Supplementary Information S3 (Box) the Phylogenetic Tree for Cas1/COG1518 Proteins

SUPPLEMENTARY INFORMATION In format provided by Makarova et al. (JUNE 2011)

Supplementary information S3 (box) | The phylogenetic tree for Cas1/COG1518 proteins.

The maximum likelihood tree was constructed using the PHYML program 39 from 182 informative positions in the multiple alignment of a representative set of 228 Cas1 proteins from 442 complete genomes (those that encode Cas1 from the set of 703 genomes listed in the Supplementary table 1). The BLASTCLUST program was used to cluster the Cas1 sequences by similarity (with the following parameters: Sequence length to be covered = 70%, score identity threshold = 1.0), and one representative from each cluster was chosen (see the list in the Supplementary Material). Six major CRISPR/Cas system subtypes of Type I systems as well as type II and type III systems are color-coded. Dashed lines show cas1 genes found in “hybrid” CRISPR loci containing genes from both Type I and Type III CRISPR/Cas systems (see text). The subtypes of CRISPR/Cas systems are denoted as in Figure 2. Subtypes I-U, II-U and III-U (U for unclassified) denote CRISPR/Cas systems that lack currently defined subtype-specific signature genes (see main text).

Parts of the supplementary material:

Part 1: The Cas1 tree in Nexus format

Part 2: The Cas1 alignment used for tree reconstruction

Part 3: The list of Cas1 proteins used for tree reconstruction (information about the lineage and the species names are provided).

Part 1:

((((((((((((((((((75910374:0.003624,17229060:0.022179):0.541901,((163848915:0.167070,148657121:0.174931):0.081565,159898907:0.472163):0.114733):0.120182,(((30248142:0.308458,52425690:0.537125):0.247462,206890539:0.509417):0.165872,(121997419:0.549532,288947693:0.710065):0.125350):0.321208):0.094115,(((116748794:0.549572,85858452:0.420177):0.132273,154250301:0.755976):0.102524,((((134299482:0.168730,258516129:0.155942):0.268107,159898755:0.555911):0.049485,(218438692:0.166424,38505684:0.163962):0.443025):0.115782,(268318378:0.317181,55978328:0.605306):0.185607):0.046666):0.062299):0.053109,(((((17228961:0.496609,119357853:0.386569):0.078439,119357846:0.325450):0.071105,86608317:0.542016):0.164285,37677204:0.677186):0.056598,((209966743:0.059240,83592490:0.137063):0.623986,261415948:0.618419):0.200395):0.077616):0.042206,((((((86742032:0.580773,94984342:0.378452):0.029665,(78222290:0.225317,83589357:0.228900):0.133248):0.140939,((((21673956:0.270564,46562259:0.224825):0.146373,((21244566:0.169570,34496684:0.116275):0.044164,83592169:0.302844):0.040049):0.102187,108763792:0.482318):0.030193,((15612904:0.151042,161507871:0.333386):0.090167,15675454:0.477441):0.151009):0.072378):0.116825,55978407:0.511943):0.086883,((283458258:0.295273,241196732:0.159087):0.385287,114567264:0.572214):0.161436):0.089762,(116754851:0.155839,76802276:0.151519):0.551555):0.067391):0.052021,((220910738:0.163671,17227877:0.056562):0.088913,38505739:0.108151):0.529322):0.077514,(20094748:0.784701,((((294828260:0.289259,108761389:0.468992):0.125001,162457462:0.379250):0.080350,170078384:0.308814):0.446132,(83591519:0.379560,39995168:0.274367):0.270282):0.080423):0.061767):0.071966,((269798874:0.746495,88602029:0.822484):0.177996,((288957883:0.781595,220934970:0.569096):0.216822,(116627764:0.705656,15609954:0.548136):0.264306):0.101485):0.087551):0.092644,(((289596068:0.198197,147921327:0.362327):0.287478,21229351:0.306074):0.493708,((11499462:0.408882,((((118431380:0.632826,(218884093:0.431861,((15898286:0.446930,15922975:0.214014):0.280330,((124027534:0.340083,156937921:0.579957):0.232519,(70607609:0.604740,156937861:0.498047):0.595053):0.056168):0.098728):0.050056):0.073724,((18311772:0.602345,18311699:0.343577):0.185841,(((260893609:0.291241,159901591:0.337537):0.118198,(15898245:0.485975,34541577:0.766446):0.259138):0.060668,(34557933:0.288860,54296139:0.438216):0.356025):0.150963):0.061254):0.052774,(((284040851:0.538448,((21226661:0.149482,150401497:0.510369):0.071731,((134045811:0.175169,150398872:0.387626):0.158888,125975696:0.268362):0.097626):0.036328):0.040945,224367660:0.343920):0.095465,257125862:0.384674):0.432509):0.072513,((288932203:0.169062,170290046:0.197214):0.037603,126465226:0.369532):0.527616):0.043399):0.156479,(((((38232679:0.338404,283456134:0.315141):0.203796,117929157:0.324954):0.316811,(187250661:0.123852,189485060:0.264755):0.449542):0.097152,((((261414554:0.180878,60683388:0.152140):0.053769,150025576:0.222320):0.238830,((209542526:0.188937,90425960:0.453728):0.118372,(((((34557789:0.282769,189485226:0.431923):0.104862,220930481:0.285491):0.095735,((15602991:0.162570,218767587:0.111698):0.177329,222109284:0.435303):0.085902):0.016004,57238545:0.662687):0.036708,((157149930:0.043571,55820736:0.060650):0.396688,((269123825:0.814517,238924076:0.333311):0.072642,(((71894593:0.189622,294660601:0.274967):0.269350,47458867:0.432986):0.207461,((((169823756:0.363459,42525844:0.297408):0.113782,15675042:0.426833):0.116868,90961086:0.452759):0.172784,57865886:0.525778):0.097975):0.192763):0.040478):0.273707):0.118617):0.061506):0.065008,((((75675148:0.221281,288957740:0.127407):0.028147,121608212:0.267264):0.042346,159042957:0.335135):0.093861,154250554:0.390363):0.156302):0.076834):0.172175,187736488:0.935931):0.454074):0.037126):0.083635):0.100639,283778924:1.090547):0.131001,((((((((15679095:0.198651,(15668554:0.141964,14591064:0.104798):0.271844):0.093727,20092470:0.264532):0.071323,11500011:0.236929):0.072917,((((146295386:0.216732,206900365:0.138093):0.020529,206889560:0.189777):0.107341,(((222099688:0.021870,148270212:0.028389):0.125236,83590562:0.213124):0.069711,15605875:0.289435):0.079940):0.045626,((((15644541:0.218877,221632058:0.265086):0.067157,((239617067:0.332248,288818552:0.184406):0.054861,(160903306:0.251141,(154249624:0.160869,(219669947:0.162450,20809002:0.229881):0.088898):0.039477):0.019845):0.017025):0.070893,150021526:0.523966):0.100183,((34541603:0.388795,212638614:0.325551):0.074873,(189345988:0.253189,(257125579:0.310157,19704512:0.209647):0.050205):0.107788):0.034960):0.030151):0.054464):0.037364,((41614813:0.570882,((268679538:0.170612,28211139:0.254966):0.108127,114567318:0.252030):0.266610):0.081376,((84489236:0.289837,14590110:0.348141):0.098626,(289596694:0.325227,13540937:0.412493):0.095733):0.076548):0.125946):0.099556,48477075:0.661210):0.076948,(157164052:0.046287,154174048:0.086401):0.792193):0.161958,111224947:0.711050):0.210181):0.911131,(((((((89885834:0.591263,((((((219852205:0.103761,91772628:0.157972):0.032629,39996494:0.083182):0.026463,((((47104059:0.060105,158522999:0.058725):0.045162,92112367:0.078484):0.043402,((16130662:0.050404,16766244:0.034407):0.051364,146308770:0.053385):0.051011):0.053768,(220925254:0.129219,162147988:0.067836):0.046853):0.027907):0.029163,88602656:0.231027):0.038619,83591509:0.183852):0.062612,220904201:0.186592):0.151760):0.154738,(((((94972104:0.227851,167628317:0.206650):0.052342,(55978376:0.259868,(218439403:0.175355,86605441:0.112564):0.143819):0.038284):0.025363,(((269838937:0.106534,148654810:0.161588):0.014897,51891801:0.163836):0.040904,147920423:0.265855):0.008735):0.055873,73749217:0.284904):0.092963,116327441:0.332653):0.039250):0.066429,((147674033:0.153898,(21674788:0.155016,189501080:0.099527):0.081341):0.101107,218782762:0.091093):0.448767):0.029141,((269126905:0.131627,256393069:0.119659):0.205372,(((290580135:0.081284,283783235:0.167109):0.060014,(104773928:0.095297,116493922:0.083914):0.103435):0.077528,(68535718:0.309905,((111219951:0.055162,86738746:0.064221):0.168383,257055753:0.026095):0.144039):0.039086):0.078706):0.188766):0.089714,((72161989:0.281113,257055744:0.150049):0.056253,29834079:0.219680):0.158147):0.080489,((((197121198:0.249365,268316057:0.253978):0.100336,53804737:0.170775):0.077479,83591687:0.215772):0.064607,209966592:0.444561):0.384881):0.166130,38234755:0.713021):0.139175):0.648216,(50085564:0.491769,77166205:0.269512):0.099159):0.091669,54303647:0.144101):0.110541,((((34497211:0.096720,116050364:0.121980):0.028729,121592920:0.089758):0.034960,239908820:0.168204):0.044934,15602176:0.188438):0.065034):0.056322,91209921:0.204142):0.060214,22125615:0.046584,50122600:0.072090);

Part 2:

50085564 PEKNTAFLLLGKGSSLTDAAARRLAESNVMVGFCGSGGSPLFSSLIWMKAWLD-DDARLLMAKILLLERI------VLVSQLLA----AEGRWAKALYKELNNYLDHGNY-IAYGYAAVALNGMGISFALPILH-GKTRRGGLVFDLADLVKDAFVMPTAFI

77166205 PPANTNVILLGSGTSLTQAAARLLASEQVMVAFVGGGGSPLFLASAWMRLWQD-NDQRLKVAKTFQRNRA------EFLMQILA----QEAKFAKKLYKFWNSYLDHGNY-LVYGIAAAVLWVLGIPHSLPVIH-GTTRRGALVFDVADIIKDTCVMPIAFQ

54303647 PIANTTVLLLGNGTSITQAAMRMLAQAGVLVGFSGGGGTPLYMANGWMSFWFD-DQKRLEVAKTFQQARL------TFLQKLLL----TEAQLTKYLYKFANDFLNHGNY-LAYGLAASTLWVLGIPHGFAVMH-GKTRRGALVFDVADLIKDTIVLPWAFI

15602176 PIANTSCLLLGSGTSITQAAMRELSKAGVMVGFCSGGGTPLFNGTQWCKFWFD-DEKRLAVAKALQQQRL------ALLEPLLA----AEGRLTTKLYALANQFLDHGNY-LAYGLGATACWVLGLPHGLAVLH-GKTRRGGLVFDAADIIKDSMILPQAFI

239908820 PIANTTTVLLGSGTSVTQAAMRELAKSGVLVGFCGTGGTPLYSANSWVKLWLN-DNMRLQAAQKLQVLRL------KYLCKLLT----EEGRLTKALYKFANRFLDHGNY-LAYGLGATATWVLGLPHGLSVLH-GKTRRGGLVFDAADLIKDALILPQAFL

34497211 PIANTTTLLLGTGTSVTQAAMRELAKAGVMVGFCGGGGTPLFSAGWWARFWFD-DDKRLQAAKQLQQARL------ARIRALLT----EEARLSKQLFRLANRFLDHGNY-LAYGLGATAAWVLGLPHSLAILH-GKTRRGGLVFDAADLVKDAAILPQAFV

116050364 PIANTTSLLLGTGTSITQAAMRELARAGVLVGFCGGGGTPLFSANRWVGFWFD-EEKRLVAARHFQRARL------ERIRHLLT----EEARLSKRLFKLANRFLDHGNY-LAYGLAATATWVLGIPHGLAVLH-GKTRRGGLVFDVADLIKDSLILPQAFL

121592920 PIANTTSILLGTGTSITQAAMRELAKAGVLVGFCGGGGTPLFAANYWVKFWFD-EELRLHAAKQLQTWRL------QRLAALLT----DEARLTKALFRLANRFLDHGNY-LAYGLGATATWVLGLPHGLAVLH-GKTRRGGLVFDAADLIKDAAILPQAFL

50122600 PIANTSVVMLGTGTSVTQAAMREFARAGVMIGFCGGGGTPLFAANDWVSFWFD-DEKRLAAAIAFQQVRI------TQIRQVLV----QEAMMTKALYRLANRFLDHGNY-LAYGLAAVSTWVLGLPHGLAVLH-GKTRRGGLVFDVADLIKDALVLPQAFI

22125615 PIANTTVIMLGTGTSVTQAAMREFARAGVLVGFCGGGGTPLFAANDWVSFWFD-DEKRLAAAVAFQRIRI------AQIQQLMV----QEAVLTKALYKLANRFLDHGNY-LAYGLAATATWVIGLPHGLSVLH-GKTRRGGLVFDVADLIKDALVLPQAFI

91209921 PIANTTALILGMGTSVTQAAMREFAHAGVMVGFCGTDGTPLYSANQWVSFWFV-EDKRLAAAKRFQLIRL------THIDKLML----VEAKLTKALYKMVNRFLDQGNY-LAYGLAAVAAWVTGIPHGLAVMH-GKTRRGGLVFDLADLIKDALVMPQAFI

