CURICULUM VITAE

Name: NIRIT LEV, M.D.

Identification No.024538738

FacultySackler School of Medicine, Tel Aviv University, Israel

Home Address124/8 Uziel St., Ramat Gan, Israel

Tel:03-5717625, 052-4373986

E-mail:

Date of Birth25/1/1970, Israel

Marital StatusMarried + 2

Zahal Military service:Intelligence, 1988-1990

A. Education:

2004-present PhD in Neuroscience, FelsensteinMedicalResearchCenter, Sackler School of Medicine, Tel Aviv University, Israel

Supervisors: Prof. Eldad Melamed and Dr. Daniel Offen.

PhD thesis: “Molecular and biochemical mechanisms in the pathogenesis of Parkinson’s disease”

1998-2004 Residency in Neurology, RabinMedicalCenter, Campus Beilinson, Petah-Tikva, Israel

2002 Laboratory of Neuroscience, FMRC, Sackler School of Medicine, Tel-AvivUniversity (Advisor: Dr Daniel Offen)

1998 Laboratory of Neuroscience, Weizman Institute of Science (Advisor: Prof. Z Vogel)

1990- 1997 Bachelor of Medicine and M.D., SacklerSchool of Medicine, Tel Aviv University, Israel

1997 M.D. Thesis: “The prognostic significance of chest CT findings during diagnosis of Hodgkin disease” (Advisors: Dr. S Apter, Prof. Ben Basat)

B. Academic and clinical experience:

2004-present Ph.D. in Neuroscience, Sackler School of Medicine, Tel-Aviv University, Israel.

2004Specialist Diploma in Neurology

2004Instructor of Neurology, SacklerSchool of Medicine, TelAvivUniversity

1998-2004 Residency in the Department of Neurology, Rabin medical center, Campus Beilinson, Petah-Tiqva, Israel.

2000-2004 Tutor of medical students in the clerkship of Neurology, Rabin Medical center, Campus Beilinson, Petah-Tiqva, Israel.

1992-1996 Instructor and tutor of pre-clinical courses, New York program, Sackler School of Medicine, Tel Aviv University, Israel.

1992Anatomy instructor, Sackler School of Medicine, Tel Aviv University, Israel.

C. Academic awards:

1987- Award for excellence for high school achievements

1989- Award for excellence during the military service, Intelligence, Zahal

1991- Dean award for outstanding academic achievements, Sackler School of Medicine, TelAvivUniversity

1991- The Anatomy award for excellence, Sackler School of Medicine, TelAvivUniversity

1992- Rector award for high academic achievements, TelAvivUniversity

1993- The “Kneset” (the Israeli parliament) award for outstanding academic achievements

1994- Dean award for high academic achievements, Sackler School of Medicine, TelAvivUniversity

1995- Dean award for high academic achievements, first of class for pre-clinical studies, Sackler School of Medicine, TelAvivUniversity

1996- Dean award for high academic achievements, Sackler School of Medicine, TelAvivUniversity

1997- Dean award for outstanding academic achievements, first of her class in the medical school, Sackler School of Medicine, TelAvivUniversity

1998-Doctor of Medicine (M.D.) diploma, Suma Cum Laude

2000- Outstanding resident award, RabinMedicalCenter, Campus Beilinson, Petah-Tikva, Israel

2003- Excellence in the Neurological Internship Exam

2004- The young investigator award – The 20th annual meeting of the Israel society of oxigen toxicity and free radical research, 12 December 2004.

D. Social activities:

1980-1987 Guide and active in the “Scouts”

1985-1986 Volunteer in “Magen David Adom”

1991-1992 “Education for health”, voluntary work with underprivileged youth

1992-1996 Volunteer in the “International Education Foundation” (ISEF)

1996- Henri Glasberg award for voluntary work in the community, Tel Aviv University

