Table S1 Derivation of  like cells from various types of cells

Cell Types / Species / Steps / Compounds / Markers / Reference
ES-EB / Mouse / 4 / bFGF,
nicotinamide / GATA-4,HNF3β, PDX-1, InsulinⅠ,Ⅱ, IAPP, Glucagon, nestin / [8]
Mouse / 5 / bFGF,
nicotinamide,
B27 or LY294002 / Insulin-1(weak),
PDX-1(weak), insulin-2, Amylase-2 , Glucagon/Insulin, c-peptide / [11]
Human / 5 / bFGF,
nicotinamide / Kir 6.2, SUR1,
Ngn3, Pax4, Pax6,
Nkx6.1, Isl1, Glu2,
PC1/3, GCK, PC2
Glucagon, Somatostatin, IAPP, Insulin/C-peptide, / [12]
ES/iPS / Human / 4 / Actinvin A, Wortannin,ITS, RA, FGF7, Noggin, EGF, NICOTINAMIDE,EXExendin-4, BMP4 / (ES)Pdx-1, Glut 2, MafA, Nkx6.1, Isl-1, Neuro D, Insulin/C-peptide
(iPS)Pdx-1, MafA, Glut2, Insulin, Amylase, C-peptide / [82]
ES-DE / Human / 3 / Activin A, Wnt 3a,
noggin, RA, FGF 10 / FOXA2,SOX17,PDX1, NKX6.1, PTF1a/P48,
NGN3, SOX9, CK19, Vimentin, E-cadherin,
Insulin, Alpha-fetoprotine
(negative) / [13]
Human / 4 / Activin A,
Sodium butyrate, EGF, bFGF, noggin, nicotinamide,
IGFⅡ / Pdx1, Ptf1a, Ngn3,
Isl1, Nkx6.1, Insulin,
Gluagon, C-peptide / [14]
Human / 3 / Activin A, FGF2, BMP-4, LY294002 / Insulin, Glucagon, somatostatin, Ptf1a, Sox9, Ngn3, MafB, Nkx6.1 / [18]
Mouse / 3 / Actinvin A, bFGF,
nicotinamide / Nkx6.1, Neurog 3,
Insulin, Glucagon, Amylase, Somatostatin, Kir6.2, Cytokeratin 19, Iapp, Glut2, etc / [17]
Mouse / 3 / _ / Ptf1a, Sim1, NeuroD1, Nkx2.2, Pax4, Insulin, Glucagon,Somatostatin / [19]
Overexpressed-ES / Human / 5 / Activin A, FGF10, KAAD-cyclopamine, RA / EpCAM, E-cadherin, PDX1,SOX9, ChrA, CDX2, ALBUMIN, FOXA2, NGN3, insulin, amlyase / [20]
Human / _ / _ / Pdx1, Pax4, Nkx2.2, ISL1, NGN3, insulin / [21]
Mouse / 4 / MTG, Activin A, BMP4, bFGF, (RA) / Pdx1, Ngn3, Pax6, Neuro D, Ins, Sst, Chga, Pcsk2, Insulin, C-peptide / [22]
ES-ADE / Mouse / 5 / BMP4, Actinvin A, EGF, FGF4, RA, PD173074/SU5402, FGF-2,-5,-8b,-10, KAAD-cyclopamine / Cer1, Foxa2, Pdx1,
Hnf4α, Nkx2.2 / [15]
iPS-DE / Human / 4 / Activin A,
Sodium butyrate,
EGF, bFGF, noggin, nicotinamide,
IGFⅡ / Pdx1, Ptf1,
Nkx6.1, Insulin,
C-peptide, Glucagon / [16]
pSCs / Human / 4 / Actinvin A, TSA, Wnt3a / SOX7, AFP, FOXF1, BMP4, MEOX1, FLK1, SOX1, SOX2,HCG, CDX2 / [26]
BMSC / Human / 2 / FGF2, EGF, IGF1, SDF-1α, BTC, ghrelin, gastrin-1,
exendin-4,
Activin A / Pdx1, Ngn3, Insulin, Isl1 / [3]
Mouse / 2 / TSA, GLP-1 / Pdx1, HNF-3β, Ngn3, IAPP, GLUT2, Glucagon, SUR1, Somatostain, / [2]
Mouse / _ / _ / CK, PECAM-1 / [27]
Modified / Rat / 3 / 1%DMSO / Pdx1, Insulin / [29]
Rat / 3 / Nicotinamide, RA / Ngn3, Nkx6.1, Pdx1, Glut-2, BTC, insulin, C-peptide / [30]
Human / 3 / _ / FOXA2, PAX4, ISL1, Insulin / 31]
Human / 2 / _ / Pdx1, Mafa / [32]
PMPs / Mouse & Human / 2 / B27,FGF2,Heparin, EGF, GLP-1 / Pdx1, Nkx6.1, Ngn3, Pax6, Pax4, Glut2, Insulin, C-peptide, / [40]
Pancreatic endocrine cells / Porcine / 2 / nicotinamide, conophylline / Pdx1, Ngn3,
NeuroD/Beta 2, Insulin / [41]
PDPs / Rat / _ / (CMRL Medium) / Insulin, Glucagon, C-peptide / [42]
IEFs-IPLC / Mouse / 3 / bFGF, BMP-4(+/-),
nicotinamide, noggin / Nkx6.1, Pax6, E-cadherin, Insulin/C-peptide, Glut2 / [43]
Mouse / 3 / bFGF,nicotinamide,
RA, Actinvin A / Insulin-1, Glut 2, C-peptide, PDX-1, Hnf3β, Isl1 / [44]
Adipose-
Derived / Mouse / 3 / ITS, GLP-1, Actinvin A, nicotinamide / PDX-1, C-peptide, Insulin, Glucagon, Somatostatin, pancreatic polypeptide / [4]
gSDSCs / Porcine / 4 / BMP4, EGF, bFGF, Actinvin A, GLP-1, nicotinamide / Neuro D, Nkx6.1, Nkx2.2, Ngn3, Insulin, Nestin, Vimentin / [5]
Cord Blood / Human / _ / _ / CD45+, Insulin, C-peptide / [33]
Hepatic cells / Human / 3 / Laminin, Fibronectin / Pdx-1, Ngn-3, Maf A / [34]
Rat / 3 / _ / Pdx-1, Insulin1, Insulin2 / [35]
Splenocyte / Mouse / _ / _ / Insulin / [36]
Labia minora dermis-
derived / Human / 3 / ITS,
nitotinamide / PDX-1, NKX6.1, Kir6.2, PC1/3, PAX6, Insulin, C-peptide / [37]
Mouse / _ / _ / Ngn3, Reg3b, Pdx1, Insulin, Glucagon / [48]
α cells / Mouse / _ / Alloxan(&PDL) / PDX-1,Nkx6.1,MafB Glucagon, Insulin, C-peptide / [49]

[82] Efrat S (2010) Stem cell therapy for diabetes. 2010. 10.1007/978-1-60761-366-4. http://www.springer.com/cn/book/9781607613657