CURRICULUM VITAE

NAME :Umang Gunvantray Thakkar

E-MAIL:

Registration Number: G 12700

EDUCATIONAL QUALIFICATION

SSC : Gujarat Secondary Education Board- 1994

HSSC : Gujarat Higher Secondary Education Board- 1996

MBBS : M P Shah Medical College, Jamnagar, Saurashtra University- 2001

DCH : M P Shah Medical College, Jamnagar, Saurashtra University- 2004

WORK EXPERIENCE

  • Residency In Pediatrics,Shri M.P.Shah Medical College, Jamnagar, Gujarat: 16/08/’02 to 30/06/’04.
  • Full Time Consultant Pediatrician,Shri Jalaram Arogya Seva Trust, Meghraj, Gujarat: 12/07/’04 to 30/04/’05.
  • Consultant Pediatrician (NICU, PICU, ward),Medisurge Hospital, Ahmedabad, Gujarat: 05/05/’05 to 17/09/’05.
  • Pediatrician (OPD, Pediatric cardiology and I.C.U, Cardiothoracic surgery and NICU, wards and Govt. School Health Program), U.N.Mehta Institute ofCardiology & Research Centre, Ahmedabad, Gujarat: 19/09/’05 to 08/01/’07.
  • Tutor in Nephrology and Pediatrics (Newborn delivery, NICU, ICU, Stem cell program, OPD, IPD and govt. school health program),G.R.Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre & Dr.H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, Gujarat:11/01/’07 to 30/11/’08.
  • Assistant Professor, Dept. of Regenerative Medicine & Stem Cell Therapy, IKDRC-ITS, Ahmedabad, Gujarat: 1/12/’08 to 31/3/’13.
  • Associate Professor, Dept. of Regenerative Medicine & Stem Cell Therapy, IKDRC-ITS:1/4/’13 onwards till date.

CLINICAL EXPERIENCE IN PAEDIATRICS AND NEONATOLOGY

  • Attended >5000 neonatal delivery calls
  • Intracath insertion
  • Taking venous blood samples by scalp vein & needles
  • Taking arterial blood samples for ABG
  • Lumbar puncture
  • Bone marrow aspiration
  • Liver biopsy
  • Neonatal and pediatric cardio-pulmonaryresuscitation
  • Ventricular tapping
  • Paediatric catheterization
  • Ryle’s tube insertion
  • Endotracheal tube intubation
  • Immunization
  • Double volume exchange transfusion
  • Ventilator therapy

ADVANCED COURSES/ CONFERENCES

1.2002- Neonatal Advance Life Support Course, Jamnagar.

2.2003- Pediatric Advance Life Support Course, Jamnagar.

CME and Workshop on Advances in Neonatal Intensive Care, Jamnagar.

3.2008- Conference- Transplant Update 2008, IKDRC -ITS, Ahmedabad.

4.2009- Conference- Transplant Update 2009, IKDRC - ITS, Ahmedabad.

5.2011- Conference- Transplant Update 2011, IKDRC - ITS, Ahmedabad.

6.2012- Conference- Transplant Update 2012, IKDRC - ITS, Ahmedabad.

7.2013- Conference- Transplant Update 2013, IKDRC - ITS, Ahmedabad.

8.2013- 12th Congress of “The Cell Transplant Society”, Milan, Italy.

9.2015- Conference- Transplant Update 2015, IKDRC -ITS, Ahmedabad.

10.2016- Conference- Transplant Update 2016, IKDRC -ITS, Ahmedabad.

11.2016- 26th International Congress of The Transplantation Society- TTS 2016, Hong Kong.

12.2017- Course-Good Clinical Practice, 12th September, 2017; IKDRC-ITS, Ahmedabad.

13.2018-Conference- Transplant Update 2018, IKDRC -ITS, Ahmedabad.

