Senior Scientific Officer (Assistant Director Grade)
Chittarajan National Cancer Institute, Dept. of Cancer Chemoprevention,
37, S.P.Mukherjee Road Kolkata - 700 026 West Bengal, India
E-mail:sudin.bhattacharaya @cnci.org.in
Phone:+91-33-24765101, Extn.316 Fax:+91-33-4757606, Mobile; 9830446739
URL: http://www.cnci.org.in/research/research_main.html
Positions Held:
Position / Affiliation / Time PeriodSenior Scientific Officer (Assistant Director Grade) & Head, Dept. of Cancer Chemoprevention / Chittarajan National Cancer Institute / Present
Area of Specialization:
/ Medicinal Chemistry (Anticarcinogenesis Drug Development)· / Pharmacology
/ Oncology (Cancer Chemoprevention)
Research Summary:
/ Synthesis and evaluation of antioxidative as well as cancer chemopreventive properties of novel synthetic compounds such as organoselenium compounds, thiazolidinedione derivatives etc and naturally occurring tea polyphenols against carbon tetrachloride, cadmium, lead and arsenic etc. induced acute toxicity model in mice and on a number of animal carcinogenesis models viz. skin, colon and lung.To reduce the toxic manifestation imparted by different cancer chemotherapeutic drugs by novel organoselenium compounds , nanoselenium and complementary alternative medicines
Education
:: / M.Sc.
:: / Ph.D.
Type of Neoplasms
Skin
Pulmonary system
Lung
Gastrointestinal tract
Colon
Publications:
1. Prosenjit Ghosh , Somnath Singha Roy , Pramita Chakraborty ,Sulekha Ghosh , Sudin Bhattacharya, Effects of organoselenium compound 2-(5-selenocyanato-pentyl)-benzo[de]isoquinoline 1,3-dione on cisplatin induced nephrotoxicity and genotoxicity: an investigation of the influence of the compound on oxidative stress and antioxidant enzyme system. Biometals 2012 ( )
2. Somnath Singha Roy, Pramita Chakraborty, Prosenjit Ghosh, Sulekha Ghosh Jaydip Biswas, Sudin Bhattacharya. Influence of novel naphthalimide based organoselenium on genotoxicity induced by an alkylating agent: the role of reactive oxygen species and selenoenzymes. Redox report 2012, 4, 157-166.
3. Jayanta Kumar Das, Sibani Sarkar , Ugir Hossain Sk, Pramita Chakraborty, Rajat Kumar Das & Sudin Bhattacharya., Diphenylmethyl selenocyanate attenuates malachite green induced oxidative injury through antioxidation and inhibition of DNA damage in mice. Indian Journal of Medical Research 2012 (in press).
4. Sayaree Dhar , Dipak Kumar Rana , Somnath Singha Roy , Swapnadip Roy , Sudin Bhattacharya , Subhash Chandra Bhattacharya Effect of solvent environment on the Photophysics of a newly synthesized bioactive 7-oxy(5-selenocyanato-pentyl)-2H-1-benzopyran-2-one. Journal of Luminescence, 2012, Volume 132, Issue 4, Pages 957-964.
5. Ila Das, Asha Acharya, Deborah L. Berry, Supti Sen, Elizabeth Williams, Eva Permaul, Archana Sengupta1, Sudin Bhattacharya and Tapas Saha. Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-kB signalling pathways. British Journal of Nutrition 2012 ,108(6), 984-97.
6. Somnath Singha Roy, Pramita Chakraborty, Prosensenjit Ghosh, Sudin Bhattacharya. Micronutrient for Prevention of Cancer Chemotherapeutic Drugs Induced DNA Damage and Cellular Toxicities, With Special Reference to Selenium. Perspectives in Cytology and Genetics, 2011, Vol.-XV, 123-138
7. Sayaree Dhar, Somnath Singha Roy, Dipak Rana, Sudin Bhattacharya, Sumanta Bhattacharya, Subhash Bhattacharya Tunable Solvatochromic Response of Newly Synthesized Antioxidative Naphthalimide Derivatives: Intramolecular Charge Transfer Associated with Hydrogen Bonding Effect
The Journal of Physical Chemistry A. 2011, 115 (11), 2216–2224.
8. A.Chatterjee, J. Biswas, AK Chatterjee , S.Bhattacharya , B. Mukhopadhyay, S.Mandal . Psorinum Therapy in treating stomach, gall bladder, pancreatic and liver cancers: A prospective clinical study. Evidence Based Complementary & Alternative Medicine (eCAM) 2011, 2011, 724743.
