Supplementary Table 4. Serological profile and HBV DNA mutations in 14 CLD families with anti-HBc-positive children

Family
No. / Relation / Age
(year) / Serological profile / HBV DNA/ Genotype / HBV DNA Mutations /
HBsAg / Anti-HBc / anti-HBs / HBeAg / anti-HBe / S-gene† / Pre-core G1896A‡ / BCP A1762T/G1764A‡ /
1 / Father (Index/LC) / 55 / + / + / - / + / - / +/C / T1261, T143S, Y161F / - / +
Mother / 48 / + / + / - / - / + / +/B / Y161S / + / -
Son (Subject 1) / 16 / - / + / + / - / - / +/B / T143M / + / +
4 / Father / 50 / - / + / - / -
Mother (Index/LC) / 49 / + / + / - / + / - / +/C / T126N, T143S, Y161F / - / +
Daughter (subject 7) / 18 / - / + / + / - / + / +/C / T1261, T143S, Y161F / - / -
Daughter (subject 8) / 14 / - / - / +
6 / Father / 42 / - / + / - / -
Mother (Index/CHB) / 39 / + / + / - / + / - / +/B / wt / - / -
Daughter (Subject 11) / 9 / - / - / + / - / - / -
Son (Subject 12) / 7 / - / + / + / - / - / +/B / T143M / - / +
Daughter (Subject 13) / 5 / - / - / + / - / - / -
8 / Father / 45 / - / + / - / -
Mother (Index/CHB) / 45 / + / + / - / - / + / +/C / T1261, T143S, G145R, Y161F / - / +
Son (Subject 16) / 13 / + / + / - / + / - / +/C / T1261, T143S, Y161F / - / +
9 / Father (Index/LC) / 44 / + / + / - / + / + / +/B / M133L / - / +
Mother / 42 / - / + / - / - / - / -
Son (Subject 17) / 16 / + / + / - / - / - / +/B / wt / - / -
Son (Subject 18) / 9 / - / - / + / - / - / -
Daughter (Subject 19) / 8 / - / - / + / - / - / -
12 / Father / 34 / - / - / - / - / - / -
Mother (Index/CHB) / 30 / + / + / - / + / - / +/B / wt / - / -
Daughter (Subject 24) / 4 / + / + / - / + / - / +/B / P142L, G145R / - / -
Son (Subject 25) / 2 / - / - / + / - / - / -
13 / Father / 39 / - / - / - / - / - / -
Mother (Index/CHB) / 35 / + / + / - / + / - / +/B / T140I / - / deletion
Son (Subject 26) / 13 / + / + / - / + / - / +/B / wt / - / -
Daughter (Subject 27) / 6 / + / + / - / + / - / +/B / wt / - / -
15 / Father (Index/CHB) / 43 / + / + / - / - / + / +/B / wt / + / -
Mother / 36 / - / + / - / - / + / +/C / T1261, C138Y, T143S, Y161F / - / -
Daughter (Subject 29) / 18 / + / + / - / + / - / +/B / wt / - / -
Son (Subject 30) / 11 / - / - / - / - / - / -
Son (Subject 31) / 8 / - / + / + / - / - / -
27 / Father (Index/HCC) / 39 / + / + / - / - / + / +/B / wt / + / -
Mother / 36 / - / - / - / - / - / -
Daughter (Subject 53) / 9 / - / + / + / - / - / -
Son (Subject 54) / 8 / - / - / - / - / - / -
Daughter (Subject 55) / 7 / - / - / - / - / - / -
28 / Father (Index/LC) / 56 / + / + / - / - / + / +/B / Y161S / - / -
Mother / 40 / + / + / - / - / + / + B / M133L / - / +
Son (Subject 56) / 16 / + / + / - / + / - / + B / M133L / - / +
Daughter (Subject 57) / 11 / + / + / - / + / - / + B / M133L / - / +
Son (Subject 58) / 3 / + / + / - / + / - / + B / wt / - / -
37 / Father (Index/LC) / 43 / + / + / - / - / + / +/C / T143S, Y161F / - / +
Mother / 47 / - / - / + / - / - / -
Son (Subject 73) / 18 / - / + / + / - / + / +/C / T143S, Y161F / - / -
Daughter (Subject 74) / 15 / - / - / + / - / - / -
39 / Father (Index/LC) / 42 / + / + / - / - / + / +/B / wt / + / -
Mother / 38 / - / + / - / + / - / +/C / T1261, T143S, Y161F / - / deletion
Daughter (Subject 76) / 17 / - / - / + / - / - / -
Daughter (Subject 77) / 16 / - / - / + / - / - / -
Daughter (Subject 78) / 12 / - / + / + / - / - / -
Son (Subject 79) / 9 / - / - / + / - / - / -
Son (Subject 80) / 3 / - / - / + / - / - / -
42 / Father (Index/CHB) / 44 / + / + / - / + / - / +/B / wt / - / -
Mother / 34 / - / - / - / - / - / -
Son (Subject 83) / 10 / - / - / - / - / - / -
Daughter (Subject 84) / 6 / - / + / + / + / - / +/C / T1261, T143S, Y161F / + / +
44 / Father / 46 / - / + / - / -
Mother (Index/CHB) / 41 / + / + / - / - / + / +/B / 140I, T143S / + / -
Son (Subject 88) / 13 / + / + / - / + / - / +/B / wt / - / -
Daughter (Subject 89) / 5 / - / + / + / - / - / +/C / T1261, Y161F / + / -

CLD = Chronic liver disease; BCP = Basal Core Promoter; CHB = chronic hepatitis B; LC = liver cirrhosis; HCC = hepatocellular carcinoma

†wt = wild type; ‡(+) = mutation detected, (-) = mutation undetected; HBeAg and anti-HBe were not tested when HBsAg was negative; Subject No: refer to Suppl. Table 1

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