ACADEMIC PARTICIPATION/ POSTER PRESENTATIONS

  1. Participated in Epilepsy Clinic, Asthma Clinic and Immunization Clinic at Shri M.P.Shah Medical College, Pediatric Department,Jamnagar, Gujarat.
  2. Poster:Autologous Adipose Tissue Derived Insulin-Secreting Mesenchymal Stem Cell Transplantation In Latent Autoimmune Diabetes Of Adulthood (LADA) - Case Report, Transplant Update 2012.
  3. Poster–Co-infusion of insulin-secreting adipose tissueDerivedmesenchymal stem cells and bone marrow derived hematopoietic Stem cells – novel approach for management of Type-1 DM- Transplant Update 2013.
  4. Poster- Infusion Of Autologous Adipose Tissue Derived Neuronal Differentiated Mesenchymal Stem Cells And Bone Marrow Derived HematopoieticStem Cells In Post-traumatic Paraplegia Offers A Viable Therapeutic Approach, Transplant Update 2015.

ORAL PRESENTATIONS

  1. “Stem Cell Therapy in Neuronal Diseases - Ahmedabad Experience”- Govt. Medical College, Bhavnagar, Gujarat, 10thApril, 2011.
  2. “Stem cell therapy in diabetes mellitus, where are we?” B J Medical College, Ahmedabad, 22nd March,2013.
  3. “Co-infusion of insulin-secreting adipose tissue derived mesenchymal stem cells and hematopoietic stem cells – novel approach for management of type 1 DM”,12th Congress of the Cell Transplant Society, Milan, Italy, 9th July, 2013.
  4. “Co-Infusion Of Insulin-Secreting Adipose Tissue Derived Mesenchymal Stem Cells And Hematopoietic Stem Cells Along With CD4+CD25highCD127low forkhead Box P3 (Foxp3+) T-Regulatory Cells: The Preliminary Experience For Treatment Of Type-1 Diabetes Mellitus”, Transplant Update-2015, Ahmedabad, India, 9th January, 2015.
  5. “Cell Therapy for Type-1 Diabetes Mellitus”. CME at Trichyby Tamilnadu IMA branch with Mother Cell Regenerative Centre in IMA hall, on 13-9-2015. (Tiruchirappalli)
  6. “Neuronal Differentiated Mesenchymal Stem Cell Therapy For Post-Traumatic Paraplegia: A Single Centre 5 Years’ Experience” CME at Trichy by Tamilnadu IMA branch with Mother Cell Regenerative Centre in IMA hall, on 13-9-2015. (Tiruchirappalli)
  7. “Co-infusion of allogeneic adipose tissue derived mesenchymal stem cells and bone marrow derived hematopoietic stem cells for renal parenchymal diseases“Transplant Update-2016”, Ahmedabad, India, 22nd January, 2016.
  8. “Stem Cell TherapyAs An Emerging Modality For Post-Traumatic Paraplegia And For Renal Parenchymal Diseases” - 26th International Congress of The Transplantation Society, Hong Kong, 21st August, 2016.
  9. “Stem Cells: From Laboratory To Clinics” IFFCO, Kalol, 20th April, 2018.
  10. Plenary speaker invitation (ACCEPTED) for “Stem cell therapy for glomerular diseases” -3rd Annual Kidney Congress “Kidney 2018”, New York, USA, October 18th to 20th‘2018.

SCHOLARSHIP/ PRIZES/ AWARDS

  1. From Govt. of Gujarat got the scholarship certificate for getting distinction in SSC examination in 1994.
  2. Poster- “Human Adipose Tissue Derived Insulin Making Mesenchymal Stem cells For Treatment of Type 1 DM” (in 2008)- Transplant Update 2008 - 1st prize
  3. Poster- “Human Adipose Tissue Derived Neuronal Differentiated Mesenchymal Stem Cell to Treat the Spinal Cord and Brachial Plexus Injured Patient”, Transplant Update 2009- 1st prize
  4. Poster- “Human Adipose Tissue Derived Cardiomyocytes for Advanced Heart Failure” - Transplant Update 2011, 1st prize.
  5. Poster -Autologous Adipose Tissue Derived Neuronal Differentiated Mesenchymal Stem Cell Transplantation for Neuronal Disorders, Transplant Update 2012- 1st prize.
  6. Paper of distinction- “Co-infusion of allogeneic adipose tissue derived mesenchymal stem cells and bone marrow derived hematopoietic stem cells for renal parenchymal diseases” Transplant Update-2016, Ahmedabad, India, 2016.
  7. TTS 2016 Young Investigator Scientific Award in “26th International Congress of “The Transplantation Society” at Hong Kong, 21st August, 2016.
  8. Certificate of appreciation by Ministry of Finance, Government of India, Central board of direct taxes for the assessment year 2016-17;as Bronze category in recognition of taxes towards building of the great nation;. (201641756554).
  9. Certificate of appreciation by Ministry of Finance, Government of India, Central board of direct taxes for the assessment year 2017-18; as Bronze category in recognition of taxes towards building of the great nation. (201746279510).