E. Membership in professional societies:

1999- present Israel Neurological association

2005-presentIsrael Society for Neuroscience

F. Active participation in scientific meetings:

  1. The Annual Israel Neurologic Association Meeting, Tel Aviv, Israel, June 1999.
  2. The Annual Israel Neurologic Association Meeting, Tel Aviv, Israel, November 1999.
  3. The Annual Israel Neurologic Association Meeting, Zichron Yaakov, Israel, November 2000.
  4. European Neurological Society, Paris, France, April 2001.
  5. 10th Congress of the International Headache Society and the American Association for the study of Headache Scientific Meeting, New York, USA, June 2001.
  6. The Annual Israel Neurologic Association Meeting, Israel, November 2001.
  7. The 7th International Congress of Parkinson’s Disease and Movement Disorders, Miami, USA, November 2002.
  8. The Annual Israel Neurologic Association Meeting, Israel, November 2002.
  9. Israel Society for Neuroscience 11th Annual Meeting and INMHA of Canada/ISFN Joint Symposium, Eilat, Israel, December 2002.
  10. The Annual Israel Neurologic Association Meeting, Israel, November 2003.
  11. Israel Society for Neuroscience 13th Annual Meeting, Eilat, Israel, November 2004.
  12. The Annual Israel Neurologic Association Meeting, Tel Aviv, Israel, December 2004.
  13. The 20th annual meeting of the Israel society of oxigen toxicity and free radical research, Jerusalem, Israel, December 2004.
  14. ADPD 2005, Sorento Italy, March 2005.
  15. Israel Society for Neuroscience 14th Annual Meeting, Eilat, Israel, December 2005.
  16. The Annual Israel Neurologic Association Meeting, Israel, Tel Aviv, Israel, December 2005.
  17. The 21th annual meeting of the Israel society of oxigen toxicity and free radical research, Beer Sheva, Israel, January 2006.
  18. The 58th annual meeting of the American Academy of Neurology, San Diego, California, USA, April 2006.

G. Publications:

B.1. Original articles:

  1. N Lev, S Maimon, ZH Rappaport, E Melamed, Spinal dural arteriovenous fistulae – a diagnostic challenge. Isr Med Assoc J 2001;3(7):492-496.
  2. N Lev, Barhum Y, Melamed E, Offen D, Resistance of bax-deficient mice to MOG-induced experimental autoimmune encephalomyelitis. Neuroscience Lett 2004;359(3):139-42.
  3. Y shoenfeld, S Lev, I blatt, M Blank M, J Font, P Von Landberg, N Lev, J Zaech, R Cervera, JC Piette, ML Bertolaccini, GR Hughes, P Youinou et al., Features associated with epilepsy in the antiphospholipid syndrome. J Rheumatol 2004;31(7):1344-8.
  4. D Steiner, T Avidor-Reiss, E Schallmach, E Butovsky,N Lev, Z Vogel, Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. Biochem J. 2005;386(Pt 2):341-8.
  5. D Shitrit, N Lev, Bar-Gil-Shitrit A, Kramer MR. Progressive multifocal leukoencephalopathy in transplant recipients. Transpl Int. 2005;17(11):658-65.
  6. N Lev, S Lev, E Melamed, A Kuritzky, Heredity in menstrual migraine. Cephalalgia (submitted)
  7. N Lev, E Melamed, D Offen. Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage. Neuroscience Lett 2006;399(1-2):27-32.
  8. N Lev, D Ickowicz, Y Barhum, N Blondheim, E Melamed, D Offen. Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in Multiple Sclerosis. Antioxidants and Redox Signaling 2006 (accepted).

B.2.Case reports:

  1. N Lev, S Michowiz, E Inbar, CI Coire, S Pitlik, E Melamed, Neurocysticercosis. Isr Med Assoc J 2002;4(1):65-66.
  2. D Shitrit, N Lev, SI Shiran, G Izbicki, D Sofer, E Melamed, MR Kramer, Progressive multifocal leukoencephalopathy in a lung transplanted patient. J Heart Lung Transplant 2003;22:946-950.

B.3. Reviews:

  1. N Lev, S Maimon, E Melamed, E Inbar, Z Rappaport, Spinal dural arteriovenous fistula. Harefua, 1999; 137(10):471-4.
  2. N Lev, E Melamed, Sensory symptoms and pain in Parkinson disease. Harefua, 2000; 138(4):324-6.
  3. N Lev, E Melamed, Heredity in Parkinson’s disease: new findings. Isr Med Assoc J 2001; 3(6):435-8.
  4. N Lev, Melamed E, Neurological complications in Down’s syndrome. Harefua 2002;141(9):820-823. (Hebrew)
  5. R Djaldetti R, N Lev, E Melamed, Neuroprotection in progressive brain disorders. Isr Med Assoc J 2003; 5(8): 576-80.
  6. N Lev, E Melamed, D Offen, Apoptosis and Parkinson’s disease, Prog Neuropsychopharmacol biol psychiatry, special topic: Apoptosis and Human Neurodegenerative diseases, 2003; 27(2): 245-50.
  7. N Lev, D Roncevic, D Ickwicz, E Melamed, D Offen. The role of DJ-1 in Parkinson’s disease. J Mol Neurosc, 2006 (accepted).

B.4. Chapters in books:

  1. N Lev, D Offen, E Melamed. Toxic causes of Parkinson’s disease. Handbook of Neurology. In “Handbook of Clinical Neurology: Parkinson's disease and related disorders”, edited by W. C. Koller and E. Melamed 2006 (accepted).
  2. N Lev, Y Gilgun-Sherki, D Offen, E Melamed. Oxidative stress in Multiple Sclerosis. The role of oxidative stress in the pathogenesis of multiple sclerosis: Current state. In “Oxidative stress and neurological disorders”, edited by Prof. G.A.Qureshi Elsevier books. To be publisged in may 2006 (accepted).