38234755 PVASLAVLCLGPGTSISNAAMTSCTRSGCTVIFTGGGGVNAYSHAAQACLVSN-TEYQKKAALAFYKRQFGGNAITGGSISV--MRG----LEGRIMRNTYRENNVGLNISNS-ILYGAAATVCTAIGVNPALGIIH--RGDTRSLLFDLADLYKASIVIPLVFS

209966592 PYQRLNAVLLGPGSSITHDAVRHCSGHGTCLAFVGSDGTRLYTAPQQATWWAG-ESTRIMVAKRMYAKRFG-ETPRA--TSLDSLRG----MEAARIRHSYELINQAINHVVT-AVEACVAIAVQATGTLPPLGFLH--EDSAKSWTLDICDLYRTSVTVPLAFR

53804737 PYQGLSMILLAPGTTVSHDALRLLARHGTLLAAVGDGGVKFYTAPAHARLWAD-EKARLDVARHMYAFRFG-RILPH--KDIAVLRG----IEGARVKETYQLLNQAINHAAT-FVEAAADVAVAAVGGLPPLGFIH--EESSNAFTLDIADLFRAEVTLPLAFS

268316057 PLQQVSNILLGPGTVVSHDALRLLARQQTGLLAVGSGGVRLYAVSRHARLWAD-ETRRLEIARAMYAIRLG-GALPPYIQDLDTLRG----IEGARVKESYRQLNNAINHAAV-AVYAAARIAVAVTGTIPQLGFIH--EASGHAFALDIADLFRTTVTVPVAFR

197121198 PFQMVTAVLLEPGTTVSHDALRLLARHGTGLVAVGEEGTRFYASMRQVTAWASAADGRLRVARRMYAWRFG-EVLPD--EDITVLRG----IEGARMREIYRRLNQAINHAAS-AVEAAALVAVAVTGTVPQLGFIH--EDSGNAFALDVADLFRSAIALPAAFS

83591687 PHQAVSIILLGPGSSVTHDALRLLARHGCALAAIGQGAVRFYTAPAQVTLWAD-PKTRMEVARAMYAMRFG-EIVRT--RDIEVLRG----QEGARIKRSYQLANQAINHAAT-AMTAAASVAVAAVGAIPQLGFVH--EDSGQSFVLDIADLYRHDITLDIAFG

89885834 PGSMVSCLMIEPGVSVTHEAMKLCGENGTLLMWVGEGGTRFYAAARQAAIHTN-QRERIAAASRLYGLMFD-DHMPPS-FTIEKLRG----LEGSRVKEIYVNLNTSIGFATS-CLYALCEVAILAAGYHPGIGVVH--SGNPRSLVFDLADTVKFKTVVPLAFE

189501080 PVAQLNCLLLGPGTAVTHEAVKVMAAANCGICWVGEDSLIFYAAGRQMVLSAD-SDKSLKVARRMFARRFP-DAKLET-KSLKQMMG----MEGLRVRQLYVQKNRILTSANA-ALYGIICSAVHSMGYSPHMGFIH--TGSPLPFIYDLADLYKESLSIDLAFR

21674788 PVAMLNCILLGPGTTVTHEAVKVMAAANCGICWVGDDSLMFYASGHQMKLAAN-PAKALEVARRLFAYRFP-DANLEN-KTLPQMMG----MEGLRVRKLYEEMNKILTASNA-ALYSIILSAVHSMGYSPHIGFIH--SGSPLPFIYDLADLYKQQVSIDLAFS

218782762 PAAVINTLLLGPGTSITHEAVKVLAAANCNVCWVGEDSLLFYAAGSQMLLAAD-KKKSLEVARRMFAMRFP-QEDLTG-KSLKEMMG----MEGHRVRALYKDLNQVLTSANA-ALYGILTSSVYSLGYSPHIGFIH--SGSPLPFIYDLADLYKKDLCIDLAFA

147674033 PVATINTLLLGPGTSVTHDAIKTATAANCSISWVGEDSLLFYAAGKQMLLAAS-EESALKVARMMFAKRFP-DADLED-KTLKSMMG----MEGNRVKALYQQKNQIMTASNA-ALYGILCSAIHSMGYSPHIGFIH--SGSPLPFVYDMADLYKEHLCIDLAFS

72161989 PTASLACVLLGPGTSITSPAMATFMRHNTTVVTCGAGGILNYGSFRQARAYSD-DRRRRDVAVRMYEMRFG-EEPPPG-ASIERLRQ----LEGARMKALYRSLNKALSASNA-ALYGVVHSVLAHLGCHPALGFIH--SGKQDAFVYDIADLYKARTTIPLAFS

257055744 PVAAISCILFGTGTSVTQPAMATCARHNTTVLWTGSGGVRMYSGSRQVRAWAD-DSTRLAVAARMYSMRFG-AEVPAG-TSLNTLRG----LEGQRMKALYRSLNQALSAANT-ALYGAVHSALLALGCSPALGFIH--SGKQHSFVYDVADLYKAKHTIPLAFA

29834079 PTAALGCVLLGPGTSITARALATFARHGTTVLITGAGGVRCYAAARQTRAWAD-DTRRLAVATAMYEKRFGEATVPPG-TTLAQLRG----FEGQHVKAHYRVLNLALSAANT-CLYGIVHAAILALGCSAALGFVH--NGNQQAFVYDIADLYKADLTIPLAFS

83591509 PVGGLACLMLEPGTRITHAAIVLCARVGCLVIWVGERGTRLYAAGFQARNALD-ETARLNVVREMYRRRFD-DDPPAR-RSVDQLRG----MEGVRVREIYRLLNRCLSAATA-CLYGLCEAAILAAGYAPAIGFLH--RGKPQSFVYDVADLYKVETVVPTAFS

88602656 PVGGLASLMLEPGSRVSHAAVSLASKVGCLLVFVGEGGVRLYSVGYQARLALD-EVLRLKVVKKMFSLRFG-EDFSDA-YSVEQLRG----LEGVRVREGYRKINRCLSAATA-SLYGICEAAVLAAGYSPSIGFLH--TGKPLSFVYDIADLFKFETVVPAAFK

220904201 PVGGVACLFLEPGTTVTHAALALAADCGTLMVWVGEGGVRLYSAGYQARLALD-DELRLRVVRAMYRMRFN-EEPPQR-RSIEQLRG----VEGARVRALYKFLNKAVSVACH-CLYGICEAAVLAAGYAPAIGFIH--SGKPLSFVYDVADLFKFETAIPAALS

162147988 PIGGLACLMLEPGTRVSHAAAALAARAGTLLIWVGEAGVRLYASGLQARLALD-DAARLKVVRKMYALRFG-EDAPER-RSVDQLRG----IEGSRVRETYRLLNRCLSAATA-ALYGITEAAILAAGYAPAIGFLH--TGKPQSFVYDIADIVKFETVVPEAFR

91772628 PVGGIACLMLEPGTRVSHAAISLAARVGCLLIWVGEAGVRLYSAGYQAKLALD-EELRLKVVRNMYEMRFN-EPVSEG-YSVEQMRG----MEAARVKKMYKIFNRCLSSATS-CIYGVAEAAILAAGYSPAVGFIH--TGKPRSFVYDVADIFKFETVVPIAFR

219852205 PIGSVACLMLEPGTRVSHAAVVLAARVGCLLIWVGEAGVRLYAAGYQAKLALD-PEARLKVVQKMYEIRFQ-GPVPSH-YSIEQLRG----MEGARVREMYVQINRCLSSATA-CLYGICEAAILAAGYAPAIGFIH--SGKPQSFVYDIADLFKFETVVPVAFR

39996494 PVGGVACLMLEPGTRVSHAAVTLASRIGCLLVWIGEAGVRLYASGYQAKLALD-DSARLKVVRKMYALRFR-EEPPER-RSVEQLRG----IEGVRVRKMYELLNRCLSSATA-CLYGICEAAILAAGYAPAVGFIH--TGKPQSFVYDIADIFKFETVVPVAFR

146308770 PVGSVACIMLEPGTRVSHAAVHLASTVGTLLVWVGESGVRLYASGYQAKLALD-DELRLKVVRKMYELRFQ-EPAPAR-RSVEQLRG----IEGSRVRETYKLLNRCLSAATS-CLYGITEAAVLAAGYAPAVGFIH--TGKPLSFVYDIADLFKFETVVPLAFR

16766244 PVGSVACIMLEPGTRVSHAAVRLASTVGTLLVWVGEAGVRVYSSGYQAKLALD-DDLRLKVVRKMYELRFR-EPPPAR-RSVEQLRG----IEGSRVRATYALLNRCISAATS-CLYGISEAAILAAGYAPAIGFIH--SGKPLSFVYDIADIIKFESVVPKAFE

16130662 PVGSVACIMLEPGTRVSHAAVRLAAQVGTLLVWVGEAGVRVYASGYQAKLALD-EDLRLKVVRKMFELRFG-EPAPAR-RSVEQLRG----IEGSRVRATYALLNQCISAATS-CLYGVTEAAILAAGYAPAIGFVH--TGKPLSFVYDIADIIKFDTVVPKAFE

92112367 PVGSVACLLLEPGTRVSHAAVKLASVVGTLLIWVGDAGVRLYSAGYQAQLARD-EKLRLKVVRKMFELRFG-EEPPSR-RSVDQLRG----MEGARVRKTYQLLNQCLSAATA-CLYGITEAAILAAGYAPAIGFLH--TGKPLSFVYDIADIVKFETVVPAAFR

158522999 PVGSVACIMLEPGTRISHAAVKLAATTGTLLIWVGEAGVRLYSAGYQAKLALD-EQLRLKVVRRMFEIRFG-EKPPER-RSVDQLRG----IEGARVRKIYELMNKCLSAATS-CLYGVTEAAILAAGYAPAVGFIH--SGKPLSFVYDIADIYKFDTVVPVAFR

47104059 PVGSVVCIMLEPGTRISHAAVKLAATTGTLLIWVGEAGVRLYSVGYQAKLALD-ETLRLKVVRKMFELRFG-EPAPER-RSVDQLRG----IEGARVRKIYQMLNQCISAATS-CLYGVTEAAILAAGYAPAIGFLH--SGKPLSFVYDIADVIKFETVVPVAFL

220925254 PIGGLVCLMLEPGTRVSHAAVALAARAGTLLVWVGEAGVRLYAAGWQARLALD-ESARLKVVRRMFELRFG-EAAPER-RSIDQLRG----IEGARVRRLYQLYNRCLSAATA-CLHGLAEAAVLAAGYAPAIGFLH--TGRPRSFVYDVADLFKFETVVPAAFR

257055753 PAALVAVVLLGPGTRVTHGAMQLLADSGTAVCWVGEQGVRMYAAGRQAYLVSR-TTTRLEVARAMYAMRFP-GEDVST-LTMQQLRG----REGARVRKVYRQQNRLLSAANA-ALYGICHAVIVGLGASPGLGFIH--TGSATSFVMDIADLYKAEYTIPLAFQ

86738746 PAAFVATVLLGPGTRITSAAVRLLADSGTALCWVGDRGVRMYAAGRQAYLVTR-TSERLDVARRMYAKRFP-DDDVTT-ATMQQLRG----REGARIKKIYRDHNRLLSAGHS-CLYGICHAAIVGIGASPALGFVH--TGAATSFVLDIADLYKADYTIPLAFD

111219951 PAAFVATLLIGPGTRVTHAAVRLLADSGTAVCWVGDRGVRMYAGGRQAYLVTR-TQHRLAVARRMYGMRFP-DDDVST-ATMQQLRG----REGARIKKVYRAHNRLLSAGHS-CLYGICHAAIIGIGASPALGFVH--TGSAISFVLDIADLYKAEYTIPLAFD

116493922 PAALISVLMLGPGVDVTHRAMELMGDAGMSVVWVGERGVRQYAPGAQAKLVSN-NRLRVGVARQMYQMRFP-DDDVST-LSMQELRG----KEGARVRRIYREENQALTAAHA-ALYGLSYSVIVALGASPGLGFVH--TGHDLSFVYDFADLYKAEVTIPIAFT

104773928 PAAIISVLLLGPGVDVTHRAMELMGDSGMAVVWVGEQGVRQYAHGAQAKLVSN-VRSRVAVARKMYQLRFP-DEDVTK-LTMEEMRG----KEGTRVRRVYREQNKALTAAHQ-ALYGLSYSVIVALGASPGLGFIH--TGHDLAFVYDFADLYKADISIPIAFE

283783235 PAAMIGVLLLGPGTEITHRAMELLGDVGASIVWVGEHGVRNYAHGKQSKLVTN-SRSRLNVARKMYQMRFP-NENVSS-YTLQQLRG----REGARVRHLYREMNKALSVGNV-CLYGLVHSIISALGLAPGLGFVH--TGHDLSLVYDIADLYKAELTIPASFE

290580135 PAAMLGVLLLGPGTDISHRAVELIGDTGTSIVWIGERGVRQYAHGKQARLVSN-SRSRLKVARKMYQMRFP-NEDVSS-LTMQQLRG----REGARIRKVYKLQNQSLSAANV-ALYGLVHSIVVALGASPGLGFVH--TGHDLSFVYDVADLYKAEFTIPIAFE

68535718 PAASIAALLLGPGTKVTYAAMALLGDSGVSVVWVGEKGVRYYASGAQASIVSN-QRRRLFCARQMYAMRFP-GEDISR-ATMAQLRG----REGSRMKKVYLAENRTLTAANA-ALYGVAHAVIASLGFIPSLGVIH--QGTERAFVYDIADLYKAEISIPAAFD