PUBLICATIONS

  1. Nehal Patel, Halak Joshipura, Umang Thakkar, Shaunak Shah.“A rare case of intracardiac RV tumor in an infant: Embryonal Rhabdomyosarcoma”- Case Report. Paediatric Cardiac Society of India, News Letter December, 2006: 3-5.
  2. H L Trivedi, A V Vanikar, U Thakker,et al. Human Adipose Tissue-Derived Mesenchymal Stemcells Combined with HematopoieticStem cell Transplantation Synthesize insulin, Transplant Proc. 2008; 40: 1135-1139.
  3. T Mehta, A Feroz,U Thakkar,et al. Subarachnoid Placement of Stem Cells in Neurological Disorders. Transplant Proc. 2008,40: 1145-1147.
  4. A. V. Vanikar, S. D. Dave, U. G. Thakkar and H. L. Trivedi. Co-transplantation of Adipose Tissue-Derived Insulin-Secreting Mesenchymal Stem Cells and Hematopoietic Stem Cells: A Novel Therapy for Insulin-Dependent Diabetes Mellitus, Stem Cells International: 2010; 2010, Article ID 582382, 5 pages,doi:10.4061/2010/582382.
  5. Trivedi HL, Thakkar UG, Vanikar AV, Dave SD. Treatment of Polyglandular autoimmune syndrome type 3 using co-transplantation of insulin-secreting mesenchymal stem cells and hematopoietic stem cells. BMJ Case Reports2011;10.1136/bcr.07.2011.4436.
  6. Kute VB, Vanikar AV, Shah PR, Gumber MR, Patel HV, Engineer DP, Thakkar UG, Trivedi HL. Down syndrome with end-stage renal disease. Indian J Clin Biochem. 2013 Oct;28(4):429-32. doi: 10.1007/s12291-013-0308-1. Epub 2013 Feb 16. PubMed. PMID: 24426250; PubMed Central PMCID: PMC3783915.
  7. Thakkar UG,Vanikar AV, HL Trivedi. Alkaptonuria in 17 Month-Old Female Child: A Case Report.Kuwait Medical Journal 2013; 45 (2): 138 – 140.
  8. Thakkar UG,Vanikar AV, Trivedi HL.Polyglandular autoimmune syndrome type III: Two cases Sri Lanka Journal of Child Health, 2013; 42: 217-218.
  9. Thakkar UG, Vanikar AV, Trivedi HL. Co-infusion of autologous adipose tissue derived insulin-secreting mesenchymal stem cells and bone marrow derived hematopoietic stem cells: Viable therapy for type III.C.a diabetes mellitus. Biomed J 2013;36:304-7.
  10. Thakkar UG, Vanikar AV, Trivedi HL. Co-infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and bone marrow derived hematopoietic stem cells, a viable therapy for post-traumatic brachial plexus injury: A case report. Biomed J 2014;37:237-40.
  11. Dave SD, Vanikar AV, Trivedi HL, Thakkar UG. Autologous Adipose Tissue Derived Insulin-Secreting Mesenchymal Stem Cell Transplantation In Late Onset of Autoimmune Mediated Diabetes Mellitus (LADA) – Case Report. IJBR (2013) 04 (03). DOI:10.7439/ijbr.
  12. Dave SD, Vanikar AV, Trivedi HL, Thakkar UG, Gopal SC, Chandra T. Novel therapy for insulin-dependent diabetes mellitus: infusion of in vitro-generated insulin-secreting cells. Clin Exp Med. 2015; 15(1):41-45.
  13. Thakkar UG,Mishra VV, Vanikar AV, Patel HV, Agrawal RS, Shah VR, Trivedi HL.Assessment of children born to mothers who are renal allograftrecipients.Sri Lanka Journal of Child Health, 2014; 43(1): 27-32.
