BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Susan Freeman Sencer, MD / POSITION TITLE
Medical Director, Pediatric Hematology/Oncology, Children’s Hospitals and Clinics
eRA COMMONS USER NAME (credential, e.g., agency login)
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / MM/YY / FIELD OF STUDY
Grinnell College, Grinnell, Iowa / B.A. / 06/76 / Psychology
University of Minnesota, Minneapolis, Minnesota
Medicine / M.D. / 06/84 / Medicine
University of Minnesota, Minneapolis, Minnesota / 06/88 / Residency Pediatrics
University of Minnesota, Minneapolis, Minnesota / 06/91 / Fellowship Pediatric Hematology/Oncology

NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions below.

A. Personal Statement

As a practicing oncologist, I have become increasingly concerned by the rising rates of obese patients within our practice and the worsened toxicities they experience because of their obesity. I have helped start several innovative programs to combat this problem, including the STOPLIGHT program of physical therapy in leukemia patients and am now starting a nutrition program for pediatric cancer patients. I co-wrote a cookbook for children, ChowKids Cookbook, for this population.

B. Positions and Honors

List in chronological order previous positions, concluding with the present position. List any honors. Include present membership on any Federal Government public advisory committee.

Previous Positions:

Minnesota Department of Health, Minneapolis, Minnesota 1976 – 1979
Coordinator, Cervical Cancer Screening Program

University of Minnesota, Minneapolis, Minnesota 1977 – 1980
Post-baccalaureate work in basic sciences

Cedar Riverside People’s Center, Minneapolis, Minnesota 1979 – 1980
Administrative Coordinator

Fremont Community Clinic, Minneapolis, Minnesota 1979 – 1980
Adolescent Health Counselor

Medical Director, Integrative Therapies Program, 1998 - 2000
Children's Hospitals and Clinics

Current position:

Children’s Hospitals and Clinics – Minneapolis, Minneapolis, Minnesota
Pediatric Hematologist/Oncologist 1991-present

Medical Director, Pediatric Hematology/Oncology, Children’s Hospitals and Clinics

Past Chief of Staff, Children’s Hospitals and Clinics

Director, Integrative Cancer Care, Children's Hospitals and Clinics

Clinical Faculty, University of Minnesota, Departments of Pediatrics and Center for Spirituality and Healing

Faculty, CancerGuides, Center for Mind Body Medicine

Honors:

Phi Beta Kappa

Mortar Board National Honorary Women’s Scholastic Society
Graduation with honors in psychology from Grinnell College 1976
Chief Resident, Department of Pediatrics 1987 – 1988
American Cancer Society Clinical Oncology Fellowship 1988 – 1990
Variety Club Fellowship 1990 – 1991
Children’s Cancer Research Fund - Monoclonal 1990 – 1991
Antibodies to Induce Programmed Cell Death

Bush Foundation, Physicians Mid-Career Fellowship 1998

International Pediatric Oncology Society (SIOP), Best Poster 1998

Mpls. St. Paul Magazine Top Doctors 2009, 2012

C. Selected Peer-reviewed Publications

NIH encourages applicants to limit the list of selected peer-reviewed publications or manuscripts in press to no more than 15. Do not include manuscripts submitted or in preparation. The individual may choose to include selected publications based on recency, importance to the field, and/or relevance to the proposed research. When citing articles that fall under the Public Access Policy, were authored or co-authored by the applicant and arose from NIH support, provide the NIH Manuscript Submission reference number (e.g., NIHMS97531) or the PubMed Central (PMC) reference number (e.g., PMCID234567) for each article. If the PMCID is not yet available because the Journal submits articles directly to PMC on behalf of their authors, indicate "PMC Journal - In Process." A list of these Journals is posted at: http://publicaccess.nih.gov/submit_process_journals.htm. Citations that are not covered by the Public Access Policy, but are publicly available in a free, online format may include URLs or PMCID numbers along with the full reference (note that copies of publicly available publications are not accepted as appendix material.)