256393069 PSATIGTLLLGPGTRITHQAMAVLGDCGANVAWVGEHGARFYAAAAQATLWAN-RRTRLDIARAMYRMRFP-DEDPSG-FMRQQLLG----MEGRRLKDCYRQQNQAITAAAQ-CMYGVAHTIITALGCSPGLGFIH--SGHELSFVMDIADLYKTEIGIPVAFD

269126905 PSATIGCLLLGPGTRVTHQAMSVLGDSGAGVVWVGEQGVRFYSGGAQAIKWAN-RRTRLEVARAMYRMRFP-DEDPAG-LTRQELLG----REGRRVKERYRQENQAVTAAAQ-CMYGIAQTTVAALGCSPGLGFIH--SGHELAFVLDIADLYKTEFALPIAFR

116327441 PIETIGLLLLGPGTSITHEAIKRISDSRCLLAWTGEGGVRFYSAGRQVEAYGN-PKERVSVIRKMYQFRFS-DEIPAD-ATIEQIRG----LEGARVRKIYREWNRALSSANA-CLYGVVHAAILQSGFSPAIGFVH--TGKQLSFVYDIADLYKAEITIPLAFE

73749217 PIDQLGVVMLGPGSTVTHAAIKSLSQNNCLIAWTGQDGVRLYAASRQARLVSD-DEKRLEVAWRMYRFRFN-EVIPPV-VSLESIRG----MEGIRVRRAYAKANRALSAANA-CLYGICHAGILSAGYSSALGFVH--TGKMLSFVYDVADLYKTELTIPVAFK

86605441 PCASLTTLMLGPGTAITHAAIKNLADGLCSVQWVGEDGLRFYASGHQAKLWAD-PVQHMEVVRRMYSFRFP-EPLKEG-LTLEQIRG----LEGVRVRTVYSRLNRALSVANT-CLYAVCQAALNAVGYSTALGFIH--IGKPLSFVYDVADLYKTEITIPVAFK

218439403 PCANLSTLLLGPGSHITHAAMKTLADNACEVQWVGEDSFRFYSSGHQAKMWAD-PQQHLAVVRKMYQFRFC-EPLSED-LTLQQIRG----LEGVRVRTVYQRMNRALSSANS-YLYAVCQVALVSVGYSPALGFIH--TGKPLSFVYDIADLYKADTTIPAAFE

94972104 PAASLSVLLLGPGCSVSHEAVKALSDTGCSLLWVGEGGVRLYASGRQALLWAN-PQSRLRVVRQMYAMRFP-EGLPPD-LTLEQIRG----REGARVRDAYARSNKAISAGNA-CLYGLAHAAILSMGYSPALGFIH--TGKMLSFVYDVADLYKLEVVLPVAFR

167628317 PCASLSVLMLGPGTKVSHAAMRTLADCGCSVLWVGEGGLRVYGQGRQVSLWSN-PDTRMAVVRRMYELRFR-EPVSPE-MTLRQIRG----MEGGRVRQIYARLNRALSAANA-CLYGVCHAAIVSMGYSPAVGFIH--TGKQLSFVYDVADIYKTDTTIPVAFT

55978376 PVAGLGVLFLGPGTRITHAAVRLLAENGCTVAWVGEGMARFYAQGRQARAWAD-PALHLEVVMRLYRMRFS-EPLPEG-LTLEQVRG----LEGVRVRNAYARWNRALSAGAS-YLYGLAHAAIVSLGFSPALGFIH--TGKLLSFVYDIADLYKADYLVPAAFR

147920423 PCASLALLMLGPGTSITHEAVKTLADNGCLAAWCGEGGIRFYAQGKQALLVSH-PALRLKVVEKMYRMRFK-E-IPEN-LSIQQLRG----MEGYRVRQTYALANRALSVANS-CLYGICSAAIISVGYSTALGFIH--TGKQLSFVYDIADLYKASITIPLSFR

269838937 PCASLSLLMLGPGTSITHAAIQTLADNGCLVAWVGEEGVRFYAQGRQAMLWSD-PELHLQVVRRMYEIRFR-HPINPN-TSLKQIRG----MEGARVRGAYLQLNRAISAANS-CLYGVCHAAIVSAGYSTALGFIH--TGKMLSFVYDVADLYKTEISMPAAFY

148654810 PCATLSLLMLGPGISITHQAIKTLAENGCMVAWVGEEGVRFYAVGRQAAMHSD-PDLRLRIVRRMYEMRFP-EKLDPG-LTIKQIRG----KEGARVRDTYARWNRAISAANS-CLYGIVHAAIVAAGYSPALGFIH--TGKMLSFVYDVADLYKTDIAIPAAFR

51891801 PCASLSLLMLGPGTSVTHAAVMAMVEAGCLVAWCGEQGVRFYAQGQQARFWAD-PQRRMQVVRRMYEMRFG-EPLDPS-LSLRQIRG----KEGARVRTAYARANRALSAANA-CLYGVCHAAIVAAGYSPALGFIH--TGKMLSFVYDVADLYKTEITIPAAFM

220934970 PLETLAGVLLGPH-QVSTQLLGALLDRGIPLALATGQG-RLRGVLRQAACFED-DARALEAARAVVDARL------RQQRELNG----LEGQAARLYFGALNVLLSLGYT-VLHAHVDTVVRLNGLYPWRGFYHQPHGLHPALASDLMEPFRH-LVERVALN

57865886 -FEEIEAIFDHYKSYFSHKLVIKCIENDIAIIFCDKKH-SPVTQLSQFQLSGR-TKDR--IWKKIVINKI------FNQTRSSGDKSNKEAHATRIYFKDLNSGLNYGYS-ILRSFINKELAIHGFEMSLGIKHQSKENPFNLADDIIEVFRP-FVDNIVYE

47458867 NIRDIDTIFNNQYSTISIRLLTFLAKNNVNIIFMNEKN-EPNSYLEQVKWTKE-YKAI--LWKDIIKNKI------HNQKNNLFDISNREGHAAKVYWNMTNAILNYGYS-ILRSSAIQSIIKKGLDPRFSIFHKSFSNFFALASDLIEIFRP-LVDEIAY-

294660601 PLKTLDTIITNPYCNISVPLLNKIVENNINLIVCNTKF-QPTMQIWQIRWTDE-QKNQ--IWKQLVKLKI------INYARVDGDLNNCEGHAAKLSFKLLNKYLNYGYI-VLMTYVSRTLVKNGLDNRIGIFHKSFNNHFALSCDIMEPFRP-IIDYLTFS

71894593 PLSDIDTIISNPYCTISVPLINAIVSNNINLIICNKDF-EPNVQLSQINWTQE-FKDK--TWEKIIKLKT------TNYVNIPGDKNSMEGHIAKLTFKNLNKFLNYGYT-ILMTYVSRNLVKKGYDNRIGVFHKSFNNHFALATDLMEPFRF-LIDKLVYE

90961086 PLVDMDILISTTQAVITSALVSKLAESGIKVIFTDNKN-EPVTETQQYEWNDH-VKEI--LWTKIVRSKI------INQIKEINDMTNREAVVARKYFEKLNAALNYGYS-ILLSAVNKEIVSAGYVTYLGIHHQSQENMFNFGSDLMESFRP-VVDYWLAD

15675042 HLSEIDILLETTDIVLSTMLVKRLVDENVLVIFCDDKR-LPTAMLKQMSWSET-VKSQ--VWTTIIAQKI------LNQSCENFDPSNREGHAARIYFNTLNAGLDYGYT-LLLSMFAREVVVSGCMTQFGLKHANQFNQFNFASDIMEPFRP-LVDKIVYE

42525844 FIEEISVLIETTAVSITAALLNELIKQKVKVIFCDEKR-NPASELLQIKWDKN-IKQL--VWTEVVTEKI------RQQKYDINDKTNKEAHAAKAYFAALNAALNYGYS-ILLSAFNREIIANGYITQLGIFHDNMFNPFNLGSDLMEPFRP-LVDAEVFK

169823756 HIPEIAVLIDSTMVSFTTALIEKLIAEKVKIIFCGKDH-NTIGEIKQISWQNN-SKQK--TWREITKEKI------NRQALQDGDVSNREGHAAKVYFNSLNAMLNFGYS-ILLSIFTREITSSGYLTQLGIFHENQFNYYNLSSDLMEPLRP-MIDNIVYF

187736488 PLEDVGAVLSSFKATLTSNLLIELARKRIGFVLC-ESY-RPAVLLHLADMPAR-LRNR--LWQKTLDAKC------GNQTAAVTEKTAREAECARLFWSVFNNLFNYAYA-ILLSCILQYLFALGLDPCFGIFHQSREHAAPLAYDLMEPFRP-AFDANVAR

189485060 NFSDINCILHGNGITYTNSAIQKCLKNEIPIVFCDETH-TPAGMLIQLSASQP-IRKQ--AWKQIITEKL------INQSAKTGDNTFREGIGAKIYFGELNSSLNYGYA-VLRSGIARAVVSCGLNPAIGVFHSKNKNPFCLVDDLIEPLRP-MVDYIVKS

187250661 LFDDINSILYGNNITISNTCIQKCLEHKVPVIFCDKTY-NPAGMLLQINASKP-QIKQ--AWQQIITSKL------NNQAERSGDATFKEGVGAKVYFENLNSALNYGYA-IVRSSIARAVVSAGLNPAIGIFHSKNHNPFCLIDDLIEPLRP-LIDFMVKN

57238545 FLKDINIILESLQVSISSALFNAFARHKIILLTCDETH-SINGVFEQMNVSAQ-KKAI--LWQKIIKNKI------LNQAFSLNDSKNIEAVAAALYFKTLNSALNYGYA-IIRACIIRAVCISGLLPWLGIKHDNIYNSFALCDDLIEVFRA-SVDDCVLK

269123825 PISDISIIFESLESYISLRIISELSLRNITMIFCDYRH-MPVAYSLQGQQTSK-SKEF--VWEKLLKAKI------RNSKKIGSDVQNREGTAAKVFFNYLNMALDYGYG-VFRSAITRLLCTYGFATYIGVHHSSMMNAFNLTYDFIEPYRP-IIDYYVFN

238924076 PLDDISMILDNLASNLSTRLMCQLAEQGIGLMLYNQQH-LPTGFYFQIDKEQD-YYGK--LWQQIVKIKI------ENQAKLIGDKSNREAHAAKVYFNLLNSGLDYGYA-VIRGYIARACVGYGLNTQIGIHHKSEYNRFNLVDDLMEPLRP-IVDIVAYN

55820736 PLSDISIIAEGGDTVVTLRLLSALSKYNIALVVCDNEH-LPTGIYEQLDWSQK-QKEK--AWQIVTYYKI------NNQEDEPGDRTNREGHAAKVYFNELNAGLNYGYA-IMRAQMARIVAGYGLNGLLGIFHKNEYNQFNLVDDLMEPFRQ-IVDVWVYD

157149930 PLSDISIIAEGGETVVTLRLLSALSKYNIALIVCDNEH-LPTGIYEQLFWTQE-QKDK--LWQIVTYFKI------NNQQDEYGDKTNREGHAAKVYFNELNAGLNYGYA-IMRAQMARIVSGYGLNPLIGIFHKNEYNQFNLVDDLMEPFRQ-IIDVWVYQ

189485226 PIEDISVILESNRINLTSALISECSQSNIVIFSCDSSH-IPCGIYSQVKWDTA-FKNR--IWQKIVKQKI------CNQAEQSGDKTNCEAFAAKIYWESINSALNYGYA-IVRGVVARSLASSGFITCFGVHHSNDLNAFNLADDIIEPFRP-FVDDIAID

222109284 PFEDIAVILNHREITLTHPVLSACGEYGIGLYSTGDNH-QPNGVFLQLDLDKP-SAKR--AWAHIVQVKI------GNQARRSGDGGNLEAQASAYYFPQVNAALDYGYA-VMRGACARALVAHGMLPSLGLFHRSEQNAFNLADDLIEPYRP-VVDLHVAQ

220930481 PIDDINTILDSADVTITSALLSKLAEEDIALYSCDGKH-TPNGVLTQINLSAP-FKKR--CWQRVVQQKI------ENQAFLSGDSTNVEAHAAKYYFSVLNYALNYGYS-ILRGAVARTIASYGFIPSIGIHHRSELNNFNLADDFIEPFRP-IVDMWVKQ

218767587 PLEDIAVIIENRETLITAPLLSALAEHGATLLTCDEQF-LPCGQWLQLNISEP-LKKQ--LWQHIVRQKI------LNQAFRSGDTGNREAQAAALYFQALNAALNYTYA-VLRAAVARALTLYGWLPALGLFHRSELNPFNLADDFIEPLRP-LADLTVIH

15602991 PLEDIAVIIESKETLITAPLLSALAQYGVTLLTCDEQF-LPCGQWLQLETTLP-QKKQ--LWQKIVQQKI------RNQGFKSGDKENVEAQAALIYFQTLNAHLNYAYT-VLRSAIARALVLYGWLPQLGIFHRSEVNPFNLADDFVEPFRP-LVDLMVWQ

117929157 PLVDVAMMLTGPYVSLHGSVIDRAAAFGVGVVHCDWRG-VPVAATAQAELSLP-RQKN--AWMNIVKTKI------RNQAARSGDASNAEGAAARVYWARLNGLLDYGYA-ILRGCCLRAVVGAGLAPSLGLWHRRHDNPFTLVDDLIEPFRP-AVDKTVIE

283456134 PLAQAAVVI-GLRVCCSSAVLHEMAKAGVSVMLCDWRG-IPDAALAQSEMTLP-RKKN--AWAKIVKAKI------RGQASRSGDTSNYEGYAAREYWKRINAQLDYAYT-ILRGFAVKAILSAGLIPTLGVNHHGRSNYFCLADDLLEVYRP-AIDYWVAQ

