Supplementary Table 1. Gene list of IGF-1 ligand (Yale) activation signature
4239 MFAP4
8404 SPARCL1
10186 LHFP
8436 SDPR
10351 ABCA8
90865 IL33
58494 JAM2
1879 EBF1
57088 PLSCR4
2791 GNG11
374864 C18orf34
79785 RERGL
9079 LDB2
11185 INMT
51705 EMCN
79974 FLJ21986
6359 CCL15
2532 DARC
8406 SRPX
9452 ITM2A
9353 SLIT2
858 CAV2
80310 PDGFD
730 C7
7048 TGFBR2
5168 ENPP2
5627 PROS1
1901 EDG1
10628 TXNIP
116159 CYYR1
358 AQP1
6387 CXCL12
219348 PLAC9
25960 GPR124
2205 FCER1A
4629 MYH11
857 CAV1
3489 IGFBP6
152503 SH3D19
128553 TSHZ2
2934 GSN
5239 PGM5
7102 TSPAN7
5166 PDK4
10252 SPRY1
84417 C2orf40
286133 SCARA5
8611 PPAP2A
256691 MAMDC2
25890 ABI3BP
4222 MEOX1
219654 C10orf56
125 ADH1B
1511 CTSG
10112 KIF20A
25927 C2orf32
7450 VWF
54510 PCDH18
3075 CFH
25891 DKFZP586H2123
28984 C13orf15
8490 RGS5
220323 OAF
133584 EGFLAM
2151 F2RL2
7123 CLEC3B
3397 ID1
115207 KCTD12
127435 PODN
32 ACACB
91653 BOC
7122 CLDN5
22974 TPX2
338328 GPIHBP1
6790 AURKA
4692 NDN
124 ADH1A
83700 JAM3
2327 FMO2
730525 LOC730525
3202 HOXA5
388815 C21orf34
4311 MME
10580 SORBS1
1149 CIDEA
51170 HSD17B11
1063 CENPF
1033 CDKN3
1805 DPT
1675 CFD
5468 PPARG
338773 TMEM119
731049 LOC731049
168537 GIMAP7
1959 EGR2
4128 MAOA
2597 GAPDH
57124 CD248
64151 NCAPG
4147 MATN2
221476 PI16
9319 TRIP13
2167 FABP4
1058 CENPA
5156 PDGFRA
991 CDC20
5649 RELN
3512 IGJ
301 ANXA1
3161 HMMR
891 CCNB1
9133 CCNB2
216 ALDH1A1
2353 FOS
9787 DLG7
51203 NUSAP1
259266 ASPM
6414 SEPP1
8140 SLC7A5
128239 IQGAP3
11332 ACOT7
9232 PTTG1
57678 GPAM
1306 COL15A1
2487 FRZB
6422 SFRP1
1308 COL17A1
9833 MELK
11065 UBE2C
5346 PLIN
6867 TACC1
10124 ARL4A
113130 CDCA5
1843 DUSP1
2192 FBLN1
9123 SLC16A3
2819 GPD1
29089 UBE2T
55165 CEP55
2034 EPAS1
5159 PDGFRB
667 DST
83699 SH3BGRL2
4023 LPL
54443 ANLN
3149 HMGB3
7049 TGFBR3
1717 DHCR7
7018 TF
7538 ZFP36
55872 PBK
7083 TK1
116362 RBP7
80704 SLC19A3
8483 CILP
9055 PRC1
948 CD36
120 ADD3
29128 UHRF1
23521 RPL13A
2273 FHL1
7272 TTK
222166 C7orf41
55839 CENPN
3815 KIT
4915 NTRK2
4638 MYLK
284119 PTRF
1346 COX7A1
51659 GINS2
55502 HES6
8910 SGCE
7153 TOP2A
51514 DTL
7060 THBS4
5730 PTGDS
51309 ARMCX1
10234 LRRC17
79901 CYBRD1
25925 ZNF521
83604 TMEM47
50486 G0S2
4173 MCM4
8878 SQSTM1
4501 MT1X
2 A2M
2354 FOSB
1634 DCN
3952 LEP
57214 KIAA1199
8322 FZD4
217 ALDH2
3043 HBB
124222 PAQR4
