Supplementary Table 1 the Recombinant Proteins Or Peptides Expressed in Plants Bioreactors
Supplementary Table 1 The recombinant proteins or peptides expressed in plants bioreactors
Categories of Proteins / Proteins or peptides / Plant Species / Country / ReferenceAntibodies / Hybridoma-derived antibody / Tobacco / USA / (Hiatt, Cafferkey et al. 1989)
Mature heavy chain of a monoclonal antibody / Tobacco / Germany / (During, Hippe et al. 1990)
Immunoglobulin heavy-chain variable (VH) domains / Tobacco / Italy / (Benvenuto, Ordas et al. 1991)
Anti-phytochrome single-chain Fv protein / Tobacco / UK / (Owen, Gandecha et al. 1992)
Single-chain Fv protein / Tobacco / UK / (Firek, Draper et al. 1993)
IgG1 antibody and its derived Fabfragment / Tobacco / Germany / (de Neve, De Loose et al. 1993)
Single-chain variable antibody / Tobacco / Belgium / (Bruyns, De Jaeger et al. 1996)
Antigen-binding MAK33 antibody and Fab fragment / Arabidopsis / Belgium / (De Wilde, De Neve et al. 1996)
Diagnostic monoclonal antibody / Alfalfa / Canada / (Khoudi, Laberge et al. 1999)
Anti-HSV-2 monoclonal IgG / Soybean / USA / (Zeitlin, Olmsted et al. 1998)
Single-chain variable antibody / Tobacco / Italy / (Franconi, Roggero et al. 1999)
Single-chain Fv antibody (ScFvT84.66) against carcinoembryonic antigen (CEA), / Rice / Germany / (Stoger, Vaquero et al. 2000)
Single-chain Fv fragment (scFV) antibody / Pea / Germany / (Perrin, Vaquero et al. 2000)
Fab fragment / Arabidopsis / Belgium / (Peeters, De Wilde et al. 2001)
Single-chain variable antibody / Tobacco / Cuba / (Ramirez, Ayala et al. 2002)
SimpliRED™ HIV diagnostic reagent / Barley,potato, tobacco / Australia / (Schünmann, Coia et al. 2002)
Human IL-4 and IL-6 scFvs / Tobacco / Iran / (Ehsani, Meunier et al. 2003)
Anti-rabies mAb / Tobacco / UK / (Ko, Tekoah et al. 2003)
Unique large single-chain (lsc) antibody / Alga / USA / (Mayfield, Franklin et al. 2003)
Anti-botulinum toxin A neutralizing single-chain Fv recombinant antibody / Tobacco / Canada / (Almquist, McLean et al. 2006)
Humanized anti-West Nile virus mAb / Tobacco / USA / (Lai, Engle et al. 2010)
Antibody specific to microcystin-LR / Tobacco / UK / (Drake, Barbi et al. 2010)
Mouse-human version of mAb 62-71-3 / Tobacco / UK / (Both, van Dolleweerd et al. 2013)
Cytokines / Human epidermal growth factor (hEGF) / Tobacco / Japan / (Higo, Saito et al. 1993)
Erythropoietin / Tobacco / Japan / (Matsumoto, Ikura et al. 1995)
IL-2 / Tobacco / USA / (Magnuson, Linzmaier et al. 1998)
IL-4 / Tobacco / USA / (Magnuson, Linzmaier et al. 1998)
GM-CSF / Tobacco / USA / (James, Wang et al. 2000)
IFN-α2 / Squash,cucumber / Israel / (Arazi, Slutsky et al. 2001)
IFN-α2b / Potato / Japan / (Ohya, Matsumura et al. 2001)
IFNα / Potato / USA / (Mor, Sternfeld et al. 2001)
G-CSF / Tobacco / South Korea / (Hong, Kwon et al. 2002)
GM-CSF / Tobacco / USA / (Lee, Kim et al. 2002)
GM-CSF / Tobacco / Canada / (Sardana, Alli et al. 2002)
IFNα / Tomato / Egypt / (Sawahel 2002)
IL-2 / Potato / South Korea / (Park and Cheong 2002)
TNF-α / Potato / Japan / (Ohya, Itchoda et al. 2002)
IL-2 / Potato / Korea / (Park and Cheong 2002)
GM-CSF / Rice / South Korea / (Shin, Hong et al. 2003)
IL-12 / Tobacco / South Korea / (Kwon, Seo et al. 2003)
IL-18 / Tobacco / China / (Zhang, Yang et al. 2003)
IFNγ / Rice / China / (Chen, Lin et al. 2004)
IL-10 / Tobacco / Canada / (Menassa, Kennette et al. 2004)
IL-12 / Tobacco / Mexico / (Gutiérrez-Ortega, Avila-Moreno et al. 2004)
Human epidermal growth factor（hEGF） / Tobacco / Argentina / (Wirth, Calamante et al. 2004)
Insulin-like growth factor / Tobacco,Rice / Canada / (Panahi, Alli et al. 2004)
GM-CSF / Sugarcane / USA / (Wang, Goldstein et al. 2005)
IL-12 / Tomato / Mexico / (Gutiérrez-Ortega, Sandoval-Montes et al. 2005)
IL-4 / Tobacco / Canada / (Ma, Huang et al. 2005)
GM-CSF / Tobacco / USA / (Zhou, Wang et al. 2006)
Basic fibroblast growth factor / Soybean / China / (Ding, Huang et al. 2006)
Insulin-like growth factor / Arabidopsis / Canada / (Nykiforuk, Boothe et al. 2006)
Macrophage colony-stimulating factor / Tobacco / China / (Zheng, Yang et al. 2006)
GM-CSF / Tobacco / Canada / (Sardana, Dudani et al. 2007)
IFN-α2b / Tobacco / USA / (Arlen, Falconer et al. 2007)
IFNβ / Lettuce / China / (Li, Chen et al. 2007)
IL-10 / Tobacco / Canada / (Patel, Zhu et al. 2007)
IL-4 / Tobacco / Canada / (Patel, Zhu et al. 2007)
Human epidermal growth factor (hEGF) / Tobacco / China / (Bai, Zeng et al. 2007)
Human granulocyte-macrophage colony-stimulating factor / Rice / Canada / (Sardana, Dudani et al. 2007)
cardiotrophin-1 / Tobacco / Spain / (Farran, Río-Manterola et al. 2008)
Chicken IFN-α / Lettuce / China / (Song, Zhao et al. 2008)
Fibroblast growth factor 8 isoform b (FGF8b) / Tobacco / India / (Potula, Kathuria et al. 2008)
GM-CSF / Rice / South Korea / (Kim, Kim et al. 2008)
GM-CSF / Rice / China / (Ning, Xie et al. 2008)
IL-13 / Tobacco / Canada / (Wang, Brandsma et al. 2008)
Insulin like growth factor 1 (IGF-1) / Rice / China / (Xie, Qiu et al. 2008)
IL-10 / Tobacco / Italy / (Bortesi, Rossato et al. 2009)
Insulin like growth factor 1 (IGF-1) / Tobacco / USA / (Daniell, Ruiz et al. 2009)
Fish IFN-α1 / Rice / Japan / (Fukuzawa, Tabayashi et al. 2010)
IL-10 / Rice / Japan / (Fujiwara, Aiki et al. 2010)
Murine GM-CSF / Tobacco / Poland / (Góra-Sochacka, Redkiewicz et al. 2010)
IFN-α2b / Carrot / Ukarine / (Luchakivskaya, Kishchenko et al. 2011)
Murine IL-2 / Arabidopsis,tobacco / Italy / (Morandini, Avesani et al. 2011)
Human Growth Hormone / Soybean / Brazil / (Cunha, Murad et al. 2011)
Humanasic fibroblast growth factor / Rice / China / (An, Ou et al. 2013)
Other proteins / Human Growth Hormone / Tobacco / Australia / (Barta, Sommergruber et al. 1986)
Human muscarinic cholinergic receptors / Tobacco / USA / (Mu, Chua et al. 1997)
Human lactotransferrin / Potato / USA / (Chong and Langridge 2000)
Human lactoferrin / Rice / USA / (Nandi, Suzuki et al. 2002)
Gastric intrinsic factor / Arabidopsis / Denmark / (Fedosov, Laursen et al. 2003)
Glutamic acid decarboxylase / Tobacco / Italy / (Avesani, Falorni et al. 2003)
Human Lysozyme / Rice / USA / (Yang, Guo et al. 2003)
Human acid β-glucosidase / Tobacco / Italy / (Reggi, Marchetti et al. 2005)
Thrombomodulin / Tobacco / Germany / (Schinkel, Schiermeyer et al. 2005)
Glucagon-like peptide / Rice / Japan / (Yasuda, Tada et al. 2005)
Human bone morphogenetic protein-2 / Tobacco / China / (Suo, Chen et al. 2006)
Human coagulation factor IX / Tomato / China / (Zhang, Zhao et al. 2007)
Human a-1-antitrypsin / Tomato / India / (Agarwal, Singh et al. 2008)
Human apolipoprotein / Tobacco / Italy / (Chiaiese, Minutolo et al. 2011)
Human serum albumin / Rice / China / (He, Ning et al. 2011)
Human apolipoprotein / Safflower / Canada / (Nykiforuk, Shen et al. 2011)
Human alpha-antitrypsin / Rice / China / (Zhang, Shi et al. 2012)
Vaccines / Hepatitis B surface antigen / Tobacco / USA / (Mason, Lam et al. 1992)
E. coli heat-labile enterotoxin / Potato / USA / (Haq, Mason et al. 1995)
Glycoprotein (G-protein) coats the outer surface of the rabies virus / Tomato / USA / (McGarvey, Hammond et al. 1995)
Hepatitis B surface antigen / Tobacco / USA / (Thanavala, Yang et al. 1995)
Norwalk virus capsid protein / Potato / USA / (Mason, Ball et al. 1996)
Cholera toxin B subunit oligomers / Potato / USA / (Arakawa, Chong et al. 1997)
Hepatitis B surface antigen / Potato / Iran / (Ehsani, Khabiri et al. 1997)
Foot-and-mouth disease virus with VP1 / Arabidopsis / Argentina / (Carrillo, Wigdorovitz et al. 1998)
Immunogenic glycoprotein S polypeptides / Arabidopsis / Spain / (Gomez, Carrillo et al. 1998)
E. coli heat-labile enterotoxin / Potato / USA / (Mason, Haq et al. 1998)
VP60 of rabbit hemorrhagic disease virus (RHDV) / Potato / Spain / (Castanon, Marin et al. 1999)
Hepatitis B surface antigen / Lupin, lettuce / USA / (Kapusta, Modelska et al. 1999)
Human cytomegalovirus glycoprotein B (UL55) / Tobacco / Canada / (Tackaberry, Dudani et al. 1999)
Immunogenic glycoprotein S polypeptides / Potato / Spain / (Gomez, Wigdorovitz et al. 2000)
Respiratory syncytial virus-F protein / Tomato / USA / (Sandhu, Krasnyanski et al. 2000)
Immunogenic glycoprotein S polypeptides / Tobacco / Canada / (Tuboly, Yu et al. 2000)
Virus-specific antibody response to foot and mouth disease virus / Potato / Argentina / (Carrillo, Wigdorovitz et al. 2001)
Peptide vaccine of virulent canine parvovirus / Arabidopsis / Spain / (Gil, Brun et al. 2001)
Measles virus hemagglutinin protein / Tobacco / Australia / (Huang, Dry et al. 2001)
Mannheimia haemolytica A1 leukotoxin 50 fusion protein / Trifolium repens / Canada / (Lee, Strommer et al. 2001)
Human acetylcholinesterase / Tomato / USA / (Mor, Sternfeld et al. 2001)
Transmissible gastroenteritis virus (TGEV) glycoprotein / Maize / Netherlands / (Streatfield, Jilka et al. 2001)
Rotavirus enterotoxin and enterotoxigenic Escherichia coli fimbrial antigen genes / Potato / USA / (Yu and Langridge 2001)
Bacillus anthracis protective antigen / Tobacco / India / (Aziz, Singh et al. 2002)
Heat labile enterotoxin (LT-) B subunit of Escherichia coli / Maize / USA / (Chikwamba, Cunnick et al. 2002)
Virus-specific antibody response to foot and mouth disease virus / Alfalfa / Argentina / (Dus Santos, Wigdorovitz et al. 2002)
Cholera toxin B subunit / Tomato / India / (Jani, Meena et al. 2002)
Immunogenic VP6 protein / Potato / Japan / (Matsumura, Itchoda et al. 2002)
Measles virus hemagglutinin protein / Tobacco / Australia / (Webster, Cooney et al. 2002)
Papillomavirus virus-like particles / Tobacco Potato / Germany / (Biemelt, Sonnewald et al. 2003)
HBVsAG / Cherry / China / (Gao, Ma et al. 2003)
Hemagglutinin protein of rinderpest virus / Peanut / India / (Khandelwal, Lakshmi Sita et al. 2003)
Cholera toxin B subunit full-length rotavirus NSP4 fusion protein / Potato / Korea / (Kim and Langridge 2003)
Measles virus hemagglutinin protein / Carrot / Luxembourg / (Marquet-Blouin, Bouche et al. 2003)
Hepatitis B surface antigen HBsAG-VSPαS / Tobacco / USA / (Sojikul, Buehner et al. 2003)
Tetanus toxin Fragment C / Tobacco / USA / (Tregoning, Nixon et al. 2003)
B subunit of E. coli heat-labile enterotoxin as a fusion protein / Tomato / USA / (Walmsley, Alvarez et al. 2003)
Papilloma virus capsid protein / Potato / USA / (Warzecha, Mason et al. 2003)
Rotavirus capsid glycoprotein VP7 / Potato / China / (Wu, Li et al. 2003)
Cholera toxin B subunit / Tobacco / India / (Jani, Singh et al. 2004)
Hepatitis B surface antigen / Potato / Korea / (Joung, Youm et al. 2004)
Virulent canine parvovirus fused with the cholera toxin B subunit (CTB) / Tobacco / Spain / (Molina, Hervas-Stubbs et al. 2004)
Enterotoxigenic E. coli heat-labile toxin B subunit and a tuberculosis antigen / Arabidopsis / USA / (Rigano, Alvarez et al. 2004)
Edible peptide vaccine / Alfalfa / USA / (Wigdorovitz, Mozgovoj et al. 2004)
Rabies virus glycoprotein RGP / Tobacco / India / (Ashraf, Singh et al. 2005)
VP6 protein of human group A rotavirus / Alfalfa / China / (Dong, Liang et al. 2005)
Hepatitis B surface antigen / Tobacco / USA / (Huang, Elkin et al. 2005)
Yersinia pestis F1-V fusion protein / Tomato / USA / (Alvarez, Pinyerd et al. 2006)
Bluetongue VP2 gene / Peanut / India / (Athmaram, Bali et al. 2006)
Cholera toxin B subunit / Tobacco / India / (Mishra, Yadav et al. 2006)
Smallpox subunit vaccine / Tobacco / USA / (Golovkin, Spitsin et al. 2007)
Recombinant HIV-1/HBV virus-like particles / Tobacco / France / (Greco, Michel et al. 2007)
Synthetic peptides (KETc1, KETc12, KETc7) / Pawpaw / Mexico / (Hernandez, Cabrera-Ponce et al. 2007)
Cholera toxin B subunit / Tomato / China / (Jiang, He et al. 2007)
Papilloma virus capsid protein / Arabidopsis / South Africa / (Kohl, Hitzeroth et al. 2007)
HBV PRS-S1S2S / Tomato / China / (Lou, Yao et al. 2007)
Heat labile enterotoxin (LT-) B subunit of Escherichia coli / Soybean / USA / (Moravec, Schmidt et al. 2007)
Cholera toxin B subunit / Rice / Japan / (Nochi, Takagi et al. 2007)
Human immunodeficiency virus type 1 tat / Tomato / Mexico / (Ramirez, Tasciotti et al. 2007)
Epitopes of the diphtheria, pertussis and tetanus exotoxins / Tomato / Spain / (Soria-Guerra, Rosales-Mendoza et al. 2007)
NDV envelopefusion glycoprotein / Rice / China / (Yang, Liu et al. 2007)
Hepatitis B surface antigen / Potato / Korea / (Youm, Won et al. 2007)
Yersinia pestis F1-V fusion protein / Tobacco / USA / (Arlen, Singleton et al. 2008)
Type II-collagen tolerogenic peptide / Rice / Japan / (Hashizume, Hino et al. 2008)
Cholera toxin B subunit / Tomato / China / (He, Jiang et al. 2008)
Cholera toxin B subunit / Rice / Hungary / (Oszvald, Kang et al. 2008)
Heat labile enterotoxin (LT-) B subunit of Escherichia coli / Carrot / USA / (Rosales-Mendoza, Soria-Guerra et al. 2008)
Cholera toxin B subunit / Tomato / India / (Sharma, Jani et al. 2008)
Synthetic cry1EC gene for resistance against Spodoptera litura / Peanut / India / (Tiwari, Mishra et al. 2008)
Cholera toxin B subunit full-length rotavirus NSP4 fusion protein / Tomato / Korea / (Youm, Jeon et al. 2008)
E. coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin / Tobacco / USA / (Rosales-Mendoza, Alpuche-Solis et al. 2009)
Avian flu H5/HA1 variants / Tobacco / USA / (Spitsin, Andrianov et al. 2009)
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