Supplementary Table. Pooled multivariate relative risks (95% confidence intervals) of epithelial ovarian cancer for categories of vitamin intake based on absolute cut points

p-value, test for trend / p-value, test for between-studies heterogeneity, highest category
Total vitamin A
Intake category (μg/day) / ≤1000 / >1000-1500 / >1500-2000 / >2000-2500 / >2500-4000 / >40002
Number of cases / 381 / 322 / 208 / 172 / 253 / 129
Pooled multivariate RR1 / 1.00 (ref) / 0.87 (0.70-1.09) / 1.02 (0.84-1.23) / 0.95 (0.75-1.20) / 0.88 (0.73-1.06) / 1.02 (0.80-1.30) / 0.69 / 0.40
Total vitamin C
Intake category (mg/day) / ≤100 / >100-150 / >150-200 / >200-250 / >250-600 / >6002
Number of cases / 296 / 320 / 256 / 148 / 227 / 218
Pooled multivariate RR1 / 1.00 (ref) / 0.93 (0.79-1.10) / 1.00 (0.84-1.20) / 0.94 (0.75-1.16) / 0.91 (0.75-1.11) / 0.87 (0.69-1.10) / 0.27 / 0.32
Total vitamin E
Intake category (mg/day) / ≤6 / >6-9 / >9-12 / >12-25 / >25-200 / >2002
Number of cases / 230 / 365 / 196 / 275 / 205 / 194
Pooled multivariate RR1 / 1.02 (0.81-1.27) / 1.00 (ref) / 0.99 (0.79-1.25) / 0.93 (0.79-1.10) / 1.02 (0.75-1.38) / 1.02 (0.82-1.28) / 0.85 / 0.26
Total folate
Intake category (μg/day) / ≤2003 / >200-250 / >250-300 / >300-400 / >400-600 / >600-8002 / >8002
Number of cases / 147 / 161 / 205 / 228 / 181 / 246 / 89
Pooled multivariate RR1 / 0.94 (0.71-1.23) / 0.90 (0.67-1.22) / 1.00 (ref) / 0.96 (0.76-1.21) / 0.78 (0.63-0.96) / 1.05 (0.77-1.42) / 0.84 (0.65-1.10) / 0.92 / 0.91

1 Adjusted for parity (0,1,2,3+), oral contraceptive use (never, ever), menopausal status and postmenopausal hormone use (premenopausal, unknown menopausal status, postmenopausal never use, postmenopausal past use, postmenopausal current use), age at menarche (<13, 13, 14+ years), body mass index (<23, 23 to <25, 25 to <30, 30+ kg/m2), physical activity (low, medium, high), smoking status (never, past, current) and total energy intake (kcal/day, continuous); age in years and year of questionnaire return were included as stratification variables

2 The Netherlands Cohort Study did not include any cases with vitamin intakes in these categories.

3 The New York State Cohort did not include any cases with folate in take in this category.