Polybrominateddiphenyl Ethers

References for Associations between Prenatal Chemical Exposures (to chemicals found in Consumer, Household and Personal Care Products) and Adverse Neurodevelopmental Effects AgnesLobscheid, PhD

PolybrominatedDiphenyl Ethers

Castorina et al. (2011).Determinants of Serum PolybrominatedDiphenyl Ether (PBDE) Levels among Pregnant Women in the CHAMACOS Cohort.Environmental Science & Technology45(15), 6553-6560.

Chen et al. (2014). Prenatal polybrominateddiphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study. Environ Health Perspect. 122(8):856-62.

Chevrier et al., (2010).Polybrominateddiphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environ Health Perspect. 118(10):1444-9.

Darnerud et al. (2001).Polybrominateddiphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect.109 Suppl 1:49-68.

Eskanazi et al. (2013).In Utero and Childhood PolybrominatedDiphenyl Ether (PBDE) Exposures and Neurodevelopment in the CHAMACOS Study. Environ Health Perspect.121(2), 257–262.

Herbstman et al. (2010) Prenatal exposure to PBDEs and neurodevelopment.Environ Health Perspect. 118(5):712-9.

Stapleton et al. (2011) Identification of Flame Retardants in Polyurethane Foam Collected from Baby Products. Environmental Science & Technology45(12), 5323-5331.

Phthalates

Mallow and Fox (2014).Phthalates and critically ill neonates: device-related exposures and non-endocrine toxic risks. Journal of Perinatology34, 892-897.

Factor-Litvak et al. (2014). Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years. PLoS ONE, 9(12), e114003.

Kim et al. (2011). Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children's Environmental Health (MOCEH) study. Environ Health Perspect. 119(10):1495-500.

Kobrosly et al. (2014).Prenatal phthalate exposures and neurobehavioral development scores in boys and girls at 6–10 years of age.Environ Health Perspect. 122:521–528.

Lien et al. (2015). Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan maternal and infant cohort study. Environ Health Perspect. 123(1):95-100.

Téllez-Rojo MM, et al. (2013). Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age.Sci Total Environ. 461-462:386-90.

Whyatt et al. (2012). Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age.Environ Health Perspect. 120(2):290-5.

Bisphenol A (BPA)

Braun et al. (2009) Prenatal BisphenolA Exposure and Early Childhood Behavior. Environ Health Perspect. 117(12): 1945–1952.

Braun et al. (2011). Impact of Early-Life BisphenolA Exposure on Behavior and Executive Function in Children. Pediatrics 128(5): 873–882.

Chapin et al. (2008).NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Res B Dev ReprodToxicol.83(3):157-395.

Harley et al. (2013) Prenatal and Early Childhood Bisphenol A Concentrations and Behavior in School-Aged Children.Environ Res. 126: 43–50.

Kawai et al. (2003).Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A. Environ Health Perspect.111(2), 175–178.

Miodovnik et al. (2011). Endocrine Disruptors and Childhood Social Impairment. Neurotoxicology 32(2): 261–267.

Miyagawa et al. (2007).Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A. Neuroscience Letters418(3):236–241.

Perera et al. (2012). Prenatal BisphenolA Exposure and Child Behavior in an Inner-City Cohort. Environ Health Perspect. 120(8): 1190–1194.

Richter et al. (2007).In vivoeffects of bisphenol A in laboratory rodent studies.Reproductive Toxicology 24(2): 199–224.

Zoeller et al. (2005).Bisphenol-A, an Environmental Contaminant that Acts as a Thyroid Hormone Receptor Antagonist in Vitro, Increases Serum Thyroxine, and Alters RC3/Neurogranin Expression in the Developing Rat Brain.Endocrinology146(2):607-612.

Pesticides (primarily Organophosphate Pesticides, OPs)

Berkowitz et al. (2004). In utero pesticide exposure, maternal paraoxinase activity, and head circumference. Environ. Health Perspect. 112:388-91.

Bouchard et al. (2011).Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children.Environ. Health Perspect. 119(8):1189-95.

EPA (2011). information and report released Feb 2011.

Eskanazi et al. (2007). Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.Environ Health Perspect. 115(5):792-8.

Grube et al. (2011).Pesticides Industry Sales and Usage 2006 and 2007 Market Estimates.

Holland et al. (2006). Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns.Environ Health Perspect. 114(7): 985-991.

Lovasi et al. (2011).Chlorpyrifos Exposure and Urban Residential Environment Characteristics as Determinants of Early Childhood Neurodevelopment. Am J Public Health. 101(1): 63–70.

Marks et al. (2010). Organophosphate Pesticide Exposure and Attention in Young Mexican-American Children.Environ Health Perspect.118:1768-1774.

Rauh et al. (2011). Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide. Environ Health Perspect. 119(8): 1196–1201.

Rauh et al. (2012). Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc Natl AcadSci U S A. 109(20): 7871–7876.

USGS (2012).National Water Quality Assessment Program.Pesticide Use Maps – Glyphosate0 2012. Located at:

Perflourooctanoic acid (PFOA) & Perfluorooctane Sulfonate (PFOS)

Fei and Olson (2011). Prenatal exposure to perfluorinated chemicals and behavioral or coordination problems at age 7 years.Environ. Health Perspect.119(4): 573-578.

Høyer et al. (2015). Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study. Environ Health. 14(1):2.

Ode et al. (2014).Fetal exposure to perfluorinated compounds and attention deficit hyperactivity disorder in childhood.PLoS One. 9(4):e95891.

Stein et al. (2013).Perfluorooctanoate and neuropsychological outcomes in children.Epidemiology 24(4):590-9.

Plus, two additional studies not presented in slides:

Braun et al (2014). Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study. Environmental Health Perspectives, 122(5), 513–520.

Stein and Savitz (2011). Serum perfluorinated compound concentration and attention deficit/hyperactivity disorder in children 5-18 years of age. Environ. Health Perspect. 119(10):1466-71.