  14. Thakkar UG, Trivedi HL, Vanikar AV, Dave SD, Rawal M.Co-infusion of Insulin-secreting Adipose Tissue Derived Mesenchymal Stem Cells and Hematopoietic Stem Cells in type-1 diabetes: A Single Center Experience. Journal of Organ Dysfunction And Management, 2014:1(2);14-20
  15. Thakkar UG, Trivedi HL, Vanikar AV, Dave SD. Treatment of a Type-1 diabetic adolescent male with mitral valve prolapse with his mother’s insulin secreting adipose tissue derived mesenchymal stem cells and bone marrow derived hematopoietic stem cells. Sri Lanka Journal of Child Health, 2014; 43(4): 231-233.
  16. Thakkar UG, Mishra VV, Vanikar AV, Agrawal RS, Kadam PG. Fracture of shaft of left femur in a newborn delivered by caesarean section. Sri Lanka Journal of Child Health, 2015; 44(1):53-55.
  17. Thakkar UG, Trivedi HL, Vanikar AV, Dave SD, Raval M. Insulin-secreting Adipose Derived Mesenchymal Stem Cells With Bone Marrow Derived Hematopoietic Stem Cells From Autologous and Allogenic Sources For Type-1 Diabetes Mellitus. Int J Biol Med Res.2015; 6(2): 4920-24.
  18. Thakkar UG, Trivedi HL, Vanikar AV, Dave SD. Insulin-secreting adipose-derived mesenchymal stromal cells with bone marrow-derived hematopoietic stem cells from autologous and allogeneic sources for type 1 diabetes mellitus. Cytotherapy, 2015; 17: 940- 947 pii: S1465-3249(15)00692-1. doi: 10.1016/j.jcyt.2015.03.608. [Epub ahead of print].
  19. Dave SD, Vanikar AV, Trivedi HL, Thakkar UG, Chooramani S, Chandra T. Novel therapy for insulin-dependent diabetes mellitus: infusion of in vitro-generated insulin-secreting cells. Clin Exp Med. 2015 Feb;15(1):41-5. World Biomedical Frontiers. ISSN: 2328-0166.
  20. Thakkar UG, Vanikar AV, Trivedi HL. Anaphylactoid Purpura Manifested after Acute Gastroenteritis with Severe Dehydration in an 8-Year-Old Male Child: A Case Report. PRHSJ. 2015; 34(4):225-117.
  21. Thakkar UG, Trivedi HL, Vanikar AV, Dave SD.Co-infusion of insulin-secreting adipose tissue-derived mesenchymal stem cells and hematopoietic stem cells: novel approach to management of type-1 diabetes mellitus. Int J Diabetes Dev Ctries. 2016; 36(4):426-432. DOI 10.1007/s134 10-015-0409.
  22. Thakkar UG, Vanikar AV, Trivedi HL. Rare Case of Non-Parasitic Chyluria in Pediatric Population Treated with Dietary Modification in a 3 Years and 11 Months Male Child. KMJ2015; 47(4):333-335.
  23. Thakkar UG, Vanikar AV, Trivedi HL, Shah VR, Dave SD, Dixit SB, et al. Infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and hematopoietic stem cells in post-traumatic paraplegia offers a viable therapeutic approach. Adv Biomed Res 2016; 5:51.March 29, 2016, IP: 117.211.100.3.
  24. Trivedi HL,Vanikar AV, Patel HV, Kanodia KV, Kute VB, Nigam LA, Suthar KS, Thakkar UG, Sutaria HC, Gandhi SP. High prevalence of chronic kidney diseases in a semi urban population of Western India. Clin Kidney J 2016; 9(3):438-443. doi: 10.1093/ckj/sfw009. Epub 2016 Apr 4.
  25. Vanikar AV, Nigam LK, Patel RD, Kanodia KV, Suthar KS, Thakkar UG. Persistent mullerian duct syndrome presenting as retractile testis with hypospadias: A rare entity. World J Clin Cases. 2016, 4(6):151-154. doi: 10.12998/wjcc.v4.i6.151.