38232679 PLAQIAVVI-GNKLIISGAVLVKLSEYDIAVLVCDWRR-VPVAGSAQASLSLP-RQKS--AWAQIIKAKI------LGQARRSGDVDNREAMAAKRYWEIINGALDYAYT-VLRGHGMRAICSAGLVGTLGVFHHGRGNQFALVDDLIEPFRP-AIDYAVFS

150025576 AIEDIGVILENQQITITNGLLEKLTNNNVALINCDQQH-LPIGLLNQINASVP-LKKN--LWQQTISAKI------MNQAGTSGDALNHESRAAVFYWQSLNNLLNYGYA-ILRAITARAIVSSGMLPTLGIFHRNKYNAYCLADDIMEPYRP-YVDLIVCH

60683388 PIEDIGIVLDNKQITITSGVLEALLENNCSVITCDSRS-MPVGLMKQLDTSLP-LKKQ--LWQQTIQAKI------NNQASRSGDPDNLEARAAAYYWKSLNNLLNYGYA-ILRAVVARGLVISGLLPTLGIHHHNRYNAYCLADDIMEPYRP-YVDELVFS

261414554 AIEDIAYILDSPQITVTNALLGALLENNCAIINCDKTH-LPSGLLAQIDASLP-LKKQ--LWQQTVQQKI------LNQAARSGDVDNREAVAAAYYWKEMNNMLNYGYA-ILRGVVARALVSSGLLPTLGIHHHNRYNAYCLADDIMEPYRP-IVDKLILE

154250554 PIEDLGVVVDDLRATYTQAVFIELLEAGATVMVTGRDH-LPAGMMAQVEASEP-TKKR--AWQALIRSKI------AQQGIRSGDPDNLEAQAAQRYWPRLNALLNYGYA-VVRAATARATVAAGLIPSLGVFHRNRANPFCLADDLLEPYRP-YVDWRVRL

159042957 PLDQIAGVVHAHGTTWTTSLLTELADRGAPVVLCGANH-APRSVLAQWQARAP-LVKQ--AWKQTVIAKI------AMQAATSGDATNVEAQAARLYWPRMNALLNYGYT-VLRAATARAVVAAGLHPTIGLHHSNRGNAFALADDLMEPFRP-LVDCCVRG

121608212 PLDDIAAVANAHGLTYTNNLLVALAERGAPFVLCGPNH-NAVGMLAQIAAGLP-MHKR--LWAAVVKSKL------EQQAARSGDPENIEGQGARRYWGLLNALLNYGYT-IVRSACARAVVAAGLHPSIGLHHSNDANAMRLVDDLMEPFRP-IVDLKVWQ

288957740 PLDDIAVVANAHGLTYSNALLMALMERGAVVVMCGPNH-LPAAFVAQVDAPAP-LAKR--LWQALVRAKI------RQQAARSGDPDNLEAQAARRYWPALNALLNYGYA-ILRSATARAVTAAGLHPSIGLHHANRGNPLCLVDDLMEPFRP-FVDLAVLR

75675148 PLDDVAAVANAHGLTYSNNLLVNLAARGVPVVLCGANH-RPAAVVDQANASAP-LKKR--LWQQIVQAKI------LAQGARTGDPDNVEAEAARRYWRLLNGLLNYGYA-VLRAATARAVMAAGLHPSLGLKHSNRGNALVLVDDLMEPFRP-AVDREVHR

34557789 PLADIGVVVENPQVTLSAALLSALAQEGTALMSCDSSH-LPDGVFVQAVWSEP-FKKR--CWQKIVRAKV------SSQAETSGDTTGVEAQAAQVYWRSLNGGLNYGYA-VLRGALGRAIAGAGLIPAFGLHHAGELNSFNLADDLIEPFRP-FVDLLVWG

90425960 ALEDIAWIIDTPQATLSSALMSACMDAGVVLIFTDERH-TPSGVALQFDAKDG-VKRR--LWQAIIRRKI------LNQAAEPGDPENVEARAARFYWGRLNKMLNYGYA-VMRAGVARALVACGFLPAFGLKHESAANAFNLADDIVEPFRP-FVDGLAWT

209542526 AVEDIACLLDTRQVSITGSLLSALAENGVAMIVPDARH-HPAGILAQISISQP-LKKR--LWQTLVVAKI------RNQAAASGDPGNVEAQAARAYWASLNALLNYGYA-IMRAAIARACVALGLLPAFGVHHASKTNAFNLVDDLIEPFRP-FVDRMA--

156937861 PALDIEMAFVGKGITVSTAALQLLEEQNVPTLFHGVDW-SFV--TNQYSMGET-ELGVK-VAKEFIFGKL------EGMSNVKK----LEAEWSSKLWKDINRTLDYLYA-LLYSVCNHALVGAGLDPYAGLIHRERAGKLSFVYDFSEMFKPMAIY-VMAT

70607609 SSLDLELVIVGNNVRLTSEVILFLSSLNIPVLVHGKRN-DVV--LKFYTLSD--DMKLY-LARKFIKGKI------LGMINLRS----VEAEMSKACWEQLNRAVDYAYS-VIYALCTHSLIASGLDPYGGLMHVEYPGRTALTYDFSEMFKPVAIH-SVIA

21229351 KRIDIDGIIYGKSGNLTLEAIRWLIKHNVQVSILDWNG-KLLTTMAQYHAFED-KEARLEIAKKFIEAKF------YKSKAILG----VEGTLAGKYWIEFNTMLNYGYS-LLEAECLKAINSVGLDTHVGFLHEMAPSKNSLAYDLQEPFR-FIVDLAVIS

147921327 HQIDHDTIIDGFTGNISFEAMRWIMKHKINLTLLDWNG-NLLGTWKQYAKYLD-PTTRYNIAYQIIKEKV------KKSCNIMV----YEAKTAKAYWDRLNALLNYGYA-ILEAQIRRPINAMGLDPAMGYLHEMKGSGAPLVYDLQELYR-WLIDLSVIQ

289596068 HQINYDSLIEGYYGNISFEAIRWLMKHNITVSVLNWNG-NLLSVFRQYEIYIN-EKERLKIAEKILEEKI------RKSENLLM----YEGRVAQIYWKELNALLNYSYA-LLESMIRKHINAVGLDPSIGFLHELASSKTPLVYDLQELFR-WVSDLSVIQ

34541577 PAAQIEQIIISDGVSLSSNVTKYCRKKNIRVIFYNATG-QAYASLMEAQMRLS-EEKKREFILTLIKNKV------RNQGKFRQHAMLHEARCAQVYWRAFNQMLNYGYA-ILRSYVMKTIVLWQLNPNIGILHSTQDNKPALCFDLMEQYRAFVVDRSILA

15898245 APTELHSIVLTNS-SISSEVVKVANEYGIEIVFFNKH--EPYAKLKQLTAWKR-R--KVEFAKAFIYGKV------HNQWVVMQ----KEAEAAKVYWRGVNRALNIGYG-MLRKVVWGAVISVGLNPYIGFLHKFRSGRISLVFDLMEEFRSPFVDRKLIG

126465226 PVRRVREVISGKA-GISTELLKLLADSGIDVLVTSYTG-RPVALFEQYRSLED-GRA-CKAAAMIISGKL------SNQVSIMS----IEAQAANTYWDGMNLCLNIIYN-KLAGTVWKYVLRFSLDPFQGFLHARRPGKLSLVYDLMEPFRP-IADRFIAR

170290046 PMKSVKEVIIGKA-ALSSELLKALAQSGTDLLIATPTG-RPVARLEQYKSLED-RRG-IEIARAVIVGKI------RNQASIMA----RESKCANIYWEKINLCLNVCYN-LLSAQIWKNVLRFGLDPFLGYLHVERPGRISLVYDLMEPFRP-MVDRFVFS

288932203 PIKSVRDVISGKV-SISSELLKALAEAGVDVLFTTPMG-KPVARVEQYKSLED-ARG-VRIAKFIIAGKT------RNQMSILA----YEGEVANYYWDAINLSLNVCYN-LLSNQIWKYTLKFGLDPFAGYIHVERPGKLSLVFDLMEPFRP-MVDRFVVS

54296139 TLNRLKTIIVKQGVTLTSNLLVACAMRGIQIFILDYSG-KAVCSLSQFKYIYT-KEASN-MAARFILAKI------KKQSALLG----FEGSAARIYWETVNSMLNYAYS-ILSSWVWQAITNAGLELYAGILHTSKPGKPSLVLDLMEEFRPWCADRIIFK

34557933 PLSRLKSVILKGGISLSSDIIEACSLRGIKIFFLDFRN-VAHTAIAQFLTIES-NHGRE-IARTLIVGKL------KNQRAIMG----KEGGMAAIYFDAINSALNYGYA-ILTSFVWQSIINAGLEAYAGVLHTNRPGKPSLVLDVMEEYRAWVVDRNIIK

150401497 PATKIERILSNNG-TITTGAISLAIENNIPIIFLK-WE-EPTGMISQLKFSES-INGIR-FASNWIKQKM------GNQLNIIG----IEGIASKYYFEGINALLNYGYG-MLYPMVEKCLIVAGLDPYVGFIHADNYNKTTLVYDVIEMYRA-HIDRGVVN

224367660 SPRKVESFITNQA-MITTQAINLALENNIDMVFLDAFG-DPTGRIKQLEMDQN-DSGLM-IVKDLIKNKI------GNQVKIMG----LEGTSARAYFKVLNAVLNYCYG-MLYGKVEKACIIAGLDPFIGFLHTDNYNKKSLVFDLIEPFRI-FAETTAVY

257125862 APQKIKSLLSKGI-FLTTDVIKLAVDNNIDIVIVDDFG-NPYGRFKQLEIFGT-QKGIE-LAKQILIQKI------KNCAELMG----YEGNAAKIYYQTLNAMLNYAFG-ILYSKVEKACIIAGLDPYVGIIHTDNYGKKSLVFDLIESYRH-LASRTVFS

284040851 SAEKVTHILATGT-SLSTDAVRLAMRHNVDIVFIEQQG-DPIGRVRQLEASLG-PDGLR-WVRAWLLAKL------DNQMGLRG----LEGTAGRLYFETLNAFLNYGYG-MLYGKVEKTLMMAGLDPYVGFLHRDDYNQLSMVYDFIEPYRG-WTDEVVFR

150398872 SIENIEQVICAPS-SITTEFLELSVKNNVDVVLLNKYG-KPVGRFKQLKLTEN-WAGIS-IIKEFLSEKI------ENQIEIQG----LEGSVSKIYFRVLNCMLNYGYG-MLYSEIEKICIISGIDPTIGILHTDGQNRKSFVFDYIEKYRN-IIDKIVYE

21226661 SEKKVDSIITTSA-TITTDAIKFAVENNIDIVFLDNFG-DPYGRVRQLQISEE-PEGFR-LAKGWIEQKI------DSQILIMG----LEGMASRHYFAALNCLLNYGYG-VLYSKVEKACIIAGLDPYVGFNHTDDYNKKSFVFDLIEMYRI-HIDRTVFN

125975696 AATKVDQIITTHA-ALTTDAIELALEYNIDIIFLKNTG-QPMGRVKQLFLQDS-PLGLQ-LVKEWILEKM------DNQIRLLG----YEGTAGRVYFETLNCMLNYSYG-ILYSSVEKACIIAGLDPYIGIMHTDNYNKKALVYDMVEMYRG-YMDEIVFR

134045811 PAKKVEQIITCPS-SISTEAISLAVEENIDLVLLKMNG-KPIGRFKQLLLSEN-ELGIT-FVKEWISKKM------ENQIDVQG----YEGYASRVYFEMINCMLNYGYG-ILYSQIERSCIIAGLDPYIGILHVDNYNRKAFTFDLIEKYRI-YVDKTIFK

218884093 PLTDLEQVIETGGVWFSSKLIRKMVEYGIDFIVLDHRG-YPAGRLAQYAAYES-WRGVH-VMRELVYSKL------ANQAGLRQ----LEAEAARIYWPSLNTSLNYAYG-ILYGESWKVLVLAGLDPYAGFMHTDRSGKPVLAFDLIEMFRF-TADSTLLA

15922975 SPAEVDQIIMTSGVTVTSKAIRLALDHGIDIIFLDSRG-NPFGRLAQYLAI-L-KGEEE-IPREIIKSKI------KNQANKDD----DEATAARYYWHALNVSFNYAYA-ILYSNIQRVLQLVGLDPYAGFIHKDRSGKPSLVYDFSEMFKPVLVDYPLVS

15898286 SPSEVDEIITVS-CSISTSALSLALTHGISVMFLNSRE-TPWGILAQYEAIVV-RKDNR-YGEEIISSKI------YNQSVLDK----DEPAAARVYWQNINMALNYSYA-ILYNTIFKYLVIAGLDPYLGFIHKDRPGNESLVYDFSEMFKP-YIDFLLVR

11499462 RPEDLKQVIIGKA-AISSDAIKLLLKNRVDVVFLDFNG-EILGRLEQYLAYGD-KRGVH-LAKEFIKAKM------ANQMALLG----IEGKASKHYWDAINAMLNYGYS-ILLAECVKAVELAGLDPYAGFLHVDVSGRSSLAIDLMENFRQQVVDRVVLR

159901591 PLLILDHVIESYGVGISSDAVRACAEHGIPIHFLSSTG-IAYASLAQLQAFEN-ERGAW-LARAFVCGKL------ENQHNLLS----IEGRGAARYWFGVNSALNYGYG-ILYSQIERCLVLAGLDPYGGFMHTDRPGKPSLVLDLIEEFRQTVVDRTILG

