Po-Cheng Lin, Ph.D.林珀丞

Address:3F., No.22, Sec. 2, ShengYi Rd. Zhubei City, Hsinchu County 30261 Taiwan, R.O.C.

Phone: 886-3- 6585959

E-mail:

Affiliations

2014/06– present Vice President,Gwo Xi Stem Cell Applied Technology, Taiwan

2011/05–2014/05 Chief Technology Officer,Gwo Xi Stem Cell Applied Technology, Taiwan

2010/07 –2011/05 ResearchConsultant, Gwo Xi Stem Cell Applied Technology, Taiwan

2008/09–2011/04 Assistant investigator, Center for Neuropsychiatry, ChinaMedicalUniversity and Hospital, Taiwan

2005/11–2006/11 Assistant investigator, Neuro-MedicalScientificCenter, Buddhist Tzu-Chi General Hospital, Taiwan

Education

2006/09 -2010/07 Ph.D., Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Taiwan

2001/09 -2004/01 M.S., Department of Life Science, National Chung Hsing University, Taiwan

Research

2011/08– present Adipose-Derived Stem Cells Therapyin Liver Fibrosis

2010/07 – present Genetically Modified Stem Cell Therapy in Amyotrophic Lateral Sclerosis

2010/07–present Research and Development of Food Supplement

2005/11 –2010/07 Anti-Tumor Compounds from Chinese Herbal

2001/09– 2004/01 Characterization of the Halophilic Methanogenic Archaeon

SCI期刊論文：

第一作者

  1. Lin PC＊, Tzyy-Wen Chiou, Po-Yen Liu, Shee-Ping Chen, Hsin-I Wang, Pi-Chun Huang, Shinn-Zong Lin, and Horng-Jyh Harn. Food Supplement 20070721-GX May Increase CD34+ Stem Cells and Telomerase Activity. J Biomed Biotechnol. 2012:498051. Epub 2012 Apr 22.
  1. Liu WS, Lin PC＊, Chang LF, Harn HJ, Shiuan D, Chiou TW, Jeng JR. Inhibitory Effect of n-Butylidenephthalide on Neointimal Hyperplasia in Balloon Injured Rat Carotid Artery. Phytother Res.2011 Oct;25(10):1494-502[SCI IF= 1.746, 25/46=54 %CHEMISTRY, MEDICINAL]
  1. Lin PC＊, Chang LF, Liu PY, Lin SZ, Wu WC, Chen WS, Tsai CH, Chiou TW, Harn HJ.Botanical Drugs and Stem Cells.Cell Transplant.2011;20(1):71-83.Review. [SCI IF= 5.126, 2/24 = 8 %TRANSPLANTATION]
  1. Lin PC＊,LinSZ,ChenYL, ChangJS, HoLI,LiuPY, ChangLF, HarnYC,ChenSP, SunLY,HuangPC,CheinJT, TsaiCH, Chou CW,HarnHJand ChiouTW. Butylidenephthalide suppresses human telomerase reverse transcriptase (TERT) in human glioblastomas. Annals of Surgical Oncology.2011 Nov;18(12):3514-27[SCI IF=4.130, 6/167=3 %SURGERY]
  1. Lin PC＊, Chen YL, Chiu SC, Yu YL, Chen SP, Chien MH, Chen KY, Chang WL, Lin SZ, Chiou TW, Harn HJ. Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. J Neurochem. 2008 Aug;106(3):1017-26. [SCI IF= 4.451, 37/211 = 17% NEUROSCIENCES] (NSC-96-2320-B-039-044-MY3)
  1. Chen YL,Lin PC＊, Chen SP, Lin CC, Tsai NM, Cheng YL, Chang WL, Lin SZ, Harn HJ. Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells. J Pharmacol Exp Ther. 2007 Nov;323(2):746-56. [SCI IF= 4.003, 33/205 = 16% PHARMACOLOGY & PHARMACY]