Sencer SF, Coblenz A, McCrea L, Grosse E. Sex and Self: A Health Course for Women, Emory University Publications 1975.

Sencer SF, Coulter-Knoff A, Foker J, Thompson T, Day D, Burke B. Splenic Hemangioma in a Newborn. Pediatrics. 1987 (79):960-3.

Sencer SF, Rich M, Katsanis E, Ochoa AC, Anderson PM. Anti-tumor Vaccine Adjuvant Affects of IL-2 Liposomes in Mice Immunized Against MCA-102 Sarcoma. European Cytokine Network 1991 (2): 311-8.

Anderson PM, Katsanis E, Sencer SF, Hasz D, Ochoa A, Bostrom BC. Depot Characteristics and Biodistribution of Interleukin-2 Liposomes: Importance of Route of Administration. Journal of Therapeutic Immunology 1992 (12):19-31.

Anderson PM, Hasz D, Dicrell L, Sencer SF. IL-2 Liposomes: Increased Intravenous Potency and Less Pulmonary Toxicity in the Rat. Drug Development Research 1992 (27):15-31.

Sencer SF. Long Term Survivors of Childhood Cancer. Topics in Pediatrics 1993 (11):15-9.

Sencer SF, Haake RJ, Weisdorf DJ. Hemorrhagic Cystitis Following Bone Marrow Transplantation: Risk Factors and Complications. Transplantation 1993.

Sencer SF. The Long–term Survivor of Childhood Cancer. North Memorial Medical Center Medical Staff News, January 1995.

Sencer S, Iacuone J. Alternative Medicine in Pediatric Oncology. Supportive Care of Children with Cancer, 2nd edition. Arthur Ablin,M.D., editor, Johns Hopkins Press, 1997.

Reinhardt MA, Nelson SC, Sencer SF, Bostrom BC, Kurachek SC, Nesbit ME. Treatment of childhood lymphangiomas with interferon-alpha. J Pediatr Hematolog Oncol 1997 May-Jun;19(3):232-6.

Arndt CA, Nascimento AG, Schroeder G, Schomberg PJ, Neglia JP, Sencer SF, Silberman TL, Moertel CL, Tillisch JK, Miser JS. Treatment of intermediate risk rhabdomyosarcoma and undifferentiated sarcoma with alternating cycles of vincristine/doxorubicin/cyclophosphamide and etoposide/ifosfamide. Eur J Cancer 1998 Jul; 34(8):1224-9.

Seber A, Shu XO, Defor T, Sencer S, Ramsay N. Risk Factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant 1999 Jan;23 (1):35-40.

Sencer SF, O’Leary MC, Fusselman M. Long Term Survivors of Childhood Cancers. Topics in Pediatrics 1999;17 (1).

Hirsch B, Berry S, Bostrom B, Sencer S. Constitutional chromosomal instability and predisposition to childhood solid tumors: a new syndrome? American Journal of Human Genetics 1999; 65(suppl )No.4:A63.

Post-White J, Sencer S, Fitzgerald M., Complementary and Alternative Treatments, Nursing Care of Children and Adolescents With Cancer, 3rd edition, Harcourt, 2002.

Yun H, Ettinger A, Veenstra D, Gaynon P, Sencer S, Reaman G, Lange B, Holcenberg J. A Pharmacoeconomic Analysis of Pegaspargase vs. Native E. coli L-asparaginase for the Treatment of Children with Standard Risk Acute Lymphocytic Leukemia CCG-1962 J Pediatr Hematolog Oncol 2002 March-Apr;24(3):175-81.