9. Pramita Chakraborty, Somnath Singha Roy, Ugir Hossain SK, & Sudin Bhattacharya, Amelioration of cisplatin induced nephrotoxicity in mice by oral administration of diphenylmethyl selenocyanate. Free Radical Research 2011,
45(2), 177-187.
10. Somnath Singha Roy , Prosenjit Ghosh, Ugir Hossain Sk , Pramita Chakraborty , Jaydip Biswas , Syamsundar Mandal , Arin Bhattacharjee ,
Sudin Bhattacharya, Naphthalimide based novel organo selenocyanates: Finding
less toxic forms of selenium that would retain protective efficacy. Bioorganic
and Medicinal Chemistry Letter, 2010 , 20, 6951-6955
11. Ugir Hossain Sk, Arun K. Sharma, Sulekha Ghosh, Sudin Bhattacharya. Synthesis and biological evaluation of novel spiro 6-methoxytetralin-1,30-pyrrolidine based organoselenocyanates against cadmium-induced oxidative and hepatic damage in mice. European Journal of Medicinal Chemistry 2010, 45, 3265-3273.
12. A.Chatterjee, J. Biswas, AK.Chatterjee, S. Bhattacharya, et al. A Phase II, single-arm clinical trial involving an alternative cancer treatment psorinum therapy in patients with advanced non-small cell lung cancer. J. Clin. Oncol. 2010, 28: 15s
13. A.Chatterjee , S.Bhattacharya , AKChatterjee , J.Biswas , BP Mukhopadhyay . A prospective observational clinical study involving an alternative cancer treatment, psorinum therapy, in treating stomach, gall bladder, pancreas and liver cancers. J Clin Oncol 2009; 27: 15s
14. Arindam Sarkar, Paltu Banerjee, Sk. Ugir Hossain, Sudin Bhattacharya, Subhash Chandra Bhattacharya Role of hydrogen bonding on the Spectroscopic properties of Thiazolidinedione derivatives in homogeneous solvents
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
2009, 72(5), 1097-1102.
15. Pramita Chakraborty, Ugir Hossain Sk, Nabendu Murmu, Jayanta K Das, Smarajit Pal & Sudin Bhattacharya. .Modulation of Cyclophosphamide Induced Cellular Toxicity by Diphenylmethyl Selenocyanate In Vivo, an Enzymatic Study. Journal of Cancer Molecules 2009, 4(6), 183-189.
16. Pramita Chakraborty, Ugir Hossain Sk & Sudin Bhattacharya. Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate. Cancer Chemotherapy and Pharmacology 2009, 64(5) , 971-980
17. Rajat Kumar Das, Sk. Ugir Hossain & Sudin Bhattacharya. Protective Effect of Diphenylmethyl selenocyanate against CCl4-induced hepatic injury. Journal of Applied Toxicology. 2007, 27(6), 527-537.
18. Ugir Hossain Sk. and Sudin Bhattacharya, Synthesis of some 2,4-thiazolidinedione compounds and Evaluation of their Free Radical Scavenging Activity as well as Effect on some phase II Antioxidant. Bioorganic and Medicinal Chemistry Letter, 2007, 17, 1149-1154.
19. Rajat K Das, Sarmistha Banerjee and Sudin Bhattacharya., Amelioration of benzo(a)pyrene induced lung carcinogenesis in strain A mice by diphenylmethyl selenocyanate. Experimental and Toxicologic Pathology 2007, 58(5), 351-360.
20. Sujan Chatterjee, Smritimoy Pramanik, Sk. Ugir Hossain, Sudin Bhattacharya and Subhash Chandra Bhattacharya. Synthesis and Photoinduced intramolecular charge transfer of N-substituted1,8-Naphthalimide derivatives in homogeneous solvents and in presence of reduced glutathione. Journal of Photochemistry and Photobiology A: Chemistry 2007, 187 (1), 64-71,
21. Paltu Banerjee, Sujan Chatterjee, Smritimoy Pramanik, Sk. Ugir Hossain, Sudin Bhattacharya and Subhash Chandra Bhattacharya. Spectroscopic studies of 2-(2-bromo-ethyl)-6-nitro-benzo [de]isoquinolene -1, 3-dione in water/alkanol mixed solvents and nonionic micelle of Igepal CO series. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2007, 66 (4-5), 1110-1114.
22. Ugir Hossain Sk. and Sudin Bhattacharya. Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates. Environmental Toxicology and Pharmacology. 2006, 22 (3), 298-308.