共同作者

  1. Chan TM, Harn HJ, Lin HP, Chiu SC, Lin PC, Wang HI, Ho LI, Chuu CP, Chiou TW, Hsieh AC, Chen YW, Ho WY, Lin SZ.The Use of ADSCs as a Treatment for Chronic Stroke.Cell Transplant. 2014;23(4):541-7.
  1. Huang MH, Lin SZ, Lin PC, Chiou TW, Harn YW, Ho LI, Chan TM, Chou CW, Chuang CH, Su HL, Harn HJ.Brain tumor senescence might be mediated by downregulation of S-phase kinase-associated protein 2 via butylidenephthalide leading to decreased cell viability.Tumour Biol. 2014 Jan 26. [Epub ahead of print]
  1. Harn HJ,Lin PC,SuHL,ChiouTW,LinSZ. Pre-Clinical Studies and Clinical Application of Adipose-Derived Stem Cells. Journal of Neuroscience and Neuroengineering, 2013Feb;2(1):14-28.
  1. Harn HJ, Huang MH, Huang CT, Lin PC, Yen SY, Chou YW, Ho TJ, Chu HY, Chiou TW, Lin SZ.Rejuvenation of aged pig facial skin by transplanting allogeneic granulocyte colony-stimulating factor-induced peripheral blood stem cells from a young pig.Cell Transplant. 2013Feb;22(4):755-65.
  1. Liu PY, Lin SZ, Sheu JJ, Lin CT, Lin PC, Chou YW, Huang MH, Chiou TW, Harn HJ.Regulation of androgen receptor expression by Z-isochaihulactone mediated by the JNK signaling pathway and might be related to cytotoxicity in prostate cancer.Prostate.2013 Apr;73(5):531-41.
  1. Harn HJ, Lin SZ, Hung SH, Subeq YM, Li YS, Syu WS, Ding DC, Lee RP, Hsieh DK, Lin PC, Chiou TW.Adipose-Derived Stem Cells Can Abrogate Chemical-Induced Liver Fibrosis and Facilitate Recovery of Liver Function.Cell Transplant. 2012 Jul: 21(12):2753-64.
  1. Harn HJ, Lin SZ, Lin PC, Liu CY, Liu PY, Chang LF, Yen SY, Hsieh DK, Liu FC, Tai DF, Chiou TW. Local interstitial delivery of z-butylidenephthalide by polymer wafers against malignant human gliomas. Neuro Oncol. 2011 May 12.[SCI IF=4.984, 17/167 =10 %CLINICAL NEUROLOGY]
  1. Chang LF, Lin PC, Ho LI, Liu PY, Wu WC, Chiang IP, Chang HW, Lin SZ, Harn YC, Harn HJ, Chiou TW.Overexpression of the orphan receptor Nur77 and its translocation induced by PCH4 may inhibit malignant glioma cell growth and induce cell apoptosis. J Surg Oncol.2011 Apr;103(5):442-50. [SCI IF= 2.502, 37/167 = 22 %SURGERY]
  1. Liu PY, Sheu JJ, Lin PC, Lin CT, Liu YJ, Ho LI, Chang LF, Wu WC, Chen SR, Chen J, Harn YC, Lin SZ, Tsai CH, Chiou TW, Harn HJ. Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma. Invest New Drugs. 2010 Sep 1. [Epub ahead of print]. [SCI IF=3.072, 72/237=30 %PHARMACOLOGY & PHARMACY]