260893609 PFRDISALIAARGVSLSSDVIRECIEHGIQINFLTSSG-RPYAKVEQILAYND-ARGAA-LAIAFVEGKL------KNQANIFS----IEGRAAQEYWDGVNAALNYGYG-ILYSHVWGAVMLAGLEPFAGFLHTDRPGKPSLVLDLTEEFRACVVDRTIVG

156937921 YLANLYDVLATSKVSVTGAALRAMGRLGVDLVVLEWNG-RPSGRFKQYEVVLK-GEGLK-YAKPMIVRKI------IEQGRLRA----VEAQAARLYWGLLNSAINYSYG-ILYSYAFKALSVTGLDPYAGLFHAIKSGREALVYDFSEQFKP-LVDRRALP

124027534 VTADTELVLATGSVSVSGRALRRLAELGVRLVVLGQRG-----QVEQYRVKAT-GEA-LYYAAEMVYAKI------VNQAKIRS----IEAQAARDYWDAINMALSYGYA-ILYSIAHDALTVAGLDPYAGFLHADRSGRPSLTYDYADTYKPIAVDKPLLT

118431380 VESSVERVISSSRVSISSAAVRAAAKMGIDLVFLDWDG-SPVARLGQFSANER-LRR--LIAAELVSAKI------YNQGQLLS----IEARASRRYWQCINAALNYGYG-MLYSIVEKSLLLVGLDPYLGVFHSEKSGKPSLTLDAIEPFRAPIVDRILAL

18311699 PLFQVDRIILTGGVSISSRLVRALSHHFIDVVFFDAKG-NPVARLAQYEAYLT-GRGFE-LAKLVTYGKL------INQARVLG----HEGAAASLYWDAVNLALNYGYG-VLKYAVWRQAVIHGLDPYAGYIHADKSGRPSLVLDLMEEFRP-HVDLLVIR

18311772 PLHQVDEVLLTGGISISTRALRALLRAGAVVAVFDQRG-EPLGIFCQYAAATD-GRGLQ-LAKKWVWLKI------RGQLEVME----AEAAAAEAYWAAYNAGLNYGYG-ILKALCFKSILLAGLDPYVGFLHADKSGRPSLVLDFMEQWRP-RVDAVVAQ

283778924 PLHTLREVVLGAV-SLSHRVLSAIQQNAISLLLLDESA-NRTAYIAQVDLIRN-PESSLAIARQLISAKL------HNYATLLG----IEGSGAALWYGEINILLNLAQT-VLYRMTQHAIAQAKLVDTLGFLHQPRAGHAALASDMQEPFRH-LMDRAVLE

15609954 PIETLDGILFGRP-TMTTPFIVEMLKRERDIQLFTTDG-HYQGRIQQVHRTDD-PAFCLSLSKRIVSRKI------LNQQALNG----FEGNAAKAYFTALNSMVSLGYS-LLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLR

116627764 SISLVDNVLFGNA-QLTTQLIKALSKNKVNVYYFSNVG-QFISSILQAKAYFE-EDFRLEVARSIATTKV------RHQIAIMG----YEGRLAKSYFYYLNSALNFGYS-ILYSCLMGLIKKNGLSLGFGVIHKHHQHHATLASDLMEEWRPIIVDNTLME

111224947 PITDIRDLTFDHV-DINTAAVSLLGRHGVVVHILDHYG-NYAGALAQVDLTAD-PVRRAAIARSLIAATA------ANVRWLMG----AEGTFRRSAWGVFNAFISYANS-VVYGRVLTALRATPLHPAVGFLHDTDRRRNTLALDLAEPFKPLFAERLLRR

154174048 PINAIDEIILTRV-ELDTYTLAFLADNNILLHVFSPFQ-SFRGNFSQLRAFDD-PVKRVYIAREITRAHM------LNDAAIMA----AEGAFQKLYYEKWNSFISYVNT-RIYNVCLSEIYKTELDPRIGFLHEPNYRALSLHLDLAEIFKPILGDTLIFA

157164052 PVNAIDEIMLAKV-QIDTYTIAFLADNNILLHIFSPYQ-SFRGNFCQLRSFDD-AIKRAYIAREITRTHI------INDAAIMA----VEGAFQKLYYEKWNSFISYVNT-RIYNICLSEIYKTELDPRIGFLHEPNYRALSLHLDLAEIFKPILGDTLIFN

41614813 PLESIKEIILNKV-SVTYNALKLLADRNIPIHFFKGIS-YYLGSFKQVEAYKD-IEKRTEIALEIVDAIR------YNCIKIRG----IESNIWNLFYQGLNTIVSFANT-LLYGVTLTEIYKTHLDPTISFLHELRDTRYSLALDLSENFKPIITFRILIW

48477075 PLENIESIISGNV-SITKPAISILSKKNIPVFFMSMYD-NYISSLNQAIKAYN-IDERIKIARIFVYAAA------RNMAILMS----YEGNFRNNFLNIVNALISYLNM-LLYSITESQIFLTHLNPAISFLHEPFERRNSLSLDVSEIFKPLICDRLAIK

13540937 PVMNVQEIISAKV-SLSSWALDYLSKLGIIVHIISTNG-KYMSSLQQVKAYLS--DKRFKIAAEMVNGIK------NNILAILG----VEGNIWSTYYSAFNAMISYGNA-LLYATVLTKIFITGLNPSISFLHEPSERSFSLALDIADIFKPVIVERTIAN

150021526 PLKSVSSLIFSEV-SMNKRFLDLLSKEGIPAFFYGYYE-NFIGTFLQYKHYED-INKRLKIASEILNAAV------DNMVNLMA----IEGNIRKVYYSAINALISFGNV-VLYNIVLAEIYKTSLEPRISFLHEPNKRNFSLQLDISEIFKPIVVDKVVLK

114567318 PVKDTRELCFNEV-TLSTKLMQLLAKAGIVVHFFGYYE-NYIGTFAQALAYGN---NRLTVAKPIVCGTA------KNIHFLLR----IEGAIWAGFYQTFNALISFGNT-LLYTKTITEIYHTHLNQTISFLHEPAERRFSLSLDLSEVFKPILVYRTIFD

28211139 PVENTKEICMSEV-NINSKLLDFLSQNNIIMHFFNYYE-GYSGTFKQVETYEN---RRLEVAKSIVEAIG------DNIYEIMQ----VEGETWQRFYGEFNALISFGNT-LLYGKTITAIYNTHLDQRISFLHEPSEGRFSLSLDISEAFKPVIVFKTIFD

268679538 PIEETRELCLNEV-SFNTKFLDFIARAGITMHIFNYHG-NYSGSFKQSLSFVN---ERLVIAKSIVSAIA------QNIHEIMF----VEGQIWSRFYDSFNALISFGNT-LLYTKTIASIYHTHLNQAISFLHSPREGRFSLSLDLSEAFKPVIVFKTIFD

289596694 PIHNLRDICIAPV-SFSSGAIKHVLNSGVVVHFFDMYG-NYEGTLNQAKHYIF-WEKRKYIAKEMIEGIK------HNILRLMN----REAQIWGYYYKSLNALISFGNT-LLYSAVLTEIYHTHLNPSISYLHEPSERRFSLSLDIADVFKPTMVYRHIHD

14590110 PINTISEICFAPV-TLTSGAIKLLSDNDVPVHFYNKYG-YYRGSYAQASHYID-NEKRLYIAREILEGTR------ASMISLMG----IESQLWKTFYAHFNAMISYGNS-VLYTVTLSEIRKTYLHPGISYLHEPRERRYSLALDLAEIFKPIVVFRVILR

34541603 PVEGISDFVFGSL-RANSSLYNFLGSNDIAVHFFDYYE-NYTGSFAQASAYKN-KKKRLFLARKFIEGAA------SNMQKLMG----IEGNIRQAYYDAFNALISFGNM-MCYTLCLKAIHQSQLNPTISFLHTPGERRYSLCLDISEVFKPILVDRTIFK

84489236 PIHAINEICYGKV-SLRSGAISLLQKEKIIINFFNKYG-YYEGSLKQALTYNN-ENKRCFIAKEMVNGMK------HNMIKILS----SEGKLWQSYYPSFNSLISYGNS-LLYTTTLSEIYHTYLHPSISFLHEPRERRFSLACDLADIFKPLIISRTIFK

19704512 PIEMVDDFVMSEM-NFNTKFINYISQFGIPIHFFNYYT-FYTGSFKQVEHYTN-EQKRVEIAREFIEGAS------FNIYRLMG----YEGNIRKIYYEAWNSLISFVNT-LFYTKVLGEIYKTQLNPTVSYLHQPSTRRFSLSLDISEVFKPLIVDRLIFS

257125579 KIEVTRDILFGEV-SLNTKCLNYLAQNKIPVHIFNYYG-FYTGTFKQVENYTD-NAKRIELAQLIIDAAS------TNILRLMG----IEGSIRRTYYTAWNTMISFLNT-LVYTACLSEIYVSQLNPTISYLHSVGERRFSLSLDIAEVFKPLLADRIIFS

189345988 PINNIDSFVFGEV-SFNTKFLNFLTRNRIPLHLFNYYG-FYSGSYNQVKHYSS-TKKRLEIAREFIGAAA------ANIIRLMG----VEGNIRKVYYQVWNALVSFGNS-LMYSACLTEIYRTQLNPTVSFLHEPSERRFSLALDMAEVFKPMFIDRLIFK

15605875 PVEDVEEIVFAEL-SLNTKLLNFLASKGIPLHFFNYYG-YYTGTFKQVEHYLD-AQKRLYLAKSFVIGSI------LNL--LMS----VEAEFRKLCYKKLNALISFGNS-LTYAKVLGEIYKTQLNPTVSYLHEPSTKRFSLSLDVAEVFKPIFVDNLIIR

83590562 PVEDIDHICFSEL-DLNTRLLDFLAQKQICLHFFNYYG-HYSGSFRQVEHYLD-QAKRLELARTFVEGAL------HNIRRLMS----LEAHARKAYYDTWNALISFGNA-MMYTVVLKEIYRTALNPTISYLHEPSERRYSLALDVAEIFKPVFVDRLIFR

148270212 PVENVDQIFLGEV-DLNSKFLDFAAKNNIVLHFFNYYG-YYTGSFRQVEHYLD-NEKRLSLARKFVEGAI------HNFKRLMS----CEAHARKLYYSTWNALISFGNS-LTYSVVLKELYHTHLNPTVSYLHEPGTKRFSLALDISEIFKPIFVDRIIFK

222099688 PVENIDQIFLGEV-DLNSKFLDFAAKNNIVLHFFNYYG-YYTGSFRQVEHYLD-SEKRLTLARKFVEGAV------HNFKRLMS----CEAHARKLYYSTWNALISFGNS-LTYSIVLKELYFTHLNPTISYLHEPGTKRFSLALDIAEIFKPIFVDRIIFK

14591064 AIEGIYDIIYGHV-NITSQALHYIAQKGILIHFFNHYG-YYDGTFRQAEHYLN-KEKRLFLAKSFVTGGT------KNMERIMN----VEARIRQEYYAKWNALISFLNS-RLYATIITEIYNTQLAPTISYLHEPSERRFSLSLDLSEIFKPIIADRVANR

15668554 AIEGIYDIIYGKV-SISSQALHYLAQKGIALHFFNHYG-YYDGSFNQVEHYLD-KDKRLELAKLFIIGGI------KNMEWVMN----VEGRVRTEYYRLWNALISFLNS-RLYPAIITELYNTQLTPTVSYLHEPHERRFSLALDLSEIFKPMIADRLANR

212638614 PVHQTDNLVFGEI-DLNSSLLNLLSQHDVHLHVFNYYG-FYAGTFQQSAHYLD-LEKRLYMAKAFLQSAV------HHMLRLMG----IEGRIRQHYYQSFNALISFGNS-LCYTAVLSEIYKTQLDPTISFLHEPSTKRFSLCLDLAEIFKPLIVDVVIIS

146295386 DIENIEQIIFGEV-DLNTKALNYISQYGIILHFYNYYG-FYAGSFRQALHYLD-REKRIFLAYCFVESAV------YHMMRLMG----LEGRVRNIYYSSFNALISFGNS-LIYSTVLTEIYHTQLDPSISFLHEPSEKRFSLSLDISEIFKPLVVDSVIFK

206900365 PVENIDSILFGEI-ELNTKALNFFAQKNIVIHIYNYYG-YYSGSYRQVQHYLD-EEERMYLAYSFVEGAL------FHMQRLMG----CEGRARDVYYNAFNALISFGNS-LIYSTVLSEIYKTQLNPTISYLHEPRERRFSLSLDLSEIFKPLIVDPIIFK

206889560 PIEDVDTIIFGEV-DLNTKLLNFICQQGKTVHFYNYYG-FYSGSLKQVEHFLD-PERRFYLAYSFVEGAI------FHMVRLMG----CEGRARDFYYEAFNALISFANS-MIYTTVLNEIYHTQLNPTVSYLHEPSERRYSLSLDIAEIFKPLLADAIIFK

20092470 PINKINSIAYGNL-SFSSGVVSYLSKEGIPIHFFNYYG-FYEGSMRQAENYLN-SERRLCLAGKFIEGAC------GNILKMMR----TEGKIRELYYNALNTLISFGNS-LVYSTTLSEIYNTQLNPTISYLHEPFERRFSLSLDVSEIFKPILVDRIIFK

11500011 PINSIYAIALGSL-SITSKAISLLAKEGVCIHFFNRYG-YYIGSFRQAEHHLD-SEKRLHLARAFVEGAI------LNMARLMG----AEAAARNAYYTKFNAMISFGNS-LLYSAVLSEIYHTQLNPAISYLHEPSERRFSLALDIAELFKPVIVDRLIFY