23. A. Sengupta, S .Ghosh, RK Das, S Bhattacharjee and S Bhattacharya ,
Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of COX-2 and iNOS pathways. Europ. J. Cancer Prev. 2006, 15, 301-305.
24. Sujit Kumar Ghosh, Sk. Ugir Hossain, Sudin Bhattacharya and Subhas Chandra Bhattacharya. 2-(2-Selenocyanic acid ethyl ester) –1H-benz [de] isoquonoline –1,3-(2H)- dione, synthesis photophysics and interaction with bovine serum albumin: A spectroscopic approach. Journal of Photochemistry and Photobiology B: Biology. 2005, 81, 121-128.
25. RK Das and S.Bhattacharya, Anti-tumour Promoting Activity of Diphenylmethyl Selenocyanate against Two-stage Mouse Skin Carcinogenesis. Asian Pacific J Cancer Prev., 2005, 6(2), 181-188
26. S Ghosh, RK Das, A. Sengupta, S. Bhattacharya. Inhibition of Azoxymethane induced aberrant crypt foci in rat by diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-S-transferase and lipid peroxidation. Biol. Trace Elem. Research.,2005 105(1-3), 171-186
27. Sk. Ugir Hossain, Sumitra Sengupta & Sudin Bhattacharya Synthesis and Evaluation of Antioxidative properties of a series of organo selenium compounds. Bioorganic & Medicinal Chemistry, 2005,13(20), 5750-5758
28. Rajat Kumar Dasa, SK Ugir Hossaina, Sudin Bhattacharya., Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Cancer Lettres, 2005, 230, 90-101
29. S Ghosh., RK Das, A. Sengupta and S. Bhattacharya., Induction of apoptosis and inhibition of cell proliferation by diphenylmethyl selenocyanate during azoxymethane induced rat colon carcinogenesis. International Journal of Cancer prevention, 2005 2(1), 63-70
30. R.K Das, S.Ghosh, A. Sengupta, S. Das.and S. Bhattacharya,. Inhibition of DMBA-croton oil induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate. Europ. J. Cancer Prev., 2004, 13, 411-417.
31. R.K Das, Sukta Das and S Bhattacharya,. Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride induced hepatotoxicity in vivo. J. Environ. Path. Toxicol. Oncol. 2004, 23, 287-296.
32. RK Das and S. Bhattacharya., Inhibition of DMBA-croton oil two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate through modulation of cutaneous oxidative stress and inhibition of nitric oxide production. Asian Pacific J. Cancer Prev. 2004, 5, 151-158.
33. N. Murmu, P. Ghosh, A. Gomes, S. Mitra, M. Das, A. Besra, J.Majumdar , S.Bhattacharya , P.Sur and JR Vedosiromani. Antineoplastic effect of new boron compounds against leukemic cell lines and cell from leukemic patients, J Expt. Clin. Cancer Res. 2002, 21 (3), 351-356.
34. N Murmu, S Mitra, M. Das, A. Gomes, JR. Vedasiromani, M. Ghosh, M. Bhattacharya, S.Bhattacharya and P.Sur . Boron compounds against human leukemic cell. J Expt. Clin. Cancer Res. 2001, 20 (4), 511-515.
35. Ghosh, M., Sadhu, U., Bhattacharya, S., Dutta, S., Bhattacharya, B. and Sanyal, U. Evaluation of toxicity of beta-tethymustine, a new anticancer compound, in mice. Cancer Letters. 1999. 138, 107-114. [PubMed]
36. Bhattacharya, S., Ghosh, M., Sadhu, U., Dutta, S. and Sanyal, U. Evaluation of phthalmustine, a new anticancer compound. II. Tumor inhibitory effect in murine Ehrlich ascites carcinoma and sarcoma-180. Neoplasma. 1996. 43, 209-213.
37. Sadhu, U., Ghosh, M., Bhattacharya, S., Dutta, S., Das, H. and Sanyal, U. Evaluation of toxicity of cypenhymustine, a new anticancer compound, in mice. Cancer Letters. 1994. 85, 65-72.
38. Bhattacharya, S., Ganguly, C., Sanyal, U. and Das, S. Evaluation of phthalmustine, a new anticancer compound. I. Effect on Dalton's ascitic lymphoma in mice. Neoplasma. 1994. 41, 35-38.
39. Sanyal, U., Bhattacharya, S., Sadhu, U., Dutta, S., Das, H. and Ghosh, M. Evaluation of 'cypenhymustine', a new anticancer compound, in murine tumour models. Cancer Letters. 1993. 70, 1-6.
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