  1. HarnHJ, ChenYL, LinPC,ChengYL, LeeSC,ChiouTW and YangHH. Exploration of Potential Tumor Markers for Lung Adenocarcinomas byTwo-Dimensional Gel Electrophoresis Coupled with Nano-LC/MS/MS. Journal of the Chinese Chemical Society. 2010, 57, 180-188. [SCI IF=0.77, 82/127 = 65 %CHEMISTRY, MULTIDISCIPLINARY]
  1. Yu YL, Yu SL, Su KJ, Wei CW, Jian MH, Lin PC, Tseng IH, Lin CC, Su CC, Chan DC, Lin SZ, Harn HJ, Chen YL. Extended O(6)-Methylguanine Methyltransferase Promoter Hypermethylation Following n-Butylidenephthalide Combined with 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) on Inhibition of Human Hepatocellular Carcinoma Cell Growth.Journal of agricultural and food chemistry.2010 Feb 10;58(3):1630-8[SCI IF= 2.562,2/35=5 %AGRICULTURE, MULTIDISCIPLINARY]
  1. Sun LY, Hsieh DK, Lin PC, Chiu HT, Chiou TW. Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation.Bioelectromagnetics. 2010 Apr;31(3):209-19.[SCI IF= 2.062,22/72=31 %BIOLOGY]
  1. Wei CW, Lin CC, Yu YL, Lin CY, Lin PC, Wu MT, Chen CJ, Chang W, Lin SZ, Chen YL, Harn HJ.n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2alpha and telomerase activity.Acta Pharmacologica Sinica 2009 Aug 24.30(9):1297-306. [SCI IF= 1.676,46/125 = 36 %Chemistry, Multidisciplinary]
  1. Chang YJ, Liu JW, Lin PC, Luo GH, Chen TM, Lee RP, Lin SZ, Harn HJ, Chiou TW.Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis.Life Sci.2009 Sep 23;85(13-14):517-25[SCI IF= 2.583,87/216 = 40.2 %PHARMACOLOGY & PHARMACY]
  1. Chen SP, Wu CC, Lin SZ, Kang JC, Su CC, Chen YL, Lin PC, Chiu SC, Pang CY, Harn HJ.Prognostic Significance of Interaction Between Somatic APC Mutations and 5-Fluorouracil Adjuvant Chemotherapy in Taiwanese Colorectal Cancer Subjects.Am J Clin Oncol. 2009 Apr;32(2):122-6[SCI IF= 1.792, 108/141 = 76.6 %Oncology]
  1. Chen SP, Chiu SC, Wu CC, Lin SZ, Kang JC, Chen YL, Lin PC, Pang CY, Harn HJ.The Association of Methylation in the Promoter of APC and MGMT and the Prognosis of Taiwanese CRC Patients.Genet Test. 2009 Feb;13(1):67-71.[SCI IF= 1.12,63/82 = 76.8 %MEDICINE, RESEARCH & EXPERIMENTAL]
  1. Chen YL, Jian MH, Lin CC, Kang JC, Chen SP, Lin PC, Hung PJ, Chen JR, Chang WL, Lin SZ, Harn HJ. The induction of orphan nuclear receptor Nur77 expression by n-butylidenephthalide as pharmaceuticals on hepatocellular carcinoma (HCC) cells therapy. Mol Pharmacol. 2008 Oct;74(4):1046-58.[SCI IF=4.088, 29/205=14.15 %PHARMACOLOGY & PHARMACY] (NSC-96-2320-B-197-001-MY2)
  1. Tsai NM, Chen YL, Lee CC, Lin PC, Cheng YL, Chang WL, Lin SZ, Harn HJ. The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. J Neurochem. 2006 Nov;99(4):1251-62. [SCI IF= 4.451, 37/211 = 17% NEUROSCIENCES]

