BMB 001: UNDERSTANDING THE BASES OF HUMAN DISEASE

Fall 2009

MWF 2:30 - 3:20 P.M.

102 Thomas

Instructor:Anjuli Datta, M.S.

Office:116-E S. Frear Lab

Phone:863-4172 Answering Machine is ON.

E-mail:

Office Hours:Tuesdays (3pm-5pm) and Thursdays (9am-11am), Drop-in

Texts:Starr and Taggart, Cell Biology and Genetics, Wadsworth, 12th ed., 2006.

Reading/Notepack:The “notepack” will be posted on ANGEL in the appropriate unit folder.

Exams & Grading

Policy

There will be six equally weighted and non-cumulative examinations, each worth 100 points. The first five will be given during the regular class period on the dates shown in the class schedule (below), and the sixth examination will be given at the assigned time during finals week at the end of the semester. The best 5 of 6 scores will be used to determine your final grade. The final is NOT COMPREHENSIVE. Exams and grades will be available for view and discussion in my office only until the next exam is given.

These exams will consist of mostly multiple-choice questions. You will be responsible for the assigned readings on the examinations, but examination questions will come largely from material covered in lectures. These exams will consist of mostly multiple-choice questions. Exam results will be e-mailed to you by testing services. The final class averages will be curved.

Make-up Exams:

Make-up exams will be given only with my prior approval provided there is a legitimate excuse. They will be given within 48 hours after the last exam (NO EXCEPTIONS!). I reserve the right to change the format of the make-up exam to short answer, oral, essay, etc. Make-up exams will be held in my office (116E S. Frear). You will need to bring your PSU ID and fill out a make-up exam reservation form.

Review Sessions: Dates will be given in class and posted on Angel

ANGEL:Material for this course is available on ANGEL. There are links and supplementary material posted as well. Class announcements and assignments will be posted on ANGEL.

The course objectives provide a great study sheet for each Unit exam!!

Academic Dishonesty Statement:

Academic dishonesty is not limited to simply cheating on an exam or assignment. The following is quoted directly from the "PSU Faculty Senate Policies for Students" regarding academic integrity and academic dishonesty: "Academic integrity is the pursuit of scholarly activity free from fraud and deception and is an educational objective of this institution. Academic dishonesty includes, but is not limited to, cheating, plagiarizing, fabricating of information or citations, facilitating acts of academic dishonesty by others, having unauthorized possession of examinations, submitting work of another person or work previously used without informing the instructor, or tampering with the academic work of other students." All University and Eberly College of Science policies regarding

academic integrity/academic dishonesty apply to this course and the students enrolled in this course. Refer to the following URL for further details on the academic integrity policies of the Eberly College of Science: Each student in this course is expected to work entirely on her/his own while taking any exam, to complete assignments on her/his own effort without the assistance of others unless directed otherwise by the instructor, and to abide by University and Eberly College of Science policies about academic integrity and academic dishonesty. Academic dishonesty can result in assignment of "F" by the course instructors or "XF" by Judicial Affairs as the final grade for the student.

CLASS POLICIES:

1. See Academic Dishonesty Statement.

2. Be a good Penn State citizen. Respect the other students in class by behaving in a civil and courteous manner.

3. Come to class ON TIME ready to go. Class starts at 2:30 p.m.

4. Don't be rude to me OR TO THE OTHER STUDENTS, who are paying $90/lecture (or more), by leaving early. If you must leave early for an unavoidable reason, let me know before class and sit close to an exit. Try to let me know ahead of time if you will be unavoidably late for class.

5. Beepers and phones-OFF, no exceptions!

7. Food and drink are officially banned from classrooms. If, however, you do bring something in, clean up after yourself.

8. Make sure you read, understand and agree with the above. Continuing registration in this course is tacit approval of its policies, procedures and grading method.

BMB 001 SYLLABUS

DATE #TOPICREADING

**************************************************************************************

08/241Life’s Chemical Basis S & T: Chp. 2

08/262Molecules of Life S & T: Chp. 3

08/283DNA Synthesis/Genetic CodeS & T: Chp. 13

08/31 4Genetic Code/Transcription/TranslationS & T: Chp. 14

09/025Metabolism S & T: Chp. 6

09/046 Cell: Intro and Organelles S & T: Chp. 4

09/07 Labor Day No School

09/097Transport Across the MembraneS & T: Chp. 5

09/11 Review

09/14Test 1

09/168Introduction to DiseaseNotepack

09/189Immune System/Nonspecific Defense ResponseNIH Booklet in Notepack

09/2110Antibody Mediated Defense ResponseNIH Booklet in Notepack

09/2311Vaccines/Cell Mediated Defense ResponseNIH Booklet in Notepack

09/2512Autoimmune Disease/AllergiesNIH Booklet in Notepack

09/2813Immune Deficiency Diseases/Suppressed ImmunityNIH Booklet in Notepack

09/30Test 2

10/0214Virus/Viral DiseasesNotepack and Web assignment

10/0515HIV/AIDSNotepack

10/0716Bacteria/Bacterial DiseasesS & T: Chp. 4.3 Web assignment

10/0917Other Infectious DiseasesNotepack

10/1218Foodborn Illness/SafetyArticles in Notepack

10/1419Alcohol MetabolismNotepack

10/16Test 3

10/19 20Mitosis S & T: Chps. 9 & 10

10/2121MeiosisS & T: Chps 9 & 10

10/2322Patterns of Inheritance/PedigreesS & T: Chp. 11

10/2623Autosomal Dominant DiseaseS & T: Chp. 12

10/2824Autosomal Recessive DiseaseS & T: Chp. 12

10/3025X-linked DiseaseS & T: Chp. 12

11/0226Chromosomal DiseaseS & T: Chp. 12

11/04Test 4

11/0627Cancer IntroNotepack

11/0928Normal Cell/Cancer CellNotepack

11/1129Genetics and CancerNotepack

11/1330New/Proposed Cancer TreatmentsNotepack

11/1631How Medicines WorkNotepack

11/1832Vitamin Toxicities+Food/Drug/Herb InteractionsArticles in Notepack

11/2033Test 5

11/23-11/27THANKSGIVING HOLIDAY No Class

11/3034Cardiovascular SystemNotepack

12/0235Cardiovascular Disease “

12/0436Cholesterol/Lipid Transport “

12/07 37 Diabetes“

12/09 38 Diabetes“

12/1139Review “

Final Exam to be announced: Exam 6

Course Objectives and Learning Outcomes for BMB 001,

Bases of Human Diseases

Objective 1

Students will acquire an understanding of the chemistry of life, structure and function of macromolecules, and basic cellular structure and function.

Learning Outcomes

Students will be able to:

  1. Define chemistry terms related to atoms (atomic weight, atomic number, mass number, parts of an atom)
  2. Construct a shell model of an atom and be able to explain bonding behavior between atoms
  3. List the reasons behind water’s unique properties
  4. Calculate Hydrogen ion concentration shifts with respect to the pH logarithmic scale
  5. Recall the functional roles of carbohydrates, lipids, proteins, and nucleic acids made in our body
  6. Distinguish between condensation and hydrolysis reactions
  7. Explain the investigations that led to our understanding of DNA as a molecule of inheritance
  8. Define the structure of DNA and state the base-pairing rules between DNA-DNA and DNA-RNA
  9. List the steps involved in DNA replication, transcription, and translation
  10. Compare and contrast DNA replication and transcription
  11. Correctly interpret activation energy diagrams depicting endergonic or exergonic reactions
  12. Define the first and second law of thermodynamics
  13. Use appropriate terminology to identify parts of a chemical reaction
  14. Differentiate the purpose of anabolic and catabolic pathways
  15. Compare and contrast eukaryotic and prokaryotic cells
  16. Label and provide functions of eukaryotic organelles
  17. Determine movement of water in a semipermeable membrane when immersed in an isotonic, a hypertonic, or a hypotonic solution
  18. Identify rules associated with passive diffusion versus active transport

Objective 2

Students will develop an understanding of how the immune system works and what happens when the immune system does not function properly.

Learning Outcomes

Students will be able to:

  1. Identify the three levels of immune defense, what belongs to each level and how each works. Know the cells involved (if applicable), secretions and actions.
  2. Differentiate between antibody-mediated immunity and cell-mediated immunity
  3. List the events involved in inflammation
  4. Characterize immune disorders (allergy, autoimmunity, and immune deficiencies) and give examples
  5. Identify the role and significance of the lymphatic system in immune function
  6. Describe the function of antibodies in our body.
  7. Distinguish between passive and active immunity
  8. Explain the concept of self and non-self, using ABO blood typing and Rh typing

Objective 3

Students will identify causative agents, modes of transmission, symptoms, and treatments available for a broad array of infectious diseases.

Learning Outcomes

Students will be able to:

1. For each infectious disease discussed or mentioned in the notepack, students will identify, compare and contrast:

a. etiological agent (virus, bacteria, protest, etc)

b. mode of transmission (ie. Zoonotic, vector, etc)

c. organ involved

d. symptoms

e. treatment

f. prevention

  1. Characterize and label parts of a virus (adenovirus, bacteriophage, tobacco mosaic virus)
  2. Order and differentiate the steps in viral replication (bacteriophage, enveloped virus, and retrovirus)
  3. Explain the difference between viroids and prions
  4. List the steps of ELISA
  5. Identify examples of seroconversion
  6. Define prokaryotic fission and conjugation
  7. List the steps of bacterial infection
  8. Match the food born bacteria to a common sources
  9. Define enterotoxins and list examples
  10. Match the enzyme system that make the first change to alcohol with the part of the cell that houses it in large quantities
  11. Explain the liver’s role in alcohol metabolism

Objective 4

Students will understand the steps involved in mitosis and meiosis. They will be able to classify genetic diseases that follow Mendelian patterns of inheritance.

Learning outcomes

Students will be able to:

  1. Compare and contrast mitosis and meiosis
  2. Predict the patterns of inheritance using the laws of Mendelian genetics
  3. Calculate the probability of offspring inflicted with an autosomal recessive, autosomal dominant, or X-linked disease
  4. Match genetic diseases with type of inheritance
  5. Use genetic terminology to interpret genotypic and phenotypic results of a monohybrid cross
  6. Characterize diseases based on chromosome abnormalities

Objective 5

Students will develop an understanding of risk factors, prevention and treatments available in the area of cancer research. The students will also learn about drug metabolism and vitamin toxicities.

Learning outcomes

Students will be able to:

  1. Distinguish between types of cancer
  2. Compare and contrast normal and cancer cells
  3. Identify cancer risk factors
  4. List behaviors and screening tests used to prevent cancer
  5. Define cell cycle checkpoints and their role in cell growth and regulation
  6. Explain the steps involved in metastasis and angiogenesis
  7. Distinguish between oncogenes, tumor suppressor genes, and DNA repair genes and their role in cancer
  8. Compare and contrast the pros and cons of various cancer treatment
  9. List and describe the four stages of drug metabolism
  10. Apply the concept of induction to the P450 system. How can this lead to the problems of drug tolerance, synergism, and altering the metabolism of drugs that are metabolized by P-450’s, but do not induce them.
  11. Identify and match antibiotics with their function
  12. Predict what happens in an acetaminophen overdose and the role of glutathione
  13. Differentiate between fat-soluble and water-soluble vitamins
  14. Determine what happens if a vitamin is deficient or taken in excess
  15. List food/drug/herb interactions discussed in lecture

Objective 6

Students will learn about the major "lifestyle" diseases: coronary vascular disease and diabetes. We will explore the environmental factors as well as the genetic and infection- related factors often associated with these diseases.

Learning outcomes

Students will be able to

  1. Label the 4 chambers of the heart, semilunar valves, atrioventricular valves, 3 layers of the heart, major blood vessels discussed in lecture, and the direction of blood flow
  2. Describe the systemic and pulmonary circuits of the heart
  3. Describe the cardiac cycle and blood pressure regulation
  4. Identify the types of cardiovascular disease in terms of symptoms, causes, and treatments available
  5. List the steps and lipoproteins involved in the endogenous and exogenous pathways of lipid transport
  6. Predict possible outcomes of high LDL levels in the blood
  7. Define the relationship between LDL receptors and cholesterol
  8. Distinguish between IDDM and NIDDM
  9. Describe the process of blood glucose regulation (insulin and glucagon)
  10. List the anabolic roles of insulin
  11. Correctly identify terminology associated with heart disease and diabetes

Make-up Exam Reservation Form

BMB 001

Name______

ID #______

Email ______

Local Phone Number ______

Test Missed (circle one) 123456

Documentation: (check one)

______Doctor visit (note from office)

______Other: attach documentation

I affirm that the reason for missing this exam and my documentation are legitimate. I also understand that if it is discovered that I have lied or falsified documentation, I will be brought before the Conduct Standards Board for disciplinary action.

Signature: ______

(Documentation not valid without signature)