Avramis V, Sencer S, Periclou A, Sather H, Bostrom B, Cohen L, Ettinger A, Ettinger L, Franklin J, Gaynon P, Hilden J, Lange B, Majlessipour F, Mathew P, Needle M, Neglia J, Reaman G, Holcenberg J. A Randomized Comparison of Native E. Coli Asparaginase and Polyethylene Glycol Conjugated Asparaginase for Treatment of Children with Newly Diagnosed Standard-Risk Acute Lymphocytic Leukemia: A Children’s Cancer Group Study. Blood 2002 Mar 15;99(6):1986-94.

Hirsch B, Shimamura A, Moreau L, Baldinger S, Hag-Alshiekh M, Bostrom B, Sencer S, D’Andrea A. Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood. Blood 1 Apr 2004:103(7);2554-9.

Schultz K, Sencer S, Messinger Y, Neglia J, Steiner M. Pediatric Ovarian Tumors: A Review of 67 Cases. Pediatr Blood Cancer 2005; 44:167-73.

Sencer, SF, Kelly KM. Bringing Evidence to Complementary and Alternative Medicine for Children With Cancer. J Pediatr Hematol Oncol 2006:28(3): 186-9.

Johnston DL, Nagel K, O'halloran C, Sencer SF, Kelly KM, Friebert S, Hilden JM, Friedman DL. Complementary and alternative medicine in pediatric oncology: Availability and institutional policies in Canada-a report from the Children's Oncology Group. Pediatr Blood Cancer 2006:47(7);955-8.

Sencer SF, Kelly KM. Complementary and alternative therapies in pediatric oncology. Pediatr Clin North Am Dec 2007:54(6):1043-60 xiii.

Brown J, Olson T, Sencer SF. Malignancies of the Ovary Cancer in Adolescents and Young Adults. Cancer in Adolescents and Young Adults. Editors Bleyer W, Barr R. 2007; Chapter 13, Pages 219-236.

Mertens AC, Sencer S, Myers CD, Recklitis C, Kadan-Lottick N, Whitton J, Marina N, Robison LL, Zeltzer L. Complementary and alternative therapy use in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer Jan 2008:50(1):90-7.

Arndt CA, Hawkins DS, Meyer WH, Sencer SF, Neglia JP, Anderson JR. Comparison of results of a pilot study of alternating vincristine/doxorubicin/ cyclophosphamide and etoposide/ifosfamide with IRS-IV in intermediate risk rhabdomyosarcoma: a report from the Children’s Oncology Group. Pediatr Blood Cancer Jan 2008:50(1):33-6.

Post-White J, Fitzgerald M, Hageness S, Sencer SF. Complementary and alternative medicine use in children with cancer and general and specialty pediatrics. J Pediatr Oncol Nurs 2009 Jan-Feb;26(1):7-15.

Post-White J, Fitzgerald M, Savik K, Hooke MC, Hannahan AB, Sencer SF. Massage therapy for children with cancer. J Pediatr Oncol Nurs 2009 Jan-Feb; 26(1):16-28.

Traumeel S in preventing and treating mucositis in young patients undergoing SCT: a report of the Children's Oncology Group.Sencer SF, Zhou T, Freedman LS, Ives JA, Chen Z, Wall D, Nieder ML, Grupp SA, Yu LC, Sahdev I, Jonas WB, Wallace JD, Oberbaum M. Bone Marrow Transplant. 2012 Nov;47(11):1409-14. doi: 10.1038/bmt.2012.30. Epub 2012 Apr 16.

D. Research Support

List both selected ongoing and completed research projects for the past three years (Federal or non-Federally-supported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs.

2002-2009 PI: A Randomized Double Blind Placebo Controlled Clinical Trial to Assess the Efficacy of TRAUMEEL STM for the Prevention and Treatment of Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation

This project evaluated the efficacy of a homeopathic treatment to prevent mucositis associated with chemotherapy and radiation. Dr Sencer was responsible for study design, implementation and analysis

PHS 398/2590 (Rev. 06/09) Page 8 Biographical Sketch Format Page

PHS 398/2590 (Rev. 06/09) Page 7 Continuation Format Page