研討會論文：

  1. Po-Cheng Lin and Yi-Lin Chen, Activation of NAG-1 via ERK1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells.台灣生物化學及分子生物學會96年馬武督秋令營, 2007 Oct. P22 （台灣，壁報論文）
  1. Po-Cheng Lin, Yi-Lin Chen, Shao-Chih Chiu, Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin, Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. 2008 International Conference on Biomedicine & Graduate Student Retreat of MedicalCollege in ChinaMedicalUniversity,2008 May. P035（台灣，壁報論文）
  1. Yi-Lin Chen andPo-Cheng Lin,The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma (HCC) cells therapy. 20th Meeting of the European Association for Cancer Research, 2008 Jul. P544（壁報論文）
  1. Po-Cheng Lin, Yi-LinChen,Tzyy-Wen Chiou and Horng-Jyh Harn,Orphan nuclear receptor, Nurr-77 is a possible target gene of butylidenephthalide chemotherapy in glioblastoma multiform brain tumor.The 8th International Conference of Anticancer Research, 2008 Oct 17-22. 411（希臘，演講）
  1. Po-Cheng Lin,Yi-Lin Chen, Shinn-Zong Lin, Tzyy-Wen Chiou and Horng-Jyh Harn, The chemotherapy target of n-butylidenephthalide on glioblastoma multiform brain tumor. 中華民國中西結合神經醫學會, 2009 Jan 11. p.19 (台灣，演講: Po-Cheng Lin)
  1. Po-Cheng Lin, Wan-Chen Wu, Syue-Yong Chen, Po-Yen Liu, Li-Fu Chang, Horng-Jyh Harn, Tzyy-Wen Chiou. n-Butylidenephthalide Suppress Telomerase Reverse Transcriptase Expression in Glioblastoma. The 24th Joint Annual Conference of Biomedical Science,2009 May. 21-22. P355（台灣，壁報論文）
  1. Po-yen Liu, Jung-Ting Chien, Po-Cheng Lin, Li-Fu Chang, Wan-Chen Wu, Horng-Jyh Harn. Orphan Nuclear Receptor, Nur-77 Was a Possible Target Gene of PCH4 Chemotherapy on Oral Cancer Cells. The 24th Joint Annual Conference of Biomedical Science, 2009 May 21-22. P368（台灣，壁報論文）
  1. Wan-Chen Wu, Po-Yen Liu, Po-Cheng Lin, Li-Fu Chang, Horng-Jyh Harn. Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma. Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology, 2010 Jan 20-22. No.47 （台灣，壁報論文）
  1. Horng-Jyh Harn, Po-Cheng Lin, Po-Yen Liu, Li-Fu Chang, Wan-Chen Wu, Yeu-Chern Harnand Shinn-Zong Lin. Health Food Supplement, 20070721-GX, Could Increase the CD34 Stem Cells and Might be Beneficial for Longevity without Tumorgenesis. The 3rd Pan Pacific Symposium on Stem Cells Research, 2010April 16 to 19.（台灣，演講: Po-Cheng Lin）
  2. Po-Cheng Lin, Jen-Wea Liu, Yeu-Chern Harn,Horng-Jyh Harn and Tzyy-Wen Chiou.Tracing the Transplanted Mesenchymal Stem Cells by GFP Label in the Chemically Induced Liver Damage Rat Model. The 3rd Pan Pacific Symposium on Stem Cells Research, 2010April 16 to 19. PD-02（壁報論文，佳作）
  1. Tzyy-Wen Chiou, Jen-Wea Liu, Li-Fu Chang,Po-Cheng Lin, Li-Yi Sun, Ru-Ping Lee,Yao-Jen Chang, Shinn-Zong Lin andHorng-Jyh Harn. Chemically Induced Liver Fibrosis Can Be Alleviated By Stem Cell Transplantations. The 3rd Pan Pacific Symposium on Stem Cells Research, 2010April 16 to 19.（台灣，演講: Tzyy-Wen Chiou）
  1. Li-Fu Chang, Po-Cheng Lin, Po-Yen Liu, Wan-Chen Wu, Horng-Jyh Harn and Tzyy-Wen Chiou. The orphan receptor Nur77 over expression and translocation induced by PCH4may inhibit malignant brain tumor growth and induce cell apoptosis. AACR (American Association for Cancer Reasearch) 101st Annual meeting 2010.＃770（美國，壁報論文）
