Introduction to Immunology: AS.020.229.21
Course Dates: June 29, 2015—July30, 2015
Class Times: M, W, Th 10:00am-11:45am
Class Location: Homewood Campus, Room 101Macaulay Building
Instructor: Abby Geis
Medical campus Cancer Research Building 1 Room 424
Prerequisites:Biology. Molecular biology is not required, but it is recommended that you are familiar with DNA replication and gene transcription.
Following completion of this course, students should be able to:
- Identify and express the need for an effective immune system.
- Rationalize the contributions of 1st & 2nd line innate defenses. Predict effects of various deficiencies in terms of intensity of inflammatory response & overall host immunity to pathogen-mediated damage.
- Recite 4 steps of monocyte extravasation from blood vessels to sites of infection.
- Name 3 antigen presenting cells and compare & contrast their roles in immune defense.
- Describe 3 main features that differ between innate and adaptive immunity.
- Describe the features that confer antigen specificity to T and B cells of adaptive immune system.
- Understand how 2 qualities of MHC (poly-genic & -morphic) contribute to diversity of repertoire and prevent pathogen escape from presentation. Discuss the advantages & potential disadvantages.
- Explain the 3 signals that lead to T cell activation & consequences of only 1-2 signals.
- Recall the major effector function of B cells, helper T cells, cytotoxic T lymphocytes, regulatory T cells, and mast cells. Apply this knowledge to form testable hypotheses for a variety of phenomena.
- Understand the importance of immune regulation and the consequences of an overwhelming immune response.
- Identify & explain plausible causes of particular immune-mediated disease phenotypes.
Required Text: Charles Janeway’s Immunobiology. 8th edition
Syllabus
Date / Topic / Content summary / Required Reading (due before class)June 29, 2015 / Introduction / History & overview of immune system function, cells, & organs / Chapter 1 pgs 1-25 & 29-31
July 1, 2015 / Innate Immunity 1 / First Line of Defense / Chapter 2 pgs 37-60, 64-66, & 69
July 2, 2015 / Innate Immunity 2 / Second Line of Defense: PAMPs & PRRs (Danger theory); Quiz 1 / Chapter 3 pgs 75-85, 89-90, 92, 96, 99-110, 113-115, 118-120
July 6, 2015 / Antigen Recognition & Presentation / Linking innate & adaptive immunity / Chpt 4 pgs 127-130, 134-136, 138-145, 148-153; Chpt 6 pgs 201-217, 221-228; Chpt 9 pgs 342-353; & Chpt 11 pgs 429-433
(Zinkernagel & Doherty 1974 MHC restriction Nature article)
July 8, 2015 / Adaptive Immunity 1 / V(D)J recombination (intro); T cell development & functions; tolerance / Chpt 5 pgs 157-158, 173-176; Chpt 8 pgs 290-294, 305-315; & Chpt 9 pgs 335-337, 353-355, 357-366, 369-370, 372-381
July 9, 2015 / Adaptive Immunity 2 / B cell development & functions; Quiz 2 / Chpt 5 pgs 176-179, 182, 184-185; Chpt 8 pgs 275-277, 282-290; & Chpt 10 pgs 387-392, 395, 398-400, 408-410, 412-421
July 13, 2015 / Building an effective adaptive immune response / Directional activation, communication between effector arms,regulation & establishing memory / Chpt 11
July 15, 2015 / Midterm Review / Includes ALL content covered through July 13
July 16, 2015 / Midterm
July 20, 2015 / Mucosal Immunity / MALT & GALT: More prokaryote than eukaryote (defense for the Danger theory) / Attached review article(s)
July 22, 2015 / Allergy / Distinguishing allergy from intolerance / Chpt 14; Attached Nature review
July 23, 2015 / Autoimmunity / A break in tolerance
Quiz 3 / Chpt 15; Attached JAutoimmunity review
July 27, 2015 / Cancer / Pro- & Anti-carcinogenic inflammation / Chpt 16
July 29, 2015 / Course Review / Exam will be cumulative
July 30, 2015 / Final Exam
Rubric
Quizzes20%
Midterm40%
Final Exam40%