  26. Vanikar AV, Trivedi HL, Thakkar UG. Stem cell therapy emerging as the key player in treating type 1 diabetes mellitus. Cytotherapy 2016; 18(9),1077-1086.
  27. Thakkar UG, Trivedi HL & Vanikar AV. Treating type-1 diabetes mellitus with insulin-secreting mesenchymal stem cells and hematopoietic stem cells followed by T-regulatory cells. Sri Lanka Journal of Child Health. 2016; 45(3):221-225.DOI: Vitro Generated Mesenchymal Stem Cells: Suitable Tools To Target Insulin Dependent Diabetes Mellitus?Curr Stem Cell Res Ther. 2016 Nov 21.
  28. Dave SD, Patel CN, Patel JV, Thakkar UG. In Vitro Generated Mesenchymal Stem Cells: Suitable Tools To Target Insulin Dependent Diabetes Mellitus?Curr Stem Cell Res Ther.2016;12 DOI: 10.2174/1574888X12666161121112553[Epub ahead of print].
  29. Thakkar UG, Vanikar AV, Trivedi HL. Type-1.5 Diabetes Mellitus with Autoimmune Hypothyroidism: A Rare Combination. Glob J Obes Diabetes Metab Syndr. 2016; 3(1): 008-010. DOI:
  30. Thakkar UG, Vanikar AV, Trivedi HL. Stem Cell Therapy - An Emerging Modality In Glomerular Diseases. Cytotherapy 2017;19:333-348. 2016.11.003.
  31. Thakkar UG, Vanikar AV, Trivedi HL, Vora KS, Saifee Y. Association of capillary haemangioma with bilateral hydronephrosis in an Infant. Sri Lanka Journal of Child Health, 2017; 46(1): 93-94. DOI:
  32. Thakkar UG, Vanikar AV, Trivedi HL. Should we practice stem cell therapy for type 1 diabetes mellitus as precision medicine? Cytotherapy 2017; 19(5):574-576. doi: 10.1016/j.jcyt.2017.02.001. Epub 2017 Mar 2.
  33. Thakkar UG, Vanikar AV, Trivedi HL. Revisit of a rare complication of type-1 diabetes mellitus- Mauriac syndrome. Practical Diabetes 2017; 34(4): 132-134.
  34. Thakkar UG, Vanikar AV, Trivedi HL.Stem cells: an emerging novel therapy for type-1 diabetes mellitus. Diabetes Res Clin Pract 2017; 130:130-132.
  35. Vanikar AV, Trivedi HL, Thakkar UG. Six years’ experience of tolerance induction in renal transplantation using stem cell therapy. Clin immunol 2017; Jul 27. pii: S1521-6616(17)30545-4. doi: 10.1016/j.clim.2017.07.024.
  36. Vanikar AV, Kanodia KV, Patel RD, Suthar KS, Nigam LA, Thakkar UG, Patel HV, Kute VB, Trivedi HL. Repercussions of eosinophils in a renal allograft- Predictor of early graft loss!2017; 28(5):1034-1040.
  1. Suthar KS, Vanikar AV, Nigam LA, Patel RD, Kanodia KV, Thakkar UG, Gandhi PA, Chandak SA, Prajapati AV, Patel MH. Urinary Screening for Early Detection of Kidney Diseases. Indian J Pediatr2017.
  2. Thakkar UG, Vanikar AV, Raval MN, Trivedi HL. Congenital venous malformation in an 8 years old female child treated with ethanol injection. P R Health Sci J 2017; 36:186-187.
  3. Thakkar UG, Vanikar AV, Mishra VV, Singh DR, Trivedi HL, Lamba SR, Hokaboj SA, Desai VJ. Newborn with absent thumb and imperforate anus in absence of familial context- Is it Holt-Oram syndrome? Journal of Neonatal Nursing. 2018; 24(3):119-121. 1355-1841/© 2017 Neonatal Nurses Association.