  1. Po-Yen Liu,Po-Cheng Lin,Li-Fu Chang,Wan-Chen Wu and Horng-Jyh Harn. Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma.AACR (American Association for Cancer Reasearch) 101st Annual meeting 2010.＃1275（美國，壁報論文）
  1. 林珀丞，劉柏言，林欣榮，邱紫文，韓鴻志。當歸純物質抑制人類惡性腦瘤端粒酶活性。2010年國際腫瘤醫學醫學論壇。（台灣，演講: 林珀丞）
  1. Mao-Hsuan Huang , Jia-An Lin, Cheng-Lun Lee, Lin-Syuan Lai, Po-Cheng Lin, Hong-Lin Su, Horng-Jyh Harn. Butylidenephthalide Promote Cellular Senescence in Human Brain Tumor. The 25th Symposium on Natural Products, 2010 Nov6 to 7. （台灣，壁報論文）
  1. Hsin-I Wang, Po-Cheng Lin, Po-Yen Liu, Shinn-Zong Lin, Horng-Jyh Harn Improved sexual behavior in male mice treated with Chinese herbal extract. The 4th Pan Pacific Symposium on Stem Cells Research, 2011 April 15 to 17. （台灣，演講:Po-Cheng Lin）
  1. Horng-Jyh Harn,Po-Cheng Lin,Cyong-Yue Liu,Ssu-Yin Yen, Li-Fu Chang,Po-Yen Liu,Shinn-Zong Lin,Tzyy-Wen Chiou. Local Interstitial Delivery of z-Butylidenephthalide by PolymerWafers against Malignant Human Gliomas. The 4th Pan Pacific Symposium on Stem Cells Research, 2011 April 15 to 17. （台灣，演講: Tzyy-Wen Chiou）
  1. Po Yen Liu, Tsung-Wei Chen, Meng-Ju Wu, Po-Cheng Lin, Jim Jinn-Chyuan Sheu, Cheng Tung Lin, Tzyy Wen Chiou and Horng Jyh Har. Expression of Nur77 induced by an N-butylidenephthalide Derivative promotes Apoptosis and Inhibits Cell growth in Oral Squamous Cell Carcinoma. The 4th Pan Pacific Symposium on Stem Cells Research, 2011 April 15 to 17. （台灣，壁報論文）
  1. Mao-Hsuan Huang, Tsung-Wei Chen, Jia-An Lin, Cheng-Lun Lee, Lin-Syuan Lai, Po-Cheng Lin, Hong-Lin Su, Horng-Jyh Harn. The Mechanism of Butylidenephthalide induce Cellular Senescence in Human glioblastomas. The 4th Pan Pacific Symposium on Stem Cells Research, 2011 April 15 to 17. （台灣，壁報論文，優秀論文獎第三名）
  1. Po-Cheng Lin. Stem cell therapy in chronic stroke patients-Phase II trial. The 2nd Meeting of Asian Cellular Therapy Organization, 2011 October 17 to 20. (日本，宮崎，演講:Po-Cheng Lin)
  1. Po-Cheng Lin. Stem Cell Application -- From Basic to Clinical. The 5th Pan Pacific Symposium on Stem Cells Research, 2012 April 13 to 15. （台灣，演講:Po-Cheng Lin）
  1. Chi-Ying Huang, Mao-Hsuan Huang, Ssu-Yin Yen, Po-Cheng Lin, Horng-Jyh Harn, Shinn-Zong Lin, Tzyy-Wen Chiou. Investigating the Rejuvenation of Ageing Skin by Allogeneic GCSF-Mobilized PBMC Transplantation. The 5th Pan Pacific Symposium on Stem Cells Research, 2012 April 13 to 15. （台灣，壁報論文）
  1. Kuo-Wei Hsueh, Po-Cheng Lin, Tzu-Min Chan, Pei-Chin Liu, Shinn-Zong Lin, Horng-Jyh Harn. EF-001 Prolonged the Survival of ALS Mice Through Down-Regulate Autophage Activity. The 6th Pan Pacific Symposium on Stem Cells Research, 2013 April 13 to 15. （台灣，壁報論文，優秀論文獎第三名）
  1. Po-Yen Liu, Shinn-Zong Lin, Jim Jinn-Chyuan Sheu, Cheng-Tung Lin, Po-Cheng Lin, Yi-Wen Chou, Mao-Hsuan Huang, Tzyy-Wen Chiou, Horng-Jyh Harn.Regulation of androgen receptor expression by Z-isochaihulactone mediated by the JNK signaling pathway and might be related to cytotoxicity in prostate cancer.The 6th Pan Pacific Symposium on Stem Cells Research, 2013 April 13 to 15. （台灣，壁報論文）
  1. Kuo-Wei Hsueh, Po-Cheng Lin, Tzu-Min Chan, Pei-Chin Liu, Shinn-Zong Lin, Horng-Jyh Harn. HK-001 Prolongs the Survival of ALS Mice associated Down-Regulaing Autophage in motor neurons. The 7th Pan Pacific Symposium on Stem Cells Research, 2014 April 12 to 13. （台灣，壁報論文）

