TABLE F3.- Intervention Characteristics- SCIT Vs SLIT

TABLE F3.- Intervention Characteristics- SCIT vs SLIT

Study / Arms / Conventional/ Rescue therapy / Maintenance Dose / Cumulative Dose / Maintenance Dosing Interval / Quantity of Major Protein (μg) / Treatment Duration /
Mauroa
20071 / SLIT- Tree pollen
(birch, alder, hazel)
SCIT- Tree pollen
(birch, alder, hazel) / conventional therapy / 100 IR
8 IR / 4653.1 IR
50.65 IR / Daily
Every 3 weeks / NR
NR / NR
Piazza
19932 / SLIT- Dust mite D. Per
SCIT- Dust mite D. Per
(Alum precipitated) / ONLY rescue medication / 250 STU
from 70-80,000
SQ U / NR
NR / 3 times a week
Monthly / 1 Der p 1
(maintenance)
4.2-4.8 Der p 1
(maintenance) / 2 years
Tahamiler 20063 / SLIT- Dust mite
D. Per-D. Far
SCIT- Dust mite
D. Per-D. Far / ONLY rescue medication / 1-5 drops of 1,000 STU /ml
100,000 SQ-U/ml / NR
NR / 3 times per week
Once every 6-8 weeks / NR
NR / 3 years
Khinchi
20044 / SLIT- Birch+ Placebo injections
SCIT- Birch+ Placebo drops
Placebo injections
+ Placebo drops / conventional therapy / 49.2 µg Bet v 1
3.28 µg Bet v 1 / 11182 µg
51 µg / Every other day
Monthly / 11182 Bet v 1 (cumulative)
51 Bet v 1
(cumulative) / 2 years
Eifan
20105 / SLIT
Dust mite (D. Per-D. Far)
SCIT
Dust mite(D. Per-D. Far)
Pharmacotherapy / ONLY rescue medication / 5 drops STU
(1000 STU/ml)
100000 SQ U/ml, 1cm³ / 73876.8 STU
1131540 SQU / 3 times per week
Monthly / 295.5 Der p 1, 295.5 Der f 1(cumulative)
111 Der p 1, 156 Der f 1(cumulative) / 1 year
Mungan 19996 / SLIT
Dust mite (D. Per-D. Far)
SCIT
Dust mite (D. Per-D. Far)
Placebo SLIT / conventional therapy / 20 drops of 100 IR/ml
0.15-0.75 ml of 10 IR/ml / 11316 IR
131 IR / 2 times a week
Monthly / NR
NR / 1 year
Yukselen
20117 / SCIT (plus placebo sublingual drops)
SLIT (plus placebo subcutaneous injections)
Placebo (sublingual and subcutaneous) / conventional therapy / 0.2-0.8 ml of 5000 TU/ml
28 drops of 1000 TU/ml / 43,770 TU (21,885 TU of D.pt and 21885 TU of D.f)
173733 TU (86866.5 TU of D.pt and 86,866.5 TU of D.F) / Every 4th week
Three times a week / NR
NR / 1 year
Keles
20118 / SCIT
SLIT
SCIT (build-up)+SLIT (maintenance)
Pharmacotherapy / ONLY rescue medication / 44.12 µg of Der p1 and 62.1 µg of Df1
52.8 µg of Der p1 and 52.8 µg of Df1
43.2 µg of Der p1 and 43.2 µg of Df1 / NR / Monthly
3 times a week
3 times a week / 44.12 µg of Der p1 and 62.1 µg of Df1
52.8 µg of Der p1 and 52.8 µg of Df1
43.2 µg of Der p1 and 43.2 µg of Df1
(Maintenance phase) / 1 year

F-4