1958 EGR1
6678 SPARC
2878 GPX3
718 C3
5157 PDGFRL
10381 TUBB3
2719 GPC3
10512 SEMA3C
2199 FBLN2
11067 C10orf10
8654 PDE5A
6363 CCL19
81035 COLEC12
2690 GHR
64094 SMOC2
4312 MMP1
3040 HBA2
983 CDC2
6038 RNASE4
389336 MGC23985
6376 CX3CL1
6648 SOD2
1410 CRYAB
1363 CPE
84733 CBX2
2947 GSTM3
7704 ZBTB16
5997 RGS2
116496 FAM129A
116496 C1orf24
84952 CGNL1
1301 COL11A1
4781 NFIB
6423 SFRP2
2202 EFEMP1
26577 PCOLCE2
347 APOD
5654 HTRA1
55964 SEPT3
3909 LAMA3
149428 BNIPL
10418 SPON1
8836 GGH
57586 SYT13
3861 KRT14
5284 PIGR
51050 PI15
5021 OXTR
51313 C4orf18
810 CALML3
6279 S100A8
10974 C10orf116
6280 S100A9
4256 MGP
72 ACTG2
23336 DMN
6696 SPP1
6319 SCD
4318 MMP9
1811 SLC26A3
7138 TNNT1
4320 MMP11
3899 AFF3
5304 PIP
1917 EEF1A2
25907 TMEM158
56892 C8orf4
4604 MYBPC1
4250 SCGB2A2
4886 NPY1R
3872 KRT17
6898 TAT
79679 VTCN1
3866 KRT15
57758 SCUBE2
155465 AGR3
6286 S100P
51806 CALML5
6278 S100A7
Supplementary Table 2. IGF1 gene expression and Creighton activation score Correlation in Independent Cohorts
(Pearson two-sided test) / Reference
Van deVivjer / 285 / -0.535 / 2.89e-23 / 16
Wang / 296 / -0.502 / 1.11e-19 / 15
Chin / 113 / -0.518 / 2.16e-9 / 17
Supplemental Table 3A:
Frequencies of Molecular Subtypes by Hormone Receptor Status and IGF ligand group
Subtype: / Basal / Her2 / LumA / LumB / Normal
Hormone Receptor Status / Negative / 18 / 25 / 6 / 6 / 7
Positive / 12 / 7 / 42 / 45 / 32
Missing / 0 / 1 / 1 / 1 / 1
Subtype: / Basal / Her2 / LumA / LumB / Normal
IGF group (Yale) / High / 8 / 3 / 19 / 8 / 27
Intermediate / 6 / 11 / 21 / 13 / 9
Low / 16 / 19 / 9 / 31 / 4
Hormone Receptor: / Positive / Negative / Missing
IGF group (Yale) / High / 53 / 10 / 2
Intermediate / 39 / 21 / 0
Low / 46 / 31 / 2
Subtype: / Basal / Her2 / LumA / LumB / Normal
IGF group (Creighton) / Non-activated / 1 / 1 / 27 / 6 / 23
intermediate / 15 / 17 / 22 / 39 / 17
Activated / 14 / 15 / 0 / 7 / 0
Hormone Receptor: / Positive / Negative / Missing
IGF group (Creighton) / Non-activated / 53 / 5 / 1
intermediate / 78 / 29 / 3
Activated / 7 / 28 / 0
Supplemental Table 3B:
Frequencies of IGF Activation Signature (Creighton) and Yale Signature Groups
Yale group / High / Intermediate / Low
IGF group (Creighton) / Non-activated / 32 / 18 / 8
intermediate / 32 / 37 / 41
Activated / 1 / 5 / 30