其他著作：

  1. 林珀丞，林欣榮，韓鴻志，中醫抗癌開創醫學新視野，2008，中國醫訊，（59）p.33-35。
  2. 林珀丞，劉柏言，林欣榮，邱紫文，韓鴻志，當歸純物質抑制人類惡性腦瘤端粒酶活性，2010， 2010年國際腫瘤醫學醫學論壇論文集，p.69-76。
  3. Po-Cheng Lin, Tzyy-Wen Chiou and Horng-Jyh Harn. An Evidence-based Perspective of AngelicaSinensis (Chinese Angelica) for Cancer Patients. 2011. Evidence-based Anticancer Materia Medica.Springer. Chapter 7. p131-153.

榮譽：

  1. 2010年6月1日，獲選成為中華民國斐陶斐榮譽會員
  2. Executive Committee, The 4rd Pan Pacific Symposium on Stem Cells and Cancer Researches (PPSSC 2011/4/15~17)
  3. Chair & speaker, The 2nd Meeting of Asian Cellular Therapy Organization (2011/10/17~20)
  4. Reviewer, Cell Transplant​ation (2012/9/18)
  5. 2013年，國璽幹細胞應用技術股份有限公司，第四屆董事
  6. 2013年，生技高階人才培訓與就業計畫，計畫主持人
  7. 2013年，工研院「生醫所專利權維護放棄」產學研會議，業界專家
  8. 2013年，國立清華大學動力機械工程學系，碩士班口試委員

專利：

  1. 治療腦癌或用以降低腦癌細胞對替莫唑胺之抗藥性之醫藥組合物及其應用，中華民國（證書號：I386203）
  2. PHARMACEUTICAL COMPOSITION FOR TREATING ENCEPHALOMA OR PHARMACEUTICAL COMPOSITION FOR REDUCING TEMOZOLO-MIDE RESISTANCE OF ENCEPHALOMA CELL, AND USE THEREOF，日本（證書號：5417385）
  3. 改善關節炎之食品補充品的膠囊結構，中華民國（證書號：M450383）
  4. 改善肝損傷之食品補充品的膠囊結構，中華民國（證書號：M467460）
  5. 用於改善皮膚老化之組合物，中華民國（證書號：I444197）
  6. 可增加CD34+幹細胞數量及端粒酶活性之食物補充品，（證書號：I 445503）

證書：

  1. ISO/IEC 17025:2005 檢測實驗室（認證編號2800），實驗室主管
  2. ISO/IEC 17025:2005 檢測實驗室（認證編號2800），報告簽署人
  3. 97年度實驗動物中心管理與使用訓練課程（中國醫藥大學, 97年10月3日）