15679095 PINKIYSISYGAL-TISSQALNLLSKEGIPIHFFNRYG-FYSGSFKQAEHVID-HDKRIELARSFVRGAA------LNMRRVMN----VEGRIRSDYYNAINAMISFGNS-LLYSTVITELYNTQLNPTISYLHEPFERRYSLALDLSEIFKPTLIDRMIIS

160903306 PIENISEIIFGEI-NINKRLLEFLSANNLPLHFFNHYG-FYVGSFKQVEHYIS-SEKRLVLAKKFVEGAM------QNILKLMA----QEGNYREIYYNFINTLISFGNS-LMYSTVLTQIYQTPLDPRIGYLHSTNFRKFSLNLDIAEIFKPIVVDRTIFN

15644541 PVENVMDIVFGEV-DLNKRFLEFLSQKRIPIHFFNREG-YYVGTFKQAEHYIN-QEKRMLIAREIVSRSF------QNMVDLMG----IEGNAREEYYSMINTLISFGNS-LLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLN

221632058 PVEQVSELVFGEV-DLNKRFLEFIAREGVLLHFFNRYG-FYTGTFRQVEHYLD-QAKRLTLARAFVHGAL------RNIRTLMA----LEGQAREAYYAVWNALISFGNS-LLYTAVLAQIYQTHLDPRIGYLHETNFRRHTLNLDVAEIFKPVLVDRLIFR

239617067 PVEQTDSIVFGEL-ELNKRVLDFLTKQQIPIHFFNRYD-YYSGTYEQANFYND-GAKRINLARIFVKGSM------GNMISIMA----IEGNFRDLYYKCFNALISFGNT-MLYTTVLGEIYRTHLDPRIGFLHTTNFRSFSLNLDVAEIFKPIIVDRLIFS

288818552 PINSVSEIVFGEL-DINKRALEFLTRNQIPVHFFNHYG-YYIGSFKQAEHYLD-REKRMYLAKGFVAGAV------NNILKLMQ----VEGEIRKTYYESFNALISFGNS-LLYTTVLSEIYRTHLDPRIGYLHETNQRSFSLNLDISEVFKPVIVDRVIFS

154249624 PIENINNIIFGEV-ELNKRFLDFASENEILIHFFNFYG-YYTGTFKQAEHYLD-NEKRMKLARKFVEGAI------ENILVLMS----FEGNIRDVYYKCFNSLISFGNS-LLYTTVLGEIYQTQLDPRIGYLHSTNSRKFTLNLDVAEIFKPSIVDRVIFS

20809002 PVESVRDIVFGEV-DLNKKFIEFAEEKEIILHFFGYYG-NYVGSFKQAEHYLD-SARRLDLARRFVQGAV------ANMTQLMA----LEGNIRRYYYESFNALISFGNS-LVYTKILTEIYKTHLDPRIGYLHTTNFRRFTLNLDVAEIFKPIYADRVLFT

219669947 PVEDTSELVFGEV-DINKRFLEFCTQKEIIIHYFNNYG-YYSGTFKQAEAYLN-EERRLLLARQFVNGAF------LNIRQLMA----FEGNIREHYYKAFNTLISFGNS-IVYSTVLSEIYKTHLDPRIGYLHTTNFRRFSLNLDVAEIFKPILVDRVIFT

88602029 PLG-LDLLIAGDH-SISTAAVRLVTSHGGAIALMDGLGNPFGHFLYEAQASAP-EERRLEIARSICTGAL------ENKRTLRG----VEGSGAHAYFQGFNSLLSYGYG-MLYIQARQALVLSGYSPYYGAYHETYKKQEALVYDLVEEFRQPVVDRTVVT

288947693 PLGVLGLVVHGRA-LVGCDVWRALAERGIPAVMQPGRGRGVCAWMAQHRAAEQ-VERRLMLARDLIAAKL------LAQARVMG----LEGSAAAAWFRWLNALLSLGYT-LLGGEMLSVIQQQGLDPARGLLHELVPGRESLVLDLIEPLR-PSVDLVLLG

206890539 PLSPLKRVIVGNV-KIETSVLYKLVNHGITVLFLTGKL-KYSGILKQYQKSLS-GF-SLKFAKELIKRKI------VSQRDLRG----IEGAASSIYFITYNAMLSLCYT-LLHYEIVREIQLIGLDPTIGFYHQFEYGRESLACDLVELFR-VNVDRFVYE

121997419 PLSLIDRLVIGQV-ELSSGVLTTLAESGVSLVFMPSRGQRRSAFLGQYRLIHL-EAERQAWARRLVRLRL------AGQQRLRG----QEGTAAAAFFRGYNAVLSLGYT-LAHGDALRAVTAAGLDPAIGVLHEPAWGRDSLACDLTEIAR-ARVERLTWE

52425690 PLASVDRLMKGDI-NLQISLLSKLGEKGIGVVFLQGRKNKPMQFLTQTYLADN-KLFCLTLAKNIVLNKC------IKQCQLRG----IEGRMGAIYFAAFNAVLSLTYT-LLYSEATLAVYGAGLDPYIGFFHTLHFGRKSLSCDLMEPIRP-SVDEWIAE

30248142 PIAPLTRVLRGDV-NLPAALLGKLGERGVGVVILSGRTSRPSLLLAQVRLSLD-EPASLIIARELIERKL------TRQIELRG----IEGSAAARYFTGLNALLSLTYT-LLHSEITIALHGAGFDPYIGFYHRLDFGRESLASDLLEPLR-PLADRFAFA

269798874 PIATVSNLL-GRTIQISTQVMFSLVKQGSLIQFVDHKY-QLVGTLWQVACFQN-QEFALDGAKYIVRRKI------KGQIALRG----IEGLASRTYFSVLNAILSYGYS-FLEREVRACLLTAGLDVRIGVLHSTNNRKDSLVYDVMDIFRQDIIDRFVLK

288957883 PPARLDRI-LGPGCEADDDVLRHALAHGVDVALVDGWG-DSVGTLAQARLAID-PAARLDLARRIVDGRL------RNQRALMG----LEGAAAAAYWPALNLVISYLSA-VLHRDLAAFVVRHGLHPGFGALHSARDGAQACVSDLIEEFRAPLVEGLAVY

37677204 PANTIDMMCFGAV-HLTQAVQRFCLENDISVVWLSQSG-QYLGCMAQVNSRAD-PDVRNHLAKFFIRSKI------NNALGIRG----TEGAAAREYFSWFNAMLSYGYT-LLFHNIRALVEARGLLPHLGYLHGSQPRQPSLVLDLMEGYRPWLVDELVLQ

20094748 SAVRTTGIIAGGA-QITTQAVRLALRNEVPIVYLGGN--RILGVTKQYEIASQ-PSARLAFARPLIASSI------LARAALRG----YEGRAACRYFRALNAAISFGYAGVLLPVLLSRTVAAGLEPFLGFLHGPRGRRPGLILDLMEEWRALAVDVPVLR

261415948 LLSEVDSLLFGAV-HPTTDAMLALLDKGADIAFLSSGG-RYRGRLCQYDVFRD-DDRAFALAKSCVVRKL------ENGLRLRG----FEGNGARIYFENFNALLSFGYT-LTARSLESLLESYGMDPMLGYLHEPSYGRNSLAQDMLEEFRHPLVDRLVLF

114567264 PIEGVENVIFGDA-SLSSNCVKQFMERDINLTWLSSRG-KFYGRLKQFACGED-DEFCLALAKRIILAKV------KNQITLMG----HEGMAARYYYQGLNSLLSFAYT-LLMYDLYTAAVNRGLNPYASFLHSIRRGHPALCSDLMEEWRAILADSLALY

241196732 PLDSIQALIHGNV-DVSSGLMRELMWRNIPILWCSGTG-RLMGWSAQHVASH---EGRLDLAREFISAKI------HNQIVILS----LEGQAAALYFSQFNALLDYTYS-LLLSDCIRAIVSCGLDAHAGFLHSSKRNKPALALDLMEEFRAPIADSVVQT

283458258 PLERVHSLVHGNI-DVSSALLRELMWRNCTIIWCSSTG-RVYGWSQQHVLSA---QGYLPIASAMIASKI------ANQATLLG----LEGEAASLYFGNFNILLNYAYG-MLSSECIRGILTCGLDPHAGFLHSSSRNKPALALDLMEEFRAVIADSVVVS

83592490 EPHRLESLLLGFT-TITANAMRLCMANKIAVSLLDGGGGLAARVVHQYALHLD-PPERLIRARAVVTAKL------RNAAALLG----IEGNGAHQYFAGLNSLLSFGYV-LLGNRLTGLLEARGVDPCLGFFHDLRPGRPSLALDLLEELRHPVVDRLALR

209966743 EPHRLETLLLGQT-ALTPNAMRLCMAHRITVALLDGGGNLAARVVHQYTLHHT-PEERLIRARGVVAAKL------HNAAELLG----IEGNGARQYFAGLNSMLSFGYV-LLGNRIAGLLEARGIDPCLGFFHALRPGRPSLALDLLEELRQPVVDRLVLR

154250301 PLKKIERILLGNI-TLTSQMINYCLDNKIEVIFMTQHG-RYRGKLKQYERATD-KQFQLEISKSIVQGKL------QNYYNVRG----YEGIGSKIYFSGFNAMLSLGYY-FLYVEMLLAINAVGLDPYFGNLHTIDVSKQSLLFDLVEEFRCVIIDNFVLN

162457462 GAREVSDIVHGHA-QITTQALRLCAAEEIAVHFVGAGG-AHVGVFRQFRGLTD-DVFAIGLARRLVMAKI------EMQLRLMG----QEGNAARGYFGALNALLSFGYT-LLYRDVLSAILRVGLEPGFGVLHQPRSAAFPLALDLTELFRVPVVDMAVLG

170078384 AVQQVSQVLHGFS-QISTQALHFLASHNVGIHWISGGD-RYIGSFQQYRALSQ-TDFCVDLAKKLVWCRG------QGQRKLLG----IEGNLAALYFGALNALLSFGYS-LLLKDVMNSIIAVGLEPALGFYHQPRTQASPLALDLMEIFRVPLVDMVVIA

108761389 PGRMVSALAHGAV-QVSAQALAYCVENDIGVHWFTSGG-RYLGGLRQFEALRQ-ASVCLGLARRLVAAKL------EGQLRLLG----LEGAGAARYFGALNAVLGFLFG-LVHREVEAAIRAVGLDVAFGFYHQPRGTAGPLGLDVMELFRVPLADMPLVA

294828260 PIQEIESVIHGNC-QISSQMIKFLVSEEIPVHWFSGGG-NYIGGIRQFKALTK-ETIRLNLAKKLVSAKC------ESQLRLLG----IEGSSARAYFSGLNATLSFLYS-LLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIG

159898907 PVIKVDRVVMGQGVQVSHAAIVFLAQRGIPLIFTTQSGGSQKAMVAQCRIVDN-PHLAVPLVQAIVVGKV------ANQIQLRG----LEGAGAAAYWGTWNALLSFGYT-LLLNDLMTAVQALSFDPYLGVFHTVQFGRPSLALDLEEEFRPCIVDRMVLD

148657121 PLAKIDQVLMGRGVQLSTALLIDLLERGIPVTFTNQHGSRHYATLRQMQFVGA-PDRALRLAKDIVSAKL------TNQRRLRG----HEGAAAAAYFGAWNAMLSFGYT-LALHDVITAVQITGLDTYLGVFHVIEPGRPSLALDLLEEFRPLIVDRLVID

163848915 PLNKVDQILMGRGVQISTALLVELLLRGIPVMITNQHGSRHYATLRQSQLIID-PVWSLELVRGIVAAKL------AAQRLARG----FEGAAAAAYFGAWNALLSFGYT-LLLHDVLSAVQFTGLDPYLGVFHAVETGRPSLALDVMEEFRPLVVDRLVLS

38505739 RLAEIDLLLFPGV-QLTDVAIAVLMDQGIETIFLRRDG-QFRGRLAQYRVL-D-STFGTALAQRLILGKV------TNQRALMG----IEGICAKHYYQVFNALLSWGYG-VLLARVFSAIVQAGLDPYLGFFHATQPYRPNLALDLMEEFRPVVVDQAIVR

17227877 RLAEITLIVLPGV-QLTDVVISQLLDRGIETIFLRQDG-QFRGRLAQYRTV-E-TTFGMALAQKLVIGKV------RNQRVLMG----VEGICARTYYQALNALLSWGYG-VLLARVFSACVQAGLDPYLGFFHAIEPYRPNLVLDLMEEFRPVVVDQAVIS

220910738 RLAELDIVVLPGV-QLTSVAIAQLLDRGIETIFLRGDG-GFRGRLAQYRAV-E-TPFGLSLARRMVAGKV------RNQRTLMG----MEGSCARYYYQALNALLSWGYG-VLLSRTFSACVQAGLDPYLGFFHAIAPYRPNLVLDLMEEFRPIVVDQTVIH

86608317 PLPLLEQIIFGRS-QVTTDVVRACLRRNIPIAYLSRLG-YCYGRLAHLQQALP-EEWRLQTAVQMVRAKL------LNSRVLRG----IEGAAAALYFPELNAMLSFGYM-VLWNHLLTLIELQDLDPYQGCLHASSERHAALVSDLLEEFRAPIVDSIVLW