D.2. Presentations at scientific meetings and conferences:

  1. N Lev, S Maimon, E Melamed, Spinal dural arteriovenous fistula – a diagnostic challenge. The Annual Israel Neurologic Association Meeting, Tel Aviv, Israel, June 1999.
  2. N Lev, D Steiner, T Avidor-Reiss, M Bayewitch, I Nevo, Z Vogel, Effect of acute and chronic Gi/o coupled receptor activation on the activity of tree splice variants of adenylyl cyclase type VIII. The Annual Israel Neurologic Association Meeting, Tel Aviv, Israel, November 1999.
  3. N Lev, S Lev, A Kuritaky, E Melamed, Heredity in menstrual migraine. The Annual Israel Neurologic Association Meeting, Zichron Yaakov, Israel, November 2000.
  4. N Lev, S Lev, E Melamed, A Kuritzky, Heredity in menstrual migraine. European Neurological Society, Paris, France, April 2001.
  5. N Lev, S Lev, E Melamed, A Kuritzky, Heredity in menstrual migraine. 10th Congress of the International Headache Society and the American Association for the study of Headache Scientific Meeting, New York, USA, June 2001.
  6. S Lev, N Lev, M Blank, Y Shoenfeld on behalf of the “Euro-APS study group” (20 European centers), Characteristics of epileptic patients in the antiphospholipid syndrome (APS), The Annual Israel Neurologic Association Meeting, Israel, November 2001.
  7. N Lev, E Melamed, R Djaldetti, The effect of yohimbine on falls in patients with Parkinson’s disease and parkinsonian syndromes. The 7th International Congress of Parkinson’s Disease and Movement Disorders, Miami, USA, November 2002.
  8. N Lev, Barhum Y, Melamed E, Offen D, Resistance of bax-deficient mice to MOG-induced experimental autoimmune encephalomyelitis. The Annual Israel Neurologic Association Meeting, Israel, November 2002.
  9. N Lev, Y Barhum, E Melamed, D Offen. Resistance of bax-deficient mice to MOG-induced experimental autoimmune encephalomyelitis. Israel Society for Neuroscience 11th Annual Meeting and INMHA of Canada/ISFN Joint Symposium, Eilat, Israel, December 2002.
  10. N Lev, E Melamed, D Offen. The role of proteasomal inhibition and oxidative stress in alpha-synuclein aggregates induction in dopaminergic neuronal cell lines. Israel Society for Neuroscience 13th Annual Meeting, Eilat, Israel, 28-30 November 2004.
  11. N Lev, E Melamed, D Offen. The role of proteasomal inhibition and oxidative stress in alpha-synuclein aggregates induction in dopaminergic neuronal cell lines. The Annual Meeting of the Israel Neurology Association, Tel Aviv, Israel, 30 Nov-1 December, 2004.
  12. N Lev, E Melamed, D Offen. Lewy body like aggregates induction by oxidative stress-an in vitro model for Parkinson’s disease. The 20th Annual Meeting of the Israel Society for Oxygen Toxicity and Free Radical Research, Hebrew University, Jerusalem, Israel December 12, 2004.
  13. N Lev, E Melamed, D Offen. Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage. 7th International Conference on Alzheimer’s and Parkinson’s Diseases: Insights, Progress and Perspectives. Sorrento, Italy, March 9-13, 2005.
  14. N Lev, E Melamed, D Offen. Proteasomal inhibition and oxidative stress induces alpha-synuclein aggregates in dopaminergic neuronal cell lines. The sixth research fair of the Sackler faculty of medicine, April 20, 2005.
  15. D Ickwicz , N Lev, E Melamed, D Offen. Oxidative stress induces DJ-1 changes in dopaminergic cells. Israel Society for Neuroscience 14th Annual Meeting, Eilat, Israel, December 11-14, 2005.
  16. N Lev, D Ickowicz, D Offen, E Melamed. The association of DJ-1 and oxidative stress in the pathogenesis of Parkinson’s disease. The Annual Meeting of the Israel Neurology Association, Tel Aviv, Israel, December 20-21, 2005.
  17. N Lev, D Ickowicz, D Offen, E Melamed.Oxidative stress induced changes in DJ-1 and the pathogenesis of Parkinson's disease. The 21th Annual Meeting of the Israel Society for Oxygen Toxicity and Free Radical Research, Ben Gurion University, Beer Sheva, Israel, January 1, 2006.
  18. N Lev, D Ickowicz, D Offen, E Melamed. The Association of DJ-1 and Oxidative Stress in the Pathogenesis of Parkinson’s Disease. The 58th American Academy of Neurology Annual Meeting, April 1-8, 2006, San Diego, California, USA.

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