ARTICLE (IN PRESS)

  1. Gandhi PA,Vanikar AV, Patel HV, Patel RD, Kanodia KV, Thakkar UG. Bone mineral changes after renal transplantation (KMJ)
  2. Kunal Gupte, Aruna Vanikar, Chetan Patel, Ashok Bhargava, Jignesh Patel, Umang Thakkar.Optimization of in vitro culture conditions of Interleukin-10 secreting B regulatory cells of human origin. (Cell Biology: Research & Therapy)

BOOK CHAPTER

  1. Umang G Thakkar, Aruna V. Vanikar, Hargovind L. Trivedi. Stem cell therapy for type-1 diabetes mellitus. Editor Phuc Van Pham; “Pancreas, Kidney and Skin Regeneration-STEM CELLS IN CLINICAL APPLICATION” (Springer international publishing AG 2017). 2017; page35-72. ISBN: 978-3-319-55686-4; DOI 10.1007/978-3-319-55687-1.

BOOK

  1. Umang G Thakkar, Aruna V. Vanikar, Hargovind L. Trivedi. Stem Cell Therapy: An emerging modality in glomerular diseases.Editions Universitaires Europeennes. Omni Scriptum GmbH & Co. KG. 10th May, 2017; 52 pages. ISBN(13): 978-3-330-86926-4, ISBN(10): 3330869267; (Marina Christea).

EDITORIAL BOARD

  1. Medicine
  2. ARC journal of nephrology
  3. Journal of Stem Cell and Transplantation Biology
  4. Hemato-oncology
  5. Austin Transplantation Sciences
  6. Journal of Cell Biology, Cell Metabolism and Stem Cell Research
  7. IJMCR (International Journal of Medicine and Clinical Research)
  8. Current Research in Stem Cell and Regenerative Medicine
  9. Cardiovascular & Hematological Disorders-Drug Targets

REVIEWER FOR

  1. BMJ case reports (2014, 2017, 2018)
  2. Journal of Pediatric Hematology and Oncology’ (JPHO) (2014)
  3. Journal of Occupational Medicine and Toxicology (JMET) (2015)
  4. International Journal Of Stem Cell Research And Therapy (IJSCRT) (2015)
  5. Journal of Genetic Syndrome and Gene Therapy (2015)
  6. Cytotherapy (2015)
  7. Journal of Neurology Research (JNR) (2015)
  8. Current Drug Targets (CDT) (2015)
  9. Regenerative Medicine (2016)
  10. Kidney Diseases and Transplantation (2016)
  11. Journal of Stem Cell and Transplantation Biology (JSCTB) (2016)
  12. International Journal of Clinical Medicine (IJCM) (2016)
  13. Acta Physiologica Hungarica (APH) (2016)
  14. Journal of translational medicine (JTM) (2016)
  15. Annals of Molecular and Genetic Medicine (2017)
  16. Physiotherapy Theory and Practice (2017)

AREAS OF INTEREST

  1. Stem cell therapy for treatment of various neurological disorders, cardiac disorders and autoimmune diseases like type-1 diabetes mellitus, SLE
  2. Pediatrics, pediatric nephrology and transplantation and pediatric cardiology
  3. Neonatology
  4. Diabetes
  5. Autoimmune disorders and stem cell therapy

MEMBERSHIP

  1. Member of Indian Medical Association(Life time member)
  2. Transplantation Society (2013, 2014, 2015, 2016)
  3. National Medicos Organization (Life time member)

RESEARCH ACTIVITIES

  1. Clinical application of in-vitro generated hematopoietic stem cells
  2. Clinical application of in-vitro generated mesenchymal stem cells from adipose tissue
  3. Clinical application of in-vitro generated Neuronal differentiated mesenchymal stem cells from the adipose tissue
  4. Clinical application of in-vitro generated cardiomyocytes differentiated from the adipose tissue derived mesenchymal stem cells

ONLINE VIDEO

  1. Site of 12th congress of the cell transplant society (Milan, Italy on 9th July, 2013).
  2. Site of 26th congress of the transplantation society ( Hong Kong, 21st August, 2016.)

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