85858452 FTYKLDQLIFGNV-EITHQALAQLMRYGIDVVFLSFRG-RYLGRIRQYSLLGN-ETFTLRQVRAIVAGKL------ANMATLRG----YEGRGSALYFEAFNSVLSLLYT-FLMNRVYAAVRVAGLDPYPGFLHALDYGRYSLVLDLMEEFRTIIADTLTLS

17228961 PVMRVSNVLFGCC-NVSHGAVSMALRRRIPIMYLSQKG-RYFGRLLQVERCQN-HEFTRKQAEAIVRAKL------HNSRALRG----YEGKAATLYFQGLNSLLSLGYT-LLSQNVFSFVQVIGLHTHFGNLHVPRDNHPALVSDLMEEFRAQLVDSLVAY

119357853 QSIKVGQILFGAC-MITPAAIRHCLMNRIPVVLLSQHG-EYFTRLLQFQRSAE-ESFPLECSRTIVRAKL------HNSGVVRG----YEGSGAATYFGVFNAMLSFGYS-LLFNNIFSMARLHRLHPYVGFLHADKPAHPALVSDLIEEFRT-LVDGLVIA

119357846 IVRRIEQVIFGNV-ALTTPVMQYCLQNEIPVTFLSQHG-KYFGRLFHFLRSID-EPFALETARSIVAAKI------SNSKTLRG----IEGKASALYFECYNSLLSFGYT-MLHTNIFSMVQASGLNPYIGFLHAERKGNPALVNDLVEEFRT-IVDSLVLY

76802276 PKEKLDTIVFGGV-NFSTPFVAEANEHGIVLNYFTQNG-KYRGSFAQYALT---PAKELAIAKEMIRGKI------RNQRTLRG----AEGEAAERYFDRLNSLLSLTYV-FMKNEVMSALRQYNLDPFLGVLHADRHGRPSLALDLQEEFRPIFCDALVTR

116754851 PMGQVDTIIFGNI-NFTTPFVARANEHGIVLNYFTQNG-HYRGSFRQYALSEA-D--RLRIASVIIRAKI------RNSRTLRG----LEGEAAEIYFGILNALLSLTYS-MIKNEVLSALRQYNLDPFLGILHADRHGRPALALDLLEEFRPIFCDAFTLR

116748794 PLEGLSQLLVGFS-SLSGAVLEVLIRHRIETVLLSPRG-QFRARLGQYVKLSG-ADFALRTTQSIVRGKL------RNTARLRG----IEGHAANLYFEVFNALLSFVYT-LLTQEVLTAIKVVGLDPYLGCLHAVDYGRPSLACDLVEEWRTFLGDRLVLA

55978328 PARQVRSVLWGNV-RLSTPALVFLLRQGVPVFFYSLEG-FLHGVAAQFAA------EGLPLARAFVVGKL------RSALALRG----AEGEGSRVYFQGLNAALSYGYA-LLLGRVLVAVRLAGLHPEVGFLHAEGRRSPALALDLMEEFRVPVVDQVVLS

268318378 PALLVDQVLVGPV-QITSQALRMLLRRNVDIVYLSGEG-RFEGRLAQYEAFRD-PERTLTLARLFVRGKL------QNMAGLRG----VEGTASRRYFSVFNATLGYLYA-LLLGNVVAACALAGLDPYVGYLHAPAYGRPSLALDLMEEFRAPAADRLALR

17229060 PLIKVDGLVMGRA-SISPAAIFELIDKKIPLTFLTNNG-KYLASLAQWKAAGE-SEQAIHVTQGFIRGKL------KNYRHIRG----LEGAGSAAYFGCFNSLLSLGYS-LLRHDVQGALNIVGFDPYLGYLHTERYGRPSLALDLMEEFRPLIVDAVVLT

75910374 PLIKIDGLVMGRA-SISPAAIFELIDKKIPLTFLTNNG-KYLASLAQWKAAGE-SDQAIHVTQGFVRGKL------KNYRHIRG----LEGAGSAAYFGCFNSLLSLGYS-LLRHDIQGALNIVGFDPYLGYLHTERYGRPSLALDLMEEFRPLIVDAVVLT

55978407 PLIAVEEIILGNA-VVTPALLKHCAQEGVGIHYLSPTG-TYYAGLAQFKAYLE-PTWKLALAQRFVLGKI------RNGLVLRG----AEGRAADLYFRAFNSLLSLAYT-LLAKECESALLVAGLDPYVGYLHEVRYGRPSLALDLMEEFRSVLADSVVLS

38505684 PAQTLEDILLGYP-SITGEALGYALELGLPVHYLTQFG-KYVGSAAQFRAHED-PIQRLDIVKAFVKGKV------HNQYNVRG----IEGLAAREYFASWNALLSFGYG-LLRTQVTAAVHIAGLDPYIGFLHETTRGQPAMILDLMEEFRALVADSVVLT

218438692 AAQTVEQILIGQP-SITGEALSYALELGIPVHYLSSFG-KYLGSAAQYAVHND-NDKRLALVKTIVRGKI------HNQYRVRG----VEGIAAREYFQELNALLSFAYG-LLRVQVTAAVHLAGLDPYIGYLHDTTRGQPAMVLDLMEEFRPLIADSLVLS

39995168 RLGETSQVLFGNA-TLTTAALHECLRREIPVTWLSYGG-WFMGHTYQYQRSFD-PETCLNLARRWIVAKI------ANCRTLLG----IEGASAGRYFQHFNALLSFAYA-MLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPFRPLIADSTVLM

83591519 ALDEISEVLAGPV-SLTTPAIHELLRREIPVAWMSSGF-WFLGSTAQYALAGD-ERRRQAFARDLVSAKI------RNGRTLLG----IEGEAAAVYFRAFNACLSLCYA-VLTRTLSSALSIAGLDPWKGFYHTERPGRPALALDLIESFRPVLADSTVLM

159898755 PLNVIERVVQGEI-TLTASALACLLERRICTHFLSYSG-RSQGALAQYAAHTS-IQHRFSLARTFVDGKL------RNLRTILG----CEGQGSAAYWDCWNALLSYGYV-ILTSQVLSQLAIVGFDPYIGFLHQSSFGKPALALDLMEEFRPVIVDSVVLT

86742032 PLVRVDHIVFGGV-TITDDLLQRCATDRRSVTWLTGNG-RFRARVAQHDHFRD-DERRLTLAMSYIAGKL------QNSRQAMG----VEGQAARRYIATWNAALSFGYG-ILRIAVHGALDHVGLDPHIGYLHGIRPGKPALALDLMEEFRALLVDRLVFT

258516129 PLCNLEQLLAGTV-NISAQVIKLLLDRGTEVHFVSRAG-KYYGSLAQHKAYQD-MELRLKYAVLFVQGKL------ANMRTLMG----IEGAATREYFRVFNALLSFAYT-LLTKDMIASVSIVGYDPYIGFLHRSDYGRPALALDFIEEFRPIVADSVVLT

134299482 PLCNLDQVLVGNV-NLSSQLIKLFLGRGTEVHFISTKG-KYYGCLAQHRAYQK-QEERLLYASEFVRGKL------SNMRTLMG----LEGAGSRDYFSVFNALLSFSYS-LLLKDVITAVQVVGFDPFIGFLHRSDFGRPALALDIIEEFRPVVADSVVLT

15675454 PFRIIDGICFSYL-GVSSALVKLCTENQINLSFHTPQG-RFCGRYEHYRLSDR--EESLEYAKRFILAKI------SNSRKLRG----IEGQAANQYFRIFNALLSFGYS-LLTFECQSALEAVGLDSYVGFFHTDRPGRASLALDLVEEFRSYIVDRFVFS

161507871 PLQNFEAITFGYS-GVSPSLMQKCLEQDISISFLSRTG-RLKGRVTQFFNSEN-DAASLLIAKNMIIGKV------YNHRWLRG----LEGSLANGYFSVFNALLSFSYS-LLANECADALTTNGLDPYEGFMHVDRPGRKSLALDLMEELRGVIADRFVLR

15612904 PLHNLEAIGFGYT-GASPALMGYCAERNISITFLTKNG-RFLARVTQYRISEN-DQESTKIARNFITGKV------YNSKWLRG----WEGQAAINYNKVFNAMLSFAYT-LLANDVAAALETVGLDAYVGFMHQDRPGRASLALDLMEELRGLYADRFVLS

94984342 PLHHIEGVVFGNV-LLSPFLIHRLAREHKPVTWLSEHG-RFMARTAQHACAGN-AARTLAIARLIAAGKL------QNQKVVRG----TEGTAARLYWEVFNALLNFVYT-VLANDCASACQAVGLDPQLGFLHALRPGRSSLALDLMEELRPVIADRAILT

108763792 PLRHLRSVCLTRA-WLTPELMESCLEAGIHVSFFGMTG-RFLARVQQYRAADD-IARSVAISRALVVGKL------GNARQVRG----LEGIAARDYFESFNAMLSFGYA-LLAQDCAGALTGVGLDPAVGFLHEDRPGRLSLALDLMEEFRAPVVDRLVFS

83592169 PLHMVGSVVFGGT-YVSPGLMGACAAHGITIVLLDRVG-RFQARVAQYKASEA-P---EDIVKSLILGKV------SNQRALRG----AEGEAASLYFGVFNALLSFLYT-LLTHDCRSACESVGLDPAVGFLHRDRPGRPSLALDLMEELRPVLVDRLALS

34496684 PVHMLEGLCFGRV-LVSPPLMGFCAERGIVISYLSPNG-RFLARVAQYRASDD-GPASASLARHLLLGKL------HNQRALRG----VEGEAAQNYFAVFNAVLSFLYT-LLTHDCRSALESVGLDPTVGFLHRDRPGRPSLALDLVEEFRPVLADRLALS

21244566 PVHMLESICIGRV-GVSPQLLGFCAEQGISICYLTAQG-RFLARVEQYRCSDD-PVRCAAIVRHMLAGKI------HNQRALRG----LEGEAAQSYFGVFNALLSFLYT-LLTHDCRSALETVGLDPAVGFLHRDRPGRPSLALDLAEEFRPLLGERLALS

46562259 PVHSLGGVCFGQV-SCSPFLMGFAAERGLGFSFLTEHG-RFLARVEQYRRADS-PEASAEVARSIVSAKV------VNARGVRG----IEGEAAKGYFSVFNCLLSFIYT-LLGHDVRSALEGVGLDSAVGFLHRDRPGRHGLALDVMEEFRAVVADRLALS

21673956 PLHMLNGICFGQV-SCSPFLLGHCAQLGVAVTFLTEHG-RFLCQMAQYRMADN-YDQTATLARLFVIGKI------GNARVIRG----IEGEAAKAYFSVFNCLLSFVYT-LMTHDIRSALESCGLDPAAGFLHKDRPGRPSLALDMLEEFRSYIGDRLVLS

83589357 PLHHLGSICFGDV-TLTTPLIMRCAEDKRLIVFHDQHG-RFKARVAQHEALSD-SKKTTAIARNIVAGKI------RNTRQIRG----IEGNAARHYFATLNALLSYIYA-LLLNDCLSAAEGVGLDPQIGYLHVLRSGRPALALDLMEEFRAILADRLALT

78222290 PLHHLGAITMGNV-MMSPFIMARCAEDGRALVILDRNG-KFKCRVTQYEAVRD-RERSAAIARNMVAGKV------KNARQVRG----LEGEAANAYFQVFNALLSFLYT-LLLNDCISAVEGVGLDSQMGFLHVLRPGRPSLGLDIMEEFRAVLADRLALT

Part 3:

50085564|Gamma|Acinetobacter_sp-_ADP1

77166205|Bacte|Porphyromonas_gingivalis_W83

54303647|Bacte|Porphyromonas_gingivalis_ATCC_33277

15602176|Bacte|Bacteroides_fragilis_YCH46

239908820|Metha|Methanococcoides_burtonii_DSM_6242

34497211|Bacil|Geobacillus_sp-_WCH70

116050364|Bacil|Geobacillus_sp-_Y412MC61

121592920|Bacil|Listeria_seeligeri_serovar_1-2b_str-_SLCC3954

50122600|Clost|Desulfitobacterium_hafniense_Y51

22125615|Actin|Rubrobacter_xylanophilus_DSM_9941

91209921|Therm|Thermosipho_melanesiensis_BI429

38234755|Clost|Candidatus_Desulforudis_audaxviator_MP104C

209966592|Dicty|Dictyoglomus_thermophilum_H-6-12

53804737|Therm|Thermosipho_africanus_TCF52B

268316057|Dicty|Dictyoglomus_turgidum_DSM_6724

197121198|Clost|Desulfitobacterium_hafniense_DCB-2

83591687|Halob|Halorubrum_lacusprofundi_ATCC_49239

89885834|Aquif|Sulfurihydrogenibium_azorense_Az-Fu1

189501080|Aquif|Persephonella_marina_EX-H1

21674788|Clost|Ammonifex_degensii_KC4

218782762|Clost|Thermoanaerobacter_tengcongensis_MB4

147674033|Clost|Clostridium_tetani_E88

72161989|Halob|Haloarcula_marismortui_ATCC_43049

257055744|Clost|Carboxydothermus_hydrogenoformans_Z-2901

29834079|Clost|Syntrophomonas_wolfei_subsp-_wolfei_str-_Goettingen

83591509|Clost|Clostridium_thermocellum_ATCC_27405

88602656|Clost|Desulfotomaculum_reducens_MI-1

220904201|Clost|Caldicellulosiruptor_saccharolyticus_DSM_8903

162147988|Clost|Alkaliphilus_metalliredigens_QYMF

91772628|Therm|Fervidobacterium_nodosum_Rt17-B1

219852205|Clost|Thermoanaerobacter_pseudethanolicus_ATCC_33223

39996494|Clost|Thermoanaerobacter_sp-_X514

146308770|Nitro|Thermodesulfovibrio_yellowstonii_DSM_11347

16766244|Therm|Thermosipho_africanus_TCF52B

16130662|Clost|Anaerocellum_thermophilum_DSM_6725

92112367|Halob|Halorhabdus_utahensis_DSM_12940

158522999|Fusob|Leptotrichia_buccalis_C-1013-b

47104059|Halob|Halomicrobium_mukohataei_DSM_12286

220925254|Clost|Desulfotomaculum_acetoxidans_DSM_771

257055753|Clost|Desulfotomaculum_acetoxidans_DSM_771

86738746|Therm|Thermobaculum_terrenum_ATCC_BAA-798

111219951|Clost|Thermoanaerobacter_italicus_Ab9

116493922|Aquif|Hydrogenobacter_thermophilus_TK-6

104773928|Clost|Caldicellulosiruptor_saccharolyticus_DSM_8903

283783235|Therm|Thermotoga_petrophila_RKU-1

290580135|Bacil|Anoxybacillus_flavithermus_WK1

68535718|Therm|Thermococcus_kodakarensis_KOD1

256393069|Clost|Clostridium_difficile_630

269126905|Clost|Caldicellulosiruptor_saccharolyticus_DSM_8903

116327441|Aquif|Sulfurihydrogenibium_sp-_YO3AOP1

73749217|Dicty|Dictyoglomus_thermophilum_H-6-12

86605441|Clost|Anaerocellum_thermophilum_DSM_6725

218439403|Clost|Clostridium_difficile_CD196

94972104|Clost|Clostridium_difficile_R20291

167628317|Archa|Archaeoglobus_fulgidus_DSM_4304

55978376|Therm|Pyrococcus_horikoshii_OT3

147920423|Metha|Methanocaldococcus_jannaschii_DSM_2661

269838937|Therm|Pyrococcus_furiosus_DSM_3638

148654810|Metha|Methanobrevibacter_smithii_ATCC_35061

51891801|Therm|Thermococcus_sibiricus_MM_739

220934970|Metha|Methanocaldococcus_fervens_AG86

57865886|Metha|Methanocaldococcus_vulcanius_M7

47458867|Metha|Methanobrevibacter_ruminantium_M1

294660601|Metha|Methanocaldococcus_sp-_FS406-22

71894593|Therm|Pyrococcus_horikoshii_OT3

90961086|Betap|Chromobacterium_violaceum_ATCC_12472

15675042|Alpha|Gluconacetobacter_diazotrophicus_PAl_5

42525844|Alpha|Gluconacetobacter_diazotrophicus_PAl_5

169823756|Gamma|Azotobacter_vinelandii_DJ

187736488|Gamma|Methylococcus_capsulatus_str-_Bath

189485060|Alpha|Nitrobacter_winogradskyi_Nb-255

187250661|Alpha|Rhodospirillum_rubrum_ATCC_11170

57238545|Gamma|Xanthomonas_oryzae_pv-_oryzae_MAFF_311018

269123825|Betap|Nitrosomonas_eutropha_C91

238924076|Metha|Methanocorpusculum_labreanum_Z

55820736|Gamma|Xanthomonas_oryzae_pv-_oryzae_PXO99A

157149930|envir|uncultured_Termite_group_1_bacterium_phylotype_Rs-D17

189485226|Alpha|Zymomonas_mobilis_subsp-_mobilis_NCIMB_11163

222109284|Gamma|Halothiobacillus_neapolitanus_c2

220930481|Gamma|Xanthomonas_albilineans

218767587|Bacil|Bacillus_halodurans_C-125

15602991|Chlor|Chlorobium_tepidum_TLS

117929157|delta|Desulfovibrio_vulgaris_str-_Hildenborough

283456134|Bacil|Bacillus_clausii_KSM-K16

38232679|Chlor|Chlorobium_luteolum_DSM_273

150025576|Chlor|Chlorobium_chlorochromatii_CaD3

60683388|Clost|Moorella_thermoacetica_ATCC_39073

261414554|delta|Syntrophus_aciditrophicus_SB

154250554|Actin|Bifidobacterium_adolescentis_ATCC_15703

159042957|Chlor|Chlorobium_phaeobacteroides_DSM_266

121608212|delta|Desulfovibrio_vulgaris_DP4

288957740|Clost|Desulfotomaculum_reducens_MI-1

75675148|Chlor|Chlorobium_phaeovibrioides_DSM_265

34557789|Clost|Alkaliphilus_metalliredigens_QYMF

90425960|Bacil|Lactobacillus_helveticus_DPC_4571

209542526|Bacil|Exiguobacterium_sibiricum_255-15

156937861|Bacil|Lactobacillus_fermentum_IFO_3956

70607609|Chlor|Pelodictyon_phaeoclathratiforme_BU-1

21229351|delta|Desulfovibrio_vulgaris_str-_-Miyazaki_F-

147921327|Clost|Desulfitobacterium_hafniense_DCB-2

289596068|Clost|Clostridium_cellulolyticum_H10

34541577|Acido|Acidobacterium_capsulatum_ATCC_51196

15898245|Clost|Eubacterium_rectale_ATCC_33656

126465226|delta|Desulfovibrio_magneticus_RS-1

170290046|Actin|Eggerthella_lenta_DSM_2243

288932203|Clost|Desulfotomaculum_acetoxidans_DSM_771

54296139|Actin|Bifidobacterium_dentium_Bd1

34557933|Clost|Acidaminococcus_fermentans_DSM_20731

150401497|Deino|Deinococcus_geothermalis_DSM_11300

224367660|delta|Myxococcus_xanthus_DK_1622

257125862|Clost|Syntrophomonas_wolfei_subsp-_wolfei_str-_Goettingen

284040851|uncla|Magnetococcus_sp-_MC-1

150398872|Bacte|Parabacteroides_distasonis_ATCC_8503

21226661|Gamma|Teredinibacter_turnerae_T7901

125975696|Gamma|Hahella_chejuensis_KCTC_2396

134045811|Betap|Methylobacillus_flagellatus_KT

218884093|Gamma|Cellvibrio_japonicus_Ueda107

15922975|Gamma|Mannheimia_succiniciproducens_MBEL55E

15898286|Gamma|Actinobacillus_succinogenes_130Z

11499462|Gamma|Aggregatibacter_aphrophilus_NJ8700

159901591|Gamma|Aggregatibacter_actinomycetemcomitans_D11S-1

260893609|Bacil|Streptococcus_pyogenes_M1_GAS

156937921|Bacil|Streptococcus_pyogenes_MGAS315

124027534|Bacil|Streptococcus_agalactiae_2603V-R

118431380|Bacil|Streptococcus_agalactiae_NEM316

18311699|Bacil|Streptococcus_pyogenes_SSI-1

18311772|Bacil|Streptococcus_pyogenes_MGAS6180

283778924|Bacil|Streptococcus_pyogenes_MGAS5005

15609954|Bacil|Streptococcus_agalactiae_A909

116627764|Bacil|Streptococcus_pyogenes_MGAS9429

111224947|Bacil|Streptococcus_pyogenes_MGAS10270

154174048|Bacil|Streptococcus_pyogenes_MGAS2096

157164052|Bacil|Streptococcus_pyogenes_MGAS10750

41614813|Bacil|Streptococcus_thermophilus_LMD-9

48477075|Bacil|Streptococcus_equi_subsp-_zooepidemicus_MGCS10565

13540937|Bacil|Streptococcus_pyogenes_NZ131

150021526|Bacil|Streptococcus_dysgalactiae_subsp-_equisimilis_GGS_124

114567318|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Typhimurium_str-_LT2

28211139|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Choleraesuis_str-_SC-B67

268679538|Gamma|Shigella_boydii_Sb227

289596694|Gamma|Escherichia_coli_E24377A

14590110|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Heidelberg_str-_SL476

34541603|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Agona_str-_SL483

84489236|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Dublin_str-_CT_02021853

19704512|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Gallinarum_str-_287-91

257125579|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Enteritidis_str-_P125109

189345988|Gamma|Escherichia_coli_SE11

15605875|Gamma|Escherichia_coli_55989

83590562|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Paratyphi_C_strain_RKS4594

148270212|Gamma|Escherichia_coli_O103-H2_str-_12009

222099688|Gamma|Escherichia_coli_O26-H11_str-_11368

14591064|Gamma|Escherichia_coli_O111-H-_str-_11128

15668554|Gamma|Erwinia_pyrifoliae_Ep1-96

212638614|Gamma|Escherichia_coli_str-_K-12_substr-_MG1655

146295386|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Typhi_str-_CT18

206900365|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Typhi_str-_Ty2

206889560|Gamma|Escherichia_coli_str-_K-12_substr-_W3110

20092470|Gamma|Psychromonas_ingrahamii_37

11500011|Gamma|Escherichia_coli_HS

15679095|Gamma|Escherichia_coli_ATCC_8739

160903306|Gamma|Escherichia_coli_str-_K-12_substr-_DH10B

15644541|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Newport_str-_SL254

221632058|Gamma|Salmonella_enterica_subsp-_enterica_serovar_Schwarzengrund_str-_CVM19633

239617067|Gamma|Escherichia_fergusonii_ATCC_35469

288818552|Gamma|Escherichia_coli_BW2952

154249624|Chlor|Herpetosiphon_aurantiacus_ATCC_23779

20809002|Chlor|Roseiflexus_castenholzii_DSM_13941

219669947|Chlor|Herpetosiphon_aurantiacus_ATCC_23779

88602029|Chlor|Chloroflexus_aurantiacus_J-10-fl

288947693|Chlor|Chloroflexus_aggregans_DSM_9485

206890539|Chlor|Chloroflexus_sp-_Y-400-fl

121997419|Chroo|Microcystis_aeruginosa_NIES-843

52425690|Nosto|Nostoc_punctiforme_PCC_73102

30248142|Nosto|Nostoc_sp-_PCC_7120

269798874|Nosto|Anabaena_variabilis_ATCC_29413

288957883|Bacil|Streptococcus_pyogenes_M1_GAS

37677204|Bacil|Streptococcus_pyogenes_MGAS6180

20094748|Bacil|Streptococcus_pyogenes_MGAS5005

261415948|Bacil|Streptococcus_pyogenes_MGAS9429

114567264|Bacil|Streptococcus_pyogenes_MGAS2096

241196732|Bacil|Streptococcus_pyogenes_MGAS10750

283458258|Bacil|Streptococcus_equi_subsp-_zooepidemicus_MGCS10565

83592490|Bacil|Streptococcus_pyogenes_NZ131

209966743|Bacil|Streptococcus_equi_subsp-_zooepidemicus

154250301|Gamma|Pectobacterium_atrosepticum_SCRI1043

162457462|Gamma|Yersinia_pestis_Antiqua

170078384|Gamma|Yersinia_pestis_Nepal516

108761389|Gamma|Yersinia_pestis_Pestoides_F

294828260|Gamma|Yersinia_pseudotuberculosis_IP_31758

159898907|Gamma|Yersinia_pestis_Angola

148657121|Gamma|Yersinia_pseudotuberculosis_YPIII

163848915|Gamma|Yersinia_pseudotuberculosis_PB1-

38505739|Gamma|Pectobacterium_wasabiae_WPP163

17227877|delta|Geobacter_sulfurreducens_PCA

220910738|Gamma|Thioalkalivibrio_sp-_HL-EbGR7

86608317|Alpha|Rhodospirillum_rubrum_ATCC_11170

85858452|Alpha|Azospirillum_sp-_B510

17228961|Actin|Saccharopolyspora_erythraea_NRRL_2338

119357853|Bacte|Rhodothermus_marinus_DSM_4252

119357846|delta|Haliangium_ochraceum_DSM_14365

76802276|Metha|Methanosarcina_barkeri_str-_Fusaro

116754851|Actin|Mycobacterium_tuberculosis_H37Rv

116748794|Actin|Mycobacterium_tuberculosis_CDC1551

55978328|Actin|Mycobacterium_bovis_AF2122-97

268318378|Actin|Mycobacterium_bovis_BCG_str-_Pasteur_1173P2

17229060|Actin|Mycobacterium_tuberculosis_H37Ra

75910374|Actin|Mycobacterium_tuberculosis_F11

55978407|Actin|Mycobacterium_bovis_BCG_str-_Tokyo_172

38505684|Gamma|Escherichia_coli_O157-H7_EDL933

218438692|Gamma|Escherichia_coli_O157-H7_str-_Sakai

39995168|Gamma|Escherichia_coli_SMS-3-5

83591519|Gamma|Escherichia_coli_O157-H7_str-_EC4115

159898755|Gamma|Escherichia_coli_O157-H7_str-_TW14359

86742032|Gamma|Dickeya_dadantii_Ech586

258516129|Gamma|Citrobacter_rodentium_ICC168

134299482|Chlor|Roseiflexus_castenholzii_DSM_13941

15675454|Chlor|Roseiflexus_sp-_RS-1

161507871|Chlor|Herpetosiphon_aurantiacus_ATCC_23779

15612904|Chlor|Chloroflexus_aurantiacus_J-10-fl

94984342|Chlor|Chloroflexus_aggregans_DSM_9485

108763792|Chlor|Chloroflexus_sp-_Y-400-fl

83592169|Chroo|Synechocystis_sp-_PCC_6803

34496684|Chroo|Synechococcus_sp-_PCC_7002

21244566|Chroo|Cyanothece_sp-_PCC_8801

46562259|Chroo|Cyanothece_sp-_PCC_7424

21673956|Chroo|Cyanothece_sp-_PCC_7425

83589357|Chroo|Cyanothece_sp-_PCC_8802

78222290|Therm|Petrotoga_